Hamid Morjani
Présentation
CURRICULUM VITAE
Hamid MORJANI
Date of birth: 23/06/1963
hamid.morjani@univ-reims.fr
University of Reims Champagne-Ardenne (URCA)
**SUMMARY OF BIOGRAPHY **
Hamid MORJANI (PhD) is Professor of Biochemistry at the Faculty of Pharmacy of URCA. His area of expertise and research is the role of the microenvironment in tumor progression, especially in cell proliferation, migration, invasion, and response to targeted therapies. He is involved also in nanomedicine and improvement of tumor sensitivity to chemotherapies. He is co-editor, associate and guest associate editor for several journals. He is also member of several scientific societies (American Association for Cancer Research, Federation of European Biochemical Societies, European Biophysical Societies' Association, European Association for Cancer Research, International Society of Matrix Biology).
PRESENT POSITION
2012- : Professor, Biochemistry, Faculty of Pharmacy Research Laboratory: Translational Bio-spectroscopy (BioSpecT UR 7506).
PREVIOUS POSITIONS
2007-2012: Assistant Professor, Molecular Biology, Faculty of Pharmacy (URCA). 1993-2007: Assistant Professor, Biophysics (URCA), Faculty of Pharmacy (URCA). 1992-2003: ATER, Biophysics, Faculty of Pharmacy (URCA).
**ACADEMIC QUALIFICATIONS **
1998: HDR - Mechanisms of multidrug resistance in cancer chemotherapy (URCA). 1993: PhD in Biophysics - Characterization of drug-target interactions and study of resistance in living tumor cells: contribution of Raman and fluorescence micro-spectroscopies (URCA). 1989: Master's degree- Modulation of anticancer drug accumulation in leukemic cells by multidrug-resistance inhibitors: Confocal fluorescence micro-spectroscopy approach (University of Nancy).
MISSIONS AND COLLECTIVE RESPONSIBILITIES
- National council of universities, Pharmacy, CNU 87.
- High council for evaluation of research and higher education.
- National corresponding network for open science of the “France universities”.
- Coalition for advancing Research Assessment (CoARA - France).
- Head of mission for Open Science (URCA).
- Open Science working group (URCA).
- Executive Board of URCA.
- Head of the Doctoral School “Biology, Chemistry, and Health” (URCA).
- International Relations committee (URCA).
- Executive Board of the Faculty of Pharmacy (URCA).
- Head of Biochemistry department of the Faculty of Pharmacy (URCA).
MEMBER OF SCIENTIFIC SOCIETIES
American Association for Cancer Research, Federation of European Biochemical Societies, French Society of Biophysics, European Association for Cancer Research, French Society of Biochemistry and Molecular Biology, French Society of Cancer, French Society of Oncologic Pharmacy, French Group of Clinical Oncology Pharmacology, French Society of Extracellular Matrix Biology, International Society of Matrix Biology, French Society for Mineralized Tissue Biology, EXON association, AE2BM association.
MOST RECENT AND SIGNIFICANT PUBLICATIONS (2016-2025)
Florent L, Saby C, Courageot MP, Terryn C, Van Gulick L, Vanmansart J, Slimano F, Morjani H. Age-associated changes in type I collagen promote the invasion of BRAFV600E mutated melanoma cells and their resistance to targeted therapies within three-dimensional matrix models. Biomed Pharmacother. 2025 Sep;190:118351.
Al Assaad A, Alaouta C, Desmaële D, Buache E, Fossier E, Van Gulick L, Slimano F, Dukic S, Mura S, Morjani H, Beljebbar A. Raman imaging for monitoring deuterated squalene-gemcitabine nanomedicines in single living breast cancer cells. Int J Pharm. 2024 Dec 25;667(Pt A):124870.
Van Gulick L, Saby C, Mayer C, Fossier E, Jaisson S, Okwieka A, Gillery P, Chenais B, Mimouni V, Morjani H, Beljebbar A. Biochemical and morpho-mechanical properties, and structural organization of rat tail tendon collagen in diet-induced obesity model. Int J Biol Macromol. 2024 Jan;254(Pt 3):127936.
Florent L, Saby C, Slimano F, Morjani H. BRAF V600-Mutated Metastatic Melanoma and Targeted Therapy Resistance: An Update of the Current Knowledge. Cancers (Basel). 2023 May 4;15(9):2607.
