Jérémy Denizot

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Publications

Adherent-invasive E. coli (AIEC) in Crohn’s disease: where are we in 2025? Tribute to Professor Nicolas Barnich

Anthony Buisson , Jérémy Denizot

Clinics and Research in Hepatology and Gastroenterology, 2025, 49 (10), pp.102727. ⟨10.1016/j.clinre.2025.102727⟩

Article dans une revue hal-05543843v1
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Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversary

Nicolas Barnich , Janelle C Arthur , Anthony Buisson , Barry J Campbell , Franck Carbonnel et al.

Gut, In press, pp.gutjnl-2025-335331. ⟨10.1136/gutjnl-2025-335331⟩

Article dans une revue pasteur-05265332v1

Development of a combination of probiotics and plant extracts targeting adherent-invasive Escherichia coli associated with Crohn’s disease

F. de Clercq , N. Boisseau , C. Leclaire , J. Denizot , S. Holowacz et al.

Beneficial Microbes, 2025, pp.1-17. ⟨10.1163/18762891-bja00095⟩

Article dans une revue hal-05319060v1

ChiA: a major player in the virulence of Crohn’s disease-associated adherent and invasive Escherichia coli (AIEC)

Margot Fargeas , Frederic Faure , Clara Douadi , Caroline Chevarin , Aurélien Birer et al.

Gut microbes, 2024, 16 (1), ⟨10.1080/19490976.2024.2412667⟩

Article dans une revue (data paper) hal-04809777v1
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An adherent-invasive Escherichia coli -colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease

Adeline Sivignon , Mélissa Chervy , Caroline Chevarin , Elia Ragot , Elisabeth Billard et al.

Disease Models & Mechanisms, 2022, 15 (10), pp.dmm049707. ⟨10.1242/dmm.049707⟩

Article dans une revue hal-03907399v1
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Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn’s disease patients

Mélissa Chervy , Adeline Sivignon , Flavie Dambrine , Anthony Buisson , Pierre Sauvanet et al.

Gut microbes, 2022, 14 (1), pp.1-13. ⟨10.1080/19490976.2022.2127444⟩

Article dans une revue hal-03881385v1

Propionate catabolism by CD-associated adherent-invasive E. coli counteracts its anti-inflammatory effect

Allison Agus , Damien Richard , Tiphanie Faïs , Emilie Vazeille , Mélissa Chervy et al.

Gut microbes, 2021, 13 (1), pp.1-19. ⟨10.1080/19490976.2020.1839318⟩

Article dans une revue hal-03262359v1
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Adherent-Invasive E. coli: Update on the Lifestyle of a Troublemaker in Crohn's Disease

Mélissa Chervy , Nicolas Barnich , Jérémy Denizot

International Journal of Molecular Sciences, 2020, 21 (10), pp.3734. ⟨10.3390/ijms21103734⟩

Article dans une revue (article de synthèse) hal-02917127v1

Adaptation of adherent-invasive E. coli to gut environment: Impact on flagellum expression and bacterial colonization ability

Gwladys Sevrin , Sébastien Massier , Benoit Chassaing , Allison Agus , Julien Delmas et al.

Gut microbes, 2020, 11 (3), pp.364-380. ⟨10.1080/19490976.2017.1421886⟩

Article dans une revue hal-01730371v1
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Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium

Juri Kazakevych , Jérémy Denizot , Anke Liebert , Mariana Portovedo , Mia Mosavie et al.

Genome Biology, 2020, 21 (1), pp.1-20. ⟨10.1186/s13059-020-01976-7⟩

Article dans une revue hal-02541660v1
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When adherent-invasive E. coli plays with host glycosylation: Does it open new perspectives for therapeutic strategies in Crohn's disease?

Jérémy Denizot , Nicolas Barnich

EBioMedicine, 2020, 55, pp.1-2. ⟨10.1016/j.ebiom.2020.102752⟩

Article dans une revue hal-02912994v1
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Methyl-donor supplementation prevents intestinal colonization by Adherent-invasive E. coli in a mouse model of crohn's disease

Elodie Gimier , Mélissa Chervy , Allison Agus , Adeline Sivignon , Elisabeth Billard et al.

