Gladys Mirey

Gladys Mirey, Team Leader, Genotoxicity & Signaling, Toxalim INRAE
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Identifiants chercheurs

Présentation

Gladys Mirey currently works at the French National Institute for Agricultural Research (INRA), Toulouse-France. Gladys does research in Cell Biology, genotoxicology and current projects are linked to 'food toxicology.'


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Publications

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Molecular Dynamics and Quantum Chemical Insights into the Molecular Basis of Differential Toxicity of the Mycotoxin Deoxynivalenol (DON) and Its Microbial Derivatives DOM-1 and 3-epi-DON

Kanhaya Lal , Julien Vignard , Gladys Mirey , Franck Jolibois , Isabelle P Oswald et al.

ACS Omega, 2026, 11 (6), pp.9575-9586. ⟨10.1021/acsomega.5c09756⟩

Article dans une revue hal-05495502v1
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Genotoxic interaction between deoxynivalenol and acrylamide

Chloé Huertas , Aboubacar B Coulibaly , Delphine Payros , Marie Penary , Sylvie Puel et al.

Food Research International, 2025, 214, pp.116633. ⟨10.1016/j.foodres.2025.116633⟩

Article dans une revue hal-05076454v1

Effect of cell treatment procedures on in vitro genotoxicity assessment

Cynthia Recoules , Gladys Mirey , Marc Audebert

Archives of Toxicology, 2024, 98 (4), pp.1225-1236. ⟨10.1007/s00204-024-03690-w⟩

Article dans une revue hal-04675612v1
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Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium

Julien Vignard , Aurelie Pettes-Duler , Eric Gaultier , Christel Cartier , Laurent Weingarten et al.

Nanotoxicology, 2023, 17 (4), pp.289-309. ⟨10.1080/17435390.2023.2210664⟩

Article dans une revue hal-04104748v1
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Mutagenicity and genotoxicity assessment of the emerging mycotoxin Versicolorin A, an Aflatoxin B1 precursor

Carine Al-Ayoubi , Maria Alonso-Jauregui , Amaya Azqueta , Julien Vignard , Gladys Mirey et al.

Environmental Pollution, 2023, 335, pp.122276. ⟨10.1016/j.envpol.2023.122276⟩

Article dans une revue hal-04202803v1
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Dairy By-Products and Lactoferrin Exert Antioxidant and Antigenotoxic Activity on Intestinal and Hepatic Cells

Inés Abad , Julien Vignard , Catherine Bouchenot , Dimitra Graikini , Laura Grasa et al.

Foods, 2023, 12 (10), pp.2073. ⟨10.3390/foods12102073⟩

Article dans une revue hal-04112315v1
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Cytolethal Distending Toxin Promotes Replicative Stress Leading to Genetic Instability Transmitted to Daughter Cells

William Tremblay , Florence Mompart , Elisa Lopez , Muriel Quaranta , Valérie Bergoglio et al.

Frontiers in Cell and Developmental Biology, 2021, 9, pp.1-15. ⟨10.3389/fcell.2021.656795⟩

Article dans une revue hal-03248449v1
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Repeated exposure of Caco-2 versus Caco-2/HT29-MTX intestinal cell models to (nano)silver in vitro: Comparison of two commercially available colloidal silver products

Kevin Gillois , Charlotte Stoffels , Mathilde Lévêque , Isabelle Fourquaux , Justine Blesson et al.

Science of the Total Environment, 2021, 754, ⟨10.1016/j.scitotenv.2020.142324⟩

Article dans une revue hal-02945727v1
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Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response

Benoît J Pons , Aurélie Pettes-Duler , Claire Naylies , Frédéric Taieb , Catherine Bouchenot et al.

Cellular and Molecular Life Sciences, 2021, 78 (17-18), pp.6319-6335. ⟨10.1007/s00018-021-03902-x⟩

Article dans une revue hal-03306242v1
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Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B

Benoît Pons , Nicolas Loiseau , Saleha Hashim , Souria Tadrist , Gladys Mirey et al.

Toxins, 2020, 12 (9), pp.530. ⟨10.3390/toxins12090530⟩

Article dans une revue hal-02927138v1
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Cell transfection of purified cytolethal distending toxin B subunits allows comparing their nuclease activity while plasmid degradation assay does not

Benoît Pons , Elisabeth Bezine , Mélissa Hanique , Valerie Guillet , Lionel Mourey et al.

