Jonathan CLARHAUT

52
Documents

Publications

Publications

Impact of mixed Staphylococcus aureus-Pseudomonas aeruginosa biofilm on susceptibility to antimicrobial treatments in a 3D in vitro model

Guillermo Landa , Jonathan Clarhaut , Julien Buyck , Gracia Mendoza , Manuel Arruebo et al.
Scientific Reports, 2024, 14 (1), pp.27877. ⟨10.1038/s41598-024-79573-y⟩
Article dans une revue hal-05144149 v1

Pan-azole-resistant Meyerozyma guilliermondii clonal isolates harbouring a double F126L and L505F mutation in Erg11.

Jérémy Moreau , Thierry Noël , Kévin Point , Frederic Tewes , Luc Deroche et al.
Mycoses, 2024, 67 (3), pp.e13704. ⟨10.1111/myc.13704⟩
Article dans une revue hal-04715648 v1

Combination of Targeted Therapies for Colorectal Cancer Treatment

Elodie Péraudeau , Brigitte Renoux , Sheik Emambux , Pauline Poinot , Rémi Châtre et al.
Molecular Pharmaceutics, 2023, 20 (9), pp.4537-4545. ⟨10.1021/acs.molpharmaceut.3c00224⟩
Article dans une revue hal-04508239 v1

Combination of Targeted Therapies for Colorectal Cancer Treatment

Elodie Péraudeau , Brigitte Renoux , Sheik Emambux , Pauline Poinot , Rémi Châtre et al.
Molecular Pharmaceutics, 2023, 20 (9), pp.4537-4545. ⟨10.1021/acs.molpharmaceut.3c00224⟩
Article dans une revue hal-05019569 v1
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Induced-volatolomics for the design of tumour activated therapy

Rémi Châtre , Estelle Blochouse , Rony Eid , Fabiola Djago , Justin Lange et al.
Chemical Science, 2023, 14 (18), pp.4697-4703. ⟨10.1039/d2sc06797h⟩
Article dans une revue hal-04098727 v1
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A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients

Alexia Chauzy , Salim Bouchène , Vincent Aranzana-Climent , Jonathan Clarhaut , Christophe Adier et al.
Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩
Article dans une revue hal-03906712 v1
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A β-Cyclodextrin-Albumin Conjugate for Enhancing Therapeutic Efficacy of Cytotoxic Drugs

Chad Plumet , Rémi Châtre , Fabiola Djago , Elodie Péraudeau , Quentin Blancart-Remaury et al.
Bioconjugate Chemistry, 2022, 33 (6), pp.1138-1144. ⟨10.1021/acs.bioconjchem.2c00182⟩
Article dans une revue hal-03765739 v1
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Cell–cell interactions via non-covalent click chemistry

Chad Plumet , Achmet Said Mohamed , Tanguy Vendeuvre , Brigitte Renoux , Jonathan Clarhaut et al.
Chemical Science, 2021, 12 (26), pp.9017-9021. ⟨10.1039/D1SC01637G⟩
Article dans une revue hal-03285569 v1

Cell–cell interactions via non-covalent click chemistry

Chad Plumet , Achmet Said Mohamed , Tanguy Vendeuvre , Brigitte Renoux , Jonathan Clarhaut et al.
Chemical Science, 2021, 12 (26), pp.9017-9021. ⟨10.1039/D1SC01637G⟩
Article dans une revue hal-05019654 v1
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Cx43 Present at the Leading Edge Membrane Governs Promigratory Effects of Osteoblast-Conditioned Medium on Human Prostate Cancer Cells in the Context of Bone Metastasis

Jonathan Boucher , Annie-Claire Balandre , Marjolaine Debant , Justine Vix , Thomas Harnois et al.
Cancers, 2020, 12 (10), pp.3013. ⟨10.3390/cancers12103013⟩
Article dans une revue hal-03176921 v1
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In vivo synthesis of triple-loaded albumin conjugate for efficient targeted cancer chemotherapy

Rémi Châtre , Justin Lange , Elodie Péraudeau , Pauline Poinot , Stéphanie Lerondel et al.
Journal of Controlled Release, 2020, 327, pp.19-25. ⟨10.1016/j.jconrel.2020.08.008⟩
Article dans une revue hal-03491375 v1
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Selective radical depolymerization of cellulose to glucose induced by high frequency ultrasound

Somia Haouache , Ayman Karam , Tony Chave , Jonathan Clarhaut , Prince Nana Amaniampong et al.
Chemical Science, 2020, 11 (10), pp.2664-2669. ⟨10.1039/D0SC00020E⟩
Article dans une revue hal-02921911 v1

