Jérôme DESIRE

Enseignant Chercheur Université de Poitiers
53
Documents

Domaines de recherche

Chimie

Compétences

Glycochimie

Publications

Publications

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Evaluation of GlcNAc-Configured Glycomimetics as Pharmacological Chaperones of NAGLU for the Treatment of Mucopolysaccharidosis IIIB

Nissrine Ballout , Jérôme Désiré , Angela Johana Espejo-Mojica , Katherin Niño-Traslaviña , Daniel Sandoval-Trujillo et al.

Biomolecules, 2026, 16 (2), pp.313. ⟨10.3390/biom16020313⟩

Article dans une revue hal-05523032v1

Introduction of Structural Diversity at the C2 Position of Unsaturated Iminosugars through Palladium‐Catalyzed Cross‐Coupling Reactions

Quentin Joachim , Delphine Carry , Mattéo Di Pasquale , Jérôme Marrot , Suzuka Yamamoto et al.

European Journal of Organic Chemistry, 2025, 28 (32), ⟨10.1002/ejoc.202500502⟩

Article dans une revue (article de synthèse) hal-05326462v1
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Petasis-mediated exo-iminoglycals synthesis from glyconolactams allows access to unprecedented 1-spirocyclopropyl deoxynojirimycin

Lilou Chopin , Aurélien Beato , Dylan Yorga , Nicolas Auberger , Jean-Bernard Behr et al.

Carbohydrate Research, 2025, 560, pp.109765. ⟨10.1016/j.carres.2025.109765⟩

Article dans une revue (article de synthèse) hal-05412880v1
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Addition of Lithiated 1,3-Dithiane and Nitronate to Sugar-Derived Imines: Synthesis of Homoiminosugars and Pipecolic Acid Analogues

Thanh Van Tran , Jérôme Marrot , Suzuka Yamamoto , Kosuke Yoshimura , Isabelle Gillaizeau et al.

Organic Letters, 2025, 27 (20), pp.5068-5073. ⟨10.1021/acs.orglett.5c01061⟩

Article dans une revue hal-05248874v1

Addition of Lithiated 1,3-Dithiane and Nitronate to Sugar-Derived Imines: Synthesis of Homoiminosugars and Pipecolic Acid Analogues

Thanh Van Tran , Jérôme Marrot , Suzuka Yamamoto , Kosuke Yoshimura , Isabelle Gillaizeau et al.

Organic Letters, 2025, 27 (20), pp.5068-5073. ⟨10.1021/acs.orglett.5c01061⟩

Article dans une revue hal-05326469v1

Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions

Mathilde Armand , Alba Nin-Hill , Ana Ardá , Emanuela Berrino , Jérôme Désiré et al.

Journal of the American Chemical Society, 2024, 146 (47), pp.32618-32626. ⟨10.1021/jacs.4c11677⟩

Article dans une revue hal-05326476v1
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Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions

Mathilde Armand , Alba Nin-Hill , Ana Ardá , Emanuela Berrino , Jérôme Désiré et al.

Journal of the American Chemical Society, 2024, 146 (47), pp.32618-32626. ⟨10.1021/jacs.4c11677⟩

Article dans une revue hal-05176253v1
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Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors

Jérôme Désiré , Zakaria Debbah , David Gueyrard , Jérôme Marrot , Yves Blériot et al.

Carbohydrate Research, 2023, 532, pp.108903. ⟨10.1016/j.carres.2023.108903⟩

Article dans une revue hal-04542506v1
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Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif

Jérôme Désiré , Quentin Foucart , Ana Poveda , Gurvan Gourlaouen , Yuna Shimadate et al.

Carbohydrate Research, 2022, 511, pp.108491. ⟨10.1016/j.carres.2021.108491⟩

Article dans une revue hal-04542825v1
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Stereoselective Access to Iminosugar C, C-Glycosides from 6-Azidoketopyranoses

Zakaria Debbah , Jérôme C. Marrot , Nicolas Auberger , Jérôme Désiré , Yves Blériot

Organic Letters, 2022, 24 (25), pp.4542-4546. ⟨10.1021/acs.orglett.2c01560⟩

Article dans une revue hal-03775104v1
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Stereoselective Synthesis of 1- C -Diethylphosphonomethyl and -difluoromethyl Iminosugars from Sugar Lactams

Thanh Van Tran , Jérôme Désiré , Nicolas Auberger , Yves Blériot

Journal of Organic Chemistry, 2022, 87 (11), pp.7581-7585. ⟨10.1021/acs.joc.2c00835⟩

