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Jean-Michel Escoubas

Jean-Michel ESCOUBAS researcher CNRS
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Présentation

Tout au long de ma carrière de chercheur j’ai étudié la plasticité des interactions dans le monde du vivant. C’est-à-dire j’ai exploré les mécanismes qui régissent les interactions entre les microorganismes (virus, bactéries et autres petites bêtes), leurs hôtes et leurs environnements. Ces travaux m’ont permis d’entrevoir l’incroyable capacité d’adaptation et de coopération des êtres vivants qui leur permet de s’acclimater sans cesse à un environnement en perpétuel changement. J’aspire maintenant à partager plus largement mon savoir, mon savoir-faire et mon savoir-être avec le monde socio-économique afin de contribuer à un développement socialement et écologiquement plus durable.

Domaines de recherche


Publications

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Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life

Delphine Destoumieux-Garzón , Caroline Montagnani , Luc Dantan , Noémie de San Nicolas , Marie-Agnès Travers
Philosophical Transactions of the Royal Society B: Biological Sciences, 2024, 379 (1901), ⟨10.1098/rstb.2023.0065⟩
Article dans une revue hal-04515139v1
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Inactivation of two oyster pathogens by photocatalysis and monitoring of changes in the microbiota of seawater: a case study on Ostreid Herpes Virus 1 µVar and Vibrio harveyi

Cécile Blanchon , Eve Toulza , Christophe Calvayrac , Stanislawa Eichendorff , Marie-Agnes Travers
Chemosphere, 2024, 346, pp.140565
Article dans une revue hal-04305291v1
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A core of functional complementary bacteria infects oysters in Pacific Oyster Mortality Syndrome

Camille Clerissi , Xing Luo , Aude Lucasson , Shogofa Mortaza , Julien de Lorgeril
Animal Microbiome, 2023, 5, ⟨10.1186/s42523-023-00246-8⟩
Article dans une revue hal-04107637v1
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Cooperation and cheating orchestrate Vibrio assemblages and polymicrobial synergy in oysters infected with OsHV-1 virus

Daniel Oyanedel , Arnaud Lagorce , Maxime Bruto , Philippe Haffner , Amandine Morot
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (40), pp.e2305195120. ⟨10.1073/pnas.2305195120⟩
Article dans une revue hal-04219877v1
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Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome

Janan Gawra , Alejandro Valdivieso , Fabrice Roux , Martin Laporte , Julien de Lorgeril
Science Advances , 2023, 9 (36), pp.eadh899. ⟨10.1126/sciadv.adh8990⟩
Article dans une revue hal-04202595v1
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Evaluation of tangential flow filtration coupled to long-read sequencing for ostreid herpesvirus type 1 genome assembly

Aurélie Dotto-Maurel , Camille Pelletier , Benjamin Morga , Maude Jacquot , Nicole Faury
Microbial Genomics, 2022, 8 (11), ⟨10.1099/mgen.0.000895⟩
Article dans une revue hal-03863848v1
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Genetic Diversity and Connectivity of the Ostreid Herpesvirus 1 Populations in France: A First Attempt to Phylogeographic Inference for a Marine Mollusc Disease

Jean Delmotte , Camille Pelletier , Benjamin Morga , Richard Galinier , Bruno Petton
Virus Evolution, 2022, 8 (1), pp.veac039. ⟨10.1093/ve/veac039⟩
Article dans une revue hal-03652456v1
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Functional Diversification of Oyster Big Defensins Generates Antimicrobial Specificity and Synergy against Members of the Microbiota

Noémie de San Nicolas , Aromal Asokan , Rafael D Rosa , Sébastien N Voisin , Marie-Agnès Travers
Marine drugs, 2022, 20 (12), pp.745. ⟨10.3390/md20120745⟩
Article dans une revue hal-04246173v1
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Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection

Manon Fallet , C. Montagnani , Bruno Petton , Luc Dantan , Julien de Lorgeril
Microbiome, 2022, 10, pp.85. ⟨10.1186/s40168-022-01280-5⟩
Article dans une revue hal-03635473v2
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Structural variation turnovers and defective genomes: key drivers for the in vitro evolution of the large double-stranded DNA koi herpesvirus (KHV)

