Jean-Sébastien GUEZ
- Institut Pascal (IP)
- Institut Pascal (IP)
- Institut Pascal (IP)
- Procédés Biologiques, Génie Enzymatique et Microbien - EA1026 (ProBioGEM)
- Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne)
- Université Clermont Auvergne (UCA)
Présentation
Jean-Sébastien Guez est scientifique senior à l'Institut Pascal, Université Clermont Auvergne (UMR 6602 UCA CNRS / Clermont Auvergne INP). Il est un ancien élève ingénieur de Polytech Marseille, diplômé en 1999. Il a obtenu son doctorat en génie biochimique et microbiologie appliquée à l'Université de Lille et son Habilitation à Diriger des Recherches à l'Université Clermont auvergne. Il travaille à la mise au point, la compréhension et l'optimisation des systèmes de production de molécules à haute valeur ajoutée par voie biotechnologique. Les principaux domaines applicatifs visés: agro-alimentaire, pharmaceutique et énergie. Il est co-auteur de plus de 35 publications scientifiques, 70 communications internationales et 2 brevets. Toujours soucieux de valoriser ses travaux de recherche, il est à l'origine de plusieurs transferts de technologie. Il a été associé de l'entreprise LipoFabrik, créée en 2012, et de BioUpp, co-fondée en 2024.
Domaines de recherche
Publications
Publications
Exploring Bubble Flow with Deep Learning: A Preliminary Study1st Early-Career Researchers’ Day of the DATA Programme I-SITE CAP 20-25, CAP 20-25, Feb 2026, Aubière / Clermont-Ferrand, France |
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Annotation collaborative zero-shot par deux modèle pré-entraînés dans l’étude du flux de bulles de gazORASIS, Jun 2025, Le Croisic (FR), France |
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DEEP LEARNING-BASED APPROACH: A VERSATILE DECODER FOR BUBBLE FLOW IMAGE ANALYSISSICHEM (Symposium of Chemical Engineering and Materials), Nov 2025, Bucarest, Romania |
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Biohydrogen and short chain fatty acids production by dark fermentation from agri-food residuesSociété Française de Microbiologie SFM 2025, Sep 2025, Bordeaux, France |
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Mise en œuvre d’un bioprocédé de production de biohydrogène à partir des résidus organiques industriels : Conception, cinétique, optimisationJournée Scientifique CODEGEPRA, SFGP Sud-Est, Nov 2025, Aubière, France |
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Electrocoagulation for sustainable circular economy: Purification of volatile fatty acids from real fermented food waste6th Euro-Mediterranean Conference for Environmental Integration (EMCEI-24), May 2024, Marrakech (en ligne), Morocco |
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Real-time cell population analysis in bioreactors using deep learning-enabled in situ microscopy14th European Symposium on Biochemical Engineering Science ESBES 2024, Oct 2024, Copenhagen, Denmark |
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Effect of Oxidation-Reduction Potential on Hydrogen Production by Dark FermentationWorld Hydrogen Energy Conference, Jun 2024, Cancun, Mexico, Mexico |
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Influence du potentiel d'oxydo-réduction sur la production d'hydrogène par fermentation sombre de biodéchets déconditionnés20ème Rencontre des Microbiologistes du Pôle Clermontois, Apr 2024, Aubière, France |
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Implementation of a novel reactor with the addition of supports to enhance ex-situ biomethanationEuropean Workshop on Gas Biological Conversions, DEEP TBI INSA, Jan 2024, Lyon (France), France |
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HYDROGEN GAS MASS TRANSFER IN AQUEOUS MEDIA: APPLICATION TO BIOLOGICAL METHANATIONSymposium of International Chemical Engineering and Materials (SICHEM), Apr 2024, Bucarest, Romania |
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MASS TRANSFER OF H2 IN AQUEOUS MEDIA FOR BIOLOGICAL METHANATION: INFLUENCE OF MICROORGANISMS AND OPERATING CONDITIONSInternational Chemical Engineering and Materials Symposium (SICHEM), Apr 2024, Bucarest, Romania |
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Implementation of a novel reactor with the addition of supports to enhance ex-situ biomethanation.International conference on the practical zero emissions technologies and strategies (PZETS), Dec 2023, Ho Chi Minh City, Vietnam |
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Biological Methanation: Key advances and remaining challengesInternational Conference on the Environment Technologies and Sustainable Energy "ICETSE 2023", CRAPC, Oct 2023, Alger (en ligne), Algeria |
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Bioinformatics Modelling and Metabolic Engineering of the Branched Chain Amino Acid Pathway for Specific Production of Microbial Biosurfactants and BiopesticidesCongrès BIOKET dédié aux procédés et technologies appliqués à la biomasse, May 2023, Trois Rivieres, Canada |
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Optimisation d’un procédé de méthanation biologique ex situ en colonne à agitation pneumatique18ème congrès de la Société Française de Génie des Procédés (SFGP), Nov 2022, Toulouse, France |
