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Guillaume Viault

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Documents

Publications

From Phloridzin towards Semisynthetic Bioactive Dihydrochalcones

Antonio Cala Peralta , Fabian Mayr , Guillaume Viault , Veronika Temml , Daniela Schuster
27th Annual GP2A Medicinal Chemistry Conference, Aug 2019, Notthingham, United Kingdom. Pharmaceuticals, 12 (4), pp.179, 2019, ⟨10.3390/ph12040179⟩
Poster de conférence hal-02798004v1

SEMISYNTHESIS OF BIOACTIVE C-BENZYLATED DIHYDROCHALCONES FROM RENEWABLE SOURCES

Antonio Cala Peralta , Fabian Mayr , Guillaume Viault , Veronika Temml , Daniela Schuster
RICT 2019 - Interfacing Chemical Biology and Drug Discovery - 55th International Conference on Medicinal Chemistry, Jul 2019, Nantes, France
Poster de conférence hal-02798163v1

Anti-inflammatory activity of w-oxidized tocotrienols

Chau-Phi Dinh , Alexia Ville , Anaïs Barbe , Thuy Linh To , Guillaume Viault
26th Young Research Fellows Meeting, Feb 2019, Paris, France
Poster de conférence hal-02796842v1

Extraction and purification of antifungal xanthones from Garcinia mangostana (Clusiaceae)

Guillaume Viault , Sorphon Suor-Cherer , Dimitri Bréard , Chau-Phi Dinh , Blon Nadège
3ème Symposium International AFERP-STOLON, Jul 2018, Rennes, France
Poster de conférence hal-02795479v1

Semisynthesis of δ-(R)-tocotrienols

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , David Guilet , Pascal Richomme
8ème Symposium Francophone de Synthèse Totale, May 2018, Bordeaux, France
Poster de conférence hal-02797021v1

Semisynthetic pathways starting from δ-garcinoic acid towards anti-inflammatory tocotrienols isolated from New Caledonian endemic plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
Journées des doctorants de la SFR QUASAV, 11ème édition, Oct 2018, Angers, France
Poster de conférence hal-02864443v1

Semisynthetic pathways towards anti-inflammatory tocotrienols isolated from new-caledonian endemic plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin , Pascal Richomme
14a. RIIPN (14a Reunión Internacional de Productos Naturales), May 2018, Cuernavaca Morelos, Mexico
Poster de conférence hal-02864440v1

Xanthone derivatives from NPs library as potential UPR inhibitors for alternative crop protection: Molecular modelling and biological activity

Guillaume Viault , Dimitri Bréard , Chau-Phi Dinh , Blon Nadège , Antoine Bruguière
30th International Symposium on the Chemistry of Natural Products, Nov 2018, Athens, Greece
Poster de conférence hal-02861017v1

α-amplexichromanol, a vitamin E semisynthetic analog – Valorization of its anti-inflammatory potential

Alexia Ville , Khaled Alsabil , Guillaume Viault , David Guilet , Jean-Jacques Helesbeux
Journée thématique de la SFR ICAT4208, May 2018, Angers, France
Poster de conférence hal-02864434v1

Synthèse et évaluation biologique de nouveaux actifs potentiels ciblant les dysfonctionnements mitochondriaux

Guillaume Viault , Abdel Benamar , Morgane Le Mao , R. Andriantsitohaina , Jean-Jacques Helesbeux
Journée thématique de la SFR ICAT, May 2018, Angers, France
Poster de conférence hal-02797199v1

Extraction and Purification of δ-Tocotrienol from Bixa orellana and Semi-Synthesis of 7-Formyl-δ-tocotrienol

Khaled Alsabil , Sorphon Suor-Cherer , H. Y. Lam , Guillaume Viault , Jean-Jacques Helesbeux
25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. Pharmaceuticals, 10 (4), pp.97, 2017, ⟨10.3390/ph10040097⟩
Poster de conférence hal-02797856v1

