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Guillaume Dalmasso

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ATG16L1 in myeloid cells limits colorectal tumor growth in Apc Min/+ mice infected with colibactin-producing Escherichia coli via decreasing inflammasome activation

Laurène Salesse , Angéline Duval , Pierre Sauvanet , Alison da Silva , Nicolas Barnich
Autophagy, 2024, pp.1 - 19. ⟨10.1080/15548627.2024.2359770⟩
Journal articles hal-04654209v1
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Colibactin-producing Escherichia coli enhance resistance to chemotherapeutic drugs by promoting epithelial to mesenchymal transition and cancer stem cell emergence

Guillaume Dalmasso , Antony Cougnoux , Tiphanie Faïs , Virginie Bonnin , Benoit Mottet-Auselo
Gut microbes, 2024, 16 (1), pp.2310215. ⟨10.1080/19490976.2024.2310215⟩
Journal articles hal-04530484v1
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Identification of autophagy receptors for the Crohn’s disease-associated adherent-invasive Escherichia coli

Alison da Silva , Guillaume Dalmasso , Anaïs Larabi , My Hanh Thi Hoang , Elisabeth Billard
Frontiers in Cellular and Infection Microbiology, 2024, 14, ⟨10.3389/fcimb.2024.1268243⟩
Journal articles hal-04654189v1
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Genes mcr improve the intestinal fitness of pathogenic E. coli and balance their lifestyle to commensalism

Guillaume Dalmasso , Racha Beyrouthy , Sandrine Brugiroux , Etienne Ruppé , Laurent Guillouard
Microbiome, 2023, 11 (1), pp.12. ⟨10.1186/s40168-022-01457-y⟩
Journal articles pasteur-04086913v1

Colibactin-producing Escherichia coli induce the formation of invasive carcinomas in a chronic Inflammation-associated mouse model

Laurène Salesse , Cécily Lucas , My Hanh Thi Hoang , Pierre Sauvanet , Alexandra Rezard
Cancers, 2021, 13 (9), pp.1-16. ⟨10.3390/cancers13092060⟩
Journal articles hal-03318625v1

Propionate catabolism by CD-associated adherent-invasive E. coli counteracts its anti-inflammatory effect

Allison Agus , Damien Richard , Tiphanie Faïs , Emilie Vazeille , Mélissa Chervy
Gut microbes, 2021, 13 (1), pp.1-19. ⟨10.1080/19490976.2020.1839318⟩
Journal articles hal-03262359v1
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel Klionsky , Amal Kamal Abdel-Aziz , Sara Abdelfatah , Mahmoud Abdellatif , Asghar Abdoli
Autophagy, 2021, 17 (1), pp.1-382. ⟨10.1080/15548627.2020.1797280⟩
Journal articles inserm-03285572v1
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Differential miRNA-Gene Expression in M Cells in Response to Crohn’s Disease-Associated AIEC

Anaïs Larabi , Laurène Salesse , Charlotte Cordonnier , Lucie Etienne-Mesmin , Nicolas Barnich
Microorganisms, 2020, 8 (8), pp.1205. ⟨10.3390/microorganisms8081205⟩
Journal articles hal-02935826v1

Exosomes transfer miRNAs from cell-to-cell to inhibit autophagy during infection with Crohn’s disease-associated adherent-invasive E. coli

Anaïs Larabi , Guillaume Dalmasso , Julien Delmas , Nicolas Barnich , Hang Thi Thu Nguyen
Gut microbes, 2020, 11 (6), pp.1677-1694. ⟨10.1080/19490976.2020.1771985⟩
Journal articles hal-03001063v1
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Pathogenicity Factors of Genomic Islands in Intestinal and Extraintestinal Escherichia coli

Mickaël Desvaux , Guillaume Dalmasso , Racha Beyrouthy , Nicolas Barnich , Julien Delmas
Frontiers in Microbiology, 2020, 11, ⟨10.3389/fmicb.2020.02065⟩
Journal articles hal-02948743v1

Carbapenem Resistance Conferred by OXA-48 in K2-ST86 Hypervirulent Klebsiella pneumoniae , France