Scientific Reports, 2020, 10, pp.12922. ⟨10.1038/s41598-020-69472-3⟩

Article dans une revue hal-02917129v1
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Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

Hashem Koohy , Daniel Bolland , Louise Matheson , Stefan Schoenfelder , Claudia Stellato et al.

Genome Biology, 2018, 19 (1), ⟨10.1186/s13059-018-1489-y⟩

Article dans une revue hal-01929162v1
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Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Rachel Fellows , Jérémy Denizot , Claudia Stellato , Alessandro Cuomo , Payal Jain et al.

Nature Communications, 2018, 9 (1), pp.1-15. ⟨10.1038/s41467-017-02651-5⟩

Article dans une revue hal-01759208v1
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Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.

Allison Agus , Jérémy Denizot , Jonathan Thevenot , Margarita Martinez-Medina , Sébastien Massier et al.

Scientific Reports, 2016, 6 (1), pp.19032. ⟨10.1038/srep19032⟩

Article dans une revue hal-01928173v1

Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation

Jérémy Denizot , Alexis Desrichard , Allison Agus , Nancy Uhrhammer , Nicolas Dreux et al.

Gut, 2015, 64 (3), pp.428 - 437. ⟨10.1136/gutjnl-2014-306944⟩

Article dans une revue hal-01928389v1

Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation

Jérémy Denizot , Alexis Desrichard , Allison Agus , Nancy Uhrhammer , Nicolas Dreux et al.

Gut, 2015, 64 (3), pp.428-437. ⟨10.1136/gutjnl-2014-306944⟩

Article dans une revue hal-04616080v1

Saccharomyces cerevisiae CNCM I-3856 Prevents Colitis Induced by AIEC Bacteria in the Transgenic Mouse Model Mimicking Crohnʼs Disease

Adeline Sivignon , Amélie de Vallée , Nicolas Barnich , Jérémy Denizot , Claude Darcha et al.

Inflammatory Bowel Diseases, 2015, 21 (2), pp.276 - 286. ⟨10.1097/MIB.0000000000000280⟩

Article dans une revue hal-01928174v1
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Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

Nicolas Dreux , Jérémy Denizot , Margarita Martinez-Medina , Alexander Mellmann , Maria Billig et al.

PLoS Pathogens, 2013, 9 (1), pp.e1003141. ⟨10.1371/journal.ppat.1003141⟩

Article dans une revue hal-01928191v1

E. coli-mediated gut inflammation in genetically predisposed Crohn's disease patients

N. Barnich , Jérémy Denizot , A. Darfeuille-Michaud

Pathologie Biologie, 2013, 61 (5), pp.e65 - e69. ⟨10.1016/j.patbio.2010.01.004⟩

Article dans une revue hal-01928194v1

Western diet induces dysbiosis with increased E coli in CEABAC10 mice , alters host barrier function favouring AIEC colonisation

Margarita Martinez-Medina , Jérémy Denizot , Nicolas Dreux , Frédéric Robin , Elisabeth Billard et al.

Gut, 2013, 63 (1), pp.116 - 124. ⟨10.1136/gutjnl-2012-304119⟩

Article dans une revue hal-01928324v1

Adherent-Invasive Escherichia coli Induce Claudin-2 Expression and Barrier Defect in CEABAC10 Mice and Crohnʼs Disease Patients

Jérémy Denizot , Adeline Sivignon , Frederick Barreau , Claude Darcha , Carlos H.F. Chan et al.

Inflammatory Bowel Diseases, 2012, 18 (2), pp.294 - 304. ⟨10.1002/ibd.21787⟩

Article dans une revue hal-01928192v1
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Importance of Bacteria as Trigger in Inflammatory Bowel Disease

Jérémy Denizot , Nicolas Dreux , Arlette Darfeuille-Michaud , Nicolas Barnich

Journal of Gastrointestinal & Digestive System, 2012, 01, pp.S8. ⟨10.4172/2161-069x.s8-003⟩

Article dans une revue hal-01928200v1
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Interactions with M cells and macrophages as key steps in the pathogenesis of enterohemorrhagic Escherichia coli infections

L Etienne-Mesmin , B Chassaing , P Sauvanet , J Denizot , S Blanquet-Diot et al.

