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Gulnara Yusupova

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Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents

Jidong Zhang , Christine Lair , Christine Roubert , Kwame Amaning , María Belén Barrio
Cell, 2023, 186 (5), pp.1013-1025.e24. ⟨10.1016/j.cell.2023.01.043⟩
Journal articles hal-04266217v1
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mRNA reading frame maintenance during eukaryotic ribosome translocation

Nemanja Milicevic , Lasse Jenner , Alexander Myasnikov , Marat Yusupov , Gulnara Yusupova
Journal articles hal-04323477v1
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E-site drug specificity of the human pathogen Candida albicans ribosome

Yury Zgadzay , Olga Kolosova , Artem Stetsenko , Cheng Wu , David Bruchlen
Science Advances , 2022, 8 (21), pp.eabn1062. ⟨10.1126/sciadv.abn1062⟩
Journal articles hal-03813407v1

A Path to the Atomic-Resolution Structures of Prokaryotic and Eukaryotic Ribosomes

Gulnara Yusupova , Marat Yusupov
Биохимия / Biochemistry, 2021, 86 (8), pp.926-941. ⟨10.1134/S0006297921080046⟩
Journal articles hal-03365744v1
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Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy: A Structural Perspective

Gulnara Yusupova , Simone Pellegrino , Salvatore Terrosu , Marat Yusupov
Journal articles hal-03372921v1
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Accuracy mechanism of eukaryotic ribosome translocation

Muminjon Djumagulov , Natalia Demeshkina , Lasse Jenner , Alexey Rozov , Marat Yusupov
Nature, 2021, 600 (7889), pp.543-546. ⟨10.1038/s41586-021-04131-9⟩
Journal articles hal-03800932v1
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Cryo‐EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution

Alexander Golubev , Bulat Fatkhullin , Iskander Khusainov , Lasse Jenner , Azat Gabdulkhakov
FEBS Letters, 2020, 594 (21), pp.3551 - 3567. ⟨10.1002/1873-3468.13915⟩
Journal articles hal-03373743v1
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Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach

Iskander Khusainov , Bulat Fatkhullin , Simone Pellegrino , Aydar Bikmullin , Wen-Ti Liu
Nature Communications, 2020, 11 (1), pp.1656. ⟨10.1038/s41467-020-15517-0⟩
Journal articles inserm-02649160v1

Posttranslational modification of Elongation Factor P from Staphylococcus aureus

Gulnara Yusupova , Alexander Golubev , Luc Negroni , Filipp Krasnovid , Shamil Validov
FEBS Open Bio, 2020, 10 (7), pp.1342-1347. ⟨10.1002/2211-5463.12901⟩
Journal articles hal-02997686v1
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The multiple flavors of GoU pairs in RNA

Eric Westhof , Marat M. Yusupov , Gulnara Yusupova
Journal of Molecular Recognition, 2019, pp.e2782. ⟨10.1002/jmr.2782⟩
Journal articles hal-02361230v1

Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome

Gulnara Yusupova , Simone Pellegrino , Mélanie Meyer , Zef Könst , Mikael Holm
Nucleic Acids Research, 2019, 47 (6), pp.3223-3232. ⟨10.1093/nar/gkz053⟩
Journal articles hal-03365753v1
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Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction

Alexey Rozov , Iskander Khusainov , Kamel El Omari , Ramona Duman , Vitaliy Mykhaylyk
Nature Communications, 2019, 10 (1), pp.2519. ⟨10.1038/s41467-019-10409-4⟩
Journal articles hal-03659834v1

Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome

Simone Pellegrino , Mélanie Meyer , Zef Könst , Mikael Holm , Vamsee Voora
Nucleic Acids Research, 2019, 47 (6), pp.3223-3232. ⟨10.1093/nar/gkz053⟩
Journal articles hal-03659840v1

The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth

Simone Pellegrino , Mélanie Meyer , Christiane Zorbas , Soumaya Bouchta , Kritika Saraf
Structure, 2018, 26 (3), pp.416-425.e4. ⟨10.1016/j.str.2018.01.009⟩
Journal articles hal-03661103v1
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Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria

Alexey Rozov , Philippe Wolff , Henri Grosjean , Marat Yusupov , Gulnara Yusupova
Nucleic Acids Research, 2018, 46 (14), pp.7425-7435. ⟨10.1093/nar/gky547⟩
Journal articles hal-03659841v1

Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A

Brandon Mcclary , Boris Zinshteyn , Mélanie Meyer , Morgan Jouanneau , Simone Pellegrino
Cell Chemical Biology, 2017, 24 (5), pp.605-613.e5. ⟨10.1016/j.chembiol.2017.04.006⟩
Journal articles hal-03661121v1

Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides

Zef Könst , Anne Szklarski , Simone Pellegrino , Sharon Michalak , Mélanie Meyer
Nature Chemistry, 2017, 9 (11), pp.1140-1149. ⟨10.1038/nchem.2800⟩
Journal articles hal-03659848v1

Structure of the 70S ribosome from human pathogen Staphylococcus aureus

Iskander Khusainov , Quentin Vicens , Anthony Bochler , François Grosse , Alexander G. Myasnikov
Nucleic Acids Research, 2017, 45 (2), pp.1026-1026. ⟨10.1093/nar/gkw1126⟩
Journal articles hal-02171293v1

Aminoglycoside interactions and impacts on the eukaryotic ribosome

Gulnara Yusupova , Irina Prokhorova , Roger Altman , Muminjon Djumagulov , Jaya Shrestha
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (51), pp.E10899-E10908. ⟨10.1073/pnas.1715501114⟩
Journal articles hal-03365761v1

Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF

Iskander Khusainov , Quentin Vicens , Rustam Ayupov , Konstantin Usachev , Alexander Myasnikov
EMBO Journal, 2017, 36 (14), pp.2073-2087. ⟨10.15252/embj.201696105⟩
Journal articles hal-03661109v1

Crystal structure of eukaryotic ribosome and its complexes with inhibitors

Gulnara Yusupova , Marat Yusupov
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017, 372 (1716), pp.20160184. ⟨10.1098/rstb.2016.0184⟩
Journal articles hal-03661123v1

New Structural Insights into Translational Miscoding

Alexey Rozov , Natalia Demeshkina , Eric Westhof , Marat M. Yusupov , Gulnara Yusupova
Trends in Biochemical Sciences, 2016, 41 (9), pp.798-814. ⟨10.1016/j.tibs.2016.06.001⟩
Journal articles hal-02294531v1

Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome

Irina Prokhorova , Kseniya Akulich , Desislava Makeeva , Ilya Osterman , Dmitry Skvortsov
Scientific Reports, 2016, 6 (1), pp.27720. ⟨10.1038/srep27720⟩
Journal articles hal-03661134v1

Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome

Sergey Melnikov , Justine Mailliot , Byung-Sik Shin , Lukas Rigger , Gulnara Yusupova
Journal of Molecular Biology, 2016, 428 (18), pp.3570-3576. ⟨10.1016/j.jmb.2016.05.011⟩
Journal articles hal-03661136v1
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Eukaryotic Ribosome as a Target for Cardiovascular Disease

Simone P Pellegrino , Gulnara Yusupova
Cell Chemical Biology, 2016, 17 (23), pp.1319-1321. ⟨10.1016/j.chembiol.2016.11.004⟩
Journal articles inserm-01415698v1

Molecular insights into protein synthesis with proline residues

Sergey Melnikov , Justine Mailliot , Lukas Rigger , Sandro Neuner , Byung‐sik Shin
EMBO Reports, 2016, 17 (12), pp.1776-1784. ⟨10.15252/embr.201642943⟩
Journal articles hal-03661132v1

Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code

Alexey Rozov , Natalia Demeshkina , Iskander Khusainov , Eric Westhof , Marat M. Yusupov
Nature Communications, 2016, 7 (1), pp.10457. ⟨10.1038/ncomms10457⟩
Journal articles hal-02294521v1

The ribosome prohibits the G•U wobble geometry at the first position of the codon–anticodon helix

Alexey Rozov , Eric Westhof , Marat M. Yusupov , Gulnara Yusupova
Nucleic Acids Research, 2016, 44 (13), pp.6434-41. ⟨10.1093/nar/gkw431⟩
Journal articles hal-02294675v1

Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency

Justine Mailliot , Nicolas Garreau de Loubresse , Gulnara Yusupova , Arturas Meskauskas , Jonathan Dinman
Journal of Molecular Biology, 2016, 428 (10), pp.2195-2202. ⟨10.1016/j.jmb.2016.02.013⟩
Journal articles hal-03661143v1

Structural insights into the translational infidelity mechanism

Alexey Rozov , Natalia Demeshkina , Eric Westhof , Marat Yusupov , Gulnara Yusupova
Nature Communications, 2015, 6 (1), pp.7251. ⟨10.1038/ncomms8251⟩
Journal articles hal-03661150v1

Insights into the origin of the nuclear localization signals in conserved ribosomal proteins

