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LIM Kinases: From Molecular to Pathological Features
Hélène Bénédetti
,
Béatrice Vallée
Article dans une revue
hal-04208415v1
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LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features
Elodie Villalonga
,
Christine Mosrin
,
Thierry Normand
,
Caroline Girardin
,
Amandine Serrano
Article dans une revue
hal-04208405v1
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LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo
Rayan Berabez
,
Sylvain Routier
,
Hélène Bénédetti
,
Karen Plé
,
Béatrice Vallée
Article dans une revue
hal-03721458v1
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Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper
Bojan Žunar
,
Christine Mosrin-Huaman
,
Hélène Bénédetti
,
Béatrice Vallée
Article dans une revue
hal-03820214v1
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The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes
Wissem Deraredj Nadim
,
Shalina Hassanaly
,
Hélène Bénédetti
,
Claudine Kieda
,
Catherine Grillon
Article dans une revue
hal-03007433v1
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A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation
Skander A Abboud
,
Hadji H.
,
Michel Doudeau
,
Hélène Bénédetti
,
Vincent Aucagne
Article dans une revue
hal-03447239v1
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Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors
Frédéric Buron
,
Nuno Rodrigues
,
Thibault Saurat
,
Marie-Aude Hiebel
,
Stéphane Bourg
Article dans une revue
hal-03348966v1
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Neurofibromin Structure, Functions and Regulation
Mohammed Bergoug
,
Michel Doudeau
,
Fabienne Godin
,
Christine Mosrin-Huaman
,
Béatrice Vallée
Article dans une revue
hal-03070759v2
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Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein
Béatrice Vallée
,
Michel Doudeau
,
Fabienne Godin
,
Hélène Bénédetti
Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩
Article dans une revue
hal-02282630v1
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LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability
Julie Tastet
,
Hélène Cuberos
,
Béatrice Vallée
,
Annick Toutain
,
Martine Raynaud
Article dans une revue
hal-02067472v1
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LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b
Béatrice Vallée
,
Hélène Cuberos
,
Michel Doudeau
,
Fabienne Godin
,
David Gosset
Biochemical Journal, 2018, 475 (23), pp.3745-3761
Article dans une revue
hal-01966439v1
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Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities
Viorel Simion
,
Wissem Deraredj Nadim
,
Hélène Bénédetti
,
Chantal Pichon
,
Séverine Morisset-Lopez
Article dans une revue
hal-01618771v1
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MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Wissem Deraredj Nadim
,
Simion Viorel
,
Hélène Bénédetti
,
Chantal Pichon
,
Patrick Baril
Article dans une revue
hal-01618199v1
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Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity
Wissem Deraredj Nadim
,
Séverine Chaumont-Dubel
,
Fahima Madouri
,
Laetitia Cobret
,
Marie-Ludivine de Tauzia
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩
Article dans une revue
hal-01407899v1
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Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling
L Cobret
,
M L de Tauzia
,
J Ferent
,
E Traiffort
,
I Hénaoui
Article dans une revue
hal-01170735v1
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Roles of LIM kinases in central nervous system function and dysfunction
H. Cuberos
,
B. Vallée
,
P. Vourc'H
,
J. Tastet
,
C.R. Andres
Article dans une revue
hal-02072231v1
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Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism
Julie Tastet
,
Loïc Decalonne
,
Sylviane Marouillat
,
Joëlle Malvy
,
Rose-Anne Thépault
Article dans une revue
hal-02072312v1
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New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway
Reine Nehmé
,
Hala Nehmé
,
Thibault Saurat
,
Marie-Ludivine De-Tauzia
,
Frédéric Buron
Article dans une revue
hal-01180770v1
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Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors
Amélie Bruel
,
Romain Bénéteau
,
Mylène Chabanne
,
Olivier Lozach
,
Rémy Le Guevel
Article dans une revue
hal-01086026v1
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Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects
Solene Guiheneuf
,
Ludovic Paquin
,
Francois Carreaux
,
Emilie Durieu
,
Helene Benedetti
Article dans une revue
hal-01114583v1
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Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors
Thibault Saurat
,
Frédéric Buron
,
Nuno Rodrigues
,
Marie-Ludivine de Tauzia
,
Lionel Colliandre
Article dans une revue
hal-01180887v1
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Characterization of histidine-aspartate kinase HK1 and identification of histidine phosphotransfer proteins as potential partners in a Populus multistep phosphorelay
François Hericourt
,
François Chefdor
,
Lucie Bertheau
,
Mirai Tanigawa
,
Tatsuya Maeda
Article dans une revue
hal-02070851v1
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A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.
