Jérôme Henri

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Publications

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Semi-mechanistic PK/PD modelling of enrofloxacin against sensitive Pasteurella multocida : inter-strain variability and prediction of efficacy in pigs

Alexis Viel , Anthony Khaled , Mathias Devreese , Mireille Bruneau , Jérôme Henri

Journal of Applied Microbiology, 2026, ⟨10.1093/jambio/lxag045⟩

Article dans une revue hal-05510220v1
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In vitro hepatic metabolism and associated binding of enniatin B

Ludovic Le Hégarat , Estelle Dubreil , Nicolas Le Yondre , Solenne Martin , Françoise Brée et al.

Toxicology, 2026, 521, pp.154379. ⟨10.1016/j.tox.2025.154379⟩

Article dans une revue hal-05453769v1
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Population pharmacokinetic modeling of sulfadimethoxine, sulfadiazine and sulfamethoxazole combined to trimethoprim in pigs

Marine Boulanger , Jean-François Taillandier , Jérôme Henri , Mathias Devreese , Siegrid de Baere et al.

Veterinary Quarterly, 2025, 45 (1), pp.2565351. ⟨10.1080/01652176.2025.2565351⟩

Article dans une revue hal-05290011v1
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Combining fugacity and physiologically based toxicokinetic concepts in a mechanistic model describing the fate of lipophilic contaminants in lactating cows

Sylvain Lerch , Olivier Martin , Agnés Fournier , Isabelle Ortigues-Marty , Jérôme Henri

Environment International, 2025, 199, pp.109509. ⟨10.1016/j.envint.2025.109509⟩

Article dans une revue hal-05064148v1
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Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health

Henriqueta Louro , Ariane Vettorazzi , Adela López de Cerain , Anastasia Spyropoulou , Anita Solhaug et al.

Archives of Toxicology, 2024, 98 (2), pp.425-469. ⟨10.1007/s00204-023-03636-8⟩

Article dans une revue anses-04383220v1
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Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

Antonio Hernandez‐jerez , Tamara Coja , Martin Paparella , Anna Price , Jerome Henri et al.

EFSA Journal, 2024, 22, pp.1-84. ⟨10.2903/j.efsa.2024.8759⟩

Article dans une revue anses-04700110v1
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Pharmacokinetic modeling of sulfamethoxazole-trimethoprim and sulfadiazine-trimethoprim combinations in broilers

Marine Boulanger , Jean-François Taillandier , Jérôme Henri , Mathias Devreese , Siegrid de Baere et al.

Poultry Science, 2024, 103 (11), pp.104200. ⟨10.1016/j.psj.2024.104200⟩

Article dans une revue anses-04687626v1
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PBPK Model To Predict Marbofloxacin Distribution in Edible Tissues and Intestinal Exposure in Pigs

Alexis Viel , Anis Nouichi , Mélanie Le van Suu , Jean-Guy Rolland , Pascal Sanders et al.

Journal of Agricultural and Food Chemistry, 2023, 71 (10), pp.4358-4370. ⟨10.1021/acs.jafc.2c06561⟩

Article dans une revue anses-04167240v1
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Determination of the elimination half-life of Glyphosate and its main metabolite, AMPA, in chicken plasma

Mathias Fréville , Jérôme Henri , Anthony Estienne , Loïse Serra , Christelle Ramé et al.

Toxicology Letters, 2023, 389, pp.19 - 25. ⟨10.1016/j.toxlet.2023.10.009⟩

Article dans une revue anses-04265997v1
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Ionophore coccidiostats – disposition kinetics in laying hens and residues transfer to eggs

Abubakar Bello , Jérôme Henri , Alexis Viel , Jonathan Paul Mochel , Błażej Poźniak

Poultry Science, 2023, 102 (1), pp.102280. ⟨10.1016/j.psj.2022.102280⟩

Article dans une revue anses-03922139v1
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Permeability of the Cyanotoxin Microcystin-RR across a Caco-2 Cells Monolayer

Jérôme Henri , Rachelle Lanceleur , Jean-Michel Delmas , Valérie Fessard , Antoine Huguet

Toxins, 2021, 13 (3), pp.178. ⟨10.3390/toxins13030178⟩

Article dans une revue anses-03266193v1
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A PBPK model to study the transfer of α- hexabromocyclododecane (α-HBCDD) to tissues of fast-and slow-growing broilers

Bertrand Méda , Angélique Travel , Yann Guyot , Jérôme Henri , Eric Royer et al.