PLoS ONE, 2019, 14 (3), pp.e0214313. ⟨10.1371/journal.pone.0214313⟩

Article dans une revue hal-02346660v1
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Exposure to the fungicide captan induces DNA base alterations and replicative stress in mammalian cells

Anne Fernandez-Vidal , Liana C. Arnaud , Manon Maumus , Marianne Chevalier , Gladys Mirey et al.

Environmental and Molecular Mutagenesis, 2019, 60 (3), pp.286-297. ⟨10.1002/em.22268⟩

Article dans une revue hal-02620276v1
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Cytolethal distending toxin subunit B: A review of structure–function relationship

Benoît Pons , Julien Vignard , Gladys Mirey

Toxins, 2019, 11 (10), 20 p. ⟨10.3390/toxins11100595⟩

Article dans une revue hal-02618477v1
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<em>Campylobacter jejuni</em> promotes colorectal tumorigenesis through the action of cytolethal distending toxin

Zhen He , Raad Z. Gharaibeh , Rachel C. Newsome , Jllian L. Pope , Michael W. Dougherty et al.

Gut, 2019, 68 (2), pp.289-300. ⟨10.1136/gutjnl-2018-317200⟩

Article dans une revue hal-02627995v1

Genotoxicity and mutagenicity assessment of food contaminant mixtures present in the French diet

Benjamin Kopp , Julien Vignard , Gladys Mirey , Valérie Fessard , Daniel Zalko et al.

Environmental and Molecular Mutagenesis, 2018, 59 (8), pp.1-13. ⟨10.1002/em.22214⟩

Article dans une revue anses-01880114v1
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The colibactin genotoxin generates DNA interstrand cross-links in infected cells

Nadège Bossuet-Greif , Julien Vignard , Frederic Taieb , Gladys Mirey , Damien Dubois et al.

mBio, 2018, 9 (2), pp.e02393-17. ⟨10.1128/mBio.02393-17⟩

Article dans une revue hal-02627565v1

Use of a reliable metabolically competent human rghep(+) hepatocyte model engineered with biological tracers for in vitro micronucleus test associating high-content imaging<strong></strong>

Vanessa Graillot , Thibault Metenier , Odile Mondésert , Julien Vignard , Valérie Lobjois et al.

Drug Metabolism and Pharmacokinetics, 2018, 33 (1), pp.S59. ⟨10.1016/j.dmpk.2017.11.200⟩

Article dans une revue hal-02618768v1
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Around and beyond 53BP1 nuclear bodies

Anne Fernandez-Vidal , Julien Vignard , Gladys Mirey

International Journal of Molecular Sciences, 2017, 18 (12), ⟨10.3390/ijms18122611⟩

Article dans une revue hal-02619788v1
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Cell resistance to the cytolethal distending toxin involves an association of DNA repair mechanisms

Elisabeth Bezine , Yann Malaisé , Aurore Loeuillet , Marianne Chevalier , Elisa Boutet-Robinet et al.

Scientific Reports, 2016, 6, pp.1-15. ⟨10.1038/srep36022⟩

Article dans une revue hal-01602345v1

A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging

Vanessa Graillot , Odile Mondésert , Thibault Metenier , Julien Vignard , Valerie Lobjois et al.

Toxicology Letters, 2016, 258, pp.S146. ⟨10.1016/j.toxlet.2016.06.1566⟩

Article dans une revue istex hal-01602870v1
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Genotoxicity of cytolethal distending toxin (cdt) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis

Vanessa Graillot , Inge Dormoy , Jacques Dupuy , Jerry W. Shay , Laurence Huc et al.

Frontiers in Cellular and Infection Microbiology, 2016, 6, pp.1-13. ⟨10.3389/fcimb.2016.00034⟩

Article dans une revue hal-02635460v1

Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells

Denis Jullien , Julien Vignard , Yoann Fedor , Nicolas Béry , Aurélien Olichon et al.

Development (Cambridge, England), 2016, 143 (14), ⟨10.1242/dev.141804⟩

Article dans une revue hal-01602858v1
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Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells

Denis Jullien , Julien Vignard , Yoann Fedor , Nicolas Béry , Aurélien Olichon et al.