Article dans une revue hal-03953681v1

Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C -alkylation leads to low micromolar HexAB and NagZ inhibitors

J. Bouquet , N. Auberger , R. Ashmus , D. King , A. Bordes et al.

Organic & Biomolecular Chemistry, 2022, 20 (3), pp.619-629. ⟨10.1039/d1ob02280f⟩

Article dans une revue hal-04526197v1
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Sugar-Derived Amidines and Congeners: Structures, Glycosidase Inhibition and Applications

Yves Blériot , Nicolas Auberger , Jérôme Désiré

Current Medicinal Chemistry, 2022, 29 (7), pp.1271-1292. ⟨10.2174/0929867329666211222164545⟩

Article dans une revue (article de synthèse) hal-04543430v1
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Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure

Alexandra Bordes , Ana Poveda , Nathalie Fontelle , Ana Ardá , Jérôme Guillard et al.

Carbohydrate Research, 2021, 501, pp.108258. ⟨10.1016/j.carres.2021.108258⟩

Article dans une revue hal-04336072v1
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Insight into the Ferrier rearrangement by combining flash chemistry and superacids

Naresh Bhuma , Ludivine Lebedel , Hiroki Yamashita , Yutaka Shimizu , Zahra Abada et al.

Angewandte Chemie International Edition, 2021, 60 (4), pp.2036-2041. ⟨10.1002/anie.202010175⟩

Article dans une revue hal-03007376v1
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Iminosugar-C-glycosides work as pharmacological chaperones of NAGLU, a glycosidase involved in MPS IIIB rare disease

Sha Zhu , Yerri Jagadeesh , Anh Tuan Tran , Alisdair Boraston , Dominic S Alonzi et al.

Chemistry - A European Journal, 2021, ⟨10.1002/chem.202101408⟩

Article dans une revue hal-03256952v1
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Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog

Alexandra Bordes , Ana Poveda , Thibault Troadec , Antonio Franconetti , Ana Arda et al.

Organic Letters, 2020, 22 (6), pp.2344-2349. ⟨10.1021/acs.orglett.0c00503⟩

Article dans une revue hal-02504835v1

Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo- C -allyl iminosugar

Quentin Foucart , Yuna Shimadate , Jérôme Marrot , Atsushi Kato , Jérôme Désiré et al.

Organic & Biomolecular Chemistry, 2019, 17 (30), pp.7204-7214. ⟨10.1039/c9ob01402k⟩

Article dans une revue hal-04418307v1

Site-Selective Debenzylation of C -Allyl Iminosugars Enables Their Stereocontroled Structure Diversification at the C-2 Position

Quentin Foucart , Jérôme Marrot , Jérôme Désiré , Yves Blériot

Organic Letters, 2019, 21 (12), pp.4821-4825. ⟨10.1021/acs.orglett.9b01712⟩

Article dans une revue hal-04418300v1

2-Acetamido-2-deoxy- l -iminosugar C -Alkyl and C -Aryl Glycosides: Synthesis and Glycosidase Inhibition

Balkis Eddhif , Justin Lange , Nadia Guignard , Yann Batonneau , Jonathan A. Clarhaut et al.

European Journal of Organic Chemistry, 2018, 2018 (40), pp.5477-5488. ⟨10.1002/ejoc.201800678⟩

Article dans une revue hal-02172201v1
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Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance

Grishma Vadlamani , Keith A Stubbs , Jerome Desire , Yves Blériot , David J. Vocadlo et al.

Protein Science, 2017, 26 (6), pp.1161-1170. ⟨10.1002/pro.3166⟩

Article dans une revue hal-02176780v1
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Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics

Jaufret Bouquet , Dustin King , G. Vadlamani , G. Benzie , Bogdan Iorga et al.

Organic & Biomolecular Chemistry, 2017, 15 (21), pp.4609-4619. ⟨10.1039/C7OB00838D⟩

Article dans une revue hal-02176734v1

HF-Induced Intramolecular C -Arylation and C -Alkylation/Fluorination of 2-Aminoglycopyranoses

Nicolas Probst , Amélie Martin , Jérôme Désiré , Agnès Mingot , Jerome Marrot et al.

Organic Letters, 2017, 19 (5), pp.1040 - 1043. ⟨10.1021/acs.orglett.7b00003⟩

Article dans une revue hal-01743477v1
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Multivalency To Inhibit and Discriminate Hexosaminidases

Dimitri Alvarez-Dorta , Dustin King , Thibaut Legigan , Daisuke Ide , Isao Adachi et al.

