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Isabelle SEGALAS-MILAZZO

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Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease

Anne Rovelet-Lecrux , Sebastien Feuillette , Laetitia Miguel , Catherine Schramm , Ségolène Pernet
Acta Neuropathologica Communications, 2021, 9, ⟨10.1186/s40478-021-01294-4⟩
Journal articles hal-03512083v1
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Characterization of β-turns by electronic circular dichroism spectroscopy: A coupled molecular dynamics and time-dependent density functional theory computational study

Mattia Migliore , Andrea Bonvicini , Vincent Tognetti , Laure Guilhaudis , Marc Baaden
Physical Chemistry Chemical Physics, 2020, 22 (3), pp.1611-1623. ⟨10.1039/C9CP05776E⟩
Journal articles hal-02397135v1

Biochemical and biophysical combined study of bicarinalin, an ant venom antimicrobial peptide

Nathan Téné , Elsa Bonnafé , Fanny Berger , Aline Rifflet , Laure Guilhaudis
Peptides, 2016, 79, pp.103-113. ⟨10.1016/j.peptides.2016.04.001⟩
Journal articles hal-01974252v1

Lethal Neonatal Progression of Fetal Cardiomegaly Associated to ACAD9 Deficiency

Jennifer Lagoutte-Renosi , Isabelle Ségalas-Milazzo , Marie Crahes , Florian Renosi , Laurence Menu-Bouaouiche
Journal of Inherited Metabolic Disease, 2016, 28, pp.1-10. ⟨10.1007/8904_2015_499⟩
Journal articles hal-02046219v1

Determination of Multimodal Isotopic Distributions: The Case of a (15)N Labeled Protein Produced into Hairy Roots.

Romain Trouillard , Marie Hubert-Roux , Vincent Tognetti , Laure Guilhaudis , Carole Plasson
Analytical Chemistry, 2015, 87 (12), pp.5938-5946. ⟨10.1021/acs.analchem.5b01558⟩
Journal articles hal-01186525v1

Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies

Cindy Neveu , Fabienne Dulin , Benjamin Lefranc , Ludovic Galas , Colas Calbrix
British Journal of Pharmacology, 2014, 171 (19), pp.4425-4439. ⟨10.1111/bph.12808⟩
Journal articles hal-01973604v1

Fluorinated pseudopeptide analogues of the neuropeptide 26RFa: synthesis, biological, and structural studies.

Camille Pierry , Samuel Couve-Bonnaire , Laure Guilhaudis , Cindy Neveu , Amélie Marotte
ChemBioChem, 2013, 14 (13), pp.1620-1633. ⟨10.1002/cbic.201300325⟩
Journal articles hal-01939216v1

Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-β3-pseudopeptide agonist

Cindy Neveu , Benjamin Lefranc , Olivier Tasseau , Jean-Claude Do-Rego , Adèle Bourmaud
Journal of Medicinal Chemistry, 2012, 55 (17), pp.7516-7524. ⟨10.1021/jm300507d⟩
Journal articles hal-01939210v1

Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain

Ludovic Carlier , Joël Couprie , Albane Le Maire , Laure Guilhaudis , Isabelle Milazzo-Segalas
Protein Science, 2009, 16 (12), pp.2750 - 2755
Journal articles hal-00425483v1

In Vivo and in Vitro Structure-Activity Relationships and Structural Conformation of Kisspeptin-10-Related Peptides

Ester Gutiérrez-Pascual , Jérôme Leprince , Antonio Martínez-Fuentes , Isabelle Ségalas-Milazzo , Rafael Pineda
Molecular Pharmacology, 2009, 76 (1), pp.58-67. ⟨10.1124/mol.108.053751⟩
Journal articles hal-01962751v1

Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor.

Steve Bourgault , David Vaudry , Isabelle Ségalas-Milazzo , Laure Guilhaudis , Alain Couvineau
Journal of Medicinal Chemistry, 2009, 52 (10), pp.3308-3316. ⟨10.1021/jm900291j⟩
Journal articles pasteur-00819957v1

Structure–activity relationships of urotensin II and URP

Jérôme Leprince , David Chatenet , Christophe Dubessy , Alain Fournier , Bruno Pfeiffer
Peptides, 2008, 29 (5), pp.658-673. ⟨10.1016/j.peptides.2007.08.014⟩
Journal articles hal-01972605v1

Solution structure of urotensin-II receptor extracellular loop III and characterization of its interaction with urotensin-II

Stéphane Boivin , Isabelle Ségalas-Milazzo , Laure Guilhaudis , Hassan Oulyadi , Alain Fournier
Peptides, 2008, 29 (5), pp.700-710. ⟨10.1016/j.peptides.2008.02.024⟩
Journal articles hal-02352152v1

Biological and structural analysis of truncated analogs of PACAP27.

