JM

Jean-Paul MOTTA

CR INSERM
42
Documents
Affiliations actuelles
  • Institut de Recherche en Santé Digestive (IRSD)
  • Institut National de la Santé et de la Recherche Médicale (INSERM)
  • Communauté d'universités et établissements de Toulouse (Comue de Toulouse)
Contact

Domaines de recherche

Immunité innée Hépatologie et Gastroentérologie Microbiologie et Parasitologie

Publications

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Publications

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Oral indomethacin modifies small intestine biofilms and host-microbe interaction mediators

Arezoo Haghighi , András Tóth , Zsuzsanna Demeter , Barbara Hutka , Anna Zsidai et al.

Life Sciences, 2026, 384, pp.124114. ⟨10.1016/j.lfs.2025.124114⟩

Article dans une revue inserm-05392928v1

Human fallopian tube organoids provide a favourable environment for sperm motility

Nicolas Gatimel , Guillaume Perez , Eloïse Bruno , David Sagnat , Corinne Rolland et al.

Human Reproduction, 2025, ⟨10.1093/humrep/deae258⟩

Article dans une revue hal-04932828v1
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Gut microb-aging and its relevance to frailty aging

Guillaume Le Cosquer , Nathalie Vergnolle , Jean-Paul Motta

Microbes and Infection, 2024, 26 (3), pp.105309. ⟨10.1016/j.micinf.2024.105309⟩

Article dans une revue inserm-04476654v2
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Pathogenicity of Commensal Gut Biofilm In Prefrail Aging

Guillaume Le Cosquer , Melissa Pannier , Elodie Meunier , Julie Thevenin , Sophie Guyonnet et al.

BioRxiv, 2024, 11 (1), 13 p. ⟨10.1038/s41522-025-00716-8⟩

Article dans une revue hal-04932003v1

Adjunctive intravesical EDTA-tromethamine treatment of a biofilm-associated recurrent Escherichia coli cystitis in a dog

Vincent Leynaud , Nicolas Jousserand , Marie-Noëlle Lucas , Laurent Cavalié , Jean-Paul Motta et al.

Canadian Veterinary Journal, 2024, 65 (9)

Article dans une revue hal-04870329v1
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Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice

Xavier Mas-Orea , Lea Rey , Louise Battut , Cyrielle Bories , Camille Petitfils et al.

Communications Biology, 2023, 6 (1), pp.1168. ⟨10.1038/s42003-023-05542-2⟩

Article dans une revue hal-04317210v1

Editorial: Microbial biofilms interacting with host mucosal surfaces

Jean-Paul Motta , Anders Hakansson , Samuel Lee

Frontiers in Cellular and Infection Microbiology, 2022, 12, ⟨10.3389/fcimb.2022.1049347⟩

Article dans une revue hal-04870309v1
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Identification of bacterial lipopeptides as key players in IBS

Camille Petitfils , Sarah Maurel , Gaelle Payros , Amandine Hueber , Bahija Agaiz et al.

Gut, 2022, pp.939-950. ⟨10.1136/gutjnl-2022-328084⟩

Article dans une revue hal-03833107v1

Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy

Andre Buret , Thibault Allain , Jean-Paul Motta , John Wallace

Antioxidants and Redox Signaling, 2022, 36 (4-6), pp.211-219. ⟨10.1089/ars.2021.0004⟩

Article dans une revue hal-04870308v1
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High-fat diet increases the severity of Giardia infection in association with low-grade inflammation and gut microbiota dysbiosis

Thibault Allain , Elena Fekete , Olivia Sosnowski , Dimitri Desmonts de Lamache , Jean-Paul Motta et al.

Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-98262-8⟩

Article dans une revue hal-03376671v1

Gastrointestinal biofilms in health and disease

Jean-Paul Motta , John Wallace , André Buret , Céline Deraison , Nathalie Vergnolle

Nature reviews. Gastroenterology & hepatology, 2021, 18 (5), pp.314-334. ⟨10.1038/s41575-020-00397-y⟩

Article dans une revue hal-04870341v1
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A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917

Jean-Philippe Nougayrède , Camille Chagneau , Jean-Paul Motta , Nadège Bossuet-Greif , Marcy Belloy et al.

MSphere, 2021, 6 (4), 11 p. ⟨10.1128/mSphere.00624-21⟩

Article dans une revue hal-03358727v2

PAR-1 Antagonism to Promote Gut Mucosa Healing in Crohn’s Disease Patients: A New Avenue for CVT120165

Jean-Paul Motta , Celine Deraison , Sylvie Le Grand , Bruno Le Grand , Nathalie Vergnolle

Inflammatory Bowel Diseases, 2021, 27 (Supplement_2), pp.S33-S37. ⟨10.1093/ibd/izab244⟩

Article dans une revue hal-03590828v1
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Increased mucosal thrombin is associated with Crohn's disease and causes inflammatory damage through Protease-Activated Receptors activation

Jean-Paul Motta , Simone Palese , Carmine Giorgio , Kevin Chapman , Alexandre Denadai-Souza et al.