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Mycosubtilin, a multifaceted lipopeptide from Bacillus. subtilis for plant crop protection: an overview of the last decade results obtained from lab to the field.Plant BioProtech, Jun 2022, Reims, France |
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Mycosubtilin, a multifaceted lipopeptide from Bacillus subtilis for crop protection : an overview of the last decade results obtained from lab to the fieldPlantBioProtect, Jun 2022, Reims, France |
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Mycosubtilin, a multifaceted lipopeptide from Bacillus subtilis for crop protection : an overview of the last decade results obtained from lab to the field.PlantBioProtech, Jun 2022, REIMS, France |
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Biohydrogen from organic waste: advances in process design and operation.SICHEM, Nov 2022, Bucarest, Romania |
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How can bioprocesses contribute to a reduction of global warming?International Conference on Biotechnology for Sustainable Bioresources and Bioeconomy (BSBB-2022), Dec 2022, Guwahati, India |
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Organic waste biorefinery: the key role of anaerobic building blocks.16th OPROTEH International Conference, May 2021, Bacau, Romania |
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Biological methanation: issues, challenges, and opportunities.2nd International Congress of Chemical Engineering ICChE, Jun 2021, Settat, Morocco |
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Bioprocédés innovants pour la production de biosurfactants microbiens de nature lipopeptidique17ème congrès de la Société Française de Génie des Procédés (SFGP), Oct 2019, Nantes, France |
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Intensité technologique des entreprises et structuration géographique de leurs réseaux d’affairesVIIIème Forum Innovation, Jun 2018, Montpellier, France |
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Identifier les réseaux des entreprises et leurs compétences relationnelles: proposition de méthodologieVIIIème Forum Innovation, Jun 2018, Montpellier, France |
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Overflowing Continuous Cultures: a way to manage excess of foaming during the sustainable production of surfactant in reactors6th Conference on environmental, industrial and Applied microbiology, Oct 2015, Barcelone, Spain |
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Overflowing processes for the production of surfactant in reactors.10th European Symposium of Biochemical Science (ESBES) and 6th International Forum on Industrial Bioprocesses, Sep 2014, Lille, France |
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Directed Biosynthesis of Antifungal and Biosurfactant Lipopeptides from Bacillus subtilis.10th European Symposium of Biochemical Science (ESBES) and 6th International Forum on Industrial Bioprocesses, Sep 2014, Lille, France |
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Production de molécules à haute valeur ajoutée par les micro-alguesJournée Biosourcés : matériaux et valorisation des agroressources, Dec 2014, Aubière, France |
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Novel biosurfactants with biocontrol activity and low ecotoxicity.9th European Congress of Chemical Engineering / 2nd European Congress of Applied Biotechnology, Apr 2013, The Hague, Netherlands |
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Improvement of yield and selectivity in lipopeptides production process by oxygen transfer rate control9th European Symposium of Biochemical Science (ESBES), Sep 2012, Istanbul, Turkey |
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Engineering of Bacillus subtilis physiological functionalities towards the production of mycosubtilin anteiso-C179th European Symposium of Biochemical Science (ESBES), Sep 2012, Istanbul, Turkey |
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Environmental factors and pleitropic regulators influence homologous compound pattern of mycosubtilin produced by Bacillus subtilis ATCC 6633.5th International Conference on Functional Genomics of Gram-positive Microorganisms / 16th International Conference on Bacilli, Jun 2011, Montecatini, Italy |
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On-line and real time cell counting and viability determination for animal cell process monitoring by in situ microscopy22nd meeting of the European Society Animal Cell Technology, May 2011, Vienna, Austria |
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On-line and real time cell counting and viability determination for animal cell process monitoring by in situ microscopy.22nd meeting of the European Society Animal Cell Technology, May 2011, Vienna, Austria |
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Optical Sampling in Situ Microscope for On-Line Monitoring of Animal Cell Cultures11th IFAC Symposium on Computer Applications in Biotechnology, 2010, Jul 2010, Leuven, Belgium. Paper ThM2T1.2 |
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Les lipopeptides de Bacillus sp. : des molécules à haut potentiel pour la lutte biologique contre les champignons phytopathogènes3éme Journée du Groupe Francophone d’Étude des Pesticides Organiques d’Origine Naturelle, Jun 2010, Lyon, France |