Sergey Melnikov , Adam Ben-Shem , Gulnara Yusupova , Marat Yusupov
Nature Communications, 2015, 6 (1), pp.7382. ⟨10.1038/ncomms8382⟩
Journal articles hal-03661149v1

Ribosome biochemistry in crystal structure determination

Gulnara Yusupova , Marat Yusupov
RNA, 2015, 21 (4), pp.771-773. ⟨10.1261/rna.050039.115⟩
Journal articles hal-03661153v1

Structural basis for the inhibition of the eukaryotic ribosome

Nicolas Garreau de Loubresse , Irina Prokhorova , Wolf Holtkamp , Marina Rodnina , Gulnara Yusupova
Nature, 2014, 513 (7519), pp.517-522. ⟨10.1038/nature13737⟩
Journal articles hal-03661154v1

High-Resolution Structure of the Eukaryotic 80S Ribosome

Gulnara Yusupova , Marat Yusupov
Annual Review of Biochemistry, 2014, 83 (1), pp.467-486. ⟨10.1146/annurev-biochem-060713-035445⟩
Journal articles hal-03661159v1

Recognition of Watson-Crick base pairs: constraints and limits due to geometric selection and tautomerism

Eric Westhof , Marat Yusupov , Gulnara Yusupova
F1000Prime Reports, 2014, 6, ⟨10.12703/P6-19⟩
Journal articles hal-03661156v1

New structural insights into the decoding mechanism: Translation infidelity via a G·U pair with Watson-Crick geometry

Natalia Demeshkina , Lasse Jenner , Eric Westhof , Marat Yusupov , Gulnara Yusupova
FEBS Letters, 2013, 587 (13), pp.1848-1857. ⟨10.1016/j.febslet.2013.05.009⟩
Journal articles hal-03661161v1

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

Lasse Jenner , Agata Starosta , Daniel Terry , Aleksandra Mikolajka , Liudmila Filonava
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (10), pp.3812-3816. ⟨10.1073/pnas.1216691110⟩
Journal articles hal-03661163v1

A new understanding of the decoding principle on the ribosome

Natalia Demeshkina , Lasse Jenner , Eric Westhof , Marat Yusupov , Gulnara Yusupova
Nature, 2012, 484 (7393), pp.256-259. ⟨10.1038/nature10913⟩
Journal articles hal-03661168v1

Crystal structure of the 80S yeast ribosome

Lasse Jenner , Sergey Melnikov , Nicolas Garreau de Loubresse , Adam Ben-Shem , Madina Iskakova
Current Opinion in Structural Biology, 2012, 22 (6), pp.759-767. ⟨10.1016/j.sbi.2012.07.013⟩
Journal articles hal-03661164v1

One core, two shells: bacterial and eukaryotic ribosomes

Sergey Melnikov , Adam Ben-Shem , Nicolas Garreau de Loubresse , Lasse Jenner , Gulnara Yusupova
Nature Structural and Molecular Biology, 2012, 19 (6), pp.560-567. ⟨10.1038/nsmb.2313⟩
Journal articles hal-03661166v1

The Structure of the Eukaryotic Ribosome at 3.0 Å Resolution

Adam Ben-Shem , Nicolas Garreau de Loubresse , Sergey Melnikov , Lasse Jenner , Gulnara Yusupova
Science, 2011, 334 (6062), pp.1524-1529. ⟨10.1126/science.1212642⟩
Journal articles hal-03661170v1

Crystal Structure of the Eukaryotic Ribosome

Adam Ben-Shem , Lasse Jenner , Gulnara Yusupova , Marat Yusupov
Science, 2010, 330 (6008), pp.1203-1209. ⟨10.1126/science.1194294⟩
Journal articles hal-03661172v1

Interactions of the ribosome with mRNA and tRNA

Natalia Demeshkina , Lasse Jenner , Gulnara Yusupova , Marat Yusupov
Current Opinion in Structural Biology, 2010, 20 (3), pp.325-332. ⟨10.1016/j.sbi.2010.03.002⟩
Journal articles hal-03661179v1

Structural aspects of messenger RNA reading frame maintenance by the ribosome

Lasse Jenner , Natalia Demeshkina , Gulnara Yusupova , Marat Yusupov
Nature Structural and Molecular Biology, 2010, 17 (5), pp.555-560. ⟨10.1038/nsmb.1790⟩
Journal articles hal-03661176v1

Structural rearrangements of the ribosome at the tRNA proofreading step

Lasse Jenner , Natalia Demeshkina , Gulnara Yusupova , Marat Yusupov
Nature Structural and Molecular Biology, 2010, 17 (9), pp.1072-1078. ⟨10.1038/nsmb.1880⟩
Journal articles hal-03661174v1