Racha Beyrouthy , Guillaume Dalmasso , Aurélien Birer , Frédéric Robin , Richard Bonnet
Emerging Infectious Diseases, 2020, 26 (7), pp.1529-1533. ⟨10.3201/eid2607.191490⟩
Journal articles hal-03043001v1
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Autophagy of Intestinal Epithelial Cells Inhibits Colorectal Carcinogenesis Induced by Colibactin-Producing Escherichia coli in Apc Mice

Cecily Lucas , Laurène Salesse , My Hanh Thi Hoang , Mathilde Bonnet , Pierre Sauvanet
Gastroenterology, 2020, 158 (5), pp.1373-1388. ⟨10.1053/j.gastro.2019.12.026⟩
Journal articles hal-02518438v1

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Cayetano Pleguezuelos-Manzano , Jens Puschhof , Axel Rosendahl Huber , Arne van Hoeck , Henry Wood
Nature, 2020, 580 (7802), pp.269-273. ⟨10.1038/s41586-020-2080-8⟩
Journal articles hal-03043014v1
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Metabolic adaptation of adherent-invasive Escherichia coli to exposure to bile salts

Julien Delmas , Lucie Gibold , Tiphanie Faïs , Sylvine Batista , Martin Leremboure
Scientific Reports, 2019, ⟨10.1038/s41598-019-38628-1⟩
Journal articles hal-02060120v1
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Crohn’s Disease-Associated Adherent-Invasive Escherichia coli Manipulate Host Autophagy by Impairing SUMOylation

Guillaume Dalmasso , Hang Nguyen , Tiphanie Faïs , Sébastien Massier , Nicolas Barnich
Cells, 2019, 8 (1), pp.35. ⟨10.3390/cells8010035⟩
Journal articles hal-02060087v1
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AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation

Alexis Bretin , Cecily Lucas , Anaïs Larabi , Guillaume Dalmasso , Elisabeth Billard
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-30055-y⟩
Journal articles hal-01897658v1
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Colibactin: More Than a New Bacterial Toxin

Tiphanie Faïs , Julien Delmas , Nicolas Barnich , Richard Bonnet , Guillaume Dalmasso
Toxins, 2018, 10 (4), ⟨10.3390/toxins10040151⟩
Journal articles hal-01796959v1
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MCR-1 in ESBL-producing Escherichia coli responsible for human infections in New Caledonia

Frederic Robin , Racha Beyrouthy , Julien Colot , Pierre Saint-Sardos , Anne Berger-Carbonne
Journal of Antimicrobial Chemotherapy, 2017, 72 (3), pp.946-947. ⟨10.1093/jac/dkw508⟩
Journal articles hal-01604766v1

The Vat-AIEC protease promotes crossing of the intestinal mucus layer by Crohn's disease-associated Escherichia coli

Lucie Gibold , Estelle Garénaux , Guillaume Dalmasso , Camille Gallucci , David Cia
Cellular Microbiology, 2016, 18 (5), pp.617 - 631. ⟨10.1111/cmi.12539⟩
Journal articles hal-01926372v1
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Impact of CDT Toxin on Human Diseases

Tiphanie Faïs , Julien Delmas , Arnaud Serres , Richard Bonnet , Guillaume Dalmasso
Journal articles hal-04653469v1
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Impact of CDT Toxin on Human Diseases

Tiphanie Faïs , Julien Delmas , Arnaud Serres , Richard Bonnet , Guillaume Dalmasso
Toxins, 2016, 8 (7), ⟨10.3390/toxins8070220⟩
Journal articles hal-02633294v1

Activation of the EIF2AK4-EIF2A/eIF2 alpha-ATF4 pathway triggers autophagy response to crohn disease-associated adherent-invasive escherichia coli infection

Alexis Bretin , Jessica Carrière , Guillaume Dalmasso , Agnes Bergougnoux , Wafa B'Chir
Autophagy, 2016, 12 (5), pp.770-783. ⟨10.1080/15548627.2016.1156823⟩
Journal articles hal-02640052v1

Certaines bactéries de la flore commensale exacerberaient-elles la carcinogenèse colorectale ?