Journal of Crohn's and Colitis, 2021, 15 (5), pp.787-799. ⟨10.1093/ecco-jcc/jjaa229⟩

Article dans une revue hal-03073920v2
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Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation

Jean-Paul Motta , Corinne Rolland , Anissa Edir , Ana-Carolina Florence , David Sagnat et al.

Mucosal Immunology, 2021, 14 (3), pp.667-678. ⟨10.1038/s41385-021-00375-w⟩

Article dans une revue hal-03172288v1
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Uropathogenic E. coli induces DNA damage in the bladder

Camille Chagneau , Clémence Massip , Nadège Bossuet-Greif , Christophe Fremez , Jean-Paul Motta et al.

PLoS Pathogens, 2021, 17 (2), 18 p. ⟨10.1371/journal.ppat.1009310⟩

Article dans une revue hal-03173303v1

Giardia spp. promote the production of antimicrobial peptides and attenuate disease severity induced by attaching and effacing enteropathogens via the induction of the NLRP3 inflammasome

Anna Manko-Prykhoda , Thibault Allain , Jean-Paul Motta , James Cotton , Troy Feener et al.

International Journal for Parasitology, 2020, 50 (4), pp.263-275. ⟨10.1016/j.ijpara.2019.12.011⟩

Article dans une revue hal-04870343v1
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Active thrombin produced by the intestinal epithelium controls mucosal biofilms

Jean-Paul Motta , Alexandre Denadai-Souza , David Sagnat , Laura Guiraud , Anissa Edir et al.

Nature Communications, 2019, 10 (1), pp.3224. ⟨10.1038/s41467-019-11140-w⟩

Article dans une revue inserm-02232741v1

Pathobiont release from dysbiotic gut microbiota biofilms in intestinal inflammatory diseases: a role for iron?

Andre Gerald Buret , Jean-Paul Motta , Thibault Allain , Jose Ferraz , John Lawrence Wallace

Journal of Biomedical Science, 2019, 26 (1), pp.1. ⟨10.1186/s12929-018-0495-4⟩

Article dans une revue hal-04870347v1

Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease

Jean-Paul Motta , Thibault Allain , Luke Green-Harrison , Ryan Groves , Troy Feener et al.

Inflammatory Bowel Diseases, 2018, 24 (7), pp.1493-1502. ⟨10.1093/ibd/izy116⟩

Article dans une revue hal-04870606v1
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Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface

John L. Wallace , Jean-Paul Motta , Andre G. Buret

AJP - Gastrointestinal and Liver Physiology, 2018, 314 (2), pp.G143 - G149. ⟨10.1152/ajpgi.00249.2017⟩

Article dans une revue hal-02623161v1
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Epithelial expression and function of trypsin-3 in irritable bowel syndrome

Claire Rolland , Alexandre Denadai-Souza , Carla Cirillo , Cintya Lopez , Josue Obed Jaramillo et al.

Gut, 2017, 66 (10), pp.1767-1778. ⟨10.1136/gutjnl-2016-312094⟩

Article dans une revue hal-01604269v1

Interactions of Giardia sp. with the intestinal barrier: Epithelium, mucus, and microbiota

Thibault Allain , Christina Amat , Jean-Paul Motta , Anna Manko , André Buret

Tissue Barriers , 2017, 5 (1), pp.e1274354. ⟨10.1080/21688370.2016.1274354⟩

Article dans une revue hal-04870623v1

Cysteine Protease–Dependent Mucous Disruptions and Differential Mucin Gene Expression in Giardia duodenalis Infection

Christina Amat , Jean-Paul Motta , Elena Fekete , France Moreau , Kris Chadee et al.

American Journal of Pathology, 2017, 187 (11), pp.2486-2498. ⟨10.1016/j.ajpath.2017.07.009⟩

Article dans une revue hal-04870615v1

Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms

Jennifer Beatty , Sarah Akierman , Jean-Paul Motta , Stacy Muise , Matthew Workentine et al.

International Journal for Parasitology, 2017, 47 (6), pp.311-326. ⟨10.1016/j.ijpara.2016.11.010⟩

Article dans une revue hal-04870627v1

Using murine colitis models to analyze probiotics–host interactions

Rebeca Martin Rosique , Florian Chain , Sylvie Miquel , Jean-Paul Motta , Nathalie Vergnolle et al.

FEMS Microbiology Reviews, 2017, 41 (Supp_1), pp.S49-S70. ⟨10.1093/femsre/fux035⟩

Article dans une revue (article de synthèse) hal-01602302v1
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Giardia duodenalis induces paracellular bacterial translocation and causes postinfectious visceral hypersensitivity

Marie C M Halliez , Jean-Paul Motta , Troy D Feener , Gaëtan Guerin , Laetitia Legoff et al.

AJP - Gastrointestinal and Liver Physiology, 2016, 310, pp.574 - 585. ⟨10.1152/ajpgi.00144.2015⟩

Article dans une revue hal-02317886v1

Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production

Jean-Paul Motta , Kyle Flannigan , Terence Agbor , Jennifer Beatty , Rory Blackler et al.