Nurul Novelia Fuandila , Anne-Sophie Gosselin-Grenet , Marie-Ka Tilak , Sven M Bergmann , Jean-Michel Escoubas
Peer Community Journal, 2022, ⟨10.24072/pcjournal.154⟩
Article dans une revue hal-03895944v1
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Genomic Diversity of the Ostreid Herpesvirus Type 1 Across Time and Location and Among Host Species

Benjamin Morga , Maude Jacquot , Camille Pelletier , Germain Chevignon , Lionel Dégremont
Frontiers in Microbiology, 2021, 12, pp.711377. ⟨10.3389/fmicb.2021.711377⟩
Article dans une revue hal-03313181v1
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Oyster hemolymph is a complex and dynamic ecosystem hosting bacteria, protists and viruses

Samuel Dupont , A. Lokmer , E. Corre , J.-C. Auguet , Bruno Petton
Animal Microbiome, 2020, 2 (1), pp.12. ⟨10.1186/s42523-020-00032-w⟩
Article dans une revue hal-02563300v1
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Contribution of Viral Genomic Diversity to Oyster Susceptibility in the Pacific Oyster Mortality Syndrome

Jean Delmotte , Cristian Chaparro , Richard Galinier , Julien de Lorgeril , Bruno Petton
Frontiers in Microbiology, 2020, 11, pp.1579. ⟨10.3389/fmicb.2020.01579⟩
Article dans une revue hal-02915023v1
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Microbiota Composition and Evenness Predict Survival Rate of Oysters Confronted to Pacific Oyster Mortality Syndrome

Camille Clerissi , Julien de Lorgeril , Bruno Petton , Aude Lucasson , Jean-Michel Escoubas
Frontiers in Microbiology, 2020, 11, pp.311. ⟨10.3389/fmicb.2020.00311⟩
Article dans une revue hal-02551728v1
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Unveiling protist diversity associated with the Pacific oyster Crassostrea gigas using blocking and excluding primers

Camille Clerissi , Laure Guillou , Jean-Michel Escoubas , Eve R Toulza
BMC Microbiology, 2020, 20, pp.193. ⟨10.1186/s12866-020-01860-1⟩
Article dans une revue hal-02914979v1
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Differential basal expression of immune genes confers Crassostrea gigas resistance to Pacific Oyster Mortality Syndrome

Julien de Lorgeril , Bruno Petton , Aude Lucasson , Valérie Perez , Pierre-Louis Stenger
BMC Genomics, 2020, 21 (1), pp.63. ⟨10.1186/s12864-020-6471-x⟩
Article dans une revue hal-02432454v1
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Inefficient immune response is associated with microbial permissiveness in juvenile oysters affected by mass mortalities on field

Julien de Lorgeril , Jean-Michel Escoubas , Vincent Loubiere , Fabrice Pernet , Patrik Le Gall
Fish and Shellfish Immunology, 2018, 77, pp.156 - 163. ⟨10.1016/j.fsi.2018.03.027⟩
Article dans une revue hal-01759229v1
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Protists Within Corals: The Hidden Diversity

Camille Clerissi , Sébastien Brunet , Jeremie Vidal-Dupiol , Mehdi Adjeroud , Pierre Lepage
Frontiers in Microbiology, 2018, 9, pp.2043. ⟨10.3389/fmicb.2018.02043⟩
Article dans une revue hal-01887637v1
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Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters

Julien de Lorgeril , Aude Lucasson , Bruno Petton , Eve Toulza , Caroline Montagnani
Nature Communications, 2018, 9 (1), pp.4215. ⟨10.1038/s41467-018-06659-3⟩
Article dans une revue hal-01898110v1
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Two genomes of highly polyphagous lepidopteran pests (Spodoptera frugiperda, Noctuidae) with different host-plant ranges

Anaïs Gouin , Anthony Bretaudeau , Kiwoong Nam , Sylvie Gimenez , Jean-Marc Aury
Scientific Reports, 2017, 7 (1), pp.1-12. ⟨10.1038/s41598-017-10461-4⟩
Article dans une revue hal-01633879v1
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Establishment and analysis of a reference transcriptome for Spodoptera frugiperda