Zaiou M, Morjani H. Molecular Links between Cancer and Metabolic Diseases: New Perspectives and Therapeutic Strategies for Cancer Prevention and Treatment by Targeting Nutritional Patterns and Metabolic Alterations. Cancers (Basel). 2023, 15(4):1350.
Goffin N, Buache E, Charpentier C, Lehrter V, Morjani H, Gobinet C, Piot O. Trajectory Inference for Unraveling Dynamic Biological Processes from Raman Spectral Data. Anal Chem. 2023 Feb 14.
Toussaint K, Appert-Collin A, Morjani H, Albrecht C, Sartelet H, Romier-Crouzet B, Maurice P, Duca L, Blaise S, Bennasroune A. Neuraminidase-1: A Sialidase Involved in the Development of Cancers and Metabolic Diseases. Cancers (Basel). 2022, 14(19):4868.
Ben Arfi1 K, Schneider C, Bennasroune A, Bouland N, Wolak-Thierry A, Collin G, Le CC, Toussaint K, Hachet C, Lehrter V, Dedieu S, Bouché O, Morjani H, Boulagnon-Rombi C, Aline Appert-Collin. DDR1 expression in colon cancer: roles and prognosis impact. Cancers. 2022, 14(4), 928.
Oubella A, Bimoussa A, N'ait Oussidi A, Fawzi M, Auhmani A, Morjani H, Riahi A, Esseffar M, Parish C, Ait Itto MY. New 1,2,3-Triazoles from (R)-Carvone: Synthesis, DFT Mechanistic Study and In Vitro Cytotoxic Evaluation. Molecules. 2022 27(3):769.
Van Gulick L, Saby C, Jaisson S, Okwieka A, Gillery P, Dervin E, Morjani H, Beljebbar A. An integrated approach to investigate age-related modifications of morphological, mechanical and structural properties of type I collagen. Acta Biomater. 2022 19:S1742-7061(21)00688-7.
Saby C, Maquoi E, Saltel F, Morjani H. Collagen and Discoidin Domain Receptor 1 Partnership: A Multifaceted Role in the Regulation of Breast Carcinoma Cell Phenotype. Front Cell Dev Biol. 2021 22;9:808625. doi: 10.3389/fcell.2021.808625.
Oubella A, El Mansouri AE, Fawzi M, Bimoussa A, Laamari Y, Auhmani A, Morjani H, Robert A, Riahi A, Youssef Ait Itto M. Thiazolidinone-linked1,2,3-triazoles with monoterpenic skeleton as new potential anticancer agents: Design, synthesis and molecular docking studies. Bioorg Chem. 2021 20;115:105184.
Hadami K, Saby C, Dakka N, Collin G, Attaleb M, Khyatti M, Filali-Maltouf A, Morjani H, El Mzibri M. Degradation of p53 by HPV16-E6 variants isolated from cervical cancer specimens of Moroccan women. Gene. 2021 30;791:145709.
Laamari Y, Oubella A, Bimoussa A, El Mansouri AE, Ketatni EM, Mentre O, Ait Itto MY, Morjani H, Khouili M, Auhmani A. Design, Hemiysnthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol. Bioorg Chem. 2021 115:105165.
Rammal H, Al Assaad A, Dosio F, Stella B, Maksimenko A, Mura S, Van Gulick L, Callewaert M, Desmaële D, Couvreur P, Morjani H, Beljebbar A. Investigation of squalene-doxorubicin distribution and interactions within single cancer cell using Raman microspectroscopy. Nanomedicine (Nanotechnology, Biology and Medicine). 2021;35:102404.
Girault A, Peretti M, Badaoui M, Hémon A, Morjani H, Ouadid-Ahidouch H. The N and C-termini of SPCA2 regulate differently Kv10.1 function: role in the collagen 1-induced breast cancer cell survival. Am J Cancer Res. 2021 11(1):251-263.
El Mansouri AE, Oubella A, Mehdi A, AitItto MY, Zahouily M, Morjani H, Lazrek HB. Design, synthesis, biological evaluation and molecular docking of new 1,3,4-oxadiazole homonucleosides and their double-headed analogs as antitumor agents. Bioorg Chem. 2021;108:104558.