Steve Bourgault , David Vaudry , Laure Guilhaudis , Emilie Raoult , Alain Couvineau
Journal of Molecular Neuroscience, 2008, 36 (1-3), pp.260-269. ⟨10.1007/s12031-008-9081-7⟩
Journal articles pasteur-00819989v1
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Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.

Séverine Zirah , Sergey A Kozin , Alexey K Mazur , Alain Blond , Michel Cheminant
Journal of Biological Chemistry, 2006, 281 (4), pp.2151-61. ⟨10.1074/jbc.M504454200⟩
Journal articles hal-00145835v1

NMR Assignment of Region 51–160 of Human KIN17, a DNA and RNA-binding Protein

Ludovic Carlier , Albane Le Maire , Sandrine Braud , Cédric Masson , Muriel Gondry
Journal of Biomolecular NMR, 2006, 36 (S1), pp.29. ⟨10.1007/s10858-006-0013-y⟩
Journal articles hal-02352045v1

Characterization of urotensin-II receptor structural domains involved in the recognition of U-II, URP, and urantide.

Stéphane Boivin , Laure Guilhaudis , Isabelle Milazzo , Hassan Oulyadi , Daniel Davoust
Biochemistry, 2006, 45 (19), pp.5993-6002. ⟨10.1021/bi060190b⟩
Journal articles pasteur-00820020v1

Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates

Nicolas Chartrel , Federica Bruzzone , Jérôme Leprince , Hélène Tollemer , Youssef Anouar
Peptides, 2006, 27 (5), pp.1110-1120. ⟨10.1016/j.peptides.2005.06.035⟩
Journal articles hal-01960808v1

Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity

Romain Thuau , Laure Guilhaudis , Isabelle Ségalas-Milazzo , Nicolas Chartrel , Hassan Oulyadi
Peptides, 2005, 26 (5), pp.779-789. ⟨10.1016/j.peptides.2005.01.006⟩
Journal articles hal-01974257v1

Structure–activity relationships and structural conformation of a novel urotensin II-related peptide

David Chatenet , Christophe Dubessy , Jérôme Leprince , Cédric Boularan , Ludovic Carlier
Peptides, 2004, 25 (10), pp.1819-1830. ⟨10.1016/j.peptides.2004.04.019⟩
Journal articles hal-01960815v1

Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays antimicrobial activity.

Alain Blond , Michel Cheminant , Delphine Destoumieux-Garzón , Isabelle Ségalas-Milazzo , Jean Peduzzi
European Journal of Biochemistry, 2002, 269 (24), pp.6212-22
Journal articles hal-00013189v1

Solution structure of microcin J25, the single macrocyclic antimicrobial peptide from Escherichia coli.

Alain Blond , Michel Cheminant , Isabelle Ségalas-Milazzo , Jean Péduzzi , Michel Barthélémy
European Journal of Biochemistry, 2001, 268 (7), pp.2124-2133. ⟨10.1046/j.1432-1327.2001.02090.x⟩
Journal articles hal-00086378v1

Liquid state NMR applied to enzyme/substrate/inhibitor

Laure Guilhaudis , Gaël Coadou , Muriel Sebban , Lina Truong , Isabelle Ségalas-Milazzo
Polymers for sustainable global development (POLY-CHAR, 2019), May 2019, Katmandou, Nepal
Conference papers hal-02542279v1

New insight in the structural characterization of turns in peptides: determination of NMR discriminatory parameters

Mattia Migliore , Laure Guilhaudis , Benjamin Lefranc , Jérôme Leprince , Hassan Oulyadi
Naples workshop on bioactive peptides (16, 2018), Jun 2018, Naples, Italy
Conference papers hal-02381233v1

Conformational studies of urotensinergic peptides using NMR and molecular modelling, in DPC micelles

