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Hélène Bénédetti

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Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization

Anthony Champiré , Rayan Berabez , Abdennour Braka , Aurélie Cosson , Justine Corret
European Journal of Medicinal Chemistry, 2024, 271, pp.116391-116391. ⟨10.1016/j.ejmech.2024.116391⟩
Journal articles hal-04575964v1
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LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features

Elodie Villalonga , Christine Mosrin , Thierry Normand , Caroline Girardin , Amandine Serrano
Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩
Journal articles hal-04208405v1
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LIM Kinases: From Molecular to Pathological Features

Hélène Bénédetti , Béatrice Vallée
Cells, 2023, 12 (12), pp.1649. ⟨10.3390/cells12121649⟩
Journal articles hal-04208415v1
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LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo

Rayan Berabez , Sylvain Routier , Hélène Bénédetti , Karen Plé , Béatrice Vallée
Cells, 2022, 11 (13), pp.2090. ⟨10.3390/cells11132090⟩
Journal articles hal-03721458v1
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Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper

Bojan Žunar , Christine Mosrin-Huaman , Hélène Bénédetti , Béatrice Vallée
Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩
Journal articles hal-03820214v1
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The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes

Wissem Deraredj Nadim , Shalina Hassanaly , Hélène Bénédetti , Claudine Kieda , Catherine Grillon
Biochemical and Biophysical Research Communications, 2021, 534, pp.758-764. ⟨10.1016/j.bbrc.2020.11.003⟩
Journal articles hal-03007433v1
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A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation

Skander A Abboud , Hadji H. , Michel Doudeau , Hélène Bénédetti , Vincent Aucagne
Chemical Science, 2021, 12, pp.3194 - 3201. ⟨10.1039/d0sc06001a⟩
Journal articles hal-03447239v1
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Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors

Frédéric Buron , Nuno Rodrigues , Thibault Saurat , Marie-Aude Hiebel , Stéphane Bourg
Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Journal articles hal-03348966v1
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Neurofibromin Structure, Functions and Regulation

Mohammed Bergoug , Michel Doudeau , Fabienne Godin , Christine Mosrin-Huaman , Béatrice Vallée
Journal articles hal-03070759v2
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Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein

Béatrice Vallée , Michel Doudeau , Fabienne Godin , Hélène Bénédetti
Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩
Journal articles hal-02282630v1

LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability

Julie Tastet , Hélène Cuberos , Béatrice Vallée , Annick Toutain , Martine Raynaud
Neuroscience, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩
Journal articles hal-02067472v1

LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b

Béatrice Vallée , Hélène Cuberos , Michel Doudeau , Fabienne Godin , David Gosset
Biochemical Journal, 2018, 475 (23), pp.3745-3761
Journal articles hal-01966439v1

Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities

Viorel Simion , Wissem Deraredj Nadim , Hélène Bénédetti , Chantal Pichon , Séverine Morisset-Lopez
Current Neuropharmacology, 2017, 15 (2), pp.276 - 290. ⟨10.2174/1570159X14666160630210422⟩
Journal articles hal-01618771v1

MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?

Wissem Deraredj Nadim , Simion Viorel , Hélène Bénédetti , Chantal Pichon , Patrick Baril
Current Neuropharmacology, 2017, 15 (2), pp.260 - 275. ⟨10.2174/1570159X14666160709001441⟩
Journal articles hal-01618199v1

Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity

Wissem Deraredj Nadim , Séverine Chaumont-Dubel , Fahima Madouri , Laetitia Cobret , Marie-Ludivine de Tauzia
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩
Journal articles hal-01407899v1

Roles of LIM kinases in central nervous system function and dysfunction

H. Cuberos , B. Vallée , P. Vourc'H , J. Tastet , C.R. Andres
FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩
Journal articles hal-02072231v1

Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling

L Cobret , M L de Tauzia , J Ferent , E Traiffort , I Hénaoui
British Journal of Clinical Pharmacology, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩
Journal articles hal-01170735v1

Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism

Julie Tastet , Loïc Decalonne , Sylviane Marouillat , Joëlle Malvy , Rose-Anne Thépault
Psychiatric Genetics, 2015, 25 (6), pp.263-267. ⟨10.1097/ypg.0000000000000100⟩
Journal articles hal-02072312v1

Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects

Solene Guiheneuf , Ludovic Paquin , Francois Carreaux , Emilie Durieu , Helene Benedetti
Current microwave chemistry, 2014, 1 (1), pp.33-40. ⟨10.2174/22133356114019990002⟩
Journal articles hal-01114583v1

Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors

Thibault Saurat , Frédéric Buron , Nuno Rodrigues , Marie-Ludivine de Tauzia , Lionel Colliandre
Journal of Medicinal Chemistry, 2014, 57 (3), pp.613-631. ⟨10.1021/jm401138v⟩
Journal articles hal-01180887v1
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Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors

Amélie Bruel , Romain Bénéteau , Mylène Chabanne , Olivier Lozach , Rémy Le Guevel
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5037 - 5040. ⟨10.1016/j.bmcl.2014.09.017⟩
Journal articles hal-01086026v1
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New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway

Reine Nehmé , Hala Nehmé , Thibault Saurat , Marie-Ludivine De-Tauzia , Frédéric Buron
Analytical and Bioanalytical Chemistry, 2014, 406 (15), pp.3743-3754. ⟨10.1007/s00216-014-7790-z⟩
Journal articles hal-01180770v1

Characterization of histidine-aspartate kinase HK1 and identification of histidine phosphotransfer proteins as potential partners in a Populus multistep phosphorelay

François Hericourt , François Chefdor , Lucie Bertheau , Mirai Tanigawa , Tatsuya Maeda
Physiologia Plantarum, 2013, 149 (2), pp.188-199. ⟨10.1111/ppl.12024⟩
Journal articles hal-02070851v1

Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.

Martine Beaufour , Fabienne Godin , Béatrice Vallée , Martine Cadene , Hélène Bénédetti
Journal of Proteome Research, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩
Journal articles hal-00721771v1

LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain

Julie Tastet , Patrick Vourc'H , Frédéric Laumonnier , Béatrice Vallée , Carole Michelle
Biochemical and Biophysical Research Communications, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩
Journal articles hal-01136281v1
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Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways

Béatrice Vallée , Michel Doudeau , Fabienne Godin , Aurélie Gombault , Aurélie Tchalikian-Cosson
PLoS ONE, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩
Journal articles hal-03054185v1
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Expression analysis of LIM gene family in poplar, toward an updated phylogenetic classification.

Dominique Arnaud , Annabelle Déjardin , Jean-Charles Leplé , Marie-Claude Lesage-Descauses , Nathalie Boizot
BMC Research Notes, 2012, 5, pp.102. ⟨10.1186/1756-0500-5-102⟩
Journal articles hal-00721759v1

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5Hpyridazino[4,5-b]indoles as PI3Ka inhibitors.

A. Bruel , Cedric Logé , M.-L. de Tauzia , M. Ravache , Ronan Le Guével
European Journal of Medicinal Chemistry, 2012, 57, pp.225-233
Journal articles hal-00764872v1

A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.

Fabienne Godin , Sandrine Villette , Béatrice Vallée , Michel Doudeau , Séverine Morisset-Lopez
Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩
Journal articles hal-00721861v1

A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY

Aurélie Gombault , Jonas Warringer , Robert Caesar , Fabienne Godin , Béatrice Vallée
FEMS Yeast Research, 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩
Journal articles hal-00522432v1

Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study

Aurélie Gombault , Fabienne Godin , Denise Sy , Baptiste Legrand , Hélène Chautard
Journal of Molecular Biology, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩
Journal articles hal-00181161v1

Osmotic stress sensing in Populus: components identification of a phosphorelay system

