Jérôme DESIRE

Enseignant Chercheur Université de Poitiers
53
Documents

Domaines de recherche

Chimie

Compétences

Glycochimie

Publications

Publications

Introduction of Structural Diversity at the C2 Position of Unsaturated Iminosugars through Palladium‐Catalyzed Cross‐Coupling Reactions

Quentin Joachim , Delphine Carry , Mattéo Di Pasquale , Jérôme Marrot , Suzuka Yamamoto et al.
European Journal of Organic Chemistry, 2025, 28 (32), ⟨10.1002/ejoc.202500502⟩
Article dans une revue (article de synthèse) hal-05326462 v1
Image document

Addition of Lithiated 1,3-Dithiane and Nitronate to Sugar-Derived Imines: Synthesis of Homoiminosugars and Pipecolic Acid Analogues

Thanh Van Tran , Jérôme Marrot , Suzuka Yamamoto , Kosuke Yoshimura , Isabelle Gillaizeau et al.
Organic Letters, 2025, 27 (20), pp.5068-5073. ⟨10.1021/acs.orglett.5c01061⟩
Article dans une revue hal-05248874 v1

Addition of Lithiated 1,3-Dithiane and Nitronate to Sugar-Derived Imines: Synthesis of Homoiminosugars and Pipecolic Acid Analogues

Thanh Van Tran , Jérôme Marrot , Suzuka Yamamoto , Kosuke Yoshimura , Isabelle Gillaizeau et al.
Organic Letters, 2025, 27 (20), pp.5068-5073. ⟨10.1021/acs.orglett.5c01061⟩
Article dans une revue hal-05326469 v1

Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions

Mathilde Armand , Alba Nin-Hill , Ana Ardá , Emanuela Berrino , Jérôme Désiré et al.
Journal of the American Chemical Society, 2024, 146 (47), pp.32618-32626. ⟨10.1021/jacs.4c11677⟩
Article dans une revue hal-05326476 v1
Image document

Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions

Mathilde Armand , Alba Nin-Hill , Ana Ardá , Emanuela Berrino , Jérôme Désiré et al.
Journal of the American Chemical Society, 2024, 146 (47), pp.32618-32626. ⟨10.1021/jacs.4c11677⟩
Article dans une revue hal-05176253 v1

Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors

Jérôme Désiré , Zakaria Debbah , David Gueyrard , Jérôme Marrot , Yves Blériot et al.
Carbohydrate Research, 2023, 532, pp.108903. ⟨10.1016/j.carres.2023.108903⟩
Article dans une revue (article de synthèse) hal-05326478 v1
Image document

Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors

Jérôme Désiré , Zakaria Debbah , David Gueyrard , Jérôme Marrot , Yves Blériot et al.
Carbohydrate Research, 2023, 532, pp.108903. ⟨10.1016/j.carres.2023.108903⟩
Article dans une revue hal-04542506 v1

Stereoselective Access to Iminosugar C , C -Glycosides from 6-Azidoketopyranoses

Zakaria Debbah , Jérôme Marrot , Nicolas Auberger , Jérôme Désiré , Yves Blériot
Organic Letters, 2022, 24 (25), pp.4542-4546. ⟨10.1021/acs.orglett.2c01560⟩
Article dans une revue (article de synthèse) hal-05326481 v1

Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C -alkylation leads to low micromolar HexAB and NagZ inhibitors

J. Bouquet , N. Auberger , R. Ashmus , D. King , A. Bordes et al.
Organic & Biomolecular Chemistry, 2022, 20 (3), pp.619-629. ⟨10.1039/d1ob02280f⟩
Article dans une revue hal-04526197 v1
Image document

Stereoselective Synthesis of 1- C -Diethylphosphonomethyl and -difluoromethyl Iminosugars from Sugar Lactams

Thanh Van Tran , Jérôme Désiré , Nicolas Auberger , Yves Blériot
Journal of Organic Chemistry, 2022, 87 (11), pp.7581-7585. ⟨10.1021/acs.joc.2c00835⟩
Article dans une revue hal-03953681 v1
Image document

Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif

Jérôme Désiré , Quentin Foucart , Ana Poveda , Gurvan Gourlaouen , Yuna Shimadate et al.
Carbohydrate Research, 2022, 511, pp.108491. ⟨10.1016/j.carres.2021.108491⟩
Article dans une revue hal-04542825 v1
Image document