Najjar Riham , Laure Guilhaudis , Nicolas Perzo , Hélène Castel , Isabelle Ségalas-Milazzo
Congrès du Groupe français des peptides et des protéines (GFPP, 20, 2017), Mar 2017, Arcachon, France
Conference papers hal-02381245v1

Investigating the conformational determinants of the activity of 26RFa: an orexigenic neuropeptide

Amélie Marotte , Isabelle Buchet , Laure Guilhaudis , Benjamin Lefranc , Cindy Neveu
Naples workshop on bioactive peptides (15, 2016), Jun 2016, Naples, Italy
Conference papers hal-02380461v1

Impact of a key ancestral deletion in chemokine and vasoactive peptide receptors on G protein couplings and chemotaxis

Jane Eilen Joubert , Laurence Desrues , Nicolas Perzo , B Taddese , Céline Lecointre
GPCRs: Beyond Structure Towards Therapy, Sep 2015, Prato, Italy
Conference papers hal-02296948v1

Production of uniformly 15N/13C labeled glycosylated proteins by hairy roots in view to NMR structural studies

Romain Trouillard , Marie Hubert-Roux , Vincent Tognetti , Laure Guilhaudis , Carole Plasson
Advanced Isotopic Labelling Methods for integrated structural biology (AILM, 2015), Feb 2015, Grenoble, France
Conference papers hal-02378500v1

Production of uniformly 15N/13C labeled glycosylated proteins by hairy roots in view to NMR structural studies

Romain Trouillard , Marie Hubert-Roux , Vincent Tognetti , Laure Guilhaudis , Carole Plasson
Congrès du Groupe français des peptides et des protéines (GFPP, 19, 2015), May 2015, Port-Bail, France
Conference papers hal-02543922v1

Key proline position in chemokine and vasoactive peptide receptors on chemotaxic behavior

Hélène Castel , Jane Eilen Joubert , Céline Lecointre , A Arrichiello , Laurence Desrues
International Symposium on Regulatory Peptides (REGPEP, 20, 2014), Sep 2014, Kyoto, Japan
Conference papers hal-02299536v1

Impact of a key mutation of a proline in chemokine and vasoactive peptide receptors: A structural determinant in chemotaxis?

Jane Eilen Joubert , Laurence Desrues , Nicolas Perzo , Céline Lecointre , A Arrichiello
GDR-GPCR (3, 2014), Oct 2014, Montpellier, France
Conference papers hal-02299458v1

Production de protéines marquées 15N ou 15N/13C dans un système d’expression racinaire et analyse de l’incorporation du marquage par spectrométrie de masse

Romain Trouillard , Marie Hubert , Laure Guilhaudis , Laurence Menu-Bouaouiche , Carole Plasson
Journée de l’Institut de recherche et d'innovation biomédicale (3, 2014), Jun 2014, Caugé, France
Conference papers hal-02113295v1

Production dans des plantes transgéniques de protéines marquées 13C et 15N en vue d’une étude structurale par RMN

Lucie Dubousset , Abdoul-Salam Koroney , Marie-Christine Kiefer-Meyer , Gaëlle Durambur , Laure Guilhaudis
Journée scientifique de l'IFRMP23 (17, 2011), Jun 2011, Rouen, France
Conference papers hal-02121347v1

Activité biologique d'une série d'analogues pseudopeptidiques aza-Β3 du 26RFa, le ligand endogène du GPR103

Olivier Le Marec , Cindy Neveu , Olivier Tasseau , Laure Guilhaudis , Isabelle Ségalas-Milazzo
35ème Colloque de la Société de Neuroendocrinologie, Sep 2008, Strasbourg, France
Conference papers hal-00361319v1

Etude pharmacochimique du 26RFa : relations structure-activité d'une série d'Aza-B3-pseudopeptides

Laure Guilhaudis , Cindy Neveu , Olivier Le Marec , Olivier Tasseau , Benjamin Lefranc
14EME JOURNEE SCIENTIFIQUE DE L'IFRMP23, Jun 2008, EVREUX, France
Conference papers hal-00361308v1

Three-Dimensional structure of a thermolysin-linearized microcin J25: Evidence for an essential role of the 11-16 loop in microcin J25 structure and antimicrobial activity

A. Blond , M. Cheminant , I. Ségalas-Milazzo , D. Destoumieux-Garzón , C. Goulard
Peptides 2002, 2002, France. pp.866-867
Conference papers hal-00013606v1