Chemistry - A European Journal, 2017, 23 (38), pp.9022 - 9025. ⟨10.1002/chem.201701756⟩

Article dans une revue hal-01744683v1

In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay–Sachs disease

Atsushi Kato , Izumi Nakagome , Shinpei Nakagawa , Kyoko Kinami , Isao Adachi et al.

Organic & Biomolecular Chemistry, 2017, 15 (44), pp.9297-9304. ⟨10.1039/C7OB02281F⟩

Article dans une revue hal-02176719v1

Catching elusive glycosyl cations in a condensed phase with HF/SbF₅ superacid

A. Martin , A. Arda , J. Désiré , A. Martin-Mingot , N. Probst et al.

Nature Chemistry, 2016, ⟨10.1038/nchem.2399⟩

Article dans une revue hal-01505628v1
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Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

V. Cendret , T. Legigan , A. Martin-Mingot , S. Thibaudeau , I. Adachi et al.

Organic & Biomolecular Chemistry, 2015, 13 (43), pp.10734-10744. ⟨10.1039/c5ob01526j⟩

Article dans une revue hal-01500682v1

gamma-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP

Y. Jagadeesh , A.T. Tuan , B. Luo , A. Auberger , J. Desire et al.

Organic & Biomolecular Chemistry, 2015, 13 pp.3446-3456. ⟨10.1039/c5ob00050e⟩

Article dans une revue hal-01340188v1
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Synthesis of pyrrolidine-based analogues of 2-acetamidosugars as N-acetyl glucosaminidase inhibitors

Anh Tuan Tran , Bo Luo , Jagadeesh Yerri , Nicolas Auberger , Jérôme Désiré et al.

Carbohydrate Research, 2015, 409, pp.56-62. ⟨10.1016/j.carres.2015.02.014⟩

Article dans une revue istex hal-01136039v1

γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP

Y. Jagadeesh , A. Tran , B. Luo , N. Auberger , J. Désiré et al.

Organic & Biomolecular Chemistry, 2015, 13 (11), pp.3446-3456. ⟨10.1039/C5OB00050E⟩

Article dans une revue hal-04543396v1

Synthesis of 1,2-trans-2-Acetamido-2-deoxyhomoiminosugars

Yves Blériot , Anh Tuan Tran , Giuseppe Prencipe , Jagadeesh Yerri , Nicolas Auberger et al.

Organic Letters, 2014, 16 (21 ), pp.5516-5519. ⟨10.1021/ol502929h⟩

Article dans une revue hal-01315627v1

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors

J. Désiré , M. Mondon , N. Fontelle , S. Nakagawa , Y. Hirokami et al.

Organic & Biomolecular Chemistry, 2014, 12 (44), pp.8977-8996. ⟨10.1039/c4ob00325j⟩

Article dans une revue hal-01311606v1

Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities

Fatima El Bahhaj , Jerome Desire , Christophe Blanquart , Nadine Martinet , Vincent Zwick et al.

Tetrahedron, 2014, 70 (51 ), pp.9702-9708 ⟨10.1016/j.tet.2014.10.053⟩

Article dans une revue istex hal-01314516v1

Synthesis of 1,2-cis-Homoiminosugars Derived from GlcNAc and GalNAc Exploiting a β-Amino Alcohol Skeletal Rearrangement

Yves Blériot , Nicolas Auberger , Jagadeesh Yerri , Charles Gauthier , Giuseppe Prencipe et al.

Organic Letters, 2014, 16 (21 ), pp.5512-5515. ⟨10.1021/ol502926f⟩

Article dans une revue hal-01315083v1

Cyclodextrin-glycerol dimers: synthesis and NMR conformational analysis

V. Legros , C. Vanhaverbeke , F. Souard , C. Len , J. Désiré

European Journal of Organic Chemistry, 2013, 13, pp.2583-2590. ⟨10.1002/ejoc.201201716⟩

Article dans une revue istex hal-00934169v1

Novel imino sugar α-glucosidase inhibitors as antiviral drugs

J.D. Howe , N. Smith , L.J. Marvin , N. Ardes-Guillot , J. Désiré et al.

Bioorganic and Medicinal Chemistry, 2013, 21, pp.4831-4838. ⟨10.1016/j.bmc.2013.03.014⟩

Article dans une revue istex hal-00932306v1

Novel imino sugar α-glucosidase inhibitors as antiviral compounds.