PLoS ONE, 2011, 6 (8), pp.e23594. ⟨10.1371/journal.pone.0023594⟩

Article dans une revue hal-00748909v1

Host cell alterations and pathogen multiplication in an in vitro epithelial intestinal model of co-infection with the microsporidium Encephalitozoon intestinalis and the enterovirus A71

Bélélé Siméon Bakyono , Jean-Luc Bailly , Maxime Bisseux , Jérémy Denizot , Catherine Texier

8eme journée des microscopistes clermontois, Plateforme Clermont Imagerie Confocale, Nov 2025, Clermont-Ferrand, France

Communication dans un congrès hal-05365163v1

Presentation of endochitinase ChiA, a virulence factor involved in the pathogenecity of adherent and invasive Escherichia coli associated with Crohn’s Disease

Margot Fargeas , Frédéric Faure , Clara Douadi , Caroline Chevarin , Adeline Sivignon et al.

G-REEMI, Oct 2024, Clermont-Ferrand, France

Communication dans un congrès hal-04974385v1

Élaboration d'une formulation combinant souches bactériennes et extraits végétaux ciblant les souches « Adherent Invasive Escherichia coli » (AIEC) associées à la maladie de Crohn

Fanny de Clercq , Charlotte Leclaire , Jérémy Denizot , Sophie Holowacz , Nathalie Boisseau et al.

Journée Nutrition & Microbiote (De la prévention à la thérapie), Atlanpole Biothérapies, Nov 2024, Nantes, France

Communication dans un congrès hal-04959285v1

ChiA, a major player in the pathogenicity of adherent and invasive E. coli bacteria (AIEC) associated with Crohn's disease.

Margot Fargeas , Frédéric Faure , Clara Douadi , Caroline Chevarin , Adeline Sivignon et al.

Journées scientifiques de l'école doctorale SVSAE (Sciences de la Vie, de la Santé, de l'Agronomie et de l'Environnement), Jun 2024, Clermont-Ferrand, France

Communication dans un congrès hal-04974353v1

ChiA, un acteur majeur impliqué dans le pouvoir pathogène des bactéries E. coli adhérentes et invasives (AIEC) associées à la maladie de Crohn.

Margot Fargeas , Frédéric Faure , Clara Douadi , Jérémy Denizot , Elisabeth Billard et al.

Journée des microbiologistes de Clermont-Ferrand, Apr 2024, Clermont-Ferrand, France

Communication dans un congrès hal-04974290v1
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Contribution of HIF2-a in iron bioavailability against adherent invasive Escherichia Coli infection.

Marion Falabrègue , Candice Aurrand , Benoit Chassaing , Nicolas Barnich , Jérémy Denizot et al.

European Iron Club Congress 2024, Apr 2024, Toulouse, France

Communication dans un congrès hal-05302203v1

Epigenetic eraser histone deacetylase 1 (HDAC1) limits AIEC-induced inflammatory response in intestinal epithelial cells

Jérémy Denizot , Mélissa Chervy , Flavie Dambrine , Lionel Le Bourhis , Matthieu Allez et al.

25th anniversary of AIEC discovery, Nov 2023, New york, United States

Communication dans un congrès hal-04841555v1

“pVill-hCC6”: A NEW MOUSE MODEL MIMICKING ILEAL COLONIZATION BY AIEC BACTERIA TO EVALUATE MICROBIOTA-TARGETING STRATEGIES IN CROHN’S DISEASE

Adeline Sivignon , Mélissa Chervy , Caroline Chevarin , Elisabeth Billard , Jérémy Denizot et al.