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Predictive Control of the Specific Growth Rate in a Bioreactor Process for the Production of Surfactant Using Bacillus Subtilis.IFAC Symposium Computer Applications in Biotechnology, Jul 2010, Leuven, Belgium |
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In situ microscopy for on-line monitoring of CHO cell culture21st meeting of the European Society Animal Cell Technology, Jun 2009, Dublin, Ireland |
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Relationship between temperature, branched fatty acid synthesis and mycosubtilin isoform production in Bacillus subtilis.BACELL, Apr 2009, Copenhagen, Denmark |
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Overflowing processes for the production of surfactant in bioreactors12ème Congrès de la Société Française de Génie des Procédés (SFGP), Oct 2009, Marseille, France |
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Overflowing processes for the production of surfactants in bioreactors15ème congrès CNR-IUT, Jun 2009, Villeneuve d'ascq, France |
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Bacillus lipopeptides leading to versatile weapons for plant disease biocontrol.Bacell, Mar 2008, oslo, Sweden |
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Genetic and bioprocess engineering applied to the overproduction of biosurfactant from Bacillus subtilis.International Congress on Bioprocesses in Food Industries, Nov 2008, Hyderabad, India |
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Biosynthèse dirigée de molécules peptidiques actives synthétisées par le mécanisme non ribosomal7ème congrès national de la Société Française de Microbiologie, May 2007, Nantes, France |
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Etude d’un bioprocédé en réacteur semi-discontinu accompagné de pertes par moussage : application à l’extraction de tensioactifs lipopeptidiques produits par Bacillus subtilis10ème congrès de la Société Française de Génie des Procédés (SFGP), Sep 2005, Toulouse, France |
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Optimisation de la production de biosurfactants par Bacillus subtilis10ème congrès de la Société Française de Génie des Procédés (SFGP), Sep 2005, Toulouse, France |
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Stoechiometric modeling for physiological state changes monitoring in bioprocesses9th International Symposium on Computer Applications in Biotechnology (CAB 9), Mar 2004, Nancy, France |
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Optimisation strategies of antibiotic lipopeptide production by Bacillus subtilis5th European Symposium of Biochemical Science (ESBES), Sep 2004, Stuttgart, Germany |
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In situ microscopy for in-line monitoring of hybridomal cell culture in agitated bioreactorJournées d'Etudes & de Diffusion Technologique, Jul 2002, Nantes, France |
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Effect of low temperatures on growth and biosurfactant production in Bacillus subtilis4th congress of European microbiologists FEMS, Jun 2001, Geneva, Switzerland |
Comprendre et améliorer la production de molécules biologiques : des cellules aux procédésBiotechnologies. Université Clermont Auvergne, 2025 |
Purification of anaerobic digestate from anaerobic fermentation of food wastes by electrocoagulation19th International Conference of Constructive Design and Technological Optimization in Machine Building “Oproteh 2024, May 2024, Bacau, Romania. Conference Proceedings, 2024 |
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Continuous extraction of VFAs produced during dark fermentation of food wastes using submerged anaerobic membrane bioreactor14th European Symposium on Biochemical Engineering Science ESBES 2024, Oct 2024, Copenhagen, Denmark. |
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SCFAs production by anaerobic digestion of food wasteEuropean Congress of Chemical Engineering / European Congress of Applied Biotechnology, Sep 2023, Berlin, Germany |
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Deep in-situ microscopy for immortal bioreactorEuropean Congress of Chemical Engineering / European Congress of Applied Biotechnology, Sep 2023, Berlin, Germany |
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Mass transfer of hydrogen gas in aqueous media for biological methanation: influence of microorganisms and operating conditions.European Congress of Chemical Engineering / European Congress of Applied Biotechnology, Sep 2023, Berlin, Germany |
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Effet du potentiel d’oxydo-réduction sur la production d’hydrogène par fermentation sombre18ème congrès de la Société Française de Génie des Procédés (SFGP), Nov 2022, Toulouse, France |
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Antimicrosporidian activities of lipopeptides and sulphated polysaccharides from algae and their potential to control honeybee nosemosis6th Conference on environmental, industrial and Applied microbiology, Oct 2015, Barcelone, Spain |
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Production of biosurfactants by overflowing continuous culture (O-CC)14ème congrès de la Société Française de Génie des Procédés (SFGP), Oct 2013, Lyon, France |