Inflammatory Bowel Diseases, 2015, 21 (5), pp.1006-1017. ⟨10.1097/MIB.0000000000000345⟩

Article dans une revue hal-04870631v1
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Serine protease inhibitors protect better than IL-10 and TGF-beta anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci

Luis Bermudez Humaran , Jean-Paul Motta , Camille Aubry , Pascale Kharrat , Laurence Rous-Martin et al.

Microbial Cell Factories, 2015, 14, ⟨10.1186/s12934-015-0198-4⟩

Article dans une revue hal-01204481v1

Anti-Inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics

John Wallace , Rory Blackler , Melissa Chan , Gabriela da Silva , Wagdi Elsheikh et al.

Antioxidants and Redox Signaling, 2015, 22 (5), pp.398-410. ⟨10.1089/ars.2014.5901⟩

Article dans une revue hal-04870655v1
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Novel role of the serine protease inhibitor elafin in gluten-related disorders

Heather J Galipeau , Michelle Wiepjes , Jean-Paul Motta , Jessica D Schulz , Jennifer Jury et al.

The American Journal of Gastroenterology, 2014, 109 (5), pp.748-56. ⟨10.1038/ajg.2014.48⟩

Article dans une revue hal-01204309v1

Giardia duodenalis Infection Reduces Granulocyte Infiltration in an In Vivo Model of Bacterial Toxin-Induced Colitis and Attenuates Inflammation in Human Intestinal Tissue

James Cotton , Jean-Paul Motta , L. Patrick Schenck , Simon Hirota , Paul Beck et al.

PLoS ONE, 2014, 9 (10), pp.e109087. ⟨10.1371/journal.pone.0109087⟩

Article dans une revue hal-04870647v1

Differential Induction of Antimicrobial REGIII by the Intestinal Microbiota and Bifidobacterium breve NCC2950

Jane Natividad , Christina Hayes , Jean-Paul Motta , Jennifer Jury , Heather Galipeau et al.

Applied and Environmental Microbiology, 2013, 79 (24), pp.7745-7754. ⟨10.1128/AEM.02470-13⟩

Article dans une revue hal-04870658v1

Engineering lactococci and lactobacilli for human health

Luis Bermúdez-Humarán , Camille Aubry , Jean-Paul Motta , Céline Deraison , Lothar Steidler et al.

Current Opinion in Microbiology, 2013, 16 (3), pp.278-283. ⟨10.1016/j.mib.2013.06.002⟩

Article dans une revue istex hal-01003315v1

LC–MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites

Pauline Le Faouder , Vincent Baillif , Ian Spreadbury , Jean-Paul Motta , Perrine Rousset et al.

Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2013, 932 (3), pp.123-133. ⟨10.1016/j.jchromb.2013.06.014⟩

Article dans une revue istex hal-04870662v1

Serine Protease Inhibition Reduces Post-Ischemic Granulocyte Recruitment in Mouse Intestine

Thomas Gobbetti , Nicolas Cenac , Jean-Paul Motta , Corinne Rolland , Laurence Martin et al.

American Journal of Pathology, 2012, 180 (1), pp.141-152. ⟨10.1016/j.ajpath.2011.09.031⟩

Article dans une revue hal-04870668v1

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

Jean-Paul Motta , Luis Bermudez Humaran , Céline Deraison , Laurence Martin , Corinne Rolland et al.

Science Translational Medicine, 2012, 4 (158), ⟨10.1126/scitranslmed.3004212⟩

Article dans une revue hal-01204261v1

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

Jean-Paul Motta , Luis Bermúdez-Humarán , Céline Deraison , Laurence Martin , Corinne Rolland et al.

Science Translational Medicine, 2012, 4 (158), ⟨10.1126/scitranslmed.3004212⟩

Article dans une revue hal-04870665v1
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Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis

Jean-Paul Motta* , Laurent Magne* , Delphyne Descamps , Corinne Rolland , Camila Squarzoni-Dale et al.

Gastroenterology, 2010, 140 (4), pp.1272-82. ⟨10.1053/j.gastro.2010.12.050⟩

Article dans une revue pasteur-00552947v1

Insights into the regulation of the core clock component TOC1 in the green picoeukaryote Ostreococcus

El Batoul Djouani-Tahri , Jean-Paul Motta , François-Yves Bouget , Florence Corellou

Plant Signaling and Behavior, 2010, 5 (3), pp.332-335. ⟨10.4161/psb.5.3.11212⟩

Article dans une revue hal-04870681v1

Clocks in the Green Lineage: Comparative Functional Analysis of the Circadian Architecture of the Picoeukaryote Ostreococcus

Florence Corellou , Christian Schwartz , Jean-Paul Motta , El Batoul Djouani-Tahri , Frédéric Sanchez et al.

The Plant cell, 2009, 21 (11), pp.3436-3449. ⟨10.1105/tpc.109.068825⟩

Article dans une revue hal-04870684v1

Proteases/Antiproteases in Inflammatory Bowel Diseases

Jean-Paul Motta , Laurence Martin , Nathalie Vergnolle

Proteases and Their Receptors in Inflammation, Springer Basel, pp.173-215, 2011, ⟨10.1007/978-3-0348-0157-7_8⟩

Chapitre d'ouvrage hal-04870699v1