Three-Dimensional structure of a thermolysin-linearized microcin J25: Evidence for an essential role of the 11-16 loop in microcin J25 structure and antimicrobial activity

A. Blond , M. Cheminant , I. Ségalas-Milazzo , D. Destoumieux-Garzón , C. Goulard
27th European Peptide Symposium, Sep 2002, Sorrento, Italy
Conference papers hal-00013628v1

The NMR three-dimensional structure of the peptaibol antibiotic longibrachin LGA I

G. Leclerc , M. Cheminant , I. Segalas , A. Blond , J. Peduzzi
Peptides 2000, Proceedings 26th European Peptide Symposium, Sep 2000, Montpellier, France
Conference papers hal-00087884v1

NMR-Based solution structure of the 14-residue peptaibol, harzianin HC IX

I. Segalas , Y. Prigent , D. Davoust , Bernard Bodo , S. Rebuffat
25th European Peptide Symposium, 2000, France. pp.382-383
Conference papers hal-00087888v1

The compact three-dimensional structure of the 21-residue cyclic antibiotic peptide, microcin J25

Alain Blond , M. Cheminant , Isabelle Ségalas-Milazzo , Jean Peduzzi , M. Barthélémy
Peptides 2000, Proceedings 26h European Peptide Symposium, 2000, Montpellier, France
Conference papers hal-00087869v1

Structural characterization of turns in proteins and peptides: new NMR discriminatory parameters by molecular modelling

Mattia Migliore , Laure Guilhaudis , Benjamin Lefranc , Jérôme Leprince , Hassan Oulyadi
Congrès du Groupe français des peptides et des protéines (GFPP, 21, 2019), May 2019, Amboise, France
Conference poster hal-02542520v1

Characterization of beta-turns by ECD spectroscopy. A coupled molecular dynamics and TD-DFT computational study

Andrea Bonvicini , Mattia Migliore , Isabelle Ségalas-Milazzo , Vincent Tognetti , Laurent Joubert
Conference on Chiroptical Spectroscopy - CD 2019 (17, 2019), Jun 2019, Pise, Italy
Conference poster hal-02542310v1

New insights in structural characterization of turns in peptides: in silico determination of new NMR discriminatory parameters

Mattia Migliore , Laure Guilhaudis , Benjamin Lefranc , Jérôme Leprince , Hassan Oulyadi
Journée de l’Ecole doctorale normande de chimie (JEDNC, 2019), Jul 2019, Caen, France
Conference poster hal-02542528v1

Comparative structural analyses of urotensinergic peptides by CD spectroscopy, solution NMR and molecular modelling

Riham Najjar , Laure Guilhaudis , Maxime Burnacci , Hassan Oulyadi , Hélène Castel
European Magnetic Resonance Meeting (EUROMAR, 14, 2018), Jul 2018, Nantes, France
Conference poster hal-02452551v1

New insights in structural characterization of turns in peptides: in silico determination of new NMR discriminatory parameters

Mattia Migliore , Laure Guilhaudis , Benjamin Lefranc , Jérôme Leprince , Hassan Oulyadi
Journée de l’Ecole doctorale normande de chimie (JEDNC, 2018), Jun 2018, Le Havre, France
Conference poster hal-02542538v1

A structural determinant in TM2 of chemokine and vasoactive peptide GPCRs plays a key role in cell chemotactic migration

Laurence Desrues , Eilen Joubert Jane , Pierre-Mickaël Coly , Alexandre Mutel , Nicolas. Perzo
Annual Meeting of GDR3545 (6, 2017), Nov 2017, Paris, France
Conference poster hal-02341487v1

Proline in 2.58 of chemokine and vasoactive peptide G-protein coupled receptors: A structural determinant in chemotaxis?