Fabienne Godin
,
Sandrine Villette
,
Béatrice Vallée
,
Michel Doudeau
,
Séverine Morisset-Lopez
Article dans une revue
hal-00721861v1
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Expression analysis of LIM gene family in poplar, toward an updated phylogenetic classification.
Dominique Arnaud
,
Annabelle Déjardin
,
Jean-Charles Leplé
,
Marie-Claude Lesage-Descauses
,
Nathalie Boizot
Article dans une revue
hal-00721759v1
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Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways
Béatrice Vallée
,
Michel Doudeau
,
Fabienne Godin
,
Aurélie Gombault
,
Aurélie Tchalikian-Cosson
Article dans une revue
hal-03054185v1
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Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5Hpyridazino[4,5-b]indoles as PI3Ka inhibitors.
A. Bruel
,
Cedric Logé
,
M.-L. de Tauzia
,
M. Ravache
,
Ronan Le Guével
European Journal of Medicinal Chemistry, 2012, 57, pp.225-233
Article dans une revue
hal-00764872v1
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LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain
Julie Tastet
,
Patrick Vourc'H
,
Frédéric Laumonnier
,
Béatrice Vallée
,
Carole Michelle
Article dans une revue
hal-01136281v1
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Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.
Martine Beaufour
,
Fabienne Godin
,
Béatrice Vallée
,
Martine Cadene
,
Hélène Bénédetti
Article dans une revue
hal-00721771v1
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A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY
Aurélie Gombault
,
Jonas Warringer
,
Robert Caesar
,
Fabienne Godin
,
Béatrice Vallée
Article dans une revue
hal-00522432v1
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Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study
Aurélie Gombault
,
Fabienne Godin
,
Denise Sy
,
Baptiste Legrand
,
Hélène Chautard
Article dans une revue
hal-00181161v1
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Osmotic stress sensing in Populus: components identification of a phosphorelay system
F. Chefdor
,
H. Bénédetti
,
C. Depierreux
,
Franck Delmotte
,
D. Morabito
Article dans une revue
hal-00088838v1
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Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family
S. Quevillon-Cheruel
,
N. Leulliot
,
M. Graille
,
N. Hervouet
,
F. Coste
Protein science : a publication of the Protein Society., 2005, 14, pp.1350-1356
Article dans une revue
hal-00088667v1
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Train A, an RNase-A-like protein without RNase activity is secreted and reabsorbed by the same epididymal cells under testicular control
S. Castella
,
Hélène Bénédetti
,
R. de Llorens
,
J.L. Dacheux
,
F. Dacheux
Article dans une revue
hal-00112960v1
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Train A, an RNase A-Like Protein Without RNase Activity, Is Secreted and Reabsorbed by the Same Epididymal Cells under Testicular Control
Sandrine Castella
,
H. Bénédetti
,
R. de Llorens
,
J.L. Dacheux
,
Françoise Dacheux
Biology of Reproduction, 2004, 71, pp.1677-1687
Article dans une revue
hal-02680403v1
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Tfs1, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase activating protein in Saccharomyces cerevisiae
H. Chautard
,
M. Jacquer
,
F. Schoentgen
,
N. Bureaud
,
H. Bénédetti
Article dans une revue
hal-00112967v1
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Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.
Emmanuelle Bouveret
,
Laure Journet
,
Anne Walburger
,
E. Cascales
,
Hélène Bénédetti
Biochimie, 2002, 84 (5-6), pp.413-21
Article dans une revue
hal-02130103v1
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Import of colicins across the outer membrane of Escherichia coli involves multiple protein interactions in the periplasm.