Fabrice Legeai , Sylvie Gimenez , Bernard Duvic , Jean-Michel Escoubas , Anne-Sophie Gosselin Grenet
BMC Genomics, 2014, 15 (1), pp.704. ⟨10.1186/1471-2164-15-704⟩
Article dans une revue hal-01058982v1

Evolutionary history of x-tox genes in three lepidopteran species: Origin, evolution of primary and secondary structure and alternative splicing, generating a repertoire of immune-related proteins

Emmanuelle d'Alençon , Nicolas Bierne , Pierre-Alain Girard , Ghislaine Magdelenat , Sylvie Gimenez
Insect Biochemistry and Molecular Biology, 2013, 43 (1), pp.54 - 64. ⟨10.1016/j.ibmb.2012.10.012⟩
Article dans une revue hal-01837250v1

Venom gland extract is not required for successful parasitism in the polydnavirus-associated endoparasitoid Hyposoter didymator (Hym. Ichneumonidae) despite the presence of numerous novel and conserved venom proteins

Tristan Doremus , Serge Urbach , Véronique Jouan , Francois Cousserans , Marc Ravallec
Insect Biochemistry and Molecular Biology, 2013, 43 (3), pp.292 - 307. ⟨10.1016/j.ibmb.2012.12.010⟩
Article dans une revue hal-01837249v1

Cecropins as a marker of Spodoptera frugiperda immunosuppression during entomopathogenic bacterial challenge

Bernard Duvic , Véronique Jouan , Nour Essa , Pierre-Alain Girard , Sylvie Pages
Journal of Insect Physiology, 2012, 58 (6), pp.881 - 888. ⟨10.1016/j.jinsphys.2012.04.001⟩
Article dans une revue hal-02651570v1

Recent insight into the pathogenicity mechanisms of the emergent pathogen Photorhabdus asymbiotica

Sonia C.P. Costa , Carolina Varela Chavez , Grégory Jubelin , Alain Givaudan , Jean-Michel Escoubas
Microbes and Infection, 2010, 12 (3), pp.182-189. ⟨10.1016/j.micinf.2009.12.003⟩
Article dans une revue hal-02663167v1
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Crystal structures of Cif from bacterial pathogens photorhabdus luminescens and burkholderia pseudomallei

Allister Crow , Paul Race , Grégory Jubelin , Jean-Michel Escoubas , Eric Oswald
PLoS ONE, 2009, 4 (5), pp.e5582. ⟨10.1371/journal.pone.0005582⟩
Article dans une revue hal-02661448v1
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Spodoptera frugiperda X-tox protein, an immune related defensin rosary, has lost the function ancestral defensins

Delphine Destoumieux-Garzón , Michel Brehélin , Philippe Bulet , Yvan Boublik , Pierre-Alain Girard
PLoS ONE, 2009, 4 (8), pp.e6795. ⟨10.1371/journal.pone.0006795⟩
Article dans une revue hal-02665408v1

The dlt Operon of Bacillus cereus Is Required for Resistance to Cationic Antimicrobial Peptides and for Virulence in Insects

Ziad Abi-Khattar , Agnes A. Rejasse , D. Destoumieux-Garzon , Jean-Michel Escoubas , Vincent Sanchis
Journal of Bacteriology, 2009, 191 (22), pp.7063-7073. ⟨10.1128/JB.00892-09⟩
Article dans une revue hal-04317722v1

The dlt Operon of Bacillus cereus Is Required for Resistance to Cationic Antimicrobial Peptides and for Virulence in Insects

Ziad Abi-Khattar , Agnes A. Rejasse , D. Destoumieux-Garzon , Jean-Michel Escoubas , Vincent V. Sanchis Borja
Journal of Bacteriology, 2009, 191 (22), pp.7063-7073. ⟨10.1128/JB.00892-09⟩
Article dans une revue hal-02664630v1
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Cycle inhibiting factors (CIFs) are a growing family of functional cyclomodulins present in invertebrate and mammal bacterial pathogens

