Hamid Morjani

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Présentation

CURRICULUM VITAE


Hamid MORJANI

Date of birth: 23/06/1963 hamid.morjani@univ-reims.fr
University of Reims Champagne-Ardenne (URCA)

**SUMMARY OF BIOGRAPHY **

Hamid MORJANI (PhD) is Professor of Biochemistry at the Faculty of Pharmacy of URCA. His area of expertise and research is the role of the microenvironment in tumor progression, especially in cell proliferation, migration, invasion, and response to targeted therapies. He is involved also in nanomedicine and improvement of tumor sensitivity to chemotherapies. He is co-editor, associate and guest associate editor for several journals. He is also member of several scientific societies (American Association for Cancer Research, Federation of European Biochemical Societies, European Biophysical Societies' Association, European Association for Cancer Research, International Society of Matrix Biology).

PRESENT POSITION

2012- : Professor, Biochemistry, Faculty of Pharmacy Research Laboratory: Translational Bio-spectroscopy (BioSpecT UR 7506).

PREVIOUS POSITIONS

2007-2012: Assistant Professor, Molecular Biology, Faculty of Pharmacy (URCA). 1993-2007: Assistant Professor, Biophysics (URCA), Faculty of Pharmacy (URCA). 1992-2003: ATER, Biophysics, Faculty of Pharmacy (URCA).

**ACADEMIC QUALIFICATIONS **

1998: HDR - Mechanisms of multidrug resistance in cancer chemotherapy (URCA). 1993: PhD in Biophysics - Characterization of drug-target interactions and study of resistance in living tumor cells: contribution of Raman and fluorescence micro-spectroscopies (URCA). 1989: Master's degree- Modulation of anticancer drug accumulation in leukemic cells by multidrug-resistance inhibitors: Confocal fluorescence micro-spectroscopy approach (University of Nancy).

MISSIONS AND COLLECTIVE RESPONSIBILITIES

  • National council of universities, Pharmacy, CNU 87.
  • High council for evaluation of research and higher education.
  • National corresponding network for open science of the “France universities”.
  • Coalition for advancing Research Assessment (CoARA - France).
  • Head of mission for Open Science (URCA).
  • Open Science working group (URCA).
  • Executive Board of URCA.
  • Head of the Doctoral School “Biology, Chemistry, and Health” (URCA).
  • International Relations committee (URCA).
  • Executive Board of the Faculty of Pharmacy (URCA).
  • Head of Biochemistry department of the Faculty of Pharmacy (URCA).

MEMBER OF SCIENTIFIC SOCIETIES

American Association for Cancer Research, Federation of European Biochemical Societies, French Society of Biophysics, European Association for Cancer Research, French Society of Biochemistry and Molecular Biology, French Society of Cancer, French Society of Oncologic Pharmacy, French Group of Clinical Oncology Pharmacology, French Society of Extracellular Matrix Biology, International Society of Matrix Biology, French Society for Mineralized Tissue Biology, EXON association, AE2BM association.

MOST RECENT AND SIGNIFICANT PUBLICATIONS (2016-2025)

Florent L, Saby C, Courageot MP, Terryn C, Van Gulick L, Vanmansart J, Slimano F, Morjani H. Age-associated changes in type I collagen promote the invasion of BRAFV600E mutated melanoma cells and their resistance to targeted therapies within three-dimensional matrix models. Biomed Pharmacother. 2025 Sep;190:118351.

Al Assaad A, Alaouta C, Desmaële D, Buache E, Fossier E, Van Gulick L, Slimano F, Dukic S, Mura S, Morjani H, Beljebbar A. Raman imaging for monitoring deuterated squalene-gemcitabine nanomedicines in single living breast cancer cells. Int J Pharm. 2024 Dec 25;667(Pt A):124870.

Van Gulick L, Saby C, Mayer C, Fossier E, Jaisson S, Okwieka A, Gillery P, Chenais B, Mimouni V, Morjani H, Beljebbar A. Biochemical and morpho-mechanical properties, and structural organization of rat tail tendon collagen in diet-induced obesity model. Int J Biol Macromol. 2024 Jan;254(Pt 3):127936.

Florent L, Saby C, Slimano F, Morjani H. BRAF V600-Mutated Metastatic Melanoma and Targeted Therapy Resistance: An Update of the Current Knowledge. Cancers (Basel). 2023 May 4;15(9):2607.