Laurence Desrues , Eilen Joubert Jane , Nicolas Perzo , Laure Guilhaudis , Isabelle Milazzo
Annual Meeting of the LARC-Neuroscience network (21, 2017), Oct 2017, Lille, France
Conference poster hal-02341500v1

Structural characterization of turns in bioactive peptides - Determination of NMR discriminatory parameters

Mattia Migliore , Laure Guilhaudis , Benjamin Lefranc , Jérôme Leprince , Isabelle Ségalas-Milazzo
Journée de l’Ecole doctorale normande de chimie (JEDNC, 2017), Jun 2017, Mont-Saint-Aignan, France
Conference poster hal-02542501v1

Structural analyses of urotensinergic peptides by NMR spectroscopy and molecular modelling

R. Najjar , Laure Guilhaudis , Nicolas Perzo , Hélène Castel , Isabelle Ségalas-Milazzo
Journée normande de recherche biomédicale IRIB-ICORE (1, 2016), Sep 2016, Rouen, France
Conference poster hal-02345177v1

Solution NMR studies of urotensinergic peptides in DPC micelles, a membrane mimetic medium

R. Najjar , Laure Guilhaudis , Nicolas Perzo , Hélène Castel , Isabelle Ségalas-Milazzo
International Regulatory Peptide Society Congress, Jul 2016, Rouen, France
Conference poster hal-02345192v1

Impact of a key ancestral deletion in chemokine and vasoactive peptide receptors on chemotaxis

Hélène Castel , Jane Eileen Joubert , Laurence Desrues , Nicolas Perzo , Céline Lecointre
Colloque de la Société de neuroendocrinologie (41, 2016), Oct 2016, Corte, France
Conference poster hal-02349071v1

Asymmetric synthesis of fluoropseudopeptides towards constrained prolines and analogue of neuropeptide 26 RFa

Samuel Couve-Bonnaire , Camille Pierry , Emilie Villiers , Guillaume Dutheuil , Laure Guilhaudis
Congrès du Groupe français des peptides et des protéines (GFPP, 19, 2015), May 2015, Port-Bail, France
Conference poster hal-02543329v1

Demonstration of the occurrence of a non-transmembrane -helix in the extracellular loop 2 of GPR103

Karima Alim , Laure Guilhaudis , Isabelle Ségalas-Milazzo , David Vaudry , Julien Chuquet
Congrès du Groupe français des peptides et des protéines (GFPP, 19, 2015), May 2015, Port-Bail, France
Conference poster hal-02543930v1

Impact of a key ancestral deletion in chemokine and vasoactive peptide receptors on chemotaxis

Jane Eileen Joubert , Laurence Desrues , Nicolas Perzo , Céline Lecointre , Laure Guilhaudis
Colloque de la Société des neurosciences (12, 2015), May 2015, Montpellier, France
Conference poster hal-02349910v1

Comparative structural analyses of urotensinergic peptides by CD spectroscopy, NMR and Molecular Modelling

Laure Guilhaudis , Riham Najjar , Nicolas Perzo , Hélène Castel , Isabelle Ségalas-Milazzo
Congrès du Groupe français des peptides et des protéines (19ème GFPP 2015), May 2015, Port-Bail, France.
Conference poster hal-02349922v1

Comparative structural analyses of urotensinergic peptides by CD spectroscopy, NMR and Molecular Modelling

Riham Najjar , Laure Guilhaudis , Nicolas Perzo , Hélène Castel , Isabelle Ségalas-Milazzo
Journée Scientifique de l’Institut de Recherche et d’Innovation Biomédicale (IRIB 2015), Jun 2015, Rouen, France.
Conference poster hal-02543925v1

Impact of a key mutation of a proline in chemokine and vasoactive peptide receptors: A structural determinant in chemotaxis?

Eileen Joubert , Laurence Desrues , Nicolas Perzo , Céline Lecointre , Antoine Arrichiello
Journées de l’Ecole doctorale normande Biologie Intégrative, Santé, Environnement (EdN BISE, 18, 2015), Mar 2015, Mont-Saint-Aignan, France
Conference poster hal-02349914v1

Production de protéines marquées 15N ou 15N/13C dans un système d’expression racinaire et analyse de l’incorporation du marquage par spectrométrie de masse

Romain Trouillard , Marie Hubert , Laure Guilhaudis , Laurence Menu-Bouaouiche , Carole Plasson
Journée de l’Institut de recherche et d’innovation biomédicale (2, 2013), Jun 2013, Rouen, France
Conference poster hal-02115362v1

26RFa

Jérôme Leprince , Cindy Neveu , Benjamin Lefranc , Laure Guilhaudis , Isabelle Ségalas-Milazzo
Handbook of biologically active peptides, Elsevier, pp.917-923, 2013, 978-0-12-385095-9. ⟨10.1016/B978-0-12-385095-9.00122-6⟩
Book sections hal-01972615v1