F. Chefdor , H. Bénédetti , C. Depierreux , Franck Delmotte , D. Morabito
FEBS Letters, 2006, 580 (1), pp.77-81. ⟨10.1016/j.febslet.2005.11.051⟩
Journal articles hal-00088838v1

Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family

S. Quevillon-Cheruel , N. Leulliot , M. Graille , N. Hervouet , F. Coste
Protein science : a publication of the Protein Society., 2005, 14, pp.1350-1356
Journal articles hal-00088667v1

Train A, an RNase-A-like protein without RNase activity is secreted and reabsorbed by the same epididymal cells under testicular control

S. Castella , Hélène Bénédetti , R. de Llorens , J.L. Dacheux , F. Dacheux
Biology of Reproduction, 2004, 71 (5), pp.1677-1687. ⟨10.1095/biolreprod.104.031666⟩
Journal articles hal-00112960v1

Train A, an RNase A-Like Protein Without RNase Activity, Is Secreted and Reabsorbed by the Same Epididymal Cells under Testicular Control

Sandrine Castella , H. Bénédetti , R. de Llorens , J.L. Dacheux , Françoise Dacheux
Biology of Reproduction, 2004, 71, pp.1677-1687
Journal articles hal-02680403v1

Tfs1, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase activating protein in Saccharomyces cerevisiae

H. Chautard , M. Jacquer , F. Schoentgen , N. Bureaud , H. Bénédetti
Eukaryotic Cell, 2004, 3 (2), pp.459-470. ⟨10.1128/EC.3.2.459-470.2004⟩
Journal articles hal-00112967v1

Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.

Emmanuelle Bouveret , Laure Journet , Anne Walburger , E. Cascales , Hélène Bénédetti
Biochimie, 2002, 84 (5-6), pp.413-21
Journal articles hal-02130103v1

Import of colicins across the outer membrane of Escherichia coli involves multiple protein interactions in the periplasm.

Laure Journet , E. Bouveret , A. Rigal , R Lloubes , C Lazdunski
Molecular Microbiology, 2001, 42 (2), pp.331-44
Journal articles hal-02130124v1

Crystal structures of YBHB and YBCL from Escherichia coli , two bacterial homologues to a Raf kinase inhibitor protein 1 1Edited by R. Huber

Laurence Serre , F Serre , Charles Zelwer , Nicole Bureaud , Francoise Schoentgen
Journal of Molecular Biology, 2001, 310 (3), pp.617-634. ⟨10.1006/jmbi.2001.4784⟩
Journal articles hal-02130120v1

Colicin import into Escherichia coli cells requires the proximity of the inner and outer membranes and other factors

C. Lazdunski , E. Bouveret , A Rigal , Laure Journet , R. Lloubes
International Journal of Medical Microbiology, 2000, 290 (4-5), pp.337-344. ⟨10.1016/S1438-4221(00)80037-5⟩
Journal articles hal-02130686v1

In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions.

E Bouveret , H Bénédetti , A Rigal , E. Loret , C Lazdunski
Journal of Bacteriology, 1999, 181 (20), pp.6306-11
Journal articles hal-02130134v1

Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ.

Laure Journet , A Rigal , C Lazdunski , H Bénédetti
Journal of Bacteriology, 1999, 181 (15), pp.4476-84
Journal articles hal-02130149v1

Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution.

Chantal Abergel , E. Bouveret , J.M Claverie , K Brown , A Rigal
Structure, 1999, 7 (10), pp.1291-300
Journal articles hal-02130130v1

Crystallization and preliminary crystallographic study of a component of the Escherichia coli tol system: TolB.

Chantal Abergel , A Rigal , S Chenivesse , C Lazdunski , J.M Claverie
Acta crystallographica Section D : Structural biology [1993-..], 1998, 54 (Pt 1), pp.102-4
Journal articles hal-02130160v1

Colicin import into Escherichia coli cells.

C.J Lazdunski , E. Bouveret , A. Rigal , Laure Journet , R Lloubès
Journal of Bacteriology, 1998, 180 (19), pp.4993-5002
Journal articles hal-02130152v1

Distinct regions of the colicin A translocation domain are involved in the interaction with TolA and TolB proteins upon import into Escherichia coli.