Zaiou M, Morjani H. Molecular Links between Cancer and Metabolic Diseases: New Perspectives and Therapeutic Strategies for Cancer Prevention and Treatment by Targeting Nutritional Patterns and Metabolic Alterations. Cancers (Basel). 2023, 15(4):1350.

Goffin N, Buache E, Charpentier C, Lehrter V, Morjani H, Gobinet C, Piot O. Trajectory Inference for Unraveling Dynamic Biological Processes from Raman Spectral Data. Anal Chem. 2023 Feb 14.

Toussaint K, Appert-Collin A, Morjani H, Albrecht C, Sartelet H, Romier-Crouzet B, Maurice P, Duca L, Blaise S, Bennasroune A. Neuraminidase-1: A Sialidase Involved in the Development of Cancers and Metabolic Diseases. Cancers (Basel). 2022, 14(19):4868.

Ben Arfi1 K, Schneider C, Bennasroune A, Bouland N, Wolak-Thierry A, Collin G, Le CC, Toussaint K, Hachet C, Lehrter V, Dedieu S, Bouché O, Morjani H, Boulagnon-Rombi C, Aline Appert-Collin. DDR1 expression in colon cancer: roles and prognosis impact. Cancers. 2022, 14(4), 928.

Oubella A, Bimoussa A, N'ait Oussidi A, Fawzi M, Auhmani A, Morjani H, Riahi A, Esseffar M, Parish C, Ait Itto MY. New 1,2,3-Triazoles from (R)-Carvone: Synthesis, DFT Mechanistic Study and In Vitro Cytotoxic Evaluation. Molecules. 2022 27(3):769.

Van Gulick L, Saby C, Jaisson S, Okwieka A, Gillery P, Dervin E, Morjani H, Beljebbar A. An integrated approach to investigate age-related modifications of morphological, mechanical and structural properties of type I collagen. Acta Biomater. 2022 19:S1742-7061(21)00688-7.

Saby C, Maquoi E, Saltel F, Morjani H. Collagen and Discoidin Domain Receptor 1 Partnership: A Multifaceted Role in the Regulation of Breast Carcinoma Cell Phenotype. Front Cell Dev Biol. 2021 22;9:808625. doi: 10.3389/fcell.2021.808625.

Oubella A, El Mansouri AE, Fawzi M, Bimoussa A, Laamari Y, Auhmani A, Morjani H, Robert A, Riahi A, Youssef Ait Itto M. Thiazolidinone-linked1,2,3-triazoles with monoterpenic skeleton as new potential anticancer agents: Design, synthesis and molecular docking studies. Bioorg Chem. 2021 20;115:105184.

Hadami K, Saby C, Dakka N, Collin G, Attaleb M, Khyatti M, Filali-Maltouf A, Morjani H, El Mzibri M. Degradation of p53 by HPV16-E6 variants isolated from cervical cancer specimens of Moroccan women. Gene. 2021 30;791:145709.

Laamari Y, Oubella A, Bimoussa A, El Mansouri AE, Ketatni EM, Mentre O, Ait Itto MY, Morjani H, Khouili M, Auhmani A. Design, Hemiysnthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol. Bioorg Chem. 2021 115:105165.

Rammal H, Al Assaad A, Dosio F, Stella B, Maksimenko A, Mura S, Van Gulick L, Callewaert M, Desmaële D, Couvreur P, Morjani H, Beljebbar A. Investigation of squalene-doxorubicin distribution and interactions within single cancer cell using Raman microspectroscopy. Nanomedicine (Nanotechnology, Biology and Medicine). 2021;35:102404.

Girault A, Peretti M, Badaoui M, Hémon A, Morjani H, Ouadid-Ahidouch H. The N and C-termini of SPCA2 regulate differently Kv10.1 function: role in the collagen 1-induced breast cancer cell survival. Am J Cancer Res. 2021 11(1):251-263.

El Mansouri AE, Oubella A, Mehdi A, AitItto MY, Zahouily M, Morjani H, Lazrek HB. Design, synthesis, biological evaluation and molecular docking of new 1,3,4-oxadiazole homonucleosides and their double-headed analogs as antitumor agents. Bioorg Chem. 2021;108:104558.