Jennifer Raisch , Guillaume Dalmasso , Richard Bonnet , Nicolas Barnich , Mathilde Bonnet
Médecine/Sciences, 2016, 32 (2), pp.175-82. ⟨10.1051/medsci/20163202011⟩
Journal articles pasteur-01351541v1

Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria

Anthony Cougnoux , Julien Delmas , Lucie Gibold , Tiphanie Faïs , Chiara Romagnoli
Gut, 2016, 65 (2), pp.278-285. ⟨10.1136/gutjnl-2014-307241⟩
Journal articles hal-02641378v1
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Targeting colorectal cancer-associated bacteria: A new area of research for personalized treatments

T Faïs , J Delmas , A Cougnoux , Guillaume Dalmasso , R Bonnet
Gut microbes, 2016, 7, pp.329 - 333. ⟨10.1080/19490976.2016.1155020⟩
Journal articles hal-04653468v1

Evaluation of the efficiency of cefoxitin/cefepime combination against Enterobacteriaceae resistant to expanded-spectrum cephalosporins

Arnaud Serres , Lucie Gibold , Guillaume Dalmasso , Frederic Robin , Richard Bonnet
International Journal of Antimicrobial Agents, 2015, 45 (1), pp.86-87
Journal articles hal-02630255v1

Colorectal carcinogenesis: impact of toxigenic or pro-inflammatory bacteria

Guillaume Dalmasso , Marie-Agnès Bringer , Jennifer Raisch , Anthony Cougnoux , Mathilde Bonnet
Correspondances en onco-théranostic, 2014, 3 (2), pp.58-61
Journal articles hal-01259744v1

Crohn's Disease-Associated Adherent Invasive Escherichia coli Modulate Levels of microRNAs in Intestinal Epithelial Cells to Reduce Autophagy

- Hang Thi Thu Nguyen , Guillaume Dalmasso , Stefan Mueller , Jessica Carrière , Frank Seibold
Gastroenterology, 2014, 146 (2), pp.508-519. ⟨10.1053/j.gastro.2013.10.021⟩
Journal articles hal-02640562v1
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The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment

Guillaume Dalmasso , Antony Cougnoux , Julien Delmas , Arlette Darfeuille-Michaud , Richard Bonnet
Gut microbes, 2014, 5, pp.675 - 680. ⟨10.4161/19490976.2014.969989⟩
Journal articles hal-04653449v1

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

Antony Cougnoux , Guillaume Dalmasso , Ruben Martinez , Emmanuel Buc , Julien Delmas
Gut, 2014, 63 (12), pp.1932-1942. ⟨10.1136/gutjnl-2013-305257⟩
Journal articles hal-02639382v1
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IS 1R -Mediated Plasticity of IncL/M Plasmids Leads to the Insertion of bla OXA-48 into the Escherichia coli Chromosome

R Beyrouthy , F Robin , J Delmas , L Gibold , Guillaume Dalmasso
Antimicrobial Agents and Chemotherapy, 2014, 58, pp.3785 - 3790. ⟨10.1128/aac.02669-14⟩
Journal articles hal-04653448v1

Chromosome-mediated OXA-48 carbapenemase in highly virulent Escherichia coli

Racha Beyrouthy , Frederic Robin , Antony Cougnoux , Guillaume Dalmasso , Arlette Darfeuille-Michaud
Journal of Antimicrobial Chemotherapy, 2013, 68 (7), pp.1558 - 1561. ⟨10.1093/jac/dkt051⟩
Journal articles hal-02652671v1

Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice

- Hang Thi Thu Nguyen , Guillaume Dalmasso , Yutao Yan , Hamed Laroui , Moiz Charania
Laboratory Investigation, 2012, 92 (8), pp.1203 - 1212. ⟨10.1038/labinvest.2012.83⟩
Journal articles hal-02643781v1

Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo

Oliv Eidam , Chiara Romagnoli , Guillaume Dalmasso , Sarah Barelier , Emilia Caselli
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (43), pp.17448 - 17453. ⟨10.1073/pnas.1208337109⟩
Journal articles hal-02650778v1
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Microbiota Modulate Host Gene Expression via MicroRNAs

Guillaume Dalmasso , Hang Thi Thu Nguyen , Yutao Yan , Hamed Laroui , Moiz A Charania
Journal articles hal-04653438v1
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CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice

Hang Thi , Thu Nguyen , Guillaume Dalmasso , Leif Torkvist , Jonas Halfvarson
Journal of Clinical Investigation, 2011, ⟨10.1172/JCI44631.⟩
Journal articles hal-04653435v1
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Nanomedicine in GI

Hamed Laroui , David S Wilson , Guillaume Dalmasso , Khalid Salaita , Niren Murthy
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011, ⟨10.1152/ajpgi.00466.2010.Review0193-1857/11⟩
Journal articles hal-04653432v1
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MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells

Guillaume Dalmasso , Hang Thi Thu Nguyen , Yutao Yan , Hamed Laroui , Moiz A Charania
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2010, ⟨10.1152/ajpgi.00394.2010.-⟩
Journal articles hal-04653430v1
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PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-␥-D-Glu-meso-DAP in intestinal epithelial cells

Guillaume Dalmasso , Hang Thi , Thu Nguyen , Laetitia Charrier-Hisamuddin , Yutao Yan
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2010, ⟨10.1152/ajpgi.00527.2009.-⟩
Journal articles hal-04653420v1
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Adenosine 2B Receptor Expression Is Post-transcriptionally Regulated by MicroRNA

Vasantha L Kolachala , Lixin Wang , Tracy S Obertone , Meena Prasad , Yutao Yan
Journal of Biological Chemistry, 2010, 285, pp.18184 - 18190. ⟨10.1074/jbc.m109.066555⟩
Journal articles hal-04653415v1
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Interaction of Saccharomyces boulardii with Salmonella enterica Serovar Typhimurium Protects Mice and Modifies T84 Cell Response to the Infection

Flaviano S Martins , Guillaume Dalmasso , Rosa M E Arantes , Anne Doye , Emmanuel Lemichez
Journal articles hal-04653414v1
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MicroRNA-7 Modulates CD98 Expression during Intestinal Epithelial Cell Differentiation

Hang Thi Thu Nguyen , Guillaume Dalmasso , Yutao Yan , Hamed Laroui , Stephanie Dahan
Journal of Biological Chemistry, 2009, 285, pp.1479 - 1489. ⟨10.1074/jbc.m109.057141⟩
Journal articles hal-04653411v1
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Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis

Yutao Yan , Vasantha Kolachala , Guillaume Dalmasso , Hang Nguyen , Hamed Laroui
Journal articles hal-04653408v1
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Ste20-Related Proline/Alanine-Rich Kinase (SPAK) Regulated Transcriptionally by Hyperosmolarity Is Involved in Intestinal Barrier Function

Yutao Yan , Guillaume Dalmasso , Hang Thi Thu Nguyen , Tracy S Obertone , Shanthi V Sitaraman
Journal articles hal-04653402v1
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Butyrate Transcriptionally Enhances Peptide Transporter PepT1 Expression and Activity

Guillaume Dalmasso , Hang Thi Thu Nguyen , Yutao Yan , Laetitia Charrier-Hisamuddin , Shanthi V Sitaraman
Journal articles hal-04653392v1
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Ecto-Phosphorylation of CD98 Regulates Cell-Cell Interactions

Hang Thi Thu Nguyen , Guillaume Dalmasso , Yutao Yan , Tracy S Obertone , Shanthi V Sitaraman
Journal articles hal-04653401v1
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ADAM-15/Metargidin Mediates Homotypic Aggregation of Human T Lymphocytes and Heterotypic Interactions of T Lymphocytes with Intestinal Epithelial Cells