E Bouveret , A Rigal , C Lazdunski , H Bénédetti
Molecular Microbiology, 1998, 27 (1), pp.143-57
Journal articles hal-02130155v1

The TolB protein interacts with the porins of Escherichia coli.

A Rigal , E. Bouveret , R Lloubes , C Lazdunski , H Bénédetti
Journal of Bacteriology, 1997, 179 (23), pp.7274-7279. ⟨10.1128/jb.179.23.7274-7279.1997⟩
Journal articles hal-02130169v1

The N-terminal domain of colicin E3 interacts with TolB which is involved in the colicin translocation step.

E Bouveret , A Rigal , C Lazdunski , H Bénédetti
Molecular Microbiology, 1997, 23 (5), pp.909-20
Journal articles hal-02130173v1

TolA central domain interacts with Escherichia coli porins.

R Derouiche , M Gavioli , H Bénédetti , A Prilipov , C Lazdunski
EMBO Journal, 1996, 15 (23), pp.6408-15
Journal articles hal-02130175v1

Protein complex within Escherichia coli inner membrane. TolA N-terminal domain interacts with TolQ and TolR proteins

R Derouiche , H Bénédetti , Jc Lazzaroni , C Lazdunski , R Lloubès
Journal of Biological Chemistry, 1995, 270 (19), pp.11078-11084. ⟨10.1074/jbc.270.19.11078⟩
Journal articles hal-02130187v1

Quantification of group A colicin import sites.

Denis Duché , L. Letellier , V. Geli , H. Bénédetti , D. Baty
Journal of Bacteriology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩
Journal articles hal-02440962v1

Peptidoglycan-associated lipoprotein-TolB interaction. A possible key to explaining the formation of contact sites between the inner and outer membranes of Escherichia coli

E. Bouveret , R Derouiche , R. Rigal , R Lloubès , C Lazdunski
Journal of Biological Chemistry, 1995, 270 (19), pp.11071-11077. ⟨10.1074/jbc.270.19.11071⟩
Journal articles hal-02130195v1

Transmembrane α-Helix Interactions are Required for the Functional Assembly of theEscherichia coliTol Complex

Jean Claude Lazzaroni , Anne Vianney , V Vianney , Jean Luc Popot , Hélène Bénédetti
Journal of Molecular Biology, 1995, 246 (1), pp.1-7. ⟨10.1006/jmbi.1994.0058⟩
Journal articles hal-02130202v1

Quantification of group A colicin import sites.

Denis Duché , L. Letellier , V Géli , H Bénédetti , D. Baty
Journal of Bacteriology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩
Journal articles hal-02130183v1

The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.

H Bénédetti , S Raths , F Crausaz , H. Riezman
Molecular Biology of the Cell, 1994, 5 (9), pp.1023-37
Journal articles hal-02130204v1

The colicin A pore-forming domain fused to mitochondrial intermembrane space sorting signals can be functionally inserted into the Escherichia coli plasma membrane by a mechanism that bypasses the Tol proteins

David Espesset , Yves Corda , Kyle Cunningham , Hélène Bénédetti , Roland Lloubes
Molecular Microbiology, 1994, 13 (6), pp.1121-1131. ⟨10.1111/j.1365-2958.1994.tb00503.x⟩
Journal articles hal-02130213v1

Colicin A and the Tol proteins involved in its translocation are preferentially located in the contact sites between the inner and outer membranes of Escherichia coli cells.

G. Guihard , P. Boulanger , H Bénédetti , R Lloubés , M Besnard
Journal of Biological Chemistry, 1994, 269 (8), pp.5874-80
Journal articles hal-02130218v1

Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.