Stereoselective Access to Iminosugar C, C-Glycosides from 6-Azidoketopyranoses

Zakaria Debbah , Jérôme C. Marrot , Nicolas Auberger , Jérôme Désiré , Yves Blériot
Organic Letters, 2022, 24 (25), pp.4542-4546. ⟨10.1021/acs.orglett.2c01560⟩
Article dans une revue hal-03775104 v1
Image document

Sugar-Derived Amidines and Congeners: Structures, Glycosidase Inhibition and Applications

Yves Blériot , Nicolas Auberger , Jérôme Désiré
Current Medicinal Chemistry, 2022, 29 (7), pp.1271-1292. ⟨10.2174/0929867329666211222164545⟩
Article dans une revue (article de synthèse) hal-04543430 v1
Image document

Insight into the Ferrier rearrangement by combining flash chemistry and superacids

Naresh Bhuma , Ludivine Lebedel , Hiroki Yamashita , Yutaka Shimizu , Zahra Abada et al.
Angewandte Chemie International Edition, 2021, 60 (4), pp.2036-2041. ⟨10.1002/anie.202010175⟩
Article dans une revue hal-03007376 v1
Image document

Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure

Alexandra Bordes , Ana Poveda , Nathalie Fontelle , Ana Ardá , Jérôme Guillard et al.
Carbohydrate Research, 2021, 501, pp.108258. ⟨10.1016/j.carres.2021.108258⟩
Article dans une revue hal-04336072 v1
Image document

Iminosugar-C-glycosides work as pharmacological chaperones of NAGLU, a glycosidase involved in MPS IIIB rare disease

Sha Zhu , Yerri Jagadeesh , Anh Tuan Tran , Alisdair Boraston , Dominic S Alonzi et al.
Chemistry - A European Journal, 2021, ⟨10.1002/chem.202101408⟩
Article dans une revue hal-03256952 v1
Image document

Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog

Alexandra Bordes , Ana Poveda , Thibault Troadec , Antonio Franconetti , Ana Arda et al.
Organic Letters, 2020, 22 (6), pp.2344-2349. ⟨10.1021/acs.orglett.0c00503⟩
Article dans une revue hal-02504835 v1

Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo- C -allyl iminosugar

Quentin Foucart , Yuna Shimadate , Jérôme Marrot , Atsushi Kato , Jérôme Désiré et al.
Organic & Biomolecular Chemistry, 2019, 17 (30), pp.7204-7214. ⟨10.1039/c9ob01402k⟩
Article dans une revue hal-04418307 v1

Site-Selective Debenzylation of C -Allyl Iminosugars Enables Their Stereocontroled Structure Diversification at the C-2 Position

Quentin Foucart , Jérôme Marrot , Jérôme Désiré , Yves Blériot
Organic Letters, 2019, 21 (12), pp.4821-4825. ⟨10.1021/acs.orglett.9b01712⟩
Article dans une revue hal-04418300 v1

2-Acetamido-2-deoxy- l -iminosugar C -Alkyl and C -Aryl Glycosides: Synthesis and Glycosidase Inhibition

Balkis Eddhif , Justin Lange , Nadia Guignard , Yann Batonneau , Jonathan A. Clarhaut et al.
European Journal of Organic Chemistry, 2018, 2018 (40), pp.5477-5488. ⟨10.1002/ejoc.201800678⟩
Article dans une revue hal-02172201 v1
Image document

Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics

Jaufret Bouquet , Dustin King , G. Vadlamani , G. Benzie , Bogdan Iorga et al.
Organic & Biomolecular Chemistry, 2017, 15 (21), pp.4609-4619. ⟨10.1039/C7OB00838D⟩
Article dans une revue hal-02176734 v1
Image document

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance

Grishma Vadlamani , Keith A Stubbs , Jerome Desire , Yves Blériot , David J. Vocadlo et al.
Protein Science, 2017, 26 (6), pp.1161-1170. ⟨10.1002/pro.3166⟩
Article dans une revue hal-02176780 v1

HF-Induced Intramolecular C -Arylation and C -Alkylation/Fluorination of 2-Aminoglycopyranoses

Nicolas Probst , Amélie Martin , Jérôme Désiré , Agnès Mingot , Jerome Marrot et al.
Organic Letters, 2017, 19 (5), pp.1040 - 1043. ⟨10.1021/acs.orglett.7b00003⟩
Article dans une revue hal-01743477 v1
Image document

Multivalency To Inhibit and Discriminate Hexosaminidases

Dimitri Alvarez-Dorta , Dustin King , Thibaut Legigan , Daisuke Ide , Isao Adachi et al.
Chemistry - A European Journal, 2017, 23 (38), pp.9022 - 9025. ⟨10.1002/chem.201701756⟩
Article dans une revue hal-01744683 v1

