Isabelle VILA

Documents

Publications

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses

Isabelle Vila , Yasmine Messaoud-Nacer , Clara Taffoni , Jane Jardine , Roger Eloiflin et al.

Journal of Experimental Medicine, 2026, 223 (5), pp.e20251796. ⟨10.1084/jem.20251796⟩

Article dans une revue hal-05629678v1

Cytoplasmic DNA sensors and their regulators

Roger Eloiflin , Isabelle Vila , Nadine Laguette

Biomedical journal, In press, pp.100988. ⟨10.1016/j.bj.2026.100988⟩

Article dans une revue hal-05629674v1

Deltaviruses spread through a viral Trojan Horse

Joe Mckellar , Aurélien Fouillen , Sébastien Lyonnais , Marie-Pierre Blanchard , Florian Seigneuret et al.

Cell, 2026, 189 (9), pp.2748-2761.e17. ⟨10.1016/j.cell.2026.01.037⟩

Article dans une revue hal-05553878v1

Evolutionary conservation analysis reveals a primordial function of STING as a regulator of lipid metabolism via FADS2

Soumyabrata Guha , Joanna Re , Stéphane Grégoire , Morgane Chemarin , Adeline Augereau et al.

Nature Communications, 2026, 17 (1), pp.9771. ⟨10.1038/s41467-026-76833-5⟩

Article dans une revue hal-05760249v1

The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA

Jesse Rabinowitz , Isabelle Vila , Charlotte Luchsinger , Cinzia Bertelli , Moritz Schüssler et al.

Journal of Biological Chemistry, 2025, 301 (8), pp.110430. ⟨10.1016/j.jbc.2025.110430⟩

Article dans une revue hal-05362503v1

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling

Hanane Chamma , Soumyabrata Guha , Roger Junior Eloiflin , Adeline Augereau , Pierre Le Hars et al.

Nature Communications, 2025, 16 (1), pp.9827. ⟨10.1038/s41467-025-65713-z⟩

Article dans une revue hal-05361456v1

The unexpected role of the STING protein in lipid metabolism

Isabelle K Vila , Nadine Laguette

Comptes Rendus. Biologies, 2023, 346, pp.29 - 33. ⟨10.5802/crbiol.110⟩

Article dans une revue hal-04241169v1

Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies

Clara Taffoni , Moritz Schüssler , Isabelle K Vila , Nadine Laguette

BioEssays, 2023, ⟨10.1002/bies.202300045⟩

Article dans une revue (article de synthèse) hal-04125754v1

Multiplexed targeted analysis of polyunsaturated fatty acids and oxylipins using liquid chromatography-tandem mass spectrometry

Evgenia Turtoi , Jérémy Jeudy , Gilles Valette , Christine Enjalbal , Isabelle K Vila et al.

STAR Protocols, 2023, 4 (3), pp.102226. ⟨10.1016/j.xpro.2023.102226⟩

Article dans une revue (article de synthèse) hal-04241222v1

Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions

Dylan J Harney , Michelle Cielesh , Georgia E Roberts , Isabelle K Vila , Barney Viengkhou et al.

Cell Reports, 2023, 42 (6), pp.112559. ⟨10.1016/j.celrep.2023.112559⟩

Article dans une revue hal-04241406v1

DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma

Clara Taffoni , Johanna Marines , Hanane Chamma , Soumyabrata Guha , Mathilde Saccas et al.

EMBO Journal, 2023, 42 (7), pp.e111961. ⟨10.15252/embj.2022111961⟩

Article dans une revue hal-03923380v1

STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

Isabelle Vila , Hanane Chamma , Alizée Steer , Mathilde Saccas , Clara Taffoni et al.

Cell Metabolism, 2022, 34 (1), pp.125-139.e8. ⟨10.1016/j.cmet.2021.12.007⟩

Article dans une revue hal-03520564v1

Protocol to induce and assess cGAS-STING pathway activation in vitro

Hanane Chamma , Soumyabrata Guha , Nadine Laguette , Isabelle Vila

STAR Protocols, 2022, 3 (2), pp.101384. ⟨10.1016/j.xpro.2022.101384⟩

Article dans une revue hal-03807593v1

Alternative pathways driven by STING: From innate immunity to lipid metabolism

Isabelle Vila , Soumyabrata Guha , Joanna Kalucka , David Olagnier , Nadine Laguette