Grégory Jubelin , Carolina Varela Chavez , Frederic Taieb , Mark J. Banfield , Ascel Samba-Louaka
PLoS ONE, 2009, 4 (3), pp.e4855. ⟨10.1371/journal.pone.0004855⟩
Article dans une revue hal-02659269v1

Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas

C. Montagnani , Y. Labreuche , Jean-Michel Escoubas
Developmental and Comparative Immunology, 2008, 32 (3), pp.182-190. ⟨10.1016/j.dci.2007.06.001⟩
Article dans une revue hal-02660632v1

X-tox: an atypical defensin derived family of immune related protein specific to Lepidoptera

Pierre-Alain Girard , Yvan Boublik , Christopher W. Wheat , Anne Nathalie Volkoff , Francois F. Cousserans
Developmental and Comparative Immunology, 2008, 32 (5), pp.575-584. ⟨10.1016/j.dci.2007.09.004⟩
Article dans une revue hal-02658874v1

Evidence of a bactericidal permeability increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI

Marcelo Gonzalez , Yannick Gueguen , Delphine Destoumieux-Garzón , Bernard Romestand , Julie Fievet
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (45), pp.17759-64. ⟨10.1073/pnas.0702281104⟩
Article dans une revue hal-00258926v1

A cDNA microarray for Crassostrea virginica and C. gigas.

Matthew J Jenny , Robert W Chapman , Annalaura Mancia , Yian A Chen , David J. Mckillen
Marine Biotechnology, 2007, 9 (5), pp.577-91. ⟨10.1007/s10126-007-9041-1⟩
Article dans une revue hal-00669982v1

First evidence of the activation of Cg-timp, an immune response component of pacific oysters, through a damage-associated molecular pattern pathway

C. Montagnani , J.C. Avarre , J. de Lorgeril , M. Quiquand , V. Boulo
Developmental and Comparative Immunology, 2007, 31 (1), pp.1-11. ⟨10.1016/j.dci.2006.04.002⟩
Article dans une revue hal-03895692v1
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Characterization of a defensin from the oyster Crassostrea gigas. Recombinant production, folding, solution structure, antimicrobial activities, and gene expression.

Yannick Gueguen , Amaury Herpin , André Aumelas , Julien Garnier , Julie Fievet
Journal of Biological Chemistry, 2006, 281 (1), pp.313-23. ⟨10.1074/jbc.M510850200⟩
Article dans une revue hal-00286204v1

The two mRNAs expressed in oyster hemocytes are generated by two gene families and differentially expressed during ontogenesis

C. Montagnani , A Tirape , V Boulo , Jean-Michel Escoubas
Developmental and Comparative Immunology, 2005, 29 (10), pp.831-839. ⟨10.1016/j.dci.2005.02.005⟩
Article dans une revue hal-03895679v1

Characterization of a Defensin from the Oyster Crassostrea gigas

Yannick Gueguen , Amaury Herpin , André Aumelas , Julien Garnier , Julie Fiévet
Journal of Biological Chemistry, 2005, 281 (1), pp.313-323. ⟨10.1074/jbc.M510850200⟩
Article dans une revue hal-02935243v1

Crassostrea gigas ferritin: cDNA sequence analysis for two heavy chain type subunits and protein purification

Jean-Pierre Durand , Françoise Goudard , Jacques Pieri , Jean-Michel Escoubas , Nathalie Schreiber
Gene, 2004, 338 (2), pp.187-195. ⟨10.1016/j.gene.2004.04.027⟩
Article dans une revue hal-03895667v1

Cg -Rel, the first Rel/NF-κB homolog characterized in a mollusk, the Pacific oyster Crassostrea gigas

C. Montagnani , C. Kappler , J.M. Reichhart , Jean-Michel Escoubas
FEBS Letters, 2004, 561 (1-3), pp.75-82. ⟨10.1016/S0014-5793(04)00124-3⟩
Article dans une revue hal-03895673v1

Immune gene discovery by expressed sequence tags generated from hemocytes of the bacteria-challenged oyster, Crassostrea gigas