J Rohrer , H Bénédetti , B Zanolari , H. Riezman
Molecular Biology of the Cell, 1993, 4 (5), pp.511-21
Journal articles hal-02130242v1

Recognition of the colicin A N-terminal epitope 1C11 in vitro and in vivo in Escherichia coli by its cognate monoclonal antibody

V Geli , R Lloubes , S Zaat , R van Spaendonk , C Rollin
FEMS Microbiology Letters, 1993, 109 (2-3), pp.335-342. ⟨10.1016/0378-1097(93)90042-z⟩
Journal articles hal-02130222v1

Phosphate efflux through the channels formed by colicins and phage T5 in Escherichia coli cells is responsible for the fall in cytoplasmic ATP.

G. Guihard , H Bénédetti , M Besnard , L. Letellier
Journal of Biological Chemistry, 1993, 268 (24), pp.17775-80
Journal articles hal-02130233v1

Colicin A unfolds during its translocation in Escherichia coli cells and spans the whole cell envelope when its pore has formed.

Hélène Bénédetti , R Lloubès , C Lazdunski , L. Letellier
EMBO Journal, 1992, 11 (2), pp.441-7
Journal articles hal-02130272v1

Individual domains of colicins confer specificity in colicin uptake, in pore-properties and in immunity requirement.

Hélène Bénédetti , M Frenette , D. Baty , M Knibiehler , F. Pattus
Journal of Molecular Biology, 1991, 217 (3), pp.429-39
Journal articles hal-02130283v1

Construction, expression and release of hybrid colicins.

M Frenette , H Bénédetti , A. Bernadac , D. Baty , C Lazdunski
Journal of Molecular Biology, 1991, 217 (3), pp.421-8
Journal articles hal-02130287v1

Protein import into Escherichia coli: colicins A and E1 interact with a component of their translocation system.

Hélène Bénédetti , C Lazdunski , R Lloubès
EMBO Journal, 1991, 10 (8), pp.1989-95
Journal articles hal-02130277v1

Insertion and translocation of proteins into and through membranes.

C. Lazdunski , H Bénédetti
FEBS Letters, 1990, 268 (2), pp.408-14
Journal articles hal-02130669v1

Uptake across the cell envelope and insertion into the inner membrane of ion channel-forming colicins in E coli

D. Baty , F. Pattus , M. Parker , H. Bénédetti , M. Frenette
Biochimie, 1990, 72 (2-3), pp.123-130. ⟨10.1016/0300-9084(90)90137-6⟩
Journal articles hal-02130296v1

Comparison of the Uptake Systems for the Entry of Various BtuB Group Colicins into Escherichia coli

H. Bénédetti , M. Frenette , D. Baty , R Lloubès , V. Geli
Microbiology, 1989, 135 (12), pp.3413-3420. ⟨10.1099/00221287-135-12-3413⟩
Journal articles hal-02130300v1

Séminaire invité : Signalisation cellulaire et Neurofibromatose

Béatrice Vallée , Hélène Bénédetti
Journées NF, Sep 2021, Orléans, France
Conference papers hal-03560050v1

Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel

Béatrice Vallée , Christine Mosrin-Huaman , Hélène Bénédetti , Régis Guégan , Bojan Zunar
ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria
Conference papers hal-03559939v1

Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action

Justine Corret , Sokaina Hammoud , Frédéric Buron , Pierre Daligaux , Christophe Chesné
FEBS 2021, the 45th FEBS Congress, Jul 2021, Virtual, France
Conference papers hal-03668584v1

High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells

N Laroui , C Delehedde , C Goncalves , F Godin , Federico Perche
SFNano 2021, Dec 2021, Angers, France
Conference papers hal-03668422v1

Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease

M. Bergoug , A. Cosson , D. Casas , M. Doudeau , F. Godin
6th LIA Workshop on "Biomarkers and mediators of diseases and new approaches in repair/regenerative therapies, Jun 2019, Varsovie, Poland
Conference papers hal-02928511v1

Les LIM kinases : nouvelles cibles thérapeutiques anti-cancer

H. Bénédetti , Béatrice Vallée , A. Cosson , F. Godin , M. Doudeau
Journée scientifique du réseau « Cancers hormonaux–dépendants » du Cancéropôle Grand-Ouest, Apr 2019, Nantes, France
Conference papers hal-02928496v1