Food additives & contaminants. Part A. Chemistry, analysis, control, exposure & risk assessment, 2020, 37 (2), pp.316-331. ⟨10.1080/19440049.2019.1681596⟩

Article dans une revue anses-02359869v1
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A Population WB-PBPK Model of Colistin and its Prodrug CMS in Pigs: Focus on the Renal Distribution and Excretion

Alexis Viel , Jérôme Henri , Salim Bouchène , Julian Laroche , Jean-Guy Rolland et al.

Pharmaceutical Research, 2018, 35, pp.92. ⟨10.1007/s11095-018-2379-4⟩

Article dans une revue anses-01743743v1

The present and future of withdrawal period calculations for milk in the European Union: Focus on heterogeneous, nonmonotonic data

Anne Chevance , Anne-Marie Jacques , Michel Laurentie , Pascal Sanders , Jérôme Henri

Journal of Veterinary Pharmacology and Therapeutics, 2017, 40 (3), pp.218-230. ⟨10.1111/jvp.12351⟩

Article dans une revue anses-01419605v1
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Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel , Jérôme Henri , Agnès Perrin-Guyomard , Julian Laroche , William Couet et al.

International Journal of Antimicrobial Agents, 2017, 51 (1), pp.128-131. ⟨10.1016/j.ijantimicag.2017.04.013⟩

Article dans une revue anses-01570163v1

The present and future of withdrawal period calculations for milk in the European Union: Dealing with data below the limit of quantification

Jérôme Henri , Anne-Marie Jacques , Pascal Sanders , Anne Chevance , Michel Laurentie

Journal of Veterinary Pharmacology and Therapeutics, 2017, 40 (2), pp.116-122. ⟨10.1111/jvp.12343⟩

Article dans une revue anses-01421392v1

A physiologically based pharmacokinetic model for chickens exposed to feed supplemented with monensin during their lifetime

Jérôme Henri , Romain Carrez , Bertrand Méda , Michel Laurentie , Pascal Sanders

Journal of Veterinary Pharmacology and Therapeutics, 2016, 40 (4), pp.1-13. ⟨10.1111/jvp.12370⟩

Article dans une revue anses-01418236v1

Tools to evaluate pharmacokinetics data for establishing maximum residue limits for approved veterinary drugs: examples from JECFA's work

Pascal Sanders , Jérôme Henri , Michel Laurentie

Drug Testing and Analysis, 2016, 8 (5-6), pp.565-571. ⟨10.1002/dta.2006⟩

Article dans une revue anses-01348712v1

Low in vitro permeability of the cyanotoxin microcystin-LR across a Caco-2 monolayer: With identification of the limiting factors using modelling

Jérôme Henri , Antoine Huguet , Jean-Michel Delmas , Aurore Besson , Pascal Sanders et al.

Toxicon, 2014, pp.1-11. ⟨10.1016/j.toxicon.2014.07.023⟩

Article dans une revue istex hal-01076975v1

Low or high doses of cefquinome targeting low or high bacterial inocula cure Klebsiella pneumoniae lung infections but differentially impact the levels of antibiotic resistance in fecal flora.

Maleck V. Vasseur , Michel Laurentie , Jean-Guy Rolland , Agnès Perrin-Guyomard , Jérôme Henri et al.

Antimicrobial Agents and Chemotherapy, 2014, 58 (3), pp.1744-8. ⟨10.1128/AAC.02135-13⟩

Article dans une revue hal-00978511v1

Permeability of dihydro- and cysteine-brevetoxin metabolites across a Caco-2 cell monolayer

Jérôme Henri , Ta Leighfield , Rachelle Lanceleur , Antoine Huguet , Js Ramsdell et al.