Courageot MP, Duca L, Martiny L, Devarenne-Charpentier E, Morjani H, El-Btaouri H. Thrombospondin-1 receptor CD47 overexpression contributes to P-Glycoprotein-mediated Multidrug Resistance against doxorubicin in thyroid carcinoma FTC-133 cells. Front Oncol. 2020;10:551228.

Sarazin T, Collin G, Buache E, Van Gulick L, Charpentier C, Terryn C, Morjani H, Saby C. Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. Front Oncol. 2020;10:1593.

Ouadid-Ahidouch H, Morjani H, Schnipper J, Girault A, Ahidouch A. Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression. Rev Physiol Biochem Pharmacol. 2020 doi: 10.1007/112_2020_19.

Le CC, Bennasroune A, Collin G, Hachet C, Lehrter V, Rioult D, Dedieu S, Morjani H, Appert-Collin A. LRP-1 Promotes Colon Cancer Cell Proliferation in 3D Collagen Matrices by Mediating DDR1 Endocytosis. Front Cell Dev Biol. 2020;8:412.

Le CC, Bennasroune A, Langlois B, Salesse S, Boulagnon-Rombi C, Morjani H, Dedieu S, Appert-Collin A. Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer. Front Oncol. 2020;10:527.

Van-Gulick L, Saby C, Morjani H, Beljebbar A. Age-related changes in molecular organization of type I collagen in tendon as probed by polarized SHG and Raman microspectroscopy Sci. Rep. (2019) (1):7280.

Saby C, Collin G, Maha S, Buache E, Van-Gulick L, Saltel F, Maquoi E, H Morjani. DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells. Front. Pharmacol. (2019) doi.org/10.3389/fphar.2019.00462.

Peretti M, Badaoui M, Girault A, Van Gulick L, Mabille MP, Tebbakha R, Sevestre H, Morjani H, Ouadid-Ahidouch H. Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership. Sci Rep. 2019 9(1):1175.

Saby C, Rammal H, Magnien K, Buache E, Brassart-Pasco S, Van-Gulick L, Jeannesson P, Maquoi E, Morjani H. Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. Cell Adh Migr. 2018;12(4):335-347.

Badaoui M, Mimsy-Julienne C, Saby C, Van Gulick L, Peretti M, Jeannesson P, Morjani H, Ouadid-Ahidouch H. Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway. Oncotarget. 2017 9(37):24653-24671.

Mohsen A, Collery P, Garnotel R, Brassart B, Etique N, Mohamed Sabry G, Elsherif Hassan R, Jeannesson P, Desmaële D, Morjani H. A new gallium complex inhibits tumor cell invasion and matrix metalloproteinase MMP-14 expression and activity. Metallomics. 2017 16;9(8):1176-1184.

Appert-Collin A, Bennasroune A, Jeannesson P, Terryn C, Fuhrmann G, Morjani H, Dedieu S. Role of LRP-1 in cancer cell migration in 3-dimensional collagen matrix. Cell Adh Migr. 2017 11(4):316-326.

Mohsen A, Saby C, Collery P, Sabry GM, Hassan RE, Badawi A, Jeannesson P, Desmaële D, Morjani H. Biological study of the effect of water soluble [N-(2-hydroxybenzyl)-L-aspartato] gallium complexes on breast carcinoma and fibrosarcoma cells. J Biol Inorg Chem. 2016 21(7):837-49.

Saby C, Buache E, Brassart-Pasco S, El Btaouri H, Courageot MP, Van Gulick L, Garnotel R, Jeannesson P, Morjani H. Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression. Oncotarget. 2016 7(18):24908-27.

Rammal H, Saby C, Magnien K, Van-Gulick L, Garnotel R, Buache E, El Btaouri H, Jeannesson P, Morjani H. Discoidin Domain Receptors: Potential Actors and Targets in Cancer. Front Pharmacol. 2016 14;7:55.