Courageot MP, Duca L, Martiny L, Devarenne-Charpentier E, Morjani H, El-Btaouri H. Thrombospondin-1 receptor CD47 overexpression contributes to P-Glycoprotein-mediated Multidrug Resistance against doxorubicin in thyroid carcinoma FTC-133 cells. Front Oncol. 2020;10:551228.
Sarazin T, Collin G, Buache E, Van Gulick L, Charpentier C, Terryn C, Morjani H, Saby C. Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. Front Oncol. 2020;10:1593.
Ouadid-Ahidouch H, Morjani H, Schnipper J, Girault A, Ahidouch A. Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression. Rev Physiol Biochem Pharmacol. 2020 doi: 10.1007/112_2020_19.
Le CC, Bennasroune A, Collin G, Hachet C, Lehrter V, Rioult D, Dedieu S, Morjani H, Appert-Collin A. LRP-1 Promotes Colon Cancer Cell Proliferation in 3D Collagen Matrices by Mediating DDR1 Endocytosis. Front Cell Dev Biol. 2020;8:412.
Le CC, Bennasroune A, Langlois B, Salesse S, Boulagnon-Rombi C, Morjani H, Dedieu S, Appert-Collin A. Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer. Front Oncol. 2020;10:527.
Van-Gulick L, Saby C, Morjani H, Beljebbar A. Age-related changes in molecular organization of type I collagen in tendon as probed by polarized SHG and Raman microspectroscopy Sci. Rep. (2019) (1):7280.
Saby C, Collin G, Maha S, Buache E, Van-Gulick L, Saltel F, Maquoi E, H Morjani. DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells. Front. Pharmacol. (2019) doi.org/10.3389/fphar.2019.00462.
Peretti M, Badaoui M, Girault A, Van Gulick L, Mabille MP, Tebbakha R, Sevestre H, Morjani H, Ouadid-Ahidouch H. Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership. Sci Rep. 2019 9(1):1175.
Saby C, Rammal H, Magnien K, Buache E, Brassart-Pasco S, Van-Gulick L, Jeannesson P, Maquoi E, Morjani H. Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. Cell Adh Migr. 2018;12(4):335-347.
Badaoui M, Mimsy-Julienne C, Saby C, Van Gulick L, Peretti M, Jeannesson P, Morjani H, Ouadid-Ahidouch H. Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway. Oncotarget. 2017 9(37):24653-24671.
Mohsen A, Collery P, Garnotel R, Brassart B, Etique N, Mohamed Sabry G, Elsherif Hassan R, Jeannesson P, Desmaële D, Morjani H. A new gallium complex inhibits tumor cell invasion and matrix metalloproteinase MMP-14 expression and activity. Metallomics. 2017 16;9(8):1176-1184.
Appert-Collin A, Bennasroune A, Jeannesson P, Terryn C, Fuhrmann G, Morjani H, Dedieu S. Role of LRP-1 in cancer cell migration in 3-dimensional collagen matrix. Cell Adh Migr. 2017 11(4):316-326.
Mohsen A, Saby C, Collery P, Sabry GM, Hassan RE, Badawi A, Jeannesson P, Desmaële D, Morjani H. Biological study of the effect of water soluble [N-(2-hydroxybenzyl)-L-aspartato] gallium complexes on breast carcinoma and fibrosarcoma cells. J Biol Inorg Chem. 2016 21(7):837-49.
Saby C, Buache E, Brassart-Pasco S, El Btaouri H, Courageot MP, Van Gulick L, Garnotel R, Jeannesson P, Morjani H. Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression. Oncotarget. 2016 7(18):24908-27.
Rammal H, Saby C, Magnien K, Van-Gulick L, Garnotel R, Buache E, El Btaouri H, Jeannesson P, Morjani H. Discoidin Domain Receptors: Potential Actors and Targets in Cancer. Front Pharmacol. 2016 14;7:55.
Publications
Publications
Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer ProgressionStock, C and Pardo, LA. TRANSPORTOME MALFUNCTION IN THE CANCER SPECTRUM: ION TRANSPORT IN TUMOR BIOLOGY, 181, Springer International Publishing, pp.1-38, 2021, Reviews of Physiology Biochemistry and Pharmacology, 978-3-030-90920-8; 978-3-030-90919-2. ⟨10.1007/112_2020_19⟩
Chapitre d'ouvrage
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