Journal of Cell Science, 2016, 129 (13), pp.2673-2683. ⟨10.1242/jcs.183103⟩

Article dans une revue hal-01602848v1
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DNA damage in B and T lymphocytes of farmers during onepesticide spraying season

Pierre Lebailly , Gladys Mirey , Fabrice Herin , Yannick Lecluse , Bernard Salles et al.

International Archives of Occupational and Environmental Health, 2015, 88 (7), pp.963-972. ⟨10.1007/s00420-015-1024-3⟩

Article dans une revue hal-01188319v2
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The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective.

Elisabeth Bezine , Julien Vignard , Gladys Mirey

Cells, 2014, 3 (2), pp.592-615. ⟨10.3390/cells3020592⟩

Article dans une revue hal-01192559v1
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Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells

Laëtitia Trapp-Fragnet , Djihad Bencherit , Danièle Chabanne-Vautherot , Yves Le Vern , Sylvie Rémy et al.

PLoS ONE, 2014, 9 (6), pp.1-14. ⟨10.1371/journal.pone.0100004⟩

Article dans une revue hal-02641216v1

RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex

Raghavendra A. Shamanna , Dharmendra Kumar Singh , Huiming Lu , Gladys Mirey , Guido Keijzers et al.

Carcinogenesis, 2014, 35 (11), pp.2415 - 2424. ⟨10.1093/carcin/bgu137⟩

Article dans une revue hal-02631395v1

Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up

Julien Vignard , Gladys Mirey , Bernard Salles

Radiotherapy & Oncology, 2013, 108 (3), pp.362-369. ⟨10.1016/j.radonc.2013.06.013⟩

Article dans une revue hal-02648277v1

From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin

Yoann Fedor , Julien Vignard , Marie-Laure Travers , Elisa Boutet-Robinet , Claude Watrin et al.

Cellular Microbiology, 2013, 15 (1), pp.1 - 15. ⟨10.1111/cmi.12028⟩

Article dans une revue hal-02647902v1

CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis.

Gladys Mirey , Isabelle Chartrain , Carine Froment , Muriel Quaranta , Jean-Pierre Bouché et al.

Cell Cycle, 2005, 4 (6), pp.806-11. ⟨10.4161/cc.4.6.1716⟩

Article dans une revue hal-00317422v1

The WASP/Las17p-interacting protein Bzz1p functions with Myo5p in an early stage of endocytosis.

A. Soulard , S. Friant , C. Fitterer , C. Orange , G. Kaneva et al.

Protoplasma, 2005, 226 (1-2), pp.89-101. ⟨10.1007/s00709-005-0108-4⟩

Article dans une revue istex hal-00153221v1

SH3 domain-containing proteins and the actin cytoskeleton in yeast.

Gladys Mirey , A. Soulard , C. Orange , S. Friant , B. Winsor

Biochemical Society Transactions, 2005, 33 (Pt 6), pp.1247-9. ⟨10.1042/BST20051247⟩

Article dans une revue hal-00153215v1

The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development

Young-Han Song , Gladys Mirey , Martha Betson , Daniel A Haber , Jeffrey Settleman

Current Biology, 2004, 14 (15), pp.1354-1359. ⟨10.1016/j.cub.2004.06.064⟩

Article dans une revue hal-02683413v1
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Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

Stéphanie Dutertre , Martine Cazales , Muriel Quaranta , Christine Dozier , Gladys Mirey et al.

Journal of Cell Science, 2004, 117 (Pt 12), pp.2523-31. ⟨10.1242/jcs.01108⟩

Article dans une revue hal-00317440v1
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Ral GTPases regulate exocyst assembly through dual subunit interactions

Serge Moskalenko , Chao Tong , Carine Rossé , Gladys Mirey , Etienne Formstecher et al.

Journal of Biological Chemistry, 2003, 278 (51), pp.51743-51748. ⟨10.1074/jbc.M308702200⟩

Article dans une revue hal-02679145v1
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Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site

Helen R Mott , Daniel Nietlispach , Louise J Hopkins , Gladys Mirey , Jacques H Camonis et al.

Journal of Biological Chemistry, 2003, 278 (19), pp.17053-17059. ⟨10.1074/jbc.M300155200⟩

Article dans une revue hal-02683415v1
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A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways

Gladys Mirey , Maria Balakireva , Sébastien L'Hoste , Carine Rossé , Stéphanie Voegeling et al.