Yannick Gueguen , Jean-Paul Cadoret , Didier Flament , Catherine Barreau-Roumiguière , Anne-Laure Girardot
Gene, 2003, 303, pp.139-145. ⟨10.1016/S0378-1119(02)01149-6⟩
Article dans une revue hal-02498520v1

Characterization of a Tal/SCL-like transcription factor in the pacific oyster Crassostrea gigas

Catherine Barreau-Roumiguière , C. Montagnani , Jean-Michel Escoubas
Developmental and Comparative Immunology, 2003, 27 (9), pp.793-800. ⟨10.1016/S0145-305X(03)00075-2⟩
Article dans une revue hal-03895661v1

Cg -TIMP, an inducible tissue inhibitor of metalloproteinase from the Pacific oyster Crassostrea gigas with a potential role in wound healing and defense mechanisms 1

C. Montagnani , Frédérique Le Roux , Franck Berthe , Jean-Michel Escoubas
FEBS Letters, 2001, 500 (1-2), pp.64-70. ⟨10.1016/S0014-5793(01)02559-5⟩
Article dans une revue hal-03895659v1

Characterization of a cDNA Encoding a 72 kDa Heat Shock Cognate Protein (Hsc72) from the Pacific Oyster, Crassostrea gigas

Isabelle Gourdon , Linpa Gricourt , Kristell Kellner , Philippe Roch , Jean-Michel Escoubas
DNA Sequence, 2000, 11 (3-4), pp.265-270. ⟨10.3109/10425170009033241⟩
Article dans une revue hal-03895654v1

Oyster IKK-like protein shares structural and functional properties with its mammalian homologues

Jean-Michel Escoubas , Laurence Briant , C. Montagnani , Stephanie Hez , Christian Devaux
FEBS Letters, 1999, 453 (3), pp.293-298. ⟨10.1016/S0014-5793(99)00737-1⟩
Article dans une revue hal-03895646v1

Light intensity regulation of cab gene transcription is signaled by the redox state of the plastoquinone pool

Jean-Michel Escoubas , M Lomas , J Laroche , P Falkowski
Proceedings of the National Academy of Sciences of the United States of America, 1995, 92 (22), pp.10237-10241. ⟨10.1073/pnas.92.22.10237⟩
Article dans une revue hal-03895055v1

Is the IS1 transposase, InsAB', the only IS1-encoded protein required for efficient transposition?

Jean-Michel Escoubas , D Lane , M Chandler
Journal of Bacteriology, 1994, 176 (18), pp.5864-5867. ⟨10.1128/jb.176.18.5864-5867.1994⟩
Article dans une revue hal-03895038v1

Translational control of transposition activity of the bacterial insertion sequence IS1.

Jean-Michel Escoubas , M. Prère , O. Fayet , I. Salvignol , D. Galas
The EMBO Journal, 1991, 10 (3), pp.705-712. ⟨10.1002/j.1460-2075.1991.tb08000.x⟩
Article dans une revue hal-03895013v1

Optimized conditions for electrotransformation of bacteria are related to the extent of electropermeabilization

S. Sixou , N. Eynard , Jean-Michel Escoubas , E. Werner , J. Teissié
BBA - Gene Structure and Expression, 1991, 1088 (1), pp.135-138. ⟨10.1016/0167-4781(91)90163-G⟩
Article dans une revue hal-03895024v1

The regulatory role of the IS 1-encoded InsA protein in transposition

D. Zerbib , P. Polard , Jean-Michel Escoubas , D. Galas , M. Chandler
Molecular Microbiology, 1990, 4 (3), pp.471-477. ⟨10.1111/j.1365-2958.1990.tb00613.x⟩
Article dans une revue hal-03894972v1

Nucleolin - pre-rRNA interactions and preribosome assembly

Laurence Ghisolfi , Gérard Joseph , Monique Erard , Jean-Michel Escoubas , Colette Mathieu
Molecular Biology Reports, 1990, 14 (2-3), pp.113-114. ⟨10.1007/bf00360437⟩
Article dans une revue hal-03894995v1