Harmful Algae, 2014, 32, pp.22-26. ⟨10.1016/j.hal.2013.11.007⟩

Article dans une revue istex hal-00998117v1

Comparative Cytotoxicity, Oxidative Stress, and Cytokine Secretion Induced by Two Cyanotoxin Variants, Microcystin LR and RR, in Human Intestinal Caco-2 Cells.

Antoine Huguet , Jérôme Henri , Mélanie Petitpas , Kevin Hogeveen , Valérie Fessard

Journal of Biochemical and Molecular Toxicology, 2013, 27 (5), pp.253-258. ⟨10.1002/jbt.21482⟩

Article dans une revue istex hal-00815224v1

Comparison of the oral bioavailability and tissue disposition of monensin and salinomycin in chickens and turkeys.

Jérôme Henri , R. Maurice , G. Postollec , Estelle Dubreil-Cheneau , Brigitte Roudaut et al.

Journal of Veterinary Pharmacology and Therapeutics, 2011, epub ahead of print. ⟨10.1111/j.1365-2885.2011.01285.x⟩

Article dans une revue istex hal-00601106v1

Implementation and assessment of the quality management system in research in a laboratory of the French Food Safety Agency: Application to PhD student work

Jérôme Henri , Pascal Sanders , Hélène Lelièvre , Nathalie Cadieu

Accreditation and Quality Assurance, 2009, 14 (4), pp.207-217. ⟨10.1007/s00769-009-0505-z⟩

Article dans une revue hal-00405458v1

Bioavailability, distribution and depletion of monensin in chickens

Jérôme Henri , Christine Burel , P. Sanders , M. Laurentie

Journal of Veterinary Pharmacology and Therapeutics, 2009, 32 (5), pp.451-456. ⟨10.1111/j.1365-2885.2009.01063.x⟩

Article dans une revue istex hal-01985346v1

Cytochrome P450‐dependent metabolism of monensin in hepatic microsomes from chickens and turkeys

Jérôme Henri , J. Manceau , P. Sanders , M. Laurentie

Journal of Veterinary Pharmacology and Therapeutics, 2008, 31 (6), pp.584-586. ⟨10.1111/j.1365-2885.2008.00996.x⟩

Article dans une revue istex hal-05468571v1

Liquid chromatography–electrospray tandem mass spectrometric method for quantification of monensin in plasma and edible tissues of chicken used in pharmacokinetic studies: Applying a total error approach

Estelle Chéneau , Jérôme Henri , Yvette Pirotais , Jean-Pierre Abjean , Brigitte Roudaut et al.

Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2007, 850 (1-2), pp.15-23. ⟨10.1016/j.jchromb.2006.10.072⟩

Article dans une revue istex hal-05468562v1
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Interspecies and cell models comparison of enniatin b1 in vitro hepatic clearance

Mariam Mahdjoub , Charlène Gendre , Estelle Dubreil-Chéneau , Ludovic Le Hegarat , Jérôme Henri

37th Group of Metabolism and Pharmacokinetics (GMP 2025) : Pioneering Advances in Pharmacokinetics, Oct 2025, Gentilly, France

Poster de conférence hal-05477628v1
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Mechanistic Modeling of Antibiotics Transfer across the Blood-Milk Barrier in Ruminants: Case Study of Marbofloxacin

Marc Codaccioni , Jennifer Tardiveau , Jérôme Henri , Nicolas Grégoire , Alexis Viel

59th Congress of the European Societies of Toxicology (EUROTOX 2025) : Toxicology addresses society's real life risks for sustainable health and well being, Sep 2025, Athènes, Greece. Toxicology letters, 411, pp.S195, 2025, ⟨10.1016/j.toxlet.2025.07.468⟩

Poster de conférence hal-05251265v1
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Use of New Approach Methodologies (NAMs) in unravelling interspecies Toxicokinetics of Enniatin B1

M. Mahdjoub , M. Dechir , C. Gendre , E. Dubreil , L. Le Hegarat et al.

59th Congress of the European Societies of Toxicology (EUROTOX 2025), Sep 2025, Athènes, Greece. , Toxicology letters, 411, pp.S389-S390, 2025, ⟨10.1016/j.toxlet.2025.07.897⟩

Poster de conférence anses-05460157v1
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Metabolism of Enniatin B in primary mouse, rat and human hepatocytes

Estelle Dubreil , Lada Ivanova , Charlène Gendre , Mariam Mahdjoub , Valérie Fessard et al.