Laure Journet
,
E. Bouveret
,
A. Rigal
,
R Lloubes
,
C Lazdunski
Molecular Microbiology, 2001, 42 (2), pp.331-44
Article dans une revue
hal-02130124v1
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Crystal structures of YBHB and YBCL from Escherichia coli , two bacterial homologues to a Raf kinase inhibitor protein 1 1Edited by R. Huber
Laurence Serre
,
F Serre
,
Charles Zelwer
,
Nicole Bureaud
,
Francoise Schoentgen
Article dans une revue
hal-02130120v1
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Colicin import into Escherichia coli cells requires the proximity of the inner and outer membranes and other factors
C. Lazdunski
,
E. Bouveret
,
A Rigal
,
Laure Journet
,
R. Lloubes
Article dans une revue
hal-02130686v1
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Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution.
Chantal Abergel
,
E. Bouveret
,
J.M Claverie
,
K Brown
,
A Rigal
Structure, 1999, 7 (10), pp.1291-300
Article dans une revue
hal-02130130v1
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In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions.
E Bouveret
,
H Bénédetti
,
A Rigal
,
E. Loret
,
C Lazdunski
Journal of Bacteriology, 1999, 181 (20), pp.6306-11
Article dans une revue
hal-02130134v1
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Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ.
Laure Journet
,
A Rigal
,
C Lazdunski
,
H Bénédetti
Journal of Bacteriology, 1999, 181 (15), pp.4476-84
Article dans une revue
hal-02130149v1
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Colicin import into Escherichia coli cells.
C.J Lazdunski
,
E. Bouveret
,
A. Rigal
,
Laure Journet
,
R Lloubès
Journal of Bacteriology, 1998, 180 (19), pp.4993-5002
Article dans une revue
hal-02130152v1
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Distinct regions of the colicin A translocation domain are involved in the interaction with TolA and TolB proteins upon import into Escherichia coli.
E Bouveret
,
A Rigal
,
C Lazdunski
,
H Bénédetti
Molecular Microbiology, 1998, 27 (1), pp.143-57
Article dans une revue
hal-02130155v1
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Crystallization and preliminary crystallographic study of a component of the Escherichia coli tol system: TolB.
Chantal Abergel
,
A Rigal
,
S Chenivesse
,
C Lazdunski
,
J.M Claverie
Acta crystallographica Section D : Structural biology [1993-..], 1998, 54 (Pt 1), pp.102-4
Article dans une revue
hal-02130160v1
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The TolB protein interacts with the porins of Escherichia coli.
A Rigal
,
E. Bouveret
,
R Lloubes
,
C Lazdunski
,
H Bénédetti
Article dans une revue
hal-02130169v1
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The N-terminal domain of colicin E3 interacts with TolB which is involved in the colicin translocation step.
E Bouveret
,
A Rigal
,
C Lazdunski
,
H Bénédetti
Molecular Microbiology, 1997, 23 (5), pp.909-20
Article dans une revue
hal-02130173v1
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TolA central domain interacts with Escherichia coli porins.
R Derouiche
,
M Gavioli
,
H Bénédetti
,
A Prilipov
,
C Lazdunski
EMBO Journal, 1996, 15 (23), pp.6408-15
Article dans une revue
hal-02130175v1
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Peptidoglycan-associated lipoprotein-TolB interaction. A possible key to explaining the formation of contact sites between the inner and outer membranes of Escherichia coli
E. Bouveret
,
R Derouiche
,
R. Rigal
,
R Lloubès
,
C Lazdunski
Article dans une revue
hal-02130195v1
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Protein complex within Escherichia coli inner membrane. TolA N-terminal domain interacts with TolQ and TolR proteins
R Derouiche
,
H Bénédetti
,
Jc Lazzaroni
,
C Lazdunski
,
R Lloubès
Article dans une revue
hal-02130187v1
|
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Quantification of group A colicin import sites.
Denis Duché
,
L. Letellier
,
V. Geli
,
H. Bénédetti
,
D. Baty
Article dans une revue
hal-02440962v1
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Quantification of group A colicin import sites.