In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay–Sachs disease

Atsushi Kato , Izumi Nakagome , Shinpei Nakagawa , Kyoko Kinami , Isao Adachi et al.
Organic & Biomolecular Chemistry, 2017, 15 (44), pp.9297-9304. ⟨10.1039/C7OB02281F⟩
Article dans une revue hal-02176719 v1

Catching elusive glycosyl cations in a condensed phase with HF/SbF₅ superacid

A. Martin , A. Arda , J. Désiré , A. Martin-Mingot , N. Probst et al.
Nature Chemistry, 2016, ⟨10.1038/nchem.2399⟩
Article dans une revue hal-01505628 v1

gamma-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP

Y. Jagadeesh , A.T. Tuan , B. Luo , A. Auberger , J. Desire et al.
Organic & Biomolecular Chemistry, 2015, 13 pp.3446-3456. ⟨10.1039/c5ob00050e⟩
Article dans une revue hal-01340188 v1
Image document

Synthesis of pyrrolidine-based analogues of 2-acetamidosugars as N-acetyl glucosaminidase inhibitors

Anh Tuan Tran , Bo Luo , Jagadeesh Yerri , Nicolas Auberger , Jérôme Désiré et al.
Carbohydrate Research, 2015, 409, pp.56-62. ⟨10.1016/j.carres.2015.02.014⟩
Article dans une revue hal-01136039 v1
Image document

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

V. Cendret , T. Legigan , A. Martin-Mingot , S. Thibaudeau , I. Adachi et al.
Organic & Biomolecular Chemistry, 2015, 13 (43), pp.10734-10744. ⟨10.1039/c5ob01526j⟩
Article dans une revue hal-01500682 v1

γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP

Y. Jagadeesh , A. Tran , B. Luo , N. Auberger , J. Désiré et al.
Organic & Biomolecular Chemistry, 2015, 13 (11), pp.3446-3456. ⟨10.1039/C5OB00050E⟩
Article dans une revue hal-04543396 v1

Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities

Fatima El Bahhaj , Jerome Desire , Christophe Blanquart , Nadine Martinet , Vincent Zwick et al.
Tetrahedron, 2014, 70 (51 ), pp.9702-9708 ⟨10.1016/j.tet.2014.10.053⟩
Article dans une revue istex hal-01314516 v1

Synthesis of 1,2-trans-2-Acetamido-2-deoxyhomoiminosugars

Yves Blériot , Anh Tuan Tran , Giuseppe Prencipe , Jagadeesh Yerri , Nicolas Auberger et al.
Organic Letters, 2014, 16 (21 ), pp.5516-5519. ⟨10.1021/ol502929h⟩
Article dans une revue hal-01315627 v1

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors

J. Désiré , M. Mondon , N. Fontelle , S. Nakagawa , Y. Hirokami et al.
Organic & Biomolecular Chemistry, 2014, 12 (44), pp.8977-8996. ⟨10.1039/c4ob00325j⟩
Article dans une revue hal-01311606 v1

Synthesis of 1,2-cis-Homoiminosugars Derived from GlcNAc and GalNAc Exploiting a β-Amino Alcohol Skeletal Rearrangement

Yves Blériot , Nicolas Auberger , Jagadeesh Yerri , Charles Gauthier , Giuseppe Prencipe et al.
Organic Letters, 2014, 16 (21 ), pp.5512-5515. ⟨10.1021/ol502926f⟩
Article dans une revue hal-01315083 v1

Novel imino sugar α-glucosidase inhibitors as antiviral drugs

J.D. Howe , N. Smith , L.J. Marvin , N. Ardes-Guillot , J. Désiré et al.
Bioorganic and Medicinal Chemistry, 2013, 21, pp.4831-4838. ⟨10.1016/j.bmc.2013.03.014⟩
Article dans une revue istex hal-00932306 v1

Cyclodextrin-glycerol dimers: synthesis and NMR conformational analysis

V. Legros , C. Vanhaverbeke , F. Souard , C. Len , J. Désiré
European Journal of Organic Chemistry, 2013, 13, pp.2583-2590. ⟨10.1002/ejoc.201201716⟩
Article dans une revue istex hal-00934169 v1

Novel imino sugar α-glucosidase inhibitors as antiviral compounds.

J. D. Howe , N. Smith , M. J.-R. Lee , N. Ardes-Guisot , B. Vauzeilles et al.
Bioorganic and Medicinal Chemistry, 2013, 21 (16), pp.4831-8. ⟨10.1016/j.bmc.2013.03.014⟩
Article dans une revue istex hal-00856804 v1

Access to l- and d-Iminosugar C-Glycosides from a d-gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy.

