isabelle TRANOY

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An Enzyme-Responsive Imiquimod Prodrug for Precision Immune Activation within the Tumor Microenvironment

Elsa Cannoni , Israa Al Jamal , Rony Eid , Rémi Châtre , Pauline Poinot et al.

Bioconjugate Chemistry, In press, ⟨10.1021/acs.bioconjchem.5c00541⟩

Article dans une revue hal-05456767v1
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β-Glucuronidase-Responsive Albumin-Binding Prodrug of Colchicine-Site Binders for Selective cancer Therapy

Alexandra Bordes , Isabelle Opalinski , Fabien Thoreau , Olivier Provot , Abdallah Hamze et al.

ChemMedChem, 2025, 20 (9), pp.e202400969. ⟨10.1002/cmdc.202400969⟩

Article dans une revue hal-04918349v1
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Induced-volatolomics, a new research field in chemical biology

Estelle Blochouse , Rony Eid , Elsa Cannoni , Rémi Châtre , Claude Geffroy et al.

Comptes Rendus. Chimie, 2024, 26 (S3), pp.1-11. ⟨10.5802/crchim.252⟩

Article dans une revue hal-04553048v1
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An Enzyme‐Responsive Self‐Immolative Recognition Marker for Manipulating Cell–Cell Interactions

Chad Plumet , Spyridon Katsakos , Mélissa Girard , Israa Al Jamal , Jonathan Clarhaut et al.

Advanced Science, In press, ⟨10.1002/advs.202402278⟩

Article dans une revue hal-04641807v1
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Induced-volatolomics for the design of tumour activated therapy

Rémi Châtre , Estelle Blochouse , Rony Eid , Fabiola Djago , Justin Lange et al.

Chemical Science, 2023, 14 (18), pp.4697-4703. ⟨10.1039/d2sc06797h⟩

Article dans une revue hal-04098727v1
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Stimuli‐Responsive Catenane‐Based Catalysts

Adrien Bessaguet , Quentin Blancart-Remaury , Pauline Poinot , Isabelle Opalinski , Sébastien Papot

Angewandte Chemie International Edition, 2023, 62 (6), pp.e202216787. ⟨10.1002/anie.202216787⟩

Article dans une revue hal-03919984v1
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A β-Cyclodextrin-Albumin Conjugate for Enhancing Therapeutic Efficacy of Cytotoxic Drugs

Chad Plumet , Rémi Châtre , Fabiola Djago , Elodie Péraudeau , Quentin Blancart-Remaury et al.

Bioconjugate Chemistry, 2022, 33 (6), pp.1138-1144. ⟨10.1021/acs.bioconjchem.2c00182⟩

Article dans une revue hal-03765739v1
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Diastereoselective synthesis of [1]rotaxanes via an active metal template strategy

Noël Pairault , Adrien Bessaguet , Romain Barat , Lucas Frédéric , Grégory Pieters et al.

Chemical Science, 2021, 12 (7), pp.2521-2526. ⟨10.1039/d0sc05369d⟩

Article dans une revue hal-03105942v1
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Absolute configuration of a [1]rotaxane determined from vibrational and electronic circular dichroism spectra

Andrew R Puente , Adrien Bessaguet , Noël Pairault , Grégory Pieters , Jeanne Crassous et al.

Chirality, 2021, 33 (11), pp.773-782. ⟨10.1002/chir.23365⟩

Article dans une revue hal-03360296v1
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The Lossen rearrangement from free hydroxamic acids

Mikaël Thomas , Jérôme Alsarraf , Nahla Araji , Isabelle Tranoy-Opalinski , Brigitte Renoux et al.

Organic & Biomolecular Chemistry, 2019, 17 (22), pp.5420-5427. ⟨10.1039/c9ob00789j⟩

Article dans une revue hal-02380109v1
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Enhancing tumor response to targeted chemotherapy through up-regulation of folate receptor α expression induced by dexamethasone and valproic acid

E. Peraudeau , L. Cronier , A. Monvoisin , P. Poinot , C. Mergault et al.

Journal of Controlled Release, 2018, 269, pp.36-44. ⟨10.1016/j.jconrel.2017.11.011⟩

Article dans une revue hal-02122599v1
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Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers

Brigitte Renoux , Florian Raes , Thibaut Legigan , Elodie Péraudeau , Balkis Eddhif et al.

Chemical Science, 2017, 8 (5), pp.3427-3433. ⟨10.1039/C7SC00472A⟩

Article dans une revue hal-02174996v1
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Rotaxane-based architectures for biological applications

Noël Pairault , Romain Barat , I. Tranoy-Opalinski , Brigitte Renoux , Mikaël Thomas et al.

Comptes Rendus. Chimie, 2016, 19 (1-2), pp.103-112. ⟨10.1016/j.crci.2015.05.012⟩

Article dans une revue hal-03127619v1
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A dendritic β-galactosidase-responsive folate–monomethylauristatin E conjugate

Jérôme Alsarraf , Elodie Peraudeau , Pauline Poinot , I. Tranoy-Opalinski , Jonathan Clarhaut et al.

Chemical Communications, 2015, 51 (87), pp.15792-15795. ⟨10.1039/C5CC05294G⟩

Article dans une revue hal-03127679v1
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A mechanically interlocked molecular system programmed for the delivery of an anticancer drug

Romain Barat , Thibaut Legigan , I. Tranoy-Opalinski , Brigitte Renoux , Elodie Peraudeau et al.