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Engineering of Bacillus subtilis physiological functionalities towards the production of mycosubtilin anteiso-C1715th European Congress on Biotechnology, Sep 2012, Istanbul, Turkey. 29, pp.S79-S80, 2012, ⟨10.1016/j.nbt.2012.08.222⟩ |
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Cellular Engineering of Bacillus subtilis to Enhance the Biosynthesis of Highly Active Antifungal LipopeptidesSystems Biology of Microorganisms - Institut Pasteur, Mar 2010, Paris, France |
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Temperature and productivity direct mycosubtiline antibiotic biosynthesis toward the Anteiso C-17 branched isoform5th International Conference on Functional Genomics of Gram-positive Microorganisms.15th International Conference on Bacilli., Jun 2009, San Diego, United States |
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Resistance of Bacillus subtilis ATCC 6633 cell wall to degradation is a critical parameter for isolation of high quality RNA5th International Conference on Functional Genomics of Gram-positive Microorganisms. 15th International Conference on Bacilli, Jun 2009, San Diego, United States |
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An inverse metabolic engineering strategy to direct the antibiotic mycosubtilin biosynthesis toward the anteisoC-17 branched isoform in Bacillus subtilis7th European Symposium of Biochemical Science (ESBES), Sep 2008, Faro, Portugal |
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Consequences of both constitutive synthesis of surfactin and disruption of plipastatin operon on phenotypic properties of Bacillus subtilis5th International Conference on Functional Genomics of Gram-positive Microorganisms. 15th International Conference on Bacilli, Jun 2008, San Diego, United States |
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A new feeding strategy to operate overflowing-exponential fedBatch cultures (O-EFBC) at constant specific growth rates : Application to the production of biosurfactant by Bacillus subtilis7th European Symposium of Biochemical Science (ESBES), Oct 2008, Faro, Portugal |
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La synthèse non-ribosomique, un potentiel immense de peptides à activités biologiquesClub des Bactéries Lactiques, Nov 2007, Rennes, France |
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Étude de l’effet de l’oxygène sur la synthèse de peptides d’origine non ribosomiques par Bacillus subtilis7ème congrès national de la Société Française de Microbiologie (SFM), May 2007, Nantes, France |
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Stratégies d’optimisation de la synthèse sélective de mycosubtiline C17:0 anteiso par Bacillus subtilis7ème Congrès national de la Société Française de Microbiologie (SFM), May 2007, Nantes, France |
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Directing the lipopeptide mycosubtilin biosynthesis toward C17:0 anteiso isoform influences the expression of cspB and cspC in Bacillus subtilis4th International Conference on Bacilli, Jun 2007, Pisa, Italy |
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Setting-up of overflowing exponential fed-batch cultures for the production of biosurfactants at low growth rates6th European Symposium of Biochemical Science (ESBES), Aug 2006, Salzburg, Austria |
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Production of lipopeptide biosurfactant under oxygen growth-limiting conditions in surface aerated cultures of Bacillus6th European Symposium of Biochemical Science (ESBES), Aug 2006, Salzburg, Austria |
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Influence of pH on the production of mycosubtilin, an antifungal metabolite from Bacillus subtilis with potential applications in agro-food sectorInternational Congress on Bioprocesses in Food industries (ICBF), Jul 2004, Clermond-Ferrand, France |
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In situ microscopy for in-line monitoring of hybridomal cell culture in agitated bioreactorJournées d'Etudes & de Diffusion Technologique – Instrumentation et Traitement du Signal et des Images dans les procédés agroalimentaires et biotechnologiques, Jul 2002, Nantes, France |
Replication data for : Deep in situ microscopy for real-time analysis of mammalian cell populations in bioreactors2023, ⟨10.57745/YSCL8Z⟩ |
PROCEDE DE BIOMETHANATION EX-SITUFrance, N° de brevet: FR2211561. 2022 |
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BACILLUS SP . BIOSURFACTANTS , COMPOSITION INCLUDING SAME, METHOD FOR OBTAINING SAME, AND USE THEREOFUnited States, Patent n° : US9688725 B2. 2017 |
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Biosurfactants produit par une nouvelle souche de Bacillus subtilis, composition les comprenant, procédé d'obtention et applicationFrance, N° de brevet: EP 2764126 B1. 2017 |
Advanced In Situ Microscopy for On-Line Monitoring of Animal Cell Culture5, Springer Netherlands, pp.491-496, 2012, Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), ⟨10.1007/978-94-007-0884-6_83⟩ |
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Étude de la productivité et de la sélectivité de la biosynthèse de mycosubtiline, un antibiotique surfactant de Bacillus subtilis : apports du génie biochimique et de la transcriptomiqueBiotechnologies. Université des Sciences et Technologies de Lille, 2007. Français. ⟨NNT : ⟩ |