Volatile Organic Compound Based Probe for Induced Volatolomics of Cancers

Justin Lange , Balkis Eddhif , Mehrad Tarighi , Théa Garandeau , Elodie Péraudeau et al.
Angewandte Chemie International Edition, 2019, 58 (49), pp.17563-17566. ⟨10.1002/anie.201906261⟩
Article dans une revue hal-04508274 v1

Controlled Release of a Micelle Payload via Sequential Enzymatic and Bioorthogonal Reactions in Living Systems

Karine Porte , Brigitte Renoux , Elodie Péraudeau , Jonathan A. Clarhaut , Balkis Eddhif et al.
Angewandte Chemie International Edition, 2019, 58 (19), pp.6366-6370. ⟨10.1002/anie.201902137⟩
Article dans une revue hal-02115783 v1
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Enhancing tumor response to targeted chemotherapy through up-regulation of folate receptor α expression induced by dexamethasone and valproic acid

E. Peraudeau , L. Cronier , A. Monvoisin , P. Poinot , C. Mergault et al.
Journal of Controlled Release, 2018, 269, pp.36-44. ⟨10.1016/j.jconrel.2017.11.011⟩
Article dans une revue hal-02122599 v1

A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E

Brigitte Renoux , Laure Fangous , Camille Hötten , Élodie Péraudeau , Balkis Eddhif et al.
MedChemComm, 2018, 9 (12), pp.2068-2071. ⟨10.1039/C8MD00466H⟩
Article dans une revue hal-05038390 v1

Study of a novel agent for TCA precipitated proteins washing - comprehensive insights into the role of ethanol/HCl on molten globule state by multi-spectroscopic analyses

Claude Geffroy-Rodier , Balkis Eddhif , Justin Lange , Nadia Guignard , Yann Batonneau et al.
Journal of Proteomics, 2018, 173, pp.77 - 88. ⟨10.1016/j.jprot.2017.11.016⟩
Article dans une revue insu-01823781 v1

A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E

Brigitte Renoux , Laure Fangous , Camille Hötten , Elodie Péraudeau , Balkis Eddhif et al.
MedChemComm, 2018, 9 (12), pp.2068-2071. ⟨10.1039/C8MD00466H⟩
Article dans une revue hal-04508272 v1
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Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis

Jonathan Boucher , Claire Simonneau , Golthlay Denet , Jonathan Clarhaut , Claire Balandre et al.
International Journal of Molecular Sciences, 2018, 19 (6), pp.1558. ⟨10.3390/ijms19061558⟩
Article dans une revue hal-02129345 v1

2-Acetamido-2-deoxy- l -iminosugar C -Alkyl and C -Aryl Glycosides: Synthesis and Glycosidase Inhibition

Balkis Eddhif , Justin Lange , Nadia Guignard , Yann Batonneau , Jonathan A. Clarhaut et al.
European Journal of Organic Chemistry, 2018, 2018 (40), pp.5477-5488. ⟨10.1002/ejoc.201800678⟩
Article dans une revue hal-02172201 v1

A β-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy

Guillaume Compain , Nassima Oumata , Jonathan A. Clarhaut , Elodie Péraudeau , Brigitte Renoux et al.
European Journal of Medicinal Chemistry, 2018, 158, pp.1-6. ⟨10.1016/j.ejmech.2018.08.100⟩
Article dans une revue hal-02169782 v1
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TCA precipitation and ethanol/HCl single-step purification evaluation: One-dimensional gel electrophoresis, bradford assays, spectrofluorometry and Raman spectroscopy data on HSA, Rnase, lysozyme - Mascots and Skyline data

Balkis Eddhif , Nadia Guignard , Yann Batonneau , Jonathan A. Clarhaut , Sébastien Papot et al.
Data in Brief, 2018, 17, pp.938-953. ⟨10.1016/j.dib.2018.01.095⟩
Article dans une revue hal-02169942 v1

In situ targeted activation of an anticancer agent using ultrasound-triggered release of composite droplets

Marine Bezagu , Jonathan Clarhaut , Brigitte Renoux , Fabrice Monti , Mickael Tanter et al.
European Journal of Medicinal Chemistry, 2017, 142, pp.2-7. ⟨10.1016/j.ejmech.2017.03.057⟩
Article dans une revue hal-04088862 v1

In situ targeted activation of an anticancer agent using ultrasound-triggered release of composite droplets

Sergii Kolodych , Chloé Michel , Sébastien Delacroix , Oleksandr Koniev , Anthony Ehkirch et al.
European Journal of Medicinal Chemistry, 2017, 142, pp.2-7. ⟨10.1016/j.ejmech.2017.03.057⟩
Article dans une revue hal-02174984 v1
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Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers

Brigitte Renoux , Florian Raes , Thibaut Legigan , Elodie Péraudeau , Balkis Eddhif et al.
Chemical Science, 2017, 8 (5), pp.3427-3433. ⟨10.1039/C7SC00472A⟩
Article dans une revue hal-02174996 v1