Chemical Science, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩

Article dans une revue hal-03127729v1

beta-Glucuronidase-responsive prodrugs for selective cancer chemotherapy: An update

Isabelle Tranoy-Opalinski , Thibaut Legigan , Romain Barat , Jonathan Clarhaut , Mikael Thomas et al.

European Journal of Medicinal Chemistry, 2014, 74, pp.302-313. ⟨10.1016/j.ejmech2013.12.045⟩

Article dans une revue hal-01196935v1

An enzyme-responsive system programmed for the double release of bioactive molecules through an intracellular chemical amplification process

M. Grinda , T. Legigan , J. Clarhaut , E. Peraudeau , I. Tranoy-Opalinski et al.

Organic & Biomolecular Chemistry, 2013, 11 (41), pp.7129-7133. ⟨10.1039/c3ob41536h⟩

Article dans une revue hal-00966980v1
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A galactosidase-responsive doxorubicin-folate conjugate for selective targeting of acute myelogenous leukemia blasts

Jonathan Clarhaut , Sylvain Fraineau , Joëlle Guilhot , Elodie Péraudeau , Isabelle Tranoy-Opalinski et al.

Leukemia Research, 2013, 37 (8), pp.948 - 955. ⟨10.1016/j.leukres.2013.04.026⟩

Article dans une revue istex inserm-02444614v1

Synthesis and biological evaluations of a monomethylauristatin E glucuronide prodrug for selective cancer chemotherapy

Thibaut Legigan , Jonathan Clarhaut , Brigitte Renoux , Isabelle Tranoy-Opalinski , Arnaud Monvoisin et al.

European Journal of Medicinal Chemistry, 2013, 67, pp.75-80. ⟨10.1016/j.ejmech.2013.06.037⟩

Article dans une revue (data paper) istex hal-04033523v1

Synthesis and Antitumor Efficacy of a β-Glucuronidase-Responsive Albumin-Binding Prodrug of Doxorubicin.

Thibaut Legigan , Jonathan Clarhaut , Brigitte Renoux , Isabelle Tranoy-Opalinski , Arnaud Monvoisin et al.

Journal of Medicinal Chemistry, 2012, 55 (9), pp.4516-20. ⟨10.1021/jm300348r⟩

Article dans une revue hal-00710692v1

A self-immolative dendritic glucuronide prodrug of doxorubicin

Marion Grinda , J. Clarhaut , Brigitte Renoux , Isabelle Tranoy-Opalinski , Sébastien Papot

MedChemComm, 2012, 3 (1), pp.68-70. ⟨10.1039/c1md00193k⟩

Article dans une revue hal-00682705v1

The First Generation of β-Galactosidase-Responsive Prodrugs Designed for the Selective Treatment of Solid Tumors in Prodrug Monotherapy

Thibaut Legigan , Jonathan Clarhaut , Isabelle Tranoy-Opalinski , Arnaud Monvoisin , Brigitte Renoux et al.

Angewandte Chemie International Edition, 2012, 51, pp.1 - 6. ⟨10.1002/anie.201204935⟩

Article dans une revue istex hal-00736090v1

A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier

Marion Grinda , Jonathan Clarhaut , Isabelle Tranoy-Opalinski , Brigitte Renoux , Arnaud Monvoisin et al.

ChemMedChem, 2011, 6 (12), pp.2137-2141. ⟨10.1002/cmdc.201100355⟩

Article dans une revue (data paper) istex hal-04033576v1

A Galactosidase‐Responsive “Trojan Horse” for the Selective Targeting of Folate Receptor‐Positive Tumor Cells

Mickaël Thomas , Jonathan Clarhaut , Pierre-Olivier Strale , Isabelle Tranoy-Opalinski , Joëlle Roche et al.

ChemMedChem, 2011, 6 (6), pp.1006-1010. ⟨10.1002/cmdc.201100114⟩

Article dans une revue istex hal-05326356v1

Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy.

Mickaël Thomas , Jonathan A. Clarhaut , Isabelle Tranoy-Opalinski , Jean-Pierre Gesson , Joëlle Roche et al.

Bioorganic and Medicinal Chemistry, 2008, 16 (17), pp.8109-8116. ⟨10.1016/j.bmc.2008.07.048⟩

Article dans une revue istex hal-00458881v1

Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors

Lynda Loudni , Joëlle Roche , Vincent Potiron , Jonathan Clarhaut , Christian Bachmann et al.

Bioorganic and Medicinal Chemistry Letters, 2007, 17 (17), pp.4819-4823. ⟨10.1016/j.bmcl.2007.06.067⟩

Article dans une revue istex hal-05326359v1

Future alchemy: account of the ESYOP experiment

Philippe Compain , Valérie Desvergnes , Cyril Ollivier , Frédéric Robert , Franck Suzenet et al.

Comptes Rendus. Chimie, 2006, 9, pp.127-140. ⟨10.1016/j.crci.2005.09.004⟩

Article dans une revue istex hal-00158010v1

Looking forward : a glance into the future of organic chemistry

Philippe Compain , Valérie Desvergnes , Cyril Ollivier , Frédéric Robert , Franck Suzenet et al.

New Journal of Chemistry, 2006, 30 (6), pp.823-831. ⟨10.1039/B601837H⟩

Article dans une revue istex hal-00158370v1