Molecular and Cellular Biology, 2003, 23 (3), pp.1112-1124. ⟨10.1128/MCB.23.3.1112-1124.2003⟩

Article dans une revue hal-02681953v1

p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families

Ja Garcia-Ranea , Gladys Mirey , Jacques Camonis , Alfonso Valencia

FEBS Letters, 2002, 529 (2-3), pp.162-167. ⟨10.1038/ncb728⟩

Article dans une revue hal-02683416v1
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RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis

Viviana Jullien-Flores , Yannick Mahe , Gladys Mirey , Corinne Leprince , Brigitte Meunier-Bisceuil et al.

Journal of Cell Science, 2000, 113 (16), pp.2837-2844

Article dans une revue hal-02696179v1

Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family

Béatrice Vayssière , Gérard Zalcman , Yannick Mahe , Gladys Mirey , Tanja Ligensa et al.

FEBS Letters, 2000, 467 (1), pp.91-96. ⟨10.1016/S0014-5793(99)01530-6⟩

Article dans une revue istex hal-02695354v1

Effector recognition by the small GTP-binding proteins Ras and Ral

Bettina Bauer , Gladys Mirey , Ingrid R Vetter , Ja García-Ranea , A Valencia et al.

Journal of Biological Chemistry, 1999, 274 (25), pp.17763-17770. ⟨10.1074/jbc.274.25.17763⟩

Article dans une revue hal-02696131v1
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Biotraceur chromatinien pour l'étude de la génotoxicité dans des cellules hépatiques métaboliquement compétentes.

Gladys Mirey

32. Journée Chimie-Biologie-Santé, Apr 2018, Toulouse, France

Communication dans un congrès hal-02787706v1

HepaRG hep+ and biological tracers for a new in vitro micronucleus assay in living cells

Gladys Mirey

AlterTox Academy, May 2018, Paris, France

Communication dans un congrès hal-02790937v1

Contaminants alimentaires et cancers

Gladys Mirey

33. Journées Scientifiques de l’Association Française d’Etude et de Recherche sur l’Obésité (AFERO), Jan 2017, Toulouse, France

Communication dans un congrès hal-01601087v1

A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging

Gladys Mirey

ANSES, Journée de la plateforme ASPiC, Nov 2017, Maisons-Alfort, France

Communication dans un congrès hal-02787835v1

In vitro micronucleus test in living cells associating biological tracers and high-content imaging

Gladys Mirey , Vanessa Graillot , Odile Mondésert , Thibault Metenier , Julien Vignard et al.

53. Congress of the European-Societies-of-Toxicology (EUROTOX), Sep 2017, Bratislava, Slovakia. pp.1, ⟨10.1016/j.toxlet.2017.08.072⟩

Communication dans un congrès hal-02735959v1

HepaRG hep+ and biological tracers for a new in vitro micronucleus assay

Gladys Mirey

CAAT Academy, Jun 2017, Rennes, France

Communication dans un congrès hal-01601121v1

Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells

Gladys Mirey

Les Avancées Scientifiques de la Recherche Biomedicale Toulousaine, Centre de la Recherche en Cancérologie. FRA., Nov 2016, Toulouse, France

Communication dans un congrès hal-02792179v1

A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging

Gladys Mirey , D.M. Steen , Vanessa Graillot

47. Annual Meeting of the Environmental Mutagenesis and Genomics Society, Sep 2016, Kansas City, United States

Communication dans un congrès hal-01603644v1

Chromatibody, a novel non-invasive biotracer to explore and manipulate chromatin in living cells

Gladys Mirey

7. Biosensor Group Meeting, Jun 2017, Toulouse, France

Communication dans un congrès hal-01562312v1

L’analyse des voies de réparation nous renseigne sur les dommages à l’ADN induits par la toxine CDT

Elisabeth Bezine , Julien Vignard , Yann Malaisé , Aurore Loeuillet , Elisa Boutet-Robinet et al.

Journée des doctorants de l'INRA Toxalim, Jun 2015, Toulouse, France

Communication dans un congrès hal-02800134v1

The bacterial cytolethal distending Toxin induces indirect double-strand breaks into eukaryotic cells

Elisabeth Bezine , Julien Vignard , Marianne Chevalier , Elisa Boutet-Robinet , Bernard Salles et al.