Cytokine and Growth Factor Reviews, 2022, ⟨10.1016/j.cytogfr.2022.08.006⟩

Article dans une revue hal-03807587v1

Activation of STING in the pancreatic tumor microenvironment: a novel therapeutic opportunity

Hanane Chamma , Isabelle Vila , Clara Taffoni , Andrei Turtoi , Nadine Laguette

Cancer Letters, 2022, 538, pp.215694. ⟨10.1016/j.canlet.2022.215694⟩

Article dans une revue hal-03668657v1

Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes

Clara Taffoni , Alizée Steer , Johanna Marines , Hanane Chamma , Isabelle Vila et al.

Frontiers in Immunology, 2021, 12, pp.660560. ⟨10.3389/fimmu.2021.660560⟩

Article dans une revue hal-03380383v2

Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives

Isabelle K Vila , Maxence Fretaud , Dimitrios Vlachakis , Nadine Laguette , Christelle Langevin

Journal of Molecular Biology, 2020, 432 (20), pp.5529-5543. ⟨10.1016/j.jmb.2020.08.016⟩

Article dans une revue (article de synthèse) hal-02989107v1

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

Mi Kyung Park , Yixin Yao , Weiya Xia , Stephanie Rebecca Setijono , Jae Hwan Kim et al.

Nature Communications, 2019, 10 (1), pp.636. ⟨10.1038/s41467-019-08481-x⟩

Article dans une revue hal-04765231v1

A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity

Isabelle K Vila , Mi Kyung Park , Stephanie Rebecca Setijono , Yixin Yao , Hyejin Kim et al.

JCI Insight, 2019, 4 (13), pp.e128269. ⟨10.1172/jci.insight.128269⟩

Article dans une revue hal-04793048v1

A new duet in cancer biology: AMPK the typical and UBE2O the atypical

Isabelle Vila , Su Jung Song , Min Sup Song

Molecular & Cellular Oncology, 2017, 4 (3), pp.e1304846. ⟨10.1080/23723556.2017.1304846⟩

Article dans une revue hal-04765241v1

A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy

Isabelle Vila , Yixin Yao , Goeun Kim , Weiya Xia , Hyejin Kim et al.

Cancer Cell, 2017, 31 (2), pp.208-224. ⟨10.1016/j.ccell.2017.01.003⟩

Article dans une revue hal-04765198v1

Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting

Danesh Sopariwala , Vikas Yadav , Pierre-Marie Badin , Neah Likhite , Megha Sheth et al.

Scientific Reports, 2017, 7 (1), pp.10237. ⟨10.1038/s41598-017-10238-9⟩

Article dans une revue hal-04765235v1

Exercise-like effects by Estrogen-related receptor-gamma in muscle do not prevent insulin resistance in db/db mice

Pierre-Marie Badin , Isabelle Vila , Danesh Sopariwala , Vikas Yadav , Sabina Lorca et al.

Scientific Reports, 2016, 6 (1), pp.26442. ⟨10.1038/srep26442⟩

Article dans une revue hal-04765192v1

Defective Natriuretic Peptide Receptor Signaling in Skeletal Muscle Links Obesity to Type 2 Diabetes

Marine Coué , Pierre-Marie Badin , Isabelle Vila , Claire Laurens , Katie Louche et al.

Diabetes, 2015, 64 (12), pp.4033-4045. ⟨10.2337/db15-0305⟩

Article dans une revue hal-05204309v1

Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.

Isabelle K Vila , Pierre-Marie Badin , Marie-Adeline Marques , Laurent Monbrun , Corinne Lefort et al.

Plant Cell Reports, 2014, 7 (4), pp.1116-29. ⟨10.1016/j.celrep.2014.03.062⟩

Article dans une revue inserm-00991860v1

Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.

Amandine Girousse , Geneviève Tavernier , Carine Valle , Cedric Moro , Niklas Mejhert et al.

PLoS Biology, 2013, 11 (2), pp.e1001485. ⟨10.1371/journal.pbio.1001485⟩

Article dans une revue inserm-00841328v1

High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle.

Pierre-Marie Badin , Isabelle K. Vila , Katie Louche , Aline Mairal , Marie-Adeline Marques et al.

Endocrinology, 2013, 154 (4), pp.1444-53. ⟨10.1210/en.2012-2029⟩

Article dans une revue inserm-00841051v1

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