Détermination et mise en œuvre d’un modèle in vivo pour tester de nouveaux inhibiteurs originaux des LIM kinases, cibles thérapeutiques émergentes dans le cancer

Béatrice Vallée , K. Plé , A. Cosson , M. Doudeau , F. Godin
Cancéropôle Grand Ouest, Colloque du Réseau Molécules marines, métabolisme et cancer, May 2019, Mansigné, France
Conference papers hal-02928507v1

Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose

Béatrice Vallée , Karen Plé , A. Cosson , M. Doudeau , F. Godin
Journée Fédération CBM-ICOA, Jan 2018, Orléans, France
Conference papers hal-02928530v1

Développement de modulateurs des LIM kinases

Béatrice Vallée , S. Routier , A. Cosson , M. Doudeau , F. Godin
Cancéropôle Grand Ouest - 14e colloque du Réseau Produits de la mer en cancérologie - 5e colloque du Réseau Canaux ioniques et cancer, May 2018, Mansigné, France
Conference papers hal-02928559v1

Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1

M. Bergoug , A. Cosson , M. Doudeau , F. Godin , Béatrice Vallée
Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France
Conference papers hal-02928220v1

Neurofibromatosis type I: from basic to applied research

Béatrice Vallée , A. Cosson , M. Doudeau , F Godin , A. Braka
4th LIA Workshop, Jun 2017, Cracovie, Poland
Conference papers hal-02928517v1

Study of new partners of neurofibromin: an approach to identify novel therapeutic targets for neurofibromatosis type 1

Béatrice Vallée , Hélène Bénédetti , F. Godin , M. Doudeau
17th European Neurofibromatosis meeting, Sep 2016, Albano-Terme, Italy
Conference papers hal-02928226v1

Both ChIP-SEQ and in planta gene modification demonstrate the involvement of MYB090 and MYB156 in secondary cell wall formation in poplar

Wassim Lakhal , Nathalie Boizot , Marie-Claude Lesage Descauses , Odile Rogier , Véronique Laine-Prade
INUPRAG-Meeting 2015, Oct 2015, Nancy, France
Conference papers hal-01604786v1

Expression des isoformes de LIM Kinase 2 pendant la neurogenèse et la stimulation des neurones

J. Tastet , P. Vourc'H , F. Laumonnier , C. Michelle , Anne Duittoz
22. Colloque Biotechnocentre, Oct 2009, Seillac, France
Conference papers hal-02753426v1

Les LIM kinases, des cibles thérapeutiques prometteuses pour le traitement du glioblastome : de la conception de petites molécules inhibitrices aux tests cellulo

Karen Plé , B. Vallée , R. Berabez , A. Champiré , M. Sainjon
CCCancéropôle Grand Ouest, colloque du réseau Molécules marines, métabolisme et cancer, May 2023, Mansigné, France
Conference poster hal-04556346v1

Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development

Bojan Zunar , Christine Mosrin-Huaman , Hélène Bénédetti , Régis Guégan , Béatrice Vallée
FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia
Conference poster hal-03679975v1

Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel

Bojan Zunar , Christine Mosrin-Huaman , Hélène Bénédetti , Régis Guégan , Béatrice Vallée
ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria
Conference poster hal-03679966v1

New molecular insights into the crosstalk between Rho/ROCK/LIMK2/cofilin signalling pathway and Nf1

Mélissa Thomas , Lauren Blot , Kevin Lesage , Fabienne Godin , Michel Doudeau
2021 NF1 virtual conference, Jun 2021, Virtual, France
Conference poster hal-03679999v1

Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action

Justine Corret , Sokaina Hammoud , Frédéric Buron , Pierre Daligaux , Christophe Chesné
FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia
Conference poster hal-03679980v1

Sumoylation of neurofibromin and its SecPH domain plays a role in their functions and implies unexpected structural requirements