Semisynthetics Pathways Starting from δ-Garcinoic Acid towards Anti-Inflammatory Tocotrienols Isolated from New-Caledonian Endemic Plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. Pharmaceuticals, 10 (4), pp.97, 2017, ⟨10.3390/ph10040097⟩
Poster de conférence hal-02797913v1

Total synthesis and determination of the absolute configuration of Hyperbiphenyl A and B, isolated from the roots of Hypericum perforatum

Dimitri Bréard , Guillaume Viault , Antoine Bruguière , Béatrice Charreau , Pascal Richomme
5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France.
Poster de conférence hal-02521277v1

Design, synthesis and biological evaluation of fluorescent ligands for MT1 and/or MT2 melatonin receptors

Guillaume Viault , Séverine Poupart , Sophie Mourlevat , Christine Lagaraine , Séverine Devavry
25. Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩
Poster de conférence hal-03448840v1

δ-Garcinoic Acid, a Convenient Natural Precursor to the Attractive δ-Tocotrienol

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
The 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩
Poster de conférence hal-02797528v1

δ-garcinoic acid, a platform to tocotrienol derivatives isolated from barks of New Caledonian endemics plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
5e journées scientifiques de l’école doctorale VENAM, Nov 2016, Nantes, France
Poster de conférence hal-02864424v1

mPGES-1 as a New Target for Garcinoic Acid Isoforms

Khaled Alsabil , Sorphon Suor-Cherer , Andreas Koeberle , Guillaume Viault , Daniela Schuster
The 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩
Poster de conférence hal-02797636v1

Molecular docking, semisynthesis and biological evaluations of garcinoic acid amides as 5-lipoxygenase inhibitors

Chau-Phi Dinh , Alexia Ville , Barbe Anaïs , Thuy-Linh To , Konstantin Neukirch
27th Annual GP2A Medicinal Chemistry Conference, Aug 2019, Nottingham, United Kingdom. pp.179, ⟨10.3390/ph12040179⟩
Communication dans un congrès hal-02794994v1

Anti-inflammatory activity of vitamin E derivatives

Chau-Phi Dinh , Alexia Ville , Barbe Anaïs , Thuy-Linh To , Konstantin Neukirch
Journée Des Doctorants de l’ED EGAAL, Jul 2019, Rennes, France
Communication dans un congrès hal-02795186v1

MixONat: Assistance aux analyses déréplicatives par RMN-13C

Séverine Derbré , Antoine Bruguière , Joël Dietsch , J. Leguy , V Rahier
Journée Scientifique Biogenouest « Du phénome au métabolome », Oct 2019, Angers, France
Communication dans un congrès hal-02871151v1

Structure-based modeling, semisynthesis and biological evaluations of garcinoic acid derivatives

Chau-Phi Dinh , Alexia Ville , Barbe Anaïs , Thuy-Linh To , Konstantin Neukirch
Journée Des Doctorants de la SFR QUASAV, Oct 2019, Angers, France
Communication dans un congrès hal-02794835v1

Design, semisynthesis and biological evaluations of garcinoic acid derivatives as novel anti-inflammatory agents

Chau-Phi Dinh , Guillaume Viault , Andreas Koeberle , Hermann Stuppner , Daniela Schuster
25th Young Research Fellows Meeting, Mar 2018, Orléans, France
Communication dans un congrès hal-02796904v1

Towards pharmacologically active tocotrienol derivatives starting from δ-garcinoic acid as a common natural precursor

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
24th Young Research Fellow’s Meeting, Feb 2017, Châtenay-Malabry, France
Communication dans un congrès hal-02864430v1

Hémisynthèse d’analogues originaux de la vitamine E à visée anti-inflammatoire

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
Journée des doctorants de la SFR QUASAV, 10e édition, Oct 2017, Angers, France
Communication dans un congrès hal-02864455v1

Semisynthetic pathways starting from δ-garcinoic acid towards anti-inflammatory tocotrienols isolated from New Caledonian endemic plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France
Communication dans un congrès hal-02864451v1