Martine Mondon , Nathalie Fontelle , Jérôme Désiré , Frédéric Lecornué , Jérôme Guillard et al.
Organic Letters, 2012, 14 (3), pp.870-3. ⟨10.1021/ol203385w⟩
Article dans une revue hal-00669930 v1

Synthesis and conformational analysis of bicyclic mimics of alpha- and beta-D-glucopyranosides adopting the biologically relevant 2,5B conformation

L. Amorim , Farias Marcelo , J. Désiré , M. Sollogoub , J. Jimenez-Barbero et al.
Carbohydrate Research, 2012, 361, pp.219-224. ⟨10.1016/j.carres.2012.07.005⟩
Article dans une revue istex hal-00834859 v1

A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits Tat-Mediated Transactivation of HIV-1 Transcription

I. Das , J. Désiré , D. Manvar , I. Baussanne , V.N. Pandey et al.
Journal of Medicinal Chemistry, 2012, 55 (13), pp.6021-6032. ⟨10.1021/jm300253q⟩
Article dans une revue hal-00838407 v1

Toward the Supramolecular Cyclodextrin Dimers Using Nucleobase Pairs

Vanessa Legros , Florian Hamon , Bruno Violeau , Frédéric Turpin , Florence Djedaini-Pilard et al.
Synthesis: Journal of Synthetic Organic Chemistry, 2011, 2011 (02), pp.235-242. ⟨10.1055/s-0030-1258354⟩
Article dans une revue hal-02944637 v1

Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleotide 3'-disulfides.

Béatrice Gerland , Jerome Desire , Jan Balzarini , Jean Luc Decout
Bioorganic and Medicinal Chemistry, 2008, pp.6824-6831. ⟨10.1016/j.bmc.2008.05.065⟩
Article dans une revue istex hal-00383176 v1

Covalently bonded DNA aptamer chiral stationary phase for the chromatographic resolution of adenosine.

J. Ruta , Corinne Ravelet , J. Désiré , Jean Luc Decout , E. Peyrin
Analytical and Bioanalytical Chemistry, 2008, 390, pp.1051-1057. ⟨10.1007/s00216-007-1552-0⟩
Article dans une revue istex hal-00383152 v1

Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate.

B. Chaubey , S. Tripathi , Jerome Desire , I. Baussanne , Jean Luc Decout et al.
Oligonucleotides, 2007, pp.302-313. ⟨10.1089/oli.2007.0085⟩
Article dans une revue hal-00383208 v1

Direct preparation of nucleoside vinyl disulfides from 2-(trimethylsilyl)ethyl sulfides, an access to vinylthiols.

Jean Luc Decout , J. Désiré , Béatrice Gerland , Michel Lepoivre
Organic Letters, 2007, pp.3021-3023
Article dans une revue hal-00382953 v1

Neamine dimers targeting the HIV-1 TAR RNA.

Emmanuel Riguet , Jerome Desire , Oliver Boden , Verena Ludwig , Michael Göbel et al.
Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.4651-4655
Article dans une revue hal-00382910 v1

Neamine dimers targeting the HIV-1 TAR RNA.

Jean Luc Decout , J. Désiré , E. Riguet , O. Boden , V. Ludwig et al.
Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.4651-4655. ⟨10.1016/j.bmcl.2005.07.082⟩
Article dans une revue istex hal-00123107 v1

Imino glycals in synthesis : preparation of novel deoxymannojirimycin analogues

J. Désiré , M. Shipman
SYNLETT, 2001, 8, pp.1332-1334. ⟨10.1055/s-2001-16049⟩
Article dans une revue hal-00123045 v1

Synthesis of 1-C-dithiane and 1-C-nitromethyl iminosugars from sugar lactams

Thanh Van Tran , J. Désiré , N. Auberger , Y. Blériot
The 29th days of the French Group of Glycosciences, May 2024, Obernai, France
Communication dans un congrès hal-05344140 v1
Image document

One-Step Preparation of Protected N-tert -Butanesulfinyl D-ribo and D-xylo Furanosylamines from Related Sugar Hemiacetals

Chloé Cocaud , Cyril Nicolas , Jérôme Désiré , Olivier R Martin
Christian Vogel; Paul Murphy. Carbohydrate Chemistry : Proven Synthetic Methods, Volume 4, 4, CRC Press, pp.45-52, 2017, 978-1-4987-2691-7. ⟨10.1201/9781315120300-6⟩
Chapitre d'ouvrage hal-04694840 v1