Publications

Publications

Biochemical and morpho-mechanical properties, and structural organization of rat tail tendon collagen in diet-induced obesity model

Laurence van Gulick , Charles Saby , Claire Mayer , Emilie Fossier , Stéphane Jaisson et al.
International Journal of Biological Macromolecules, 2024, 254, pp.127936. ⟨10.1016/j.ijbiomac.2023.127936⟩
Article dans une revue hal-05470946 v1

Biochemical and morpho-mechanical properties, and structural organization of rat tail tendon collagen in diet-induced obesity model

Laurence van Gulick , Charles Saby , Claire Mayer , Emilie Fossier , Stéphane Jaisson et al.
International Journal of Biological Macromolecules, 2024, 254, pp.127936. ⟨10.1016/j.ijbiomac.2023.127936⟩
Article dans une revue hal-04988106 v1
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Raman imaging for monitoring deuterated squalene-gemcitabine nanomedicines in single living breast cancer cells

Almar Al Assaad , Cherine Alaouta , Didier Desmaële , Emilie Buache , Emilie Fossier et al.
International Journal of Pharmaceutics, 2024, 667, pp.124870. ⟨10.1016/j.ijpharm.2024.124870⟩
Article dans une revue hal-04929783 v1

Molecular Links between Cancer and Metabolic Diseases: New Perspectives and Therapeutic Strategies for Cancer Prevention and Treatment by Targeting Nutritional Patterns and Metabolic Alterations

Mohamed Zaiou , Hamid Morjani
Cancers, 2023, 15 (4), pp.1350. ⟨10.3390/cancers15041350⟩
Article dans une revue hal-04319180 v1

Design, Synthesis, Cytotoxic Effect Evaluation and Molecular Docking of (R)‐Camphor‐Based Thiazolidinone‐Isoxazole and Thiazolidinone‐1,2,3‐triazole Hybrids“

Abdellah N'Ait Ousidi , Abdoullah Bimoussa , Mohammed Loubidi , Mourad Fawzi , Yassine Laamari et al.
ChemistrySelect, 2023, 8 (1), pp.e202203349. ⟨10.1002/slct.202203349⟩
Article dans une revue hal-04790719 v1

Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives

Az-Eddine El Mansouri , Saida Lachhab , Ali Oubella , Mehdi Ahmad , Johan Neyts et al.
Journal of Molecular Structure, 2023, 1272, pp.134135. ⟨10.1016/j.molstruc.2022.134135⟩
Article dans une revue hal-03789531 v1
Image document

Neuraminidase-1: A Sialidase Involved in the Development of Cancers and Metabolic Diseases

Kévin Toussaint , Aline Appert-Collin , Hamid Morjani , Camille Albrecht , Hervé Sartelet et al.
Cancers, 2022, 14, pp.4868. ⟨10.3390/cancers14194868⟩
Article dans une revue (article de synthèse) hal-04099812 v1

New 1,2,3-Triazoles from (R)-Carvone: Synthesis, DFT Mechanistic Study and In Vitro Cytotoxic Evaluation

Ali Oubella , Abdoullah Bimoussa , Abdellah N’ait Oussidi , Mourad Fawzi , Aziz Auhmani et al.
Molecules, 2022, 27 (3), pp.769. ⟨10.3390/molecules27030769⟩
Article dans une revue hal-03551211 v1
Image document

An integrated approach to investigate age-related modifications of morphological, mechanical and structural properties of type I collagen

Laurence van Gulick , Charles Saby , Stéphane Jaisson , Anaïs Okwieka , Philippe Gillery et al.
Acta Biomaterialia, 2022, 137, pp.64-78. ⟨10.1016/j.actbio.2021.10.020⟩
Article dans une revue hal-03607799 v1
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Design, Hemiysnthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol

Yassine Laamari , Ali Oubella , Abdoullah Bimoussa , Az-Eddine El Mansouri , El Mostafa Ketatni et al.
Bioorganic Chemistry, 2021, 115, pp.105165. ⟨10.1016/j.bioorg.2021.105165⟩
Article dans une revue hal-03438882 v1
Image document

Investigation of squalene-doxorubicin distribution and interactions within single cancer cell using Raman microspectroscopy

Hassan Rammal , Almar Al Assaad , Franco Dosio , Barbara Stella , Andrei Maksimenko et al.
Nanomedicine: Nanotechnology, Biology and Medicine, 2021, 35, pp.102404. ⟨10.1016/j.nano.2021.102404⟩
Article dans une revue hal-03406418 v1
Image document

The N and C-termini of SPCA2 regulate differently Kv10.1 function: role in the collagen 1-induced breast cancer cell survival