Journée de l’ecole Doctorale SEVAB, Mar 2015, Toulouse, France

Communication dans un congrès hal-02796083v1

In vivo genotoxic effects of dietary heme iron on rat colon mucosa and ex vivo effects on colon cells monitored by an optimized alkaline comet assay

Océane Martin , Marianne Chevalier , Sylviane Taché , Nathalie Naud , Bernard Salles et al.

11th International Comet Assay Workshop, Sep 2015, Antwerp, Belgium

Communication dans un congrès hal-02792818v1

VHH-based universal histone binding domains: novel tools for a different look on and manipulation of chromatin

Denis Jullien , Julien Vignard , Yoann Fedor , Aurélien Olichon , Bernard Salles et al.

FEBS EMBO 2014 Conférence, Aug 2014, Paris, France. 823 p

Communication dans un congrès hal-02741249v1

Nanobody-based universal histone binding domains for chromatin imaging and editing

Denis Jullien , Julien Vignard , Yoann Fedor , Aurélien Olichon , Michèle Crozatier et al.

4. Biosensor Meeting of the Biosensor Group of the GDR 2588 Microscopie et Imagerie du Vivant, May 2014, Bordeaux, France

Communication dans un congrès hal-02793548v1

Cell cycle modulation by Marek's Disease Virus: the tegument protein VP22 trigers S Phase arrest and DNA damage in proliferating cells

Laëtitia Trapp-Fragnet , Danièle Vautherot , Yves Le Vern , Sylvie Rémy , Elisa Boutet-Robinet et al.

5. European Congress of Virology, European Society for Virology., Sep 2013, Lyon, France. 305 p

Communication dans un congrès hal-02744756v1

Genotoxicity and repair: the cytolethal distending toxin model

Elisabeth Bezine , Yoann Fedor , Julien Vignard , Elisa Boutet-Robinet , Bernard Salles et al.

4? workshop "Genome, Structure and Functions", Hôpital Rangueil. FRA., Apr 2013, Toulouse, France

Communication dans un congrès hal-02809832v1

Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells

Laëtitia Trapp-Fragnet , Danièle Vautherot , Yves Le Vern , Sylvie Rémy , Elisa Boutet-Robinet et al.

4. ESVV Veterinary Herpesvirus Symposium, European Society for Veterinary Virology (ESVV)., Jan 2013, Zurich, Switzerland

Communication dans un congrès hal-02749312v1

Développement de nouveaux outils de détection non-invasive des cassures double brin de l’ADN

Denis Jullien , Julien Vignard , Gladys Mirey , Bernard Ducommun

Réunion du groupe Biosenseur GDR2588, Groupe Biosenseur GDR2588., Mar 2012, Montpellier, France

Communication dans un congrès hal-02807599v1

Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells

Laëtitia Trapp-Fragnet , Danièle Vautherot , Yves Le Vern , Sylvie Sylvie Rémy , Elisa Boutet-Robinet et al.

9. International Symposium on Marek's Disease and Avian Herpesviruses, Jun 2012, Berlin, Germany. pp.28

Communication dans un congrès hal-02748181v1

Régulation du cycle cellulaire de la maladie de Marek : implication de la protéine de tégument VP22 dans l'arrêt prolifératif en phase-S.

Laëtitia Trapp-Fragnet , Danièle Vautherot , Yves Le Vern , Sylvie Rémy , Jean-François Vautherot et al.

Journée scientifique de l'Association HerPAS, Association Herpesvirus et Pathologies Associées (HerPAs). FRA., Mar 2012, Paris, France. 1 p

Communication dans un congrès hal-02811446v1

A diagnostic tool to assess genotoxic activity ex vivo

Yoann Fedor , Aurélien Olichon , F. Favre , Bernard Ducommun , Bernard Salles et al.

47. Congress of the European Societies of Toxicology (EUROTOX), 2011, Paris, France. pp.S36-S36

Communication dans un congrès hal-02745572v1

Détection des cassures double brin en temps réel : un nouvel outil

Yoann Fedor , A. Olichon , G. Favre , B. Ducommun , Bernard Salles et al.

9e colloque des 3R, Ville service., May 2011, Giens, Belgique

Communication dans un congrès hal-02806589v1