Towards an Alternative to NSAIDs Based on Vitamin E Analogues

Jean-Jacques Helesbeux , Khaled Alsabil , Alexia Ville , Sorphon Suor-Cherer , Guillaume Viault
25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. pp.97, ⟨10.3390/ph10040097⟩
Communication dans un congrès hal-02797756v1

Hémisynthèse de nouveaux analogues de la vitamine E à visée anti-inflammatoire

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
Séminaire recherche du département Pharmacie, Faculté de Santé, Université d’Angers, Sep 2016, Angers, France
Communication dans un congrès hal-02864459v1

Design, synthesis and biological evaluation of fluorescent ligands for MT1 and/or MT2 melatonin receptors

G. Viault , S. Poupart , S. Mourvelat , Christine Lagaraine , Séverine Devavry
24. Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A), Université d'Angers (UA). FRA., Aug 2016, Angers, France
Communication dans un congrès hal-01603651v1
Image document

A new boronate ester-based crosslinking strategy allows the design of nonswelling and long-term stable dynamic covalent hydrogels

N. Lagneau , L. Terriac , P. Tournier , J-J. Helesbeux , Guillaume Viault
Biomaterials Science, 2023, Biomaterials Science, 11 (6), pp.2033-2045. ⟨10.1039/D2BM01690G⟩
Article dans une revue hal-03991398v1
Image document

Natural Products Targeting the Fungal Unfolded Protein Response as an Alternative Crop Protection Strategy

Thomas Charpentier , Guillaume Viault , Anne-Marie Le Ray , Nelly Bataillé-Simoneau , Jean-Jacques Helesbeux
Journal of Agricultural and Food Chemistry, 2023, 71 (37), pp.13706-13716. ⟨10.1021/acs.jafc.3c03602⟩
Article dans une revue hal-04208459v1
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Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3

Gabriele Möller , Veronika Temml , Antonio Cala Peralta , Océane Gruet , Pascal Richomme
Metabolites, 2022, 12 (2), pp.99. ⟨10.3390/metabo12020099⟩
Article dans une revue hal-03782968v1
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Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

Christian Kretzer , Paul Jordan , Katharina P.L. Meyer , Daniel Hoff , Markus Werner
Biochemical Pharmacology, 2022, 195, pp.114825. ⟨10.1016/j.bcp.2021.114825⟩
Article dans une revue hal-03533844v1
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Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3

Gabriele Möller , Veronika Temml , Antonio Cala Peralta , Océane Gruet , Pascal Richomme
Metabolites, 2022, 12 (2), pp.99. ⟨10.3390/metabo12020099⟩
Article dans une revue hal-03716164v1

Photochemical Transformations of Chalcone-Vitamin E Hybrids

Jimmy Josué Ceballos-Cruz , Jean-Jacques Helesbeux , Guillaume Viault , Denis Seraphin , Gumersindo Mirón-López
Journal of the Mexican Chemical Society, 2022, 66 (1), ⟨10.29356/jmcs.v66i1.1670⟩
Article dans une revue hal-03533848v1

Semisynthetic Vitamin E Derivatives as Potent Antibacterial Agents against Resistant Gram‐Positive Pathogens

Guillaume Viault , Marie Kempf , Alexia Ville , Khaled Alsabil , Rodolphe Perrot
ChemMedChem, 2021, 16 (5), pp.881-890. ⟨10.1002/cmdc.202000792⟩
Article dans une revue hal-03191789v1
Image document

Real-Time Analysis of Polyphenol-Protein Interactions by Surface Plasmon Resonance Using Surface-Bound Polyphenols

Daniela Mélanie Delannoy López , Dong Tien Tran , Guillaume Viault , Sofiane Dairi , Philippe Alexandre Peixoto
Chemistry - A European Journal, inPress, ⟨10.1002/chem.202005187⟩
Article dans une revue hal-03374449v1
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Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