Diminished oligomerization in the synthesis of new anti-angiogenic cyclic peptide using solution instead of solid-phase cyclization

S. Rubio , J. Clarhaut , E. Peraudeau , M. Vincenzi , C. Soum et al.
Biopolymers, 2016, pp.368-375. ⟨10.1002/bip.22814⟩
Article dans une revue istex hal-01563735 v1
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A dendritic β-galactosidase-responsive folate–monomethylauristatin E conjugate

Jérôme Alsarraf , Elodie Peraudeau , Pauline Poinot , I. Tranoy-Opalinski , Jonathan Clarhaut et al.
Chemical Communications, 2015, 51 (87), pp.15792-15795. ⟨10.1039/C5CC05294G⟩
Article dans une revue hal-03127679 v1
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Serotonin and Cancer: What Is the Link?

Denis Sarrouilhe , Jonathan Clarhaut , Norah Defamie , Marc Mesnil
Current Molecular Medicine, 2015, 15 (1), pp.62-77. ⟨10.2174/1566524015666150114113411⟩
Article dans une revue (article de synthèse) hal-04432521 v1
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A mechanically interlocked molecular system programmed for the delivery of an anticancer drug

Romain Barat , Thibaut Legigan , I. Tranoy-Opalinski , Brigitte Renoux , Elodie Peraudeau et al.
Chemical Science, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩
Article dans une revue hal-03127729 v1

beta-Glucuronidase-responsive prodrugs for selective cancer chemotherapy: An update

Isabelle Tranoy-Opalinski , Thibaut Legigan , Romain Barat , Jonathan Clarhaut , Mikael Thomas et al.
European Journal of Medicinal Chemistry, 2014, 74, pp.302-313. ⟨10.1016/j.ejmech2013.12.045⟩
Article dans une revue hal-01196935 v1

Synthesis and biological evaluations of a monomethylauristatin E glucuronide prodrug for selective cancer chemotherapy

Thibaut Legigan , Jonathan Clarhaut , Brigitte Renoux , Isabelle Tranoy-Opalinski , Arnaud Monvoisin et al.
European Journal of Medicinal Chemistry, 2013, 67, pp.75-80. ⟨10.1016/j.ejmech.2013.06.037⟩
Article dans une revue (data paper) istex hal-04033523 v1

An enzyme-responsive system programmed for the double release of bioactive molecules through an intracellular chemical amplification process

M. Grinda , T. Legigan , J. Clarhaut , E. Peraudeau , I. Tranoy-Opalinski et al.
Organic & Biomolecular Chemistry, 2013, 11 (41), pp.7129-7133. ⟨10.1039/c3ob41536h⟩
Article dans une revue hal-00966980 v1
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A galactosidase-responsive doxorubicin-folate conjugate for selective targeting of acute myelogenous leukemia blasts

Jonathan Clarhaut , Sylvain Fraineau , Joëlle Guilhot , Elodie Péraudeau , Isabelle Tranoy-Opalinski et al.
Leukemia Research, 2013, 37 (8), pp.948 - 955. ⟨10.1016/j.leukres.2013.04.026⟩
Article dans une revue istex inserm-02444614 v1
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A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates

Marina Yefimova , Nadia Messaddeq , Thomas Harnois , Annie-Claire Meunier , Jonathan Clarhaut et al.
Autophagy, 2013, 9 (5), pp.653-666. ⟨10.4161/auto.23839⟩
Article dans une revue hal-03119928 v1

Saturated fatty acids alter the late secretory pathway by modulating membrane properties.

Laurie-Anne Payet , Ludovic Pineau , Ellen C R Snyder , Jenny Colas , Ahmed Moussa et al.
Traffic, 2013, 14 (12), pp.1228-41. ⟨10.1111/tra.12117⟩
Article dans une revue hal-00990166 v1

The First Generation of β-Galactosidase-Responsive Prodrugs Designed for the Selective Treatment of Solid Tumors in Prodrug Monotherapy

Thibaut Legigan , Jonathan Clarhaut , Isabelle Tranoy-Opalinski , Arnaud Monvoisin , Brigitte Renoux et al.
Angewandte Chemie International Edition, 2012, 51, pp.1 - 6. ⟨10.1002/anie.201204935⟩
Article dans une revue istex hal-00736090 v1

Synthesis and Antitumor Efficacy of a β-Glucuronidase-Responsive Albumin-Binding Prodrug of Doxorubicin.

Thibaut Legigan , Jonathan Clarhaut , Brigitte Renoux , Isabelle Tranoy-Opalinski , Arnaud Monvoisin et al.
Journal of Medicinal Chemistry, 2012, 55 (9), pp.4516-20. ⟨10.1021/jm300348r⟩
Article dans une revue hal-00710692 v1

Down-regulation of Connexin43 expression reveals the involvement of caveolin-1 containing lipid rafts in human U251 glioblastoma cell invasion.

