Jérémy Denizot

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Publications

ChiA: a major player in the virulence of Crohn’s disease-associated adherent and invasive Escherichia coli (AIEC)

Margot Fargeas , Frederic Faure , Clara Douadi , Caroline Chevarin , Aurélien Birer et al.
Gut microbes, 2024, 16 (1), ⟨10.1080/19490976.2024.2412667⟩
Article dans une revue (data paper) hal-04809777 v1
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An adherent-invasive Escherichia coli -colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease

Adeline Sivignon , Mélissa Chervy , Caroline Chevarin , Elia Ragot , Elisabeth Billard et al.
Disease Models & Mechanisms, 2022, 15 (10), pp.dmm049707. ⟨10.1242/dmm.049707⟩
Article dans une revue hal-03907399 v1
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Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn’s disease patients

Mélissa Chervy , Adeline Sivignon , Flavie Dambrine , Anthony Buisson , Pierre Sauvanet et al.
Gut microbes, 2022, 14 (1), pp.1-13. ⟨10.1080/19490976.2022.2127444⟩
Article dans une revue hal-03881385 v1

Propionate catabolism by CD-associated adherent-invasive E. coli counteracts its anti-inflammatory effect

Allison Agus , Damien Richard , Tiphanie Faïs , Emilie Vazeille , Mélissa Chervy et al.
Gut microbes, 2021, 13 (1), pp.1-19. ⟨10.1080/19490976.2020.1839318⟩
Article dans une revue hal-03262359 v1
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Adherent-Invasive E. coli: Update on the Lifestyle of a Troublemaker in Crohn's Disease

Mélissa Chervy , Nicolas Barnich , Jérémy Denizot
International Journal of Molecular Sciences, 2020, 21 (10), pp.3734. ⟨10.3390/ijms21103734⟩
Article dans une revue (article de synthèse) hal-02917127 v1

Adaptation of adherent-invasive E. coli to gut environment: Impact on flagellum expression and bacterial colonization ability

Gwladys Sevrin , Sébastien Massier , Benoit Chassaing , Allison Agus , Julien Delmas et al.
Gut microbes, 2020, 11 (3), pp.364-380. ⟨10.1080/19490976.2017.1421886⟩
Article dans une revue hal-01730371 v1
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Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium

Juri Kazakevych , Jérémy Denizot , Anke Liebert , Mariana Portovedo , Mia Mosavie et al.
Genome Biology, 2020, 21 (1), pp.1-20. ⟨10.1186/s13059-020-01976-7⟩
Article dans une revue hal-02541660 v1
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Methyl-donor supplementation prevents intestinal colonization by Adherent-invasive E. coli in a mouse model of crohn's disease

Elodie Gimier , Mélissa Chervy , Allison Agus , Adeline Sivignon , Elisabeth Billard et al.
Scientific Reports, 2020, 10, pp.12922. ⟨10.1038/s41598-020-69472-3⟩
Article dans une revue hal-02917129 v1
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When adherent-invasive E. coli plays with host glycosylation: Does it open new perspectives for therapeutic strategies in Crohn's disease?

Jérémy Denizot , Nicolas Barnich
EBioMedicine, 2020, 55, pp.1-2. ⟨10.1016/j.ebiom.2020.102752⟩
Article dans une revue hal-02912994 v1
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Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Rachel Fellows , Jérémy Denizot , Claudia Stellato , Alessandro Cuomo , Payal Jain et al.
Nature Communications, 2018, 9 (1), pp.1-15. ⟨10.1038/s41467-017-02651-5⟩
Article dans une revue hal-01759208 v1
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Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

Hashem Koohy , Daniel Bolland , Louise Matheson , Stefan Schoenfelder , Claudia Stellato et al.
Genome Biology, 2018, 19 (1), ⟨10.1186/s13059-018-1489-y⟩
Article dans une revue hal-01929162 v1
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Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.

Allison Agus , Jérémy Denizot , Jonathan Thevenot , Margarita Martinez-Medina , Sébastien Massier et al.
Scientific Reports, 2016, 6 (1), pp.19032. ⟨10.1038/srep19032⟩
Article dans une revue hal-01928173 v1

Saccharomyces cerevisiae CNCM I-3856 Prevents Colitis Induced by AIEC Bacteria in the Transgenic Mouse Model Mimicking Crohnʼs Disease

Adeline Sivignon , Amélie de Vallée , Nicolas Barnich , Jérémy Denizot , Claude Darcha et al.
Inflammatory Bowel Diseases, 2015, 21 (2), pp.276 - 286. ⟨10.1097/MIB.0000000000000280⟩
Article dans une revue hal-01928174 v1

Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation

Jérémy Denizot , Alexis Desrichard , Allison Agus , Nancy Uhrhammer , Nicolas Dreux et al.
Gut, 2015, 64 (3), pp.428 - 437. ⟨10.1136/gutjnl-2014-306944⟩
Article dans une revue hal-01928389 v1

Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation

Jérémy Denizot , Alexis Desrichard , Allison Agus , Nancy Uhrhammer , Nicolas Dreux et al.
Gut, 2015, 64 (3), pp.428-437. ⟨10.1136/gutjnl-2014-306944⟩
Article dans une revue hal-04616080 v1

Western diet induces dysbiosis with increased E coli in CEABAC10 mice , alters host barrier function favouring AIEC colonisation

Margarita Martinez-Medina , Jérémy Denizot , Nicolas Dreux , Frédéric Robin , Elisabeth Billard et al.
Gut, 2013, 63 (1), pp.116 - 124. ⟨10.1136/gutjnl-2012-304119⟩
Article dans une revue hal-01928324 v1
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Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

Nicolas Dreux , Jérémy Denizot , Margarita Martinez-Medina , Alexander Mellmann , Maria Billig et al.
PLoS Pathogens, 2013, 9 (1), pp.e1003141. ⟨10.1371/journal.ppat.1003141⟩
Article dans une revue hal-01928191 v1

E. coli-mediated gut inflammation in genetically predisposed Crohn's disease patients

N. Barnich , Jérémy Denizot , A. Darfeuille-Michaud
Pathologie Biologie, 2013, 61 (5), pp.e65 - e69. ⟨10.1016/j.patbio.2010.01.004⟩
Article dans une revue hal-01928194 v1

Adherent-Invasive Escherichia coli Induce Claudin-2 Expression and Barrier Defect in CEABAC10 Mice and Crohnʼs Disease Patients

Jérémy Denizot , Adeline Sivignon , Frederick Barreau , Claude Darcha , Carlos H.F. Chan et al.
Inflammatory Bowel Diseases, 2012, 18 (2), pp.294 - 304. ⟨10.1002/ibd.21787⟩
Article dans une revue hal-01928192 v1
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Importance of Bacteria as Trigger in Inflammatory Bowel Disease

Jérémy Denizot , Nicolas Dreux , Arlette Darfeuille-Michaud , Nicolas Barnich
Journal of Gastrointestinal & Digestive System, 2012, 01, pp.S8. ⟨10.4172/2161-069x.s8-003⟩
Article dans une revue hal-01928200 v1
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Interactions with M cells and macrophages as key steps in the pathogenesis of enterohemorrhagic Escherichia coli infections

L Etienne-Mesmin , B Chassaing , P Sauvanet , J Denizot , S Blanquet-Diot et al.
PLoS ONE, 2011, 6 (8), pp.e23594. ⟨10.1371/journal.pone.0023594⟩
Article dans une revue hal-00748909 v1

Élaboration d'une formulation combinant souches bactériennes et extraits végétaux ciblant les souches « Adherent Invasive Escherichia coli » (AIEC) associées à la maladie de Crohn

Fanny de Clercq , Charlotte Leclaire , Jérémy Denizot , Sophie Holowacz , Nathalie Boisseau et al.
Journée Nutrition & Microbiote (De la prévention à la thérapie), Atlanpole Biothérapies, Nov 2024, Nantes, France
Communication dans un congrès hal-04959285 v1

Presentation of endochitinase ChiA, a virulence factor involved in the pathogenecity of adherent and invasive Escherichia coli associated with Crohn’s Disease

Margot Fargeas , Frédéric Faure , Clara Douadi , Caroline Chevarin , Adeline Sivignon et al.
G-REEMI, Oct 2024, Clermont-Ferrand, France
Communication dans un congrès hal-04974385 v1

ChiA, a major player in the pathogenicity of adherent and invasive E. coli bacteria (AIEC) associated with Crohn's disease.

Margot Fargeas , Frédéric Faure , Clara Douadi , Caroline Chevarin , Adeline Sivignon et al.
Journées scientifiques de l'école doctorale SVSAE (Sciences de la Vie, de la Santé, de l'Agronomie et de l'Environnement), Jun 2024, Clermont-Ferrand, France
Communication dans un congrès hal-04974353 v1

ChiA, un acteur majeur impliqué dans le pouvoir pathogène des bactéries E. coli adhérentes et invasives (AIEC) associées à la maladie de Crohn.