Konstantin Neukirch , Khaled Alsabil , Chau-Phi Dinh , Rossella Bilancia , Martin Raasch
Journal of Medicinal Chemistry, 2021, 64 (15), pp.11496-11526. ⟨10.1021/acs.jmedchem.1c00806⟩
Article dans une revue hal-03783673v1
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MixONat, a Software for the Dereplication of Mixtures Based on 13 C NMR Spectroscopy

Antoine Bruguière , Séverine Derbré , Joël Dietsch , Jules Leguy , Valentine Rahier
Analytical Chemistry, 2020, 92 (13), pp.8793-8801. ⟨10.1021/acs.analchem.0c00193⟩
Article dans une revue hal-03783604v1
Image document

Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors

Chau-Phi Dinh , Alexia Ville , Konstantin Neukirch , Guillaume Viault , Veronika Temml
European Journal of Medicinal Chemistry, 2020, 202, pp.112518. ⟨10.1016/j.ejmech.2020.112518⟩
Article dans une revue hal-02884134v1

Efficient Semi-Synthesis of Natural δ-( R )-Tocotrienols from a Renewable Vegetal Source

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , David Guilet , Pascal Richomme
Journal of Natural Products, 2019, 82 (1), pp.51-58. ⟨10.1021/acs.jnatprod.8b00517⟩
Article dans une revue hal-02358466v1

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Helmut Pein , Alexia Ville , Simona Pace , Veronika Temml , Ulrike Garscha
Nature Communications, 2018, 9 (1), pp.3834. ⟨10.1038/s41467-018-06158-5⟩
Article dans une revue hal-02521285v1
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Additional Insights into Hypericum perforatum Content: Isolation, Total Synthesis, and Absolute Configuration of Hyperbiphenyls A and B from Immunomodulatory Root Extracts

Dimitri Bréard , Guillaume Viault , Marie-Charlotte Mezier , Sylvain Pagie , Antoine Bruguière
Journal of Natural Products, 2018, 81 (8), pp.1850-1859. ⟨10.1021/acs.jnatprod.8b00325⟩
Article dans une revue inserm-02157665v1

Concise semisynthesis of novel phenazine-vitamin E hybrids via regioselective tocopheryl ortho-quinone formation

Guillaume Viault , Jean-Jacques Helesbeux , Pascal Richomme , Denis Seraphin
Tetrahedron Letters, 2018, 59 (27), pp.2627-2630. ⟨10.1016/j.tetlet.2018.05.011⟩
Article dans une revue hal-02521254v1

Efficient ortho-formylation in vitamin E series, application to the semi-synthesis of natural 5- and 7-formyl-δ-tocotrienols revealing an unprecedented 5-bromo-7-formyl exchange

Khaled Alsabil , Guillaume Viault , Sorphon Suor-Cherer , Jean-Jacques Helesbeux , Joumaa Merza
Tetrahedron, 2017, 73 (49), pp.6863-6870. ⟨10.1016/j.tet.2017.10.039⟩
Article dans une revue hal-02521270v1

Design and validation of the first cell-impermeant melatonin receptor agonist

Florence Gbahou , Erika Cecon , Guillaume Viault , Romain Gerbier , Frédéric Jean-Alphonse
British Journal of Pharmacology, 2017, 174 (14), pp.2409-2421. ⟨10.1111/bph.13856⟩
Article dans une revue hal-02873466v1

Asymmetric dearomative spirolactonization of naphthols using λ3-iodanes under chiral phase-transfer catalysis

Kevin Antien , Guillaume Viault , Laurent Pouységu , Philippe Peixoto , Stephane Quideau
Tetrahedron, 2017, 73 (26), pp.3684-3690. ⟨10.1016/j.tet.2017.04.028⟩
Article dans une revue hal-02873460v1

Asymmetric dearomative spirolactonization of naphthols using λ3-iodanes under chiral phase-transfer catalysis