Pierre-Olivier Strale , Jonathan Clarhaut , Coralie Lamiche , Laurent Cronier , Marc Mesnil et al.
Molecular Carcinogenesis, 2012, 51 (11), pp.845-60. ⟨10.1002/mc.20853⟩
Article dans une revue istex hal-00993046 v1

A self-immolative dendritic glucuronide prodrug of doxorubicin

Marion Grinda , J. Clarhaut , Brigitte Renoux , Isabelle Tranoy-Opalinski , Sébastien Papot
MedChemComm, 2012, 3 (1), pp.68-70. ⟨10.1039/c1md00193k⟩
Article dans une revue hal-00682705 v1
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The vitamin K–dependent anticoagulant factor, protein S, inhibits multiple VEGF-A–induced angiogenesis events in a Mer- and SHP2-dependent manner

Sylvain Fraineau , Arnaud Monvoisin , Jonathan Clarhaut , Julie Talbot , Claire Simonneau et al.
Blood, 2012, 120 (25), pp.5073-5083. ⟨10.1182/blood-2012-05-429183⟩
Article dans une revue inserm-02444598 v1

The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells.

Coralie Lamiche , Jonathan Clarhaut , Pierre-Olivier Strale , Sophie Crespin , Nathalie Pedretti et al.
Clinical and Experimental Metastasis, 2012, 29 (2), pp.111-22. ⟨10.1007/s10585-011-9434-4⟩
Article dans une revue istex hal-00993073 v1

A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier

Marion Grinda , Jonathan Clarhaut , Isabelle Tranoy-Opalinski , Brigitte Renoux , Arnaud Monvoisin et al.
ChemMedChem, 2011, 6 (12), pp.2137-2141. ⟨10.1002/cmdc.201100355⟩
Article dans une revue (data paper) istex hal-04033576 v1

Effect of endothelin-1 on osteoblastic differentiation is modified by the level of connexin43: comparative study on calvarial osteoblastic cells isolated from Cx43+/- and Cx43+/+ mice.

Graziello Geneau , Coralie Lamiche , Corinne Niger , Pierre-Olivier Strale , Jonathan A. Clarhaut et al.
Cell and Tissue Research, 2010, 340 (1), pp.103-15. ⟨10.1007/s00441-009-0924-5⟩
Article dans une revue istex hal-00498245 v1

ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells.

Jonathan A. Clarhaut , Robert M. Gemmill , Vincent A. Potiron , Slimane Ait-Si-Ali , Jean Imbert et al.
Neoplasia, 2009, 11 (2), pp.157-166. ⟨10.1593/neo.81074⟩
Article dans une revue hal-00416521 v1

Synthesis and Modeling of New Benzofuranone Histone Deacetylase Inhibitors that Stimulate Tumor Suppressor Gene Expression

Cédric Charrier , Jonathan A. Clarhaut , Jean-Pierre Gesson , Guillermina Estiu , Olaf Wiest et al.
Journal of Medicinal Chemistry, 2009, 52, pp.3112-3115
Article dans une revue hal-00438795 v1

Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy.

Mickaël Thomas , Jonathan A. Clarhaut , Isabelle Tranoy-Opalinski , Jean-Pierre Gesson , Joëlle Roche et al.
Bioorganic and Medicinal Chemistry, 2008, 16 (17), pp.8109-8116. ⟨10.1016/j.bmc.2008.07.048⟩
Article dans une revue istex hal-00458881 v1

Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker?

Lucie Karayan-Tapon , Michel Wager , Joëlle Guilhot , Pierre Levillain , C. Marquant et al.
British Journal of Cancer, 2008, 99 (7), pp.1153-1160. ⟨10.1038/sj.bjc.6604641⟩
Article dans une revue hal-00458867 v1

Semaphorin SEMA3F affects multiple signaling pathways in lung cancer cells

Vincent A. Potiron , Girish Sharma , Patrick Nasarre , Jonathan A. Clarhaut , Hellmut G. Augustin et al.
Cancer Research, 2007, 67 (18), pp.8708-8715. ⟨10.1158/0008-5472.CAN-06-3612⟩
Article dans une revue hal-00416414 v1

semaphorins in lung cancer

J. Clarhaut , J. Roche , H.A. Drabkin
Journal of Thoracic Oncology, 2006, 1, pp.203-204
Article dans une revue hal-00078139 v1

Enhancement of amphotericin B activity against Cryptococcus neoformans using lipid nanoparticles

Kévin Brunet , Jonathan Clarhaut , Adrien Baillod , Sandrine Marchand , Frederic Tewes
33rd ECCMID : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark
Communication dans un congrès hal-04142666 v1