Margot Fargeas , Frédéric Faure , Clara Douadi , Jérémy Denizot , Elisabeth Billard et al.
Journée des microbiologistes de Clermont-Ferrand, Apr 2024, Clermont-Ferrand, France
Communication dans un congrès hal-04974290 v1

A central contribution of HIF-2α in the nutritional immunity against AIEC

Marion Falabrègue , Candice Aurrand , Benoît Chassaing , Jérémy Denizot , Nicolas Barnich et al.
25th Anniversary of AIEC discovery, Nov 2023, New-York, United States
Communication dans un congrès hal-04977484 v1

Epigenetic eraser histone deacetylase 1 (HDAC1) limits AIEC-induced inflammatory response in intestinal epithelial cells

Jérémy Denizot , Mélissa Chervy , Flavie Dambrine , Lionel Le Bourhis , Matthieu Allez et al.
25th anniversary of AIEC discovery, Nov 2023, New york, United States
Communication dans un congrès hal-04841555 v1

“pVill-hCC6”: A NEW MOUSE MODEL MIMICKING ILEAL COLONIZATION BY AIEC BACTERIA TO EVALUATE MICROBIOTA-TARGETING STRATEGIES IN CROHN’S DISEASE

Adeline Sivignon , Mélissa Chervy , Caroline Chevarin , Elisabeth Billard , Jérémy Denizot et al.
Digestive Disease Week 2022, DDW, May 2022, San diego (Californie), United States
Communication dans un congrès hal-04959953 v1

Role of HDAC in the mechanism of infection of intestinal epithelial cells by adherent-invasive Escherichia coli bacteria isolated from patients with Crohn’s disease

Mélissa Chervy , Nicolas Barnich , Jérémy Denizot
Journées de l'Ecole doctorale SVSAE 2021, Jun 2021, Clermont-ferrand, France
Communication dans un congrès hal-04977418 v1

Development of solution based on natural polymers in order to reduce the therapeutic doses of current treatments and their adverse effects in chronic Inflammatory Bowel Diseases (IBD)

Améline Delanne , Jérémy Denizot , Ghislain Garrait , Khaled Fadhlaoui , Arthur Chervet et al.
Journée de l'Ecole Doctorale ED-SVSAE, May 2021, Clermont-Ferrand (FR), France
Communication dans un congrès hal-04841306 v1

Identification of EMP2 gene as a new therapeutic target to limit AIEC colonization in CD patients

Mélissa Chervy , Nicolas Barnich , Jérémy Denizot
UEGW 2020, Oct 2020, AMSTERDAM, France
Communication dans un congrès hal-03046335 v1

Un régime enrichi en molécules donneuses de groupements méthyles limite la colonisation intestinale par les E. coli adhérents et invasifs associées à la maladie de Crohn

Elodie Gimier , Nicolas Barnich , Jérémy Denizot
4èmes Assises Régionales de Nutrition et Santé, Sep 2019, Lyon (France), France
Communication dans un congrès hal-04977307 v1

Un régime enrichi en molécules donneuses de groupements méthyles limite la colonisation intestinale par les E. coli adhérents et invasifs associées à la maladie de Crohn

Elodie Gimier , Nicolas Barnich , Jérémy Denizot
4ème Assises Régionales de Nutrition et Santé, Sep 2019, LYON, France
Communication dans un congrès hal-02393210 v1

Involvement of type VI secretion systems in virulence of adherent-invasive <em>Escherichia coli</em> isolated from patients with Crohn's disease

Sébastien Massier , Sylvie Miquel , Nicolas Dreux , Allison Agus , S. Bouhours et al.
10. Congress of ECCO. Inflammatory Bowel Diseases, ECCO European Crohn's and Colitis Organization., Feb 2015, Barcelona, Spain
Communication dans un congrès hal-02739694 v1

Impact of western diet on short-chain fatty acids production and host susceptibility to intestinal inflammation in a context of Crohn's disease

Allison Agus , Jérémy Denizot , Jonathan Thevenot , Sébastien Massier , Sylvain Denis et al.
10. Congress of the European Crohn's and Colitis Organisation (ECCO) Inflamatory Bowel Diseases, European Crohn´s and Colitis Organisation (ECCO). INT., Feb 2015, Barcelona, Spain
Communication dans un congrès hal-02740401 v1

Interaction between Chitinase 3-like 1 (CHI3L1) and bacterial protein ChiA : a decisive step for Crohn’s disease-associated adherent and invasive E. coli to enter within human macrophages.

Margot Fargeas , Frédéric Faure , Caroline Chevarin , Clara Douadi , Adeline Sivignon et al.
Digestive Disease Week (DDW), May 2024, Washington, United States
Poster de conférence hal-04974337 v1

Interaction between Chitinase 3-like 1 (CHI3L1) and bacterial protein ChiA : a decisive step for Crohn’s disease-associated adherent and invasive E. coli to enter within human macrophages.