Kevin Antien , Guillaume Viault , Laurent Pouységu , Philippe Peixoto , Stéphane Quideau
Tetrahedron, 2017, 73 (26), pp.3684-3690. ⟨10.1016/j.tet.2017.04.028⟩
Article dans une revue hal-03034015v1

Design, synthesis and biological evaluation of fluorescent ligands for MT 1 and/or MT 2 melatonin receptors

G. Viault , S. Poupart , S. Mourlevat , C. Lagaraine , S. Devavry
RSC Advances, 2016, 6 (67), pp.62508-62521. ⟨10.1039/C6RA10812A⟩
Article dans une revue hal-03170796v1

Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors

Khaled Alsabil , Sorphon Suor-Cherer , Andreas Koeberle , Guillaume Viault , Alexis Lavaud
Planta Medica, 2016, 82 (11/12), pp.1110-1116. ⟨10.1055/s-0042-108739⟩
Article dans une revue hal-01391940v1

Hemisynthesis of selected embelin analogs and investigation of their proapoptotic activity against cancer cells

Guillaume Viault , Katragadda Suresh Babu , Fabien Gautier , Sophie Barillé-Nion , Philippe Juin
Medicinal Chemistry (Shāriqah (United Arab Emirates)), 2013, 9 (8), pp.1028--1034. ⟨10.2174/1573406411309080003⟩
Article dans une revue hal-01147397v1

Stereoselective Synthesis of a Bicyclic Norsesquiterpene Backbone - A Possible Route to Nardosinane Derivatives

Ouassila Selaimia-Ferdjani , Anirban Kar , Sambhaji P. Chavan , Maxime Horeau , Guillaume Viault
European Journal of Organic Chemistry, 2013, 2013 (31), pp.7083-7094. ⟨10.1002/ejoc.201301087⟩
Article dans une revue hal-02142396v1

The first "ready-to-use" benzene-based heterotrifunctional cross-linker for multiple bioconjugation.

Guillaume Viault , Sébastien Dautrey , Nicolas Maindron , Julie Hardouin , Pierre-Yves Renard
Organic & Biomolecular Chemistry, 2013, 11 (16), pp.2693-2705. ⟨10.1039/c3ob40086g⟩
Article dans une revue hal-00996541v1

Synthesis of a Focused Chemical Library Based on Derivatives of Embelin, a Natural Product with Proapoptotic and Anticancer Properties

Guillaume Viault , Danielle Gree , Saibal Das , Jhillu Singh Yadav , René Grée
European Journal of Organic Chemistry, 2011, 2011 (7), pp.1233-1241 (avec couverture du journal). ⟨10.1002/ejoc.201190012⟩
Article dans une revue hal-00842650v1

Mitochondrial targeting by use of lipid nanocapsules loaded with SV30, an analogue of the small-molecule Bcl-2 inhibitor HA14-1.

M. Weyland , F. Manero , A. Paillard , Danielle Gree , Guillaume Viault
Journal of Controlled Release, 2011, 151 (1), pp.74-82. ⟨10.1016/j.jconrel.2010.11.032⟩
Article dans une revue hal-00842655v1

Synthesis of new selected analogues of the proapoptotic and anticancer molecule HA 14-1.

D. Grée , S. Vorin , V.L. Manthati , F. Caijo , G. Viault
Tetrahedron Letters, 2008, 49, pp.3276-3278
Article dans une revue hal-00323433v1

Synthesis of polyhydroxylated pyrano-pyrrole derivatives from carbohydrate precursors

S. Naud , M. Pipelier , G. Viault , A. Adjou , François Huet
European Journal of Organic Chemistry, 2007, pp.3296. ⟨10.1002/ejoc.200700102⟩
Article dans une revue hal-00383767v1

Synthesis of novel polyhydroxylated tetrahydropyranopyrroles

S. Naud , M. Pipelier , C. Chaumette , G. Viault , François Huet
SYNLETT, 2007, 3, pp.403-406
Article dans une revue hal-00320962v1