Alban Girault , Marta Peretti , Mehdi Badaoui , Anais Hémon , Hamid Morjani et al.
American Journal of Cancer Research, 2021, 11 (1), pp.251+
Article dans une revue hal-03607831 v1
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New enaminone-based to the sesquiterpenic: TiCl4-catalyzed synthesis, spectral characterization, crystal structure, Hirshfeld surface analysis, DFT studies and cytotoxic activity

Abdoullah Bimoussa , Ali Oubella , Mouhi Eddine Hachim , My Youssef Ait Itto , Olivier Mentré et al.
Journal of Molecular Structure, 2021, 1241, pp.130622. ⟨10.1016/j.molstruc.2021.130622⟩
Article dans une revue hal-03438902 v1

Design, synthesis, biological evaluation and molecular docking of new 1,3,4-oxadiazole homonucleosides and their double-headed analogs as antitumor agents

Az-Eddine El Mansouri , Ali Oubella , Ahmad Mehdi , Moulay Youssef Aititto , Mohamed Zahouily et al.
Bioorganic Chemistry, 2021, 108, pp.104558. ⟨10.1016/j.bioorg.2020.104558⟩
Article dans une revue hal-03161709 v1
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LRP-1 Promotes Colon Cancer Cell Proliferation in 3D Collagen Matrices by Mediating DDR1 Endocytosis

Cao Cuong Le , Amar Bennasroune , Guillaume Collin , Cathy Hachet , Véronique Lehrter et al.
Frontiers in Cell and Developmental Biology, 2020, 8, ⟨10.3389/fcell.2020.00412⟩
Article dans une revue hal-02934154 v1

Synthesis, characterization, and biological evaluation of new heterocyclic systems 1, 2, 3-triazole-isoxazoline from eugenol by the mixed condensation reactions

Abdelmaoujoud Taia , Mohamed Essaber , Ali Oubella , Abdeljalil Aatif , Jacques Bodiguel et al.
Synthetic Communications, 2020, 50 (13), pp.2052-2065. ⟨10.1080/00397911.2020.1762224⟩
Article dans une revue hal-03241095 v1
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Thrombospondin-1 Receptor CD47 Overexpression Contributes to P-Glycoprotein-Mediated Multidrug Resistance Against Doxorubicin in Thyroid Carcinoma FTC-133 Cells

Marie-Pierre Courageot , Laurent Duca , Laurent Martiny , Emmanuelle Devarenne-Charpentier , Hamid Morjani et al.
Frontiers in Oncology, 2020, 10, ⟨10.3389/fonc.2020.551228⟩
Article dans une revue hal-03372837 v1
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Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer

Cuong Cao Le , Amar Bennasroune , Benoît Langlois , Stéphanie Salesse , Camille Boulagnon-Rombi et al.
Frontiers in Oncology, 2020, 10, ⟨10.3389/fonc.2020.00527⟩
Article dans une revue hal-03053593 v1

Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model

Marie-Pierre Courageot , Laurent Duca , Laurent Martiny , Emmanuelle Devarenne-Charpentier , Hamid Morjani et al.
Frontiers in Oncology, 2020, 10, ⟨10.3389/FONC.2020.01593⟩
Article dans une revue hal-03164545 v1

Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression

Halima Ouadid-Ahidouch , Hamid Morjani , Julie Schnipper , Alban Girault , Ahmed Ahidouch et al.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [1994-..], 2020, 251, pp.119382. ⟨10.1007/112_2020_19⟩
Article dans une revue hal-03164510 v1

Synthesis and Antitumor Activity of Novel Heterocyclic Systems with Monoterpenic Skeleton Combining Dichlorocyclopropane and 1,3,4‐Thiadiazole Nucleus

Ali Oubella , Mourad Fawzi , Aziz Auhmani , Abdelkhalek Riahi , Hamid Morjani et al.
ChemistrySelect, 2020, 5 (21), pp.6403-6406. ⟨10.1002/slct.202001284⟩
Article dans une revue hal-02882951 v1
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Triterpene saponins from the roots of Parkia bicolor A. Chev

Michel Boni Bitchi , Abdulmagid Alabdul-Magid , Philomène Akoua Yao-Kouassi , Faustin Aka Kabran , Dominique Harakat et al.
Fitoterapia, 2019, 137, pp.104264. ⟨10.1016/j.fitote.2019.104264⟩
Article dans une revue hal-02310366 v1
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Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership

Marta Peretti , Mehdi Badaoui , Alban Girault , Laurence van Gulick , Marie-Pierre Mabille et al.
Scientific Reports, 2019, 9 (1), pp.1175. ⟨10.1038/s41598-018-37602-7⟩
Article dans une revue hal-02310333 v1
Image document

Age-related changes in molecular organization of type I collagen in tendon as probed by polarized SHG and Raman microspectroscopy

Laurence van Gulick , Charles Saby , Hamid Morjani , Abdelilah Beljebbar
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-43636-2⟩
Article dans une revue hal-02309301 v1
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Triterpenes from Salvia argentea var. aurasiaca and their antibacterial and cytotoxic activities

Sara Bechkri , Abdulmagid Alabdul-Magid , Laurence Voutquenne-Nazabadioko , Berrehal Djemaa , Ahmed Kabouche et al.
Fitoterapia, 2019, pp.104296. ⟨10.1016/j.fitote.2019.104296⟩
Article dans une revue hal-02310372 v1
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Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia

Michel Boni Bitchi , Abdulmagid Alabdul-Magid , Faustin Aka Kabran , Philomène Akoua Yao-Kouassi , Dominique Harakat et al.
Phytochemistry, 2019, 167, pp.112081. ⟨10.1016/j.phytochem.2019.112081⟩
Article dans une revue hal-02310316 v2

Diastereoselective synthesis and cytotoxic evaluation of new isoxazoles and pyrazoles with monoterpenic skeleton

Ali Oubella , My Youssef Ait Itto , Aziz Auhmani , Abdelkhalek Riahi , Anthony Robert et al.
Journal of Molecular Structure, 2019, 1198, pp.126924. ⟨10.1016/j.molstruc.2019.126924⟩
Article dans une revue istex hal-02430280 v1
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DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells

Charles Saby , Guillaume Collin , Maha Sinane , Emilie Buache , Laurence van Gulick et al.
Frontiers in Pharmacology, 2019, 10, ⟨10.3389/fphar.2019.00462⟩
Article dans une revue hal-02309321 v1
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Antibacterial, antioxidant and cytotoxic activities of triterpenes and flavonoids from the aerial parts of Salvia barrelieri Etl.

Meryem Lehbili , Abdulmagid Alabdul Magid , Ahmed Kabouche , Laurence Voutquenne-Nazabadioko , Amin Abedini et al.
Natural Product Research, 2018, 32 (22), pp.2683-2691. ⟨10.1080/14786419.2017.1378207⟩
Article dans une revue hal-02008123 v1
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Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria

Meryem Lehbili , Abdulmagid Alabdul Magid , Ahmed Kabouche , Laurence Voutquenne-Nazabadioko , Hamid Morjani et al.
Phytochemistry, 2018, 150, pp.40-49. ⟨10.1016/j.phytochem.2018.03.005⟩
Article dans une revue hal-03351420 v1
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Two new bis-iridoids isolated from Scabiosa stellata and their antibacterial, antioxidant, anti-tyrosinase and cytotoxic activities

Meryem Lehbili , Abdulmagid Alabdul Magid , Jane Hubert , Ahmed Kabouche , Laurence Voutquenne-Nazabadioko et al.
Fitoterapia, 2018, 125, pp.41 - 48. ⟨10.1016/j.fitote.2017.12.018⟩
Article dans une revue hal-03351296 v1
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A new 2-alkylhydroquinone glucoside from Phagnalon saxatile (L.) Cass

Hanene Cherchar , Meriem Lehbili , Djemaa Berrehal , Hamid Morjani , Abdulmagid Alabdul Magid et al.
Natural Product Research, 2018, 32 (9), pp.1010-1016. ⟨10.1080/14786419.2017.1375918⟩
Article dans une revue hal-02929189 v1
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Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway

Mehdi Badaoui , Cloé Mimsy-Julienne , Charles Saby , Laurence van Gulick , Marta Peretti et al.
Oncotarget, 2018, 9 (37), ⟨10.18632/oncotarget.19065⟩
Article dans une revue hal-02310419 v1

Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells

Charles Saby , Hassan Rammal , Kevin Magnien , Emilie Buache , Sylvie Brassart-Pasco et al.
Cell Adhesion and Migration, 2018, 12 (4), pp.335-347. ⟨10.1080/19336918.2018.1472182⟩
Article dans une revue hal-02365694 v1

Single cell adhesion strength assessed with variable-angle total internal reflection fluorescence microscopy

Marcelina Cardoso dos Santos , Cyrille Vézy , Hamid Morjani , Rodolphe Jaffiol
AIMS Biophysics, 2017, 4 (3), pp.438-450. ⟨10.3934/biophy.2017.3.438⟩
Article dans une revue hal-02448485 v1

How Streptomyces anulatus Primes Grapevine Defenses to Cope with Gray Mold: A Study of the Early Responses of Cell Suspensions

Parul Vatsa-Portugal , Aziz Aziz , Marine Rondeau , Sandra Villaume , Hamid Morjani et al.
Frontiers in Plant Science, 2017, 8, ⟨10.3389/fpls.2017.01043⟩
Article dans une revue hal-02929447 v1

Oleanane-type triterpene saponins from Calendula stellata

Meryem Lehbili , Abdulmagid Alabdul Magid , Ahmed Kabouche , Laurence Voutquenne-Nazabadioko , Amin Abedini et al.
Phytochemistry, 2017, 144, pp.33 - 42. ⟨10.1016/j.phytochem.2017.08.015⟩
Article dans une revue hal-01834101 v1

A new gallium complex inhibits tumor cell invasion and matrix metalloproteinase MMP-14 expression and activity

Ahmed Mohsen , Philippe Collery , Roselyne Garnotel , Bertrand Brassart , Nicolas Etique et al.
Metallomics, 2017, 9 (8), pp.1176-1184. ⟨10.1039/c7mt00049a⟩
Article dans une revue hal-02929237 v1

Role of LRP-1 in cancer cell migration in 3-dimensional collagen matrix

Aline Appert-Collin , Amar Bennasroune , Pierre Jeannesson , Christine Terryn , Guy Fuhrmann et al.
Cell Adhesion and Migration, 2017, 11 (4), pp.316-326. ⟨10.1080/19336918.2016.1215788⟩
Article dans une revue hal-02184497 v1

Tomentosin Induces Telomere Shortening and Caspase-Dependant Apoptosis in Cervical Cancer Cells

Nawel Merghoub , Hassan El Btaouri , Laila Benbacer , Saïd Gmouh , Chantal Trentesaux et al.
Journal of Cellular Biochemistry, 2017, 118 (7), pp.1689-1698. ⟨10.1002/jcb.25826⟩
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Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss.

Abbes Benmerache , Abdulmagid Alabdul Magid , Amira Labed , Ahmed Kabouche , Laurence Voutquenne-Nazabadioko et al.
Natural Product Research, 2017, 31 (18), pp.2091 - 2098. ⟨10.1080/14786419.2016.1277345⟩
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Triterpene glycosides from the aerial parts of Gouania longipetala

Diane Patricia Apie Gossan , Abdulmagid Alabdul Magid , Philomène Akoua Yao-Kouassi , Antoine Ahibo Coffy , Jérôme Josse et al.
Phytochemistry, 2017, 134, pp.71 - 77. ⟨10.1016/j.phytochem.2016.11.004⟩
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Corrigendum: Discoidin Domain Receptors: Potential Actors and Targets in Cancer

Marie-Pierre Courageot , Laurent Duca , Laurent Martiny , Emmanuelle Devarenne-Charpentier , Hassan Rammal et al.
Frontiers in Pharmacology, 2016, 7, ⟨10.3389/fphar.2016.00346⟩
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Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression

Charles Saby , Emilie Buache , Sylvie Brassart-Pasco , Hassan El Btaouri , Marie-Pierre Courageot et al.
Oncotarget, 2016, 7 (18), pp.24908-24927. ⟨10.18632/oncotarget.8795⟩
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Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum

Diane Patricia Apie Gossan , Abdulmagid Alabdul Magid , Philomène Akoua Yao-Kouassi , Jérôme Josse , Sophie C. Gangloff et al.
Fitoterapia, 2016, 110, pp.89 - 95. ⟨10.1016/j.fitote.2016.03.002⟩
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Discoidin Domain Receptors: Potential Actors and Targets in Cancer