58th Congress of the European Societies of Toxicology (EUROTOX 2024), Sep 2024, Copenhagen, Denmark. , 399, pp.S125, 2024, ⟨10.1016/j.toxlet.2024.07.322⟩

Poster de conférence anses-04701403v1
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Impact of quaternary ammoniums on permeability and intestinal microbiota: a study to detect biomarkers of exposure in rats

Kahina Slimani , Sophie Mompelat , Cécile Vignal , Tahar Ait-Ali , Jean-François Taillandier et al.

16èmes JS du RFMF, Jun 2024, Saint-Malo, France

Poster de conférence hal-05034843v1
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Complements on Enniatin B metabolism for interspecies qIVIVE and risk assessment in human

Jérôme Henri , Estelle Dubreil , Valérie Fessard , Solenne Martin , Françoise Brée et al.

57th Congress of the European Societies of Toxicology - EUROTOX 2023, Sep 2023, Ljubljana, Slovenia

Poster de conférence hal-05467972v1
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Assessment of the selective effect of colistin on mcr-1-positive Escherichia coli through in vitro co-culture time-kill experiments

Alexis Viel , Charlotte Valentin , Jérôme Henri , Michel Laurentie , Pascal Sanders

Tenth International Conference on Antimicrobial Agents in Veterinary Medicine, Nov 2020, Virtual, France

Poster de conférence anses-03499578v1
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Use of PBPK modeling to explore the pharmacokinetics and renal disposition of CMS/Colistin in piglets as a model for the paediatric population

Alexis Viel , Jérôme Henri , William Couet , Michel Laurentie , Pascal Sanders et al.

CVPT/ESVNU Symposium (European College of Veterinary Pharmacology and Therapeutics & European Society of Veterinary Nephrology and Urology): Pharmacology and the kidney, Jul 2019, London, United Kingdom

Poster de conférence hal-05480054v1

Modélisation mécaniste du transfert de contaminants lipophiles chez la vache laitière : vers une meilleure maitrise de la qualité sanitaire du lait

Olivier Martin , Sylvain Lerch , Agnès Fournier , Jérôme Henri

Rencontres Recherches Ruminants, 2018, Paris, France

Poster de conférence hal-04463527v1
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Exploring the effects of dietary lipid content and digestibility on lipophilic contaminants transfer from feed to milk: insights from a Physiologically Based ToxicoKinetic model

Sylvain Lerch , Olivier Martin , Agnès Fournier , Jérôme Henri

10 th International Symposium on the Nutrition of Herbivores (ISNH), Sep 2018, Clermont-Ferrand, France

Poster de conférence hal-05468582v1

Lack of experimental evidence to support mcr-1-positive Escherichia coli strain selection during oral administration of colistin by gavage in weaned piglets

Alexis Viel , Jérôme Henri , Agnès Perrin-Guyomard , Julian Laroche , William Couet et al.

14th international congress of the European association for veterinary pharmacology and toxicology, Jun 2018, Wroclaw, Poland.

Poster de conférence anses-01985196v1

Modélisation générique du devenir d’un retardateur de flammes bromé (α-HBCD) chez le poulet de chair et le porc

Bertrand Méda , Eric Royer , Stéphanie Guérin , Andrea Garcia de Salazar , Elena Dominguez-Romero et al.