Digestive Disease Week 2022, DDW, May 2022, San diego (Californie), United States

Communication dans un congrès hal-04959953v1

Role of HDAC in the mechanism of infection of intestinal epithelial cells by adherent-invasive Escherichia coli bacteria isolated from patients with Crohn’s disease

Mélissa Chervy , Nicolas Barnich , Jérémy Denizot

Journées de l'Ecole doctorale SVSAE 2021, Jun 2021, Clermont-ferrand, France

Communication dans un congrès hal-04977418v1

Development of solution based on natural polymers in order to reduce the therapeutic doses of current treatments and their adverse effects in chronic Inflammatory Bowel Diseases (IBD)

Améline Delanne , Jérémy Denizot , Ghislain Garrait , Khaled Fadhlaoui , Arthur Chervet et al.

Journée de l'Ecole Doctorale ED-SVSAE, May 2021, Clermont-Ferrand (FR), France

Communication dans un congrès hal-04841306v1

Identification of EMP2 gene as a new therapeutic target to limit AIEC colonization in CD patients

Mélissa Chervy , Nicolas Barnich , Jérémy Denizot

UEGW 2020, Oct 2020, AMSTERDAM, France

Communication dans un congrès hal-03046335v1

Un régime enrichi en molécules donneuses de groupements méthyles limite la colonisation intestinale par les E. coli adhérents et invasifs associées à la maladie de Crohn

Elodie Gimier , Nicolas Barnich , Jérémy Denizot

4ème Assises Régionales de Nutrition et Santé, Sep 2019, LYON, France

Communication dans un congrès hal-02393210v1

Un régime enrichi en molécules donneuses de groupements méthyles limite la colonisation intestinale par les E. coli adhérents et invasifs associées à la maladie de Crohn

Elodie Gimier , Nicolas Barnich , Jérémy Denizot

4èmes Assises Régionales de Nutrition et Santé, Sep 2019, Lyon (France), France

Communication dans un congrès hal-04977307v1

Impact of western diet on short-chain fatty acids production and host susceptibility to intestinal inflammation in a context of Crohn's disease

Allison Agus , Jérémy Denizot , Jonathan Thevenot , Sébastien Massier , Sylvain Denis et al.

10. Congress of the European Crohn's and Colitis Organisation (ECCO) Inflamatory Bowel Diseases, European Crohn´s and Colitis Organisation (ECCO). INT., Feb 2015, Barcelona, Spain

Communication dans un congrès hal-02740401v1

Involvement of type VI secretion systems in virulence of adherent-invasive <em>Escherichia coli</em> isolated from patients with Crohn's disease

Sébastien Massier , Sylvie Miquel , Nicolas Dreux , Allison Agus , S. Bouhours et al.

10. Congress of ECCO. Inflammatory Bowel Diseases, ECCO European Crohn's and Colitis Organization., Feb 2015, Barcelona, Spain

Communication dans un congrès hal-02739694v1

Interaction between Chitinase 3-like 1 (CHI3L1) and bacterial protein ChiA : a decisive step for Crohn’s disease-associated adherent and invasive E. coli to enter within human macrophages.

Margot Fargeas , Frédéric Faure , Caroline Chevarin , Clara Douadi , Adeline Sivignon et al.

Digestive Disease Week (DDW), May 2024, Washington, United States

Poster de conférence hal-04974337v1

Interaction between Chitinase 3-like 1 (CHI3L1) and bacterial protein ChiA : a decisive step for Crohn’s disease-associated adherent and invasive E. coli to enter within human macrophages.

Margot Fargeas , Frédéric Faure , Clara Douadi , Adeline Sivignon , Caroline Chevarin et al.

European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Apr 2024, Barcenola, Spain

Poster de conférence hal-04974301v1

Development of a combination of probiotics and plant extracts targeting Adherent-Invasive Escherichia coli associated with Crohn's disease

Fanny de Clercq , Charlotte Leclaire , Jérémy Denizot , Sophie Holowacz , Nathalie Boisseau et al.

Final symposium of the Microbiota cross-cutting program of Inserm, Oct 2024, Paris necker, France

Poster de conférence hal-04959963v1

AIEC LF82 cobB Deacetylase Targets the Intestinal Epithelial Cell Nucleus to Enhance Adhesion and Regulate Inflammation During Infection

Flavie Dambrine , Florian Coudray , Perrine Bouvard , N. Barnich , Jérémy Denizot

Programme Transverse Microbiote Inserm 2024, Oct 2024, Paris, France

Poster de conférence hal-04977540v1

ChiA, a virulence factor playing a role in adherent and invasive E. coli (AIEC) pathogenicity

Margot Fargeas , Frédéric Faure , Clara Douadi , Jérémy Denizot , Elisabeth Billard et al.