Laetitia Charrier , Yutao Yan , Hang Thi Thu Nguyen , Guillaume Dalmasso , Christian L Laboisse
Journal of Biological Chemistry, 2007, 282, pp.16948 - 16958. ⟨10.1074/jbc.m700158200⟩
Journal articles hal-04653386v1
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Characterization of the human intestinal CD98 promoter and its regulation by interferon-gamma

Yutao Yan , Guillaume Dalmasso , Shanthi Sitaraman , Didier Merlin
AJP - Gastrointestinal and Liver Physiology, 2007, ⟨10.1152/ajpgi.00385.2006.-⟩
Journal articles hal-04653380v1
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Leptin Transcriptionally Enhances Peptide Transporter (hPepT1) Expression and Activity via the cAMP-response Element-binding Protein and Cdx2 Transcription Factors

Vivienne Nduati , Yutao Yan , Guillaume Dalmasso , Adel Driss , Shanthi Sitaraman
Journal of Biological Chemistry, 2006, 282, pp.1359 - 1373. ⟨10.1074/jbc.m604267200⟩
Journal articles hal-04653375v1

Lactobacillus casei DN-114 001 inhibits the increase of paracellular permeability in enteropathogenic Escherichia coli-infected T84 cells

Nadege Parassol , Miguel Freitas , Karine Thoreux , Guillaume Dalmasso , Raphaelle Bourdet-Sicard
Research in Microbiology, 2005
Journal articles hal-00294422v1
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Saccharomyces boulardii interferes with enterohemorrhagic Escherichia coli-induced signaling pathways in T84 cells

Stephanie Dahan , Guillaume Dalmasso , Veronique Imbert , Jean-Francois Peyron , Patrick Rampal
Infection and Immunity, 2003, 71, pp.766 - 773. ⟨10.1128/iai.71.2.766-773.2003⟩
Journal articles hal-04653363v1

The Colibactin-Producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance.

Nilmara de Oliveira Alves , Guillaume Dalmasso , Darja Nikitina , Amaury Vaysse , Richard Ruez
41 ème CECED, Mar 2024, Monptellier, France
Conference papers hal-04543437v1

Bacterial colibactin-induced lipid accumulation and loss of a c-type lectin cooperates for supporting an immune-suppressive microenvironment in right-sided colon cancer

Nilmara de Oliveira Alves , Amaury Vaysse , Guillaume Dalmasso , Darja Nikitina , Olivier Boulard
ONCOLille Days, Nov 2022, Lille, France
Conference papers hal-04543454v1

Expression of KRAS mutation and loss of a c-type lectin cooperates to sustain a bacterial-induced immune-suppressive microenvironment in right-sided colon cancer.

Nilmara de Oliveira Alves , Amaury Vaysse , Guillaume Dalmasso , Olivier Boulard , Pierre Sauvanet
INCIT congress - Immunology and new concepts in immunotherapy, Sep 2022, Nantes, France
Conference papers hal-04543562v1

Reg3A and glycerophospholipids metabolites axis promote an immune-suppressive microenvironment in right-sided colon cancer

Nilmara de Oliveira Alves , Amaury Vaysse , Guillaume Dalmasso , Olivier Boulard , Thomas Paz del Socorro
Immune Responses in Cancer and Infection, Jun 2022, Lyon, France
Conference papers hal-04543598v1

Epithelial to mesenchymal transition in response to E. coli-induced senescence-associated secretory phenotype induced chemotherapeutic drug resistance

Guillaume Dalmasso , Tiphanie Faïs , Anthony Cougnoux , Nicolas Barnich , Julien Delmas
DDW 2020, May 2020, Chicago, United States
Conference papers hal-02524390v1

Autophagy inhibits colorectal carcinogenesis induced by colibactin-producing escherichia coli

Cecily Lucas , Laurène Salesse , My Hanh Thi Hoang , Mathilde Bonnet , Pierre Sauvanet
Digestive Disease Week (DDW), May 2020, Chicago, United States
Conference papers hal-02527278v1

Colorectal cancer associated-E. coli induce the emergence of chemotherapy-resistant stem cell-like phenotype of host cells