Christine Mosrin-Huaman , Mohammed Bergoug , Fabienne Godin , Michel Doudeau , Iva Sosic
FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia
Conference poster hal-03679991v1

High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells

N Laroui , C Delehedde , Cristine Gonçalves , F Godin , F Perche
10th mRNA Health Conference, Nov 2021, Berlin, Germany
Conference poster hal-03668434v1

New insights into the regulation of actin cytoskeleton dynamics via the Rho/ROCK/LIMK2/cofilin signalling pathway: a novel mechanism of regulation of cofilin by LIMK2

Elodie Villalonga , Célina Chalal , Déborah Cassas , Michel Doudeau , Fabienne Godin
FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, virtual, Slovenia
Conference poster hal-03680139v1

Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements

Christine Mosrin-Huaman , Mohammed Bergoug , Fabienne Godin , Michel Doudeau , Iva Sosic
2021 NF1 virtual conference, Jun 2021, Virtual, France
Conference poster hal-03680001v1

Yeast biosensors to detect environmental pollutants into effluent waters

Christine Mosrin-Huaman , B. Handelaoui , H. Bénédetti , Béatrice Vallée
ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden
Conference poster hal-02924111v1

LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors

Béatrice Vallée , A. Cosson , M. Doudeau , F. Godin , A. Champiré
FEBS Meeting 2019, Jul 2019, Cracovie, Poland
Conference poster hal-02924140v1

Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease

M. Bergoug , I. Sošic , M. Doudeau , F. Godin , Béatrice Vallée
EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia
Conference poster hal-02924095v1

Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability

H. Bénédetti , Béatrice Vallée , J. Tastet , H. Cubéros , A. Toutain
NeuroFrance 2019, May 2019, Marseille, France
Conference poster hal-02924881v1

Study of the different forms of sumoylation of the neurofibromin SecPH domain

H. Bénédetti , M. Bergoug , I. Sošic , M. Doudeau , F. Godin
EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia
Conference poster hal-02924090v1

LARP6, a RNA−binding protein involved in translation and stability of collagen mRNA, is a new partner of Neurofibromin: Molecular studies and functional implications

H. Bénédetti , M. Doudeau , F. Godin , Béatrice Vallée , A. Cosson
Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France
Conference poster hal-02924084v1

Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I

Béatrice Vallée , A. Cosson , M. Doudeau , F. Godin , A. Champiré
Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France
Conference poster hal-02924077v1

Neurofibromin 1 promotes constitutive activity of native 5−HT6 receptors expressed in mouse prefrontal cortex

Séverine Morisset-Lopez , W. Deraredj Nadim , S. Chaumont−dubel , F. Madouri , L. Cobret
Neurofrance, May 2017, Bordeaux, France
Conference poster hal-02973767v1

Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1

M. Bergoug , A. Cosson , M. Doudeau , F. Godin , Béatrice Vallée
EMBO Conference "Ubiquitin and SUMO: from molecular mechanisms to system-wide responses, Sep 2017, Cavtat, Croatia
Conference poster hal-02924070v1

Design, synthesis and biological evaluation of LIMK inhibitors

A. Champiré , A. Braka , Béatrice Vallée , M. Doudeau , F. Godin
XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France
Conference poster hal-02904837v1

LIM Kinases: new anticancer therapeutic targets

Béatrice Vallée , A. Cosson , M. Doudeau , F. Godin , Anthony Champiré
Breast Cancer Symposium, Jun 2017, Nantes, France
Conference poster hal-03680148v1

LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1

A. Champiré , A. Braka , B. Vallée , M. Doudeau , F. Godin
VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria
Conference poster hal-02904794v1

A Physical Interaction between Neurofibromin and Serotonin 5-HT6 Receptor Promotes Receptor Constitutive Activity

W. Deraredj Nadim , S. Chaumont-Dubel , F. Madouri , L. Cobret , M.-L. de Tauzia
5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France
Conference poster hal-02973912v1