J. D. Howe , N. Smith , M. J.-R. Lee , N. Ardes-Guisot , B. Vauzeilles et al.

Bioorganic and Medicinal Chemistry, 2013, 21 (16), pp.4831-8. ⟨10.1016/j.bmc.2013.03.014⟩

Article dans une revue istex hal-00856804v1

Synthesis and conformational analysis of bicyclic mimics of alpha- and beta-D-glucopyranosides adopting the biologically relevant 2,5B conformation

L. Amorim , Farias Marcelo , J. Désiré , M. Sollogoub , J. Jimenez-Barbero et al.

Carbohydrate Research, 2012, 361, pp.219-224. ⟨10.1016/j.carres.2012.07.005⟩

Article dans une revue istex hal-00834859v1

Access to l- and d-Iminosugar C-Glycosides from a d-gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy.

Martine Mondon , Nathalie Fontelle , Jérôme Désiré , Frédéric Lecornué , Jérôme Guillard et al.

Organic Letters, 2012, 14 (3), pp.870-3. ⟨10.1021/ol203385w⟩

Article dans une revue hal-00669930v1

A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits Tat-Mediated Transactivation of HIV-1 Transcription

I. Das , J. Désiré , D. Manvar , I. Baussanne , V.N. Pandey et al.

Journal of Medicinal Chemistry, 2012, 55 (13), pp.6021-6032. ⟨10.1021/jm300253q⟩

Article dans une revue hal-00838407v1

Toward the Supramolecular Cyclodextrin Dimers Using Nucleobase Pairs

Vanessa Legros , Florian Hamon , Bruno Violeau , Frédéric Turpin , Florence Djedaini-Pilard et al.

Synthesis: Journal of Synthetic Organic Chemistry, 2011, 2011 (02), pp.235-242. ⟨10.1055/s-0030-1258354⟩

Article dans une revue hal-02944637v1

Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleotide 3'-disulfides.

Béatrice Gerland , Jerome Desire , Jan Balzarini , Jean Luc Decout

Bioorganic and Medicinal Chemistry, 2008, pp.6824-6831. ⟨10.1016/j.bmc.2008.05.065⟩

Article dans une revue istex hal-00383176v1

Covalently bonded DNA aptamer chiral stationary phase for the chromatographic resolution of adenosine.

J. Ruta , Corinne Ravelet , J. Désiré , Jean Luc Decout , E. Peyrin

Analytical and Bioanalytical Chemistry, 2008, 390, pp.1051-1057. ⟨10.1007/s00216-007-1552-0⟩

Article dans une revue istex hal-00383152v1

Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate.

B. Chaubey , S. Tripathi , Jerome Desire , I. Baussanne , Jean Luc Decout et al.

Oligonucleotides, 2007, pp.302-313. ⟨10.1089/oli.2007.0085⟩

Article dans une revue hal-00383208v1

Direct preparation of nucleoside vinyl disulfides from 2-(trimethylsilyl)ethyl sulfides, an access to vinylthiols.

Jean Luc Decout , J. Désiré , Béatrice Gerland , Michel Lepoivre

Organic Letters, 2007, pp.3021-3023

Article dans une revue hal-00382953v1

Neamine dimers targeting the HIV-1 TAR RNA.

Emmanuel Riguet , Jerome Desire , Oliver Boden , Verena Ludwig , Michael Göbel et al.

Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.4651-4655

Article dans une revue hal-00382910v1

Neamine dimers targeting the HIV-1 TAR RNA.

Jean Luc Decout , J. Désiré , E. Riguet , O. Boden , V. Ludwig et al.

Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.4651-4655. ⟨10.1016/j.bmcl.2005.07.082⟩

Article dans une revue istex hal-00123107v1

Imino glycals in synthesis : preparation of novel deoxymannojirimycin analogues

J. Désiré , M. Shipman

SYNLETT, 2001, 8, pp.1332-1334. ⟨10.1055/s-2001-16049⟩

Article dans une revue hal-00123045v1

Synthesis of 1-C-dithiane and 1-C-nitromethyl iminosugars from sugar lactams

Thanh Van Tran , Jérôme Désiré , Nicolas Auberger , Yves Blériot

The 29th days of the French Group of Glycosciences (CFG 2024), May 2024, Obernai, France

Communication dans un congrès hal-05344140v1
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One-Step Preparation of Protected N-tert -Butanesulfinyl D-ribo and D-xylo Furanosylamines from Related Sugar Hemiacetals

Chloé Cocaud , Cyril Nicolas , Jérôme Désiré , Olivier R Martin

Christian Vogel; Paul Murphy. Carbohydrate Chemistry : Proven Synthetic Methods, Volume 4, 4, CRC Press, pp.45-52, 2017, 978-1-4987-2691-7. ⟨10.1201/9781315120300-6⟩

Chapitre d'ouvrage hal-04694840v1