Hassan Rammal , Charles Saby , Kevin Magnien , Laurence Van-Gulick , Roselyne Garnotel et al.
Frontiers in Pharmacology, 2016, 7, ⟨10.3389/fphar.2016.00055⟩
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Inula Viscosa Extracts Induces Telomere Shortening and Apoptosis in Cancer Cells and Overcome Drug Resistance

Nawal Merghoub , Hassan El Btaouri , Laila Benbacer , Saïd Gmouh , Chantal Trentesaux et al.
Nutrition and Cancer, 2015, 68 (1), pp.131-143. ⟨10.1080/01635581.2016.1115105⟩
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Triterpenoid glycosides from the leaves of Meliosma henryi.

Abdulmagid Alabdul Magid , Hamid Morjani , Dominique Harakat , Claudie Madoulet , Vincent Dumontet et al.
Phytochemistry, 2014, 109, pp.49-56
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Microfluidity mapping using fluorescence correlation spectroscopy: A new way to investigate plasma membrane microorganization of living cells

Pascale Winckler , Aurélie Cailler , Régis Deturche , Pierre Jeannesson , Hamid Morjani et al.
Biochimica et Biophysica Acta:Biomembranes, 2012, 1818 (11), pp.2477-2485. ⟨10.1016/j.bbamem.2012.05.018⟩
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Extracellular Matrix Proteins Modulate Antimigratory and Apoptotic Effects of Doxorubicin

Georges Said , Marie Guilbert , Hamid Morjani , Roselyne Garnotel , Pierre Jeannesson et al.
Chemotherapy Research and Practice, 2012, 2012, pp.268681. ⟨10.1155/2012/268681⟩
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Accumulation of lactosylceramide and overexpression of a PSC833-resistant P-glycoprotein in multidrug-resistant human sarcoma cells.

Nassera Aouali , Hassan El Btaouri , Charles Dumontet , Lahcen Eddabra , Sophie Malagarie-Cazenave et al.
Oncology Reports, 2011, 25 (4), pp.1161-7. ⟨10.3892/or.2011.1180⟩
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Telomestatin-induced Telomere Uncapping Is Modulated by POT1 through G-overhang Extension in HT1080 Human Tumor Cells

Dennis Gomez , Thomas Wenner , Bertrand Brassart , Céline Douarre , Marie-Françoise O'Donohue et al.
Journal of Biological Chemistry, 2006, 281 (50), pp.38721-38729. ⟨10.1074/jbc.M605828200⟩
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Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

Céline Douarre , Dennis Gomez , Hamid Morjani , Jean-Marie Zahm , Marie-Françoise O'Donohue et al.
Nucleic Acids Research, 2005, 33 (7), pp.2192-2203. ⟨10.1093/nar/gki514⟩
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Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence.

Céline Douarre , Dennis Gomez , Hamid Morjani , Jean-Marie Zahm , Marie-Françoise O'Donohue et al.
Nucleic Acids Research, 2005, 33 (7), pp.2192-203. ⟨10.1093/nar/gki514⟩
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Régulation de la longueur des télomères : rendre le télomère accessible ?

Jean-François Riou , Dennis Gomez , Jean-Louis Mergny , Lionel Guittat , Rajaa Paterski et al.
Bulletin du Cancer, 2005
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Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool.

Benoît Chénais , Hamid Morjani , Jean-Claude Drapier
Journal of Neurochemistry, 2002, 81 (3), pp.615-23
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Free radical production and labile iron pool decrease triggered by subtoxic concentration of aclarubicin in human leukemia cell lines.

Doriane Richard , Hamid Morjani , Benoît Chénais
Leukemia Research, 2002, 26 (10), pp.927-31
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Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression

Halima Ouadid-Ahidouch , Hamid Morjani , Julie Schnipper , Alban Girault , Ahmed Ahidouch
Stock, C and Pardo, LA. TRANSPORTOME MALFUNCTION IN THE CANCER SPECTRUM: ION TRANSPORT IN TUMOR BIOLOGY, 181, Springer International Publishing, pp.1-38, 2021, Reviews of Physiology Biochemistry and Pharmacology, 978-3-030-90920-8; 978-3-030-90919-2. ⟨10.1007/112_2020_19⟩
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