Denis Duché
,
L. Letellier
,
V Géli
,
H Bénédetti
,
D. Baty
Article dans une revue
hal-02130183v1
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Transmembrane α-Helix Interactions are Required for the Functional Assembly of theEscherichia coliTol Complex
Jean Claude Lazzaroni
,
Anne Vianney
,
V Vianney
,
Jean Luc Popot
,
Hélène Bénédetti
Article dans une revue
hal-02130202v1
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The colicin A pore-forming domain fused to mitochondrial intermembrane space sorting signals can be functionally inserted into the Escherichia coli plasma membrane by a mechanism that bypasses the Tol proteins
David Espesset
,
Yves Corda
,
Kyle Cunningham
,
Hélène Bénédetti
,
Roland Lloubes
Article dans une revue
hal-02130213v1
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The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.
H Bénédetti
,
S Raths
,
F Crausaz
,
H. Riezman
Molecular Biology of the Cell, 1994, 5 (9), pp.1023-37
Article dans une revue
hal-02130204v1
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Colicin A and the Tol proteins involved in its translocation are preferentially located in the contact sites between the inner and outer membranes of Escherichia coli cells.
G. Guihard
,
P. Boulanger
,
H Bénédetti
,
R Lloubés
,
M Besnard
Journal of Biological Chemistry, 1994, 269 (8), pp.5874-80
Article dans une revue
hal-02130218v1
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Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.
J Rohrer
,
H Bénédetti
,
B Zanolari
,
H. Riezman
Molecular Biology of the Cell, 1993, 4 (5), pp.511-21
Article dans une revue
hal-02130242v1
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Recognition of the colicin A N-terminal epitope 1C11 in vitro and in vivo in Escherichia coli by its cognate monoclonal antibody
V Geli
,
R Lloubes
,
S Zaat
,
R van Spaendonk
,
C Rollin
Article dans une revue
hal-02130222v1
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Phosphate efflux through the channels formed by colicins and phage T5 in Escherichia coli cells is responsible for the fall in cytoplasmic ATP.
G. Guihard
,
H Bénédetti
,
M Besnard
,
L. Letellier
Journal of Biological Chemistry, 1993, 268 (24), pp.17775-80
Article dans une revue
hal-02130233v1
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Colicin A unfolds during its translocation in Escherichia coli cells and spans the whole cell envelope when its pore has formed.
Hélène Bénédetti
,
R Lloubès
,
C Lazdunski
,
L. Letellier
EMBO Journal, 1992, 11 (2), pp.441-7
Article dans une revue
hal-02130272v1
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Individual domains of colicins confer specificity in colicin uptake, in pore-properties and in immunity requirement.
Hélène Bénédetti
,
M Frenette
,
D. Baty
,
M Knibiehler
,
F. Pattus
Journal of Molecular Biology, 1991, 217 (3), pp.429-39
Article dans une revue
hal-02130283v1
|
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Construction, expression and release of hybrid colicins.
M Frenette
,
H Bénédetti
,
A. Bernadac
,
D. Baty
,
C Lazdunski
Journal of Molecular Biology, 1991, 217 (3), pp.421-8
Article dans une revue
hal-02130287v1
|
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Protein import into Escherichia coli: colicins A and E1 interact with a component of their translocation system.
Hélène Bénédetti
,
C Lazdunski
,
R Lloubès
EMBO Journal, 1991, 10 (8), pp.1989-95
Article dans une revue
hal-02130277v1
|
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Insertion and translocation of proteins into and through membranes.
C. Lazdunski
,
H Bénédetti
FEBS Letters, 1990, 268 (2), pp.408-14
Article dans une revue
hal-02130669v1
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Uptake across the cell envelope and insertion into the inner membrane of ion channel-forming colicins in E coli
D. Baty
,
F. Pattus
,
M. Parker
,
H. Bénédetti
,
M. Frenette
Article dans une revue
hal-02130296v1
|
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Comparison of the Uptake Systems for the Entry of Various BtuB Group Colicins into Escherichia coli
H. Bénédetti
,
M. Frenette
,
D. Baty
,
R Lloubès
,
V. Geli
Article dans une revue
hal-02130300v1
|