Projet Région LiCorNe: LIMK protein inhibitors, new therapeutic agents for treatment of cognitive disorders associated with type I Neurofibromatosis

Béatrice Vallée , Michel Doudeau , F. Godin , H. Cubéros , A. Champiré
Journée Fédération PCV FR2708, Jan 2016, Orléans, France
Conference poster hal-02924056v1

LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability

Béatrice Vallée , Hélène Cuberos , Julie Tastet , Michel Doudeau , Fabienne Godin
10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark.
Conference poster hal-02453486v1

The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways

Béatrice Vallée , Hélène Cuberos , Michel Doudeau , Fabienne Godin , Patrick Vourc’h
EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany.
Conference poster hal-02453489v1

LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications

Hélène Bénédetti , Fabienne Godin , Michel Doudeau , Béatrice Vallée , Marie-Ludivine De Tauzia
10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark
Conference poster hal-02453487v1
Image document

Unraveling the function of MYB090 and MYB156 in secondary cell wall formation in poplar using both ChIP-SEQ and in planta gene modification approach

Annabelle Dejardin , Wassim Lakhal , Nathalie Boizot , Marie-Claude Lesage Descauses , Odile Rogier
XIV Cell Wall Meeting, Jun 2016, Chania, Grèce. , 2016, XIV Cell Wall Meeting. Programme and Book of Abstracts
Conference poster hal-02740921v1

LIM kinases: new therapeutic targets to treat Neurofibromatosis type I

Béatrice Vallée , Michel Doudeau , Fabienne Godin , Anthony Champiré , Karen Plé
The 7th EMBO meeting, Sep 2016, Mannheim, Germany.
Conference poster hal-02453490v1

Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases

A. Champiré , A. Braka , Béatrice Vallée , M. Doudeau , F. Godin
29e colloque de Biotechnocentre, Oct 2016, Seillac, France
Conference poster hal-02904847v1

LIMK2 (LIM kinase2) isoforms are differentially expressed during neuronal differentiation

J. Tastet , P. Vourc'H , F. Laumonnier , C. Michelle , Anne Duittoz
7. FENS Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands. n.p., 2010
Conference poster hal-02818145v1

Colicin transport, channel formation and inhibition

H. Bénédetti , V. Geli
Handbook of Biological Physics, pp.665-691, 1996
Book sections hal-02130677v1

The Tol/PAL and TonB systems : two envelope-spanning protein complexes involved in colicin import in E. coli.

Emmanuelle Bouveret , Claude Lazdunski , Hélène Bénédetti
Molecular Dynamics of Biomembranes, Springer Berlin Heidelberg, pp.59-69, 1996
Book sections hal-02130680v1

Insertion of Proteins into Membranes A Survey

Vincent Géli , Hélène Bénédetti
Membrane biogenesis, pp.21-69, 1994, Subcellular Biochemistry, 978-1-4613-6018-6
Book sections hal-02130265v1

In Vivo Properties of Colicin A: Channel Activity and Translocation

L. Letellier , C. Lazdunski , H. Bénédetti , J. Bourdineaud , P. Boulanger
Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.119-125, 1992
Book sections hal-02130671v1

Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteins

C. Lazdunski , D. Baty , V. Geli , R. Lloubes , H. Bénédetti
Membrane Proteins: Structures, Interactions and Models, pp.413-425, 1992
Book sections hal-02130675v1

Study of the Import Mechanisms of Colicins Through Protein Engineering and K+ Efflux Kinetics

Hélène Bénédetti , Lucienne Letellier , Roland Lloubes , Vincent Géli , Daniel Baty
Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.215-223, 1992
Book sections hal-02130674v1

Import of Colicins into Escherichia Coli

Hélène Bénédetti , Lucienne Letellier , Roland Lloubes , Vincent Géli , Daniel Baty
Dynamics of Membrane Assembly, 63, Springer Berlin Heidelberg, pp.315-332, 1992
Book sections hal-02130670v1