Guillaume Dalmasso , Anthony Cougnoux , Tiphanie Faïs , Hang T.T. Nguyen , Nicolas Barnich
DDW2020, May 2020, Chicago, United States
Conference papers hal-02524369v1

Colorectal cancer associated-E. coli induce the emergence of chemotherapy-resistant stem clell-like phenotype of host cells

Guillaume Dalmasso , Anthony Cougnoux , Tiphanie Faïs , Nicolas Barnich , Julien Delmas
15e congrès national de la SFM, Sep 2019, PARIS, France
Conference papers hal-02196753v1

Colorectal cancer associated-E. coli induce the emergence of chemotherapy-resistant stem cell-like phenotype of host cells

Guillaume Dalmasso , Antony Cougnoux , Tiphanie Faïs , Nicolas Barnich , Julien Delmas
15eme congrès national de la SFM, Sep 2019, Paris, France
Conference papers hal-02338700v1

Epithelial to mesenchymal transition in response to E. coli-induced senescence-associated secretory phenotype induced chemotherapeutic drug resistance

Guillaume Dalmasso , Tiphanie Faïs , A Cougnoux , Nicolas Barnich , Julien Delmas
15. Congrès national de la SFM, Sep 2019, Paris, France
Conference papers hal-02524334v1

Spatial metabolomics reveals a reprogramming of lipid metabolism by bacterial colibactin supporting immunosuppressive microenvironment in right-sided colon cancer

Nilmara de Oliveira Alves , Olivier Boulard , Amaury Vaysse , Guillaume Dalmasso , Darja Nikitina
5 Metabolism & Cancer, Nov 2023, Nice, France
Conference poster hal-04543485v1

Spatially-resolved metabolomic identifies a reprogramming of lipid metabolism and immune surveillance that are caused by colibactin-producing E. coli infection.

Nilmara de Oliveira Alves , Amel Mettouchi , Guillaume Dalmasso , Amaury Vaysse , Emma Bergsten
Cross-cutting program MICROBIOTA, Jan 2023, Lyon, France
Conference poster hal-04543527v1

Le gène de résistance mcr-1 favorise l'intrusion de E. coli dans l'écosystème intestinal

Guillaume Dalmasso , Racha Beyrouthy , Sandrine Brugiroux , Pierre Saint-Sardos , Etienne Ruppé
RICAI 2020, Dec 2020, PARIS, France
Conference poster hal-03054071v1

Exosomes released from intestinal epithelial cells infected with Crohn's disease-associated adherent-invasive E. coli transfer miRNAs into recipient cells to inhibit autophagy

Anaïs Larabi , Guillaume Dalmasso , Julien Delmas , Nicolas Barnich , Hang Thi Thu Nguyen
Congres KEYSTONE, Mar 2019, MONTREAL, Canada
Conference poster hal-02393855v1

Autophagy inhibits DNA damage induced by colorectal cancer-associated Escherichia coli

Cecily Lucas , Guillaume Dalmasso , Pierre Sauvanet , Denis Pezet , Nicolas Barnich
CFATG, Oct 2017, BORDEAUX, France
Conference poster hal-01631705v1

Activation of the EIF2AK4-EIF2A/eIF2 alpha-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive escherichia coli infection

Alexis Bretin , Jessica Carrière , Guillaume Dalmasso , Agnes Bergougnoux , Wafa B'Chir
7. Proteasomes and Autophagy Workshop, Apr 2016, clermont-ferrand, France. 320 p., 2016, 7th Proteasomes and Autophagy Workshop
Conference poster hal-02740425v1
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The GCN2/eIF2α/ATF4 signaling pathway is necessary for autophagy response to infection with Crohn’s disease-associated adherent-invasive Escherichia coli

Thuy Thi Thu Nguyen , Jessica Carrière , Guillaume Dalmasso , Anne-Catherine Maurin , Alain Bruhat
6. Journée scientifique du CNRH Auvergne, Nov 2013, Clermont - Ferrand, France. , 2013, 6ème Journée scientifique du CNRH Auvergne
Conference poster hal-02750413v1