12.Journées de la recherche avicole et palmipèdes à foie gras, Apr 2017, Tours, France. 2017

Poster de conférence hal-01688926v1
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The influence of age on colistin methanosulfonate and colistin plasmatic and tissular distribution after intravenous administration of colistin methanosulfonate in pigs background

Alexis Viel , Nicolas Grégoire , Jérôme Henri , Patrice Gobin , Julian Laroche et al.

8th International Conference on Antimicrobial Agents in Veterinary Medicine (AAVM 2016), Aug 2016, Budapest, Hungary

Poster de conférence hal-05480028v1
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Fate of a brominated flame retardant (HBCD) in chickens and pigs: a generic modelling approach

Bertrand Méda , Eric Royer , Stéphanie Guerin , Andrea Garcia de Salazar , Elena Dominguez-Romero et al.

67th Annual meeting of the European Federation of Animal Science EAAP 2016, Aug 2016, Belfast, United Kingdom. , EAAP Publication, 2016, EAAP Publication

Poster de conférence hal-01367303v1
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Sensibilité aux désinfectants des Escherichia coli porteurs d'une résistance aux céphalosporines de 3ème génération (C3G) de type CTX-M

A Perrin-Guyomard , Sarah Robiolle , Patricia Le Grandois , Béatrice Anger-Lemaitre , Catherine Poirier et al.

9ème Congrès national de la Société Française de Microbiologie (SFM), Feb 2013, Lille, France

Poster de conférence hal-05477842v1
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EFFECTS OF MICROCYSTIN LR ON THE INTEGRITY OF THE IN VITRO CACO-2 INTESTINAL BARRIER MODEL

Antoine Huguet , Jérôme Henri , Aurore Besson , Valérie Fessard

EUSAAT (European society for alternatives to animal testing), Sep 2010, Linz, Austria

Poster de conférence anses-05479948v1

114. Population pharmacokinetic modelling of different sulphonamides associated with trimethoprim in pigs

Marine Boulanger , J.F. Taillandier , Jérôme Henri , Marlène Z Lacroix , Béatrice Roques et al.

57th Swine Research Days [57es Journées de la Recherche Porcine] (JRP 2025), Feb 2025, Saint-Malo, France. Animal. Science proceedings, 16 (6), pp.896, 2025, ⟨10.1016/j.anscip.2025.08.115⟩

Proceedings/Recueil des communications hal-05406887v1

Population PK modeling of different sulfonamides in association with trimethoprim in pigs

Alexis Viel , Marine Boulanger , Jean-François Taillandier , Michel Laurentie , Jérôme Henri et al.

15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Journal of Veterinary Pharmacology and Therapeutics, 46 (S1), pp.82-83, 2023, ⟨10.1111/jvp.13277⟩

Proceedings/Recueil des communications hal-04352560v1

Semi-mecanistic PKPD modeling of enrofloxacin against sensitive strains of Pasteurella multocida in pigs

Anthony Khaled , Jérôme Henri , Alexis Viel

Twelfth International Conference on Antimicrobial Agents in Veterinary Medicine (AAVM), Jun 2024, Athènes, Greece

Communication dans un congrès hal-04628898v1
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A mechanistic model of lipophilic contaminants transfer in dairy cow for improve milk safety

Sylvain Lerch , Olivier Martin , Agnès Fournier , Jérôme Henri

24e journées Rencontres Recherches Ruminants, 2018, Dec 2018, Paris, France. pp.425

Communication dans un congrès hal-05477706v1

Mechanistic modelling of lipophilic contaminant transfer in lactating cow from knowledge integration toward risk assessment tool for improve milk safety

Sylvain Lerch , Olivier Martin , Agnès Fournier , Jérôme Henri

10th International Symposium on the Nutrition of Herbivores, Sep 2018, Clermont - Ferrand, France

Communication dans un congrès hal-05477677v1
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Etude des déplétions tissulaires du monensin chez le poulet et la dinde

Brigitte Roudaut , Estelle Chéneau , Jérôme Henri , Christine Burel , Robert Maurice et al.

8. Journées de la Recherche Avicole, Mar 2009, Saint Malo, France

Communication dans un congrès hal-02052972v1