Margot Fargeas , Frédéric Faure , Clara Douadi , Adeline Sivignon , Caroline Chevarin et al.
European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Apr 2024, Barcenola, Spain
Poster de conférence hal-04974301 v1

Development of a combination of probiotics and plant extracts targeting Adherent-Invasive Escherichia coli associated with Crohn's disease

Fanny de Clercq , Charlotte Leclaire , Jérémy Denizot , Sophie Holowacz , Nathalie Boisseau et al.
Final symposium of the Microbiota cross-cutting program of Inserm, Oct 2024, Paris necker, France
Poster de conférence hal-04959963 v1

AIEC LF82 cobB Deacetylase Targets the Intestinal Epithelial Cell Nucleus to Enhance Adhesion and Regulate Inflammation During Infection

Flavie Dambrine , Florian Coudray , Perrine Bouvard , N. Barnich , Jérémy Denizot
Programme Transverse Microbiote Inserm 2024, Oct 2024, Paris, France
Poster de conférence hal-04977540 v1

ChiA, a virulence factor playing a role in adherent and invasive E. coli (AIEC) pathogenicity

Margot Fargeas , Frédéric Faure , Clara Douadi , Jérémy Denizot , Elisabeth Billard et al.
AIEC congress, Nov 2023, New York (NY), United States
Poster de conférence hal-04974276 v1

EPIGENETIC MASTER REGULATORS HDAC1 AND HDAC5 CONTROL PATHOBIONT ENTEROBACTERIA COLONIZATION IN ILEAL MUCOSA IN CROHN’S DISEASE PATIENTS

Mélissa Chervy , Adeline Sivignon , Nicolas Barnich , Jérémy Denizot
G-RREMI 2022, Sep 2022, Lyon, France
Poster de conférence hal-04977447 v1

EPIGENETIC MASTER REGULATORS HDAC1 AND HDAC5 CONTROL PATHOBIONT ENTEROBACTERIA COLONIZATION IN ILEAL MUCOSA IN CROHN'S DISEASE PATIENTS

Mélissa Chervy , Adeline Sivignon , Matthieu Allez , Lionel Le Bourhis , Nicolas Barnich et al.
Digestive Disease Week 2022, May 2022, San Diego (California), United States
Poster de conférence hal-04977395 v1

EPIGENETIC MASTER REGULATORS HDAC1 AND HDAC5 CONTROL PATHOBIONT ENTEROBACTERIA COLONIZATION IN ILEAL MUCOSA IN CROHN’S DISEASE PATIENTS

Mélissa Chervy , Adeline Sivignon , Nicolas Barnich , Jérémy Denizot
EMBO Workshow Pathogen Immunity and Signaling, Apr 2022, Saint-Malo (35400), France
Poster de conférence hal-04977437 v1

Development of a vector based on natural excipient in order to reduce the therapeutic doses of current treatments and their adverse effects in chronic inflammatory bowel diseases (IBD).

Améline Delanne , Jérémy Denizot , Ghislain Garrait , Khaled Fadhlaoui , Arthur Chevet et al.
Young Researchers of Auvergne Rhône Alpes Region Congress, Jun 2021, Virtual conference, France
Poster de conférence hal-03417146 v1

Nutritional approach to restore impaired intestinal barrier function and inflammatory after inflammation induction in cells and mice models

Améline Delanne , Jérémy Denizot , Ghislain Garrait , Khaled Fadhlaoui , Eric Beyssac et al.
12. International Symposium on Gut Microbiology, Oct 2021, En ligne, France. 2021
Poster de conférence hal-03394890 v1

Development of a synergistic vector based on natural polymers in order to reduce the therapeutic doses of current treatments and their adverse effects in chronic inflammatory diseases (IBD).

Améline Delanne , Jérémy Denizot , Ghislain Garrait , Sandrine Chalancon , Filipe Carvalho et al.
AAPS PharmSci 360 - American Association of Pharmaceutical Scientists, Oct 2020, Virtual conference, United States
Poster de conférence hal-04841211 v1

High methyl diet impair E. coli overgrowth, limits AIEC colonization and inflammation by epigenentic regulation of genes expression

Nicolas Barnich , Jérémy Denizot , Allison Agus
DDW, May 2019, SAN DIEGO, United States
Poster de conférence hal-02187861 v1

HIGH METHYL DIET IMPAIRS E. COLI OVERGROWTH, LIMITS AIEC COLONIZATION AND INFLAMMATION BY EPIGENETIC REGULATION OF GENES EXPRESSION

Elodie Gimier , Allison Agus , Nicolas Barnich , Jérémy Denizot
Digestive Disease Week 2019, May 2019, San Diego, United States
Poster de conférence hal-04977327 v1