AIEC congress, Nov 2023, New York (NY), United States

Poster de conférence hal-04974276v1

A central contribution of HIF-2α in the nutritional immunity against AIEC

Marion Falabrègue , Candice Aurrand , Benoît Chassaing , Jérémy Denizot , Nicolas Barnich et al.

25th Anniversary of AIEC discovery, Nov 2023, New-York, United States

Poster de conférence hal-04977484v1

EPIGENETIC MASTER REGULATORS HDAC1 AND HDAC5 CONTROL PATHOBIONT ENTEROBACTERIA COLONIZATION IN ILEAL MUCOSA IN CROHN’S DISEASE PATIENTS

Mélissa Chervy , Adeline Sivignon , Nicolas Barnich , Jérémy Denizot

G-RREMI 2022, Sep 2022, Lyon, France

Poster de conférence hal-04977447v1

EPIGENETIC MASTER REGULATORS HDAC1 AND HDAC5 CONTROL PATHOBIONT ENTEROBACTERIA COLONIZATION IN ILEAL MUCOSA IN CROHN'S DISEASE PATIENTS

Mélissa Chervy , Adeline Sivignon , Matthieu Allez , Lionel Le Bourhis , Nicolas Barnich et al.

Digestive Disease Week 2022, May 2022, San Diego (California), United States

Poster de conférence hal-04977395v1

EPIGENETIC MASTER REGULATORS HDAC1 AND HDAC5 CONTROL PATHOBIONT ENTEROBACTERIA COLONIZATION IN ILEAL MUCOSA IN CROHN’S DISEASE PATIENTS

Mélissa Chervy , Adeline Sivignon , Nicolas Barnich , Jérémy Denizot

EMBO Workshow Pathogen Immunity and Signaling, Apr 2022, Saint-Malo (35400), France

Poster de conférence hal-04977437v1

Nutritional approach to restore impaired intestinal barrier function and inflammatory after inflammation induction in cells and mice models

Améline Delanne , Jérémy Denizot , Ghislain Garrait , Khaled Fadhlaoui , Eric Beyssac et al.

12. International Symposium on Gut Microbiology, Oct 2021, En ligne, France. 2021

Poster de conférence hal-03394890v1

Development of a vector based on natural excipient in order to reduce the therapeutic doses of current treatments and their adverse effects in chronic inflammatory bowel diseases (IBD).

Améline Delanne , Jérémy Denizot , Ghislain Garrait , Khaled Fadhlaoui , Arthur Chevet et al.

Young Researchers of Auvergne Rhône Alpes Region Congress, Jun 2021, Virtual conference, France

Poster de conférence hal-03417146v1

Development of a synergistic vector based on natural polymers in order to reduce the therapeutic doses of current treatments and their adverse effects in chronic inflammatory diseases (IBD).

Améline Delanne , Jérémy Denizot , Ghislain Garrait , Sandrine Chalancon , Filipe Carvalho et al.

AAPS PharmSci 360 - American Association of Pharmaceutical Scientists, Oct 2020, Virtual conference, United States

Poster de conférence hal-04841211v1

High methyl diet impair E. coli overgrowth, limits AIEC colonization and inflammation by epigenentic regulation of genes expression

Nicolas Barnich , Jérémy Denizot , Allison Agus

DDW, May 2019, SAN DIEGO, United States

Poster de conférence hal-02187861v1

HIGH METHYL DIET IMPAIRS E. COLI OVERGROWTH, LIMITS AIEC COLONIZATION AND INFLAMMATION BY EPIGENETIC REGULATION OF GENES EXPRESSION

Elodie Gimier , Allison Agus , Nicolas Barnich , Jérémy Denizot

Digestive Disease Week 2019, May 2019, San Diego, United States

Poster de conférence hal-04977327v1