Marine invertebrates in a One Health context. Human and environmental drivers of diseases

Daniel Oyanedel Trigo , Aurélie Mesnil , Jamal Saad , Jean Delmotte , Jean-Michel Escoubas
ISME 18, CNRS INEE - International Symposium on Microbial Ecology, Aug 2022, Lausanne, Switzerland
Communication dans un congrès hal-03991131v1

Influence humaine et environnementale sur l’émergence et la dynamique des pathogènes en milieu marin

Daniel Oyanedel Trigo , Aurélie Mesnil , Jamal Saad , Jean Delmotte , Jean-Michel Escoubas
InfectioTron – Journée d’animation du CNRS INEE, CNRS INEE, Jun 2022, Lyon, France
Communication dans un congrès hal-03991115v1

Determinants and relative weight of genetic and epigenetic variation in the resistance of the oyster Crassostrea gigas to the Pacific Oyster Mortality Syndrome

Jeremie Vidal-Dupiol , Janan Gawra , Julien de Lorgeril , Yannick Gueguen , Fabrice Roux
EPIMAR 2022, Oct 2022, Woods Hole (MA), United States
Communication dans un congrès hal-03965076v1

Functional DIversification of Big-Defensins and the shaping of oyster microbiota

Noémie de San Nicolas , A. Asokan , R.D. Rosa , S.N. Voisin , Marie Agnès Travers
AMP 2022 7th International Symposium on Antimicrobial Peptides, Nov 2022, Paris, France
Communication dans un congrès hal-03976756v1

Cracking the code of Pacific oyster mortality syndrom

Guillaume Mitta , Julien de Lorgeril , Aude Lucasson , Bruno Petton , Eve Toulza
Aqua 2018 14th International Symposium on Aquaculture Nutrition, Aug 2018, Montpellier, France
Communication dans un congrès hal-03965691v1

Genome-wide analysis of genes and gene families involved in the immunity of Spodoptera frugiperda

Bernard Duvic , Isabelle Darboux , Jean-Michel Escoubas , Nicolas Negre , David Neunemann
2017 International Conference on Management of Destructive Agricultural Pests Spodoptera (Noctuidae), Nov 2017, Chongqing, China
Communication dans un congrès hal-02154502v1

An integrative approach to decipher the summer mortality syndrome affecting Pacific oysters

Julien de Lorgeril , Aude Lucasson , Bruno Petton , Eve Toulza , Philippe Haffner
Immuninv 2017, Jun 2017, Lyon, France
Communication dans un congrès hal-03966171v1

An integrative approach to decipher the mortality syndrome affecting juvenile Pacific oysters

Julien de Lorgeril , Aude Lucasson , Bruno Petton , Eve R Toulza , Philippe Haffner
International Conference on Holobionts, Apr 2017, Paris, France
Communication dans un congrès hal-03965715v1

Cibles moléculaires chez Spodoptera frugiperda des facteurs de virulence des bactéries des genres Xenorhabdus et Photorhabdus

Nour Essa , Mickael Chapelle , Pierre-Alain Girard , Jean-Luc Aymeric , Anne-Nathalie Volkoff
Immuninv 2014, May 2014, Dijon, France
Communication dans un congrès hal-02154473v1

Spodoptera EST sequencing and analysis of synteny among 3 species bring new perspectives for Lepidoptera genomics

Emmanuelle d'Alençon , Pascaline Audant , S. Bernard-Samain , Vincent Bidegainberry , Michel Brehelin
7. International Workshop on the Molecular Biology and Genetics of the Lepidoptera, Aug 2006, Kolympari, Greece. pp.29, ⟨10.1673/031.007.2901⟩
Communication dans un congrès hal-03896131v1
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X-tox: a new family of putative antimicrobial protein specific to Lepidoptera

Jean-Michel Escoubas , Pierre-Alain Girard , Anne Nathalie Volkoff , Y. Boublik , A. Cousserans
7. International Workshop on the Molecular Biology and Genetics of the Lepidoptera, Aug 2006, Kolympari, Greece. ⟨10.1673/031.007.2901⟩
Communication dans un congrès hal-01123360v1