Laurent Désaubry

93
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Publications

Publications

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Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination

Emma R. Wilson , Gustavo Della‐flora Nunes , Shichen Shen , Seth Moore , Joseph Gawron et al.
Article dans une revue hal-04736471 v1
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The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation

Catherine Petit , Céline Stutz , Pierre-yves Gegout , Chloé Bloch , Hayriye Özcelik et al.
BMC Oral Health, 2024, 24, ⟨10.1186/s12903-024-05209-2⟩
Article dans une revue hal-04878792 v1
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Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo

Junmei Liu , Ranran Zhang , Tong Su , Qianqian Zhou , Lin Gao et al.
Journal of experimental & clinical cancer research, 2023, 42 (1), ⟨10.1186/s13046-023-02695-0⟩
Article dans une revue hal-04268973 v1
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eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma

Sara M. Steinmann , Anabel Sánchez-Martín , Elisabeth Tanzer , Antonio Cigliano , Giovanni M. Pes et al.
International Journal of Molecular Sciences, 2023, 24 (3), pp.2055. ⟨10.3390/ijms24032055⟩
Article dans une revue hal-04268974 v1
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Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL

Anne Largeot , Vanessa Klapp , Elodie Viry , Susanne Gonder , Iria Fernandez Botana et al.
Blood, 2023, 141 (26), ⟨10.1182/blood.2022017839⟩
Article dans une revue hal-04270267 v1
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Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies

Ahmad Najem , Mohammad Krayem , Serena Sabbah , Matilde Pesetti , Fabrice Journe et al.
Cells, 2023, 12 (14), pp.1855. ⟨10.3390/cells12141855⟩
Article dans une revue hal-04268975 v1
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Triazine-Based Small Molecules: A Potential New Class of Compounds in the Antifungal Toolbox

Karen A. Conrad , Hyunjeong Kim , Mohammad Qasim , Amel Djehal , Aaron D. Hernday et al.
Pathogens, 2023, 12 (1), pp.126. ⟨10.3390/pathogens12010126⟩
Article dans une revue hal-03942199 v1

Therapeutic Potential of Targeting Prokineticin Receptors in Diseases

Martina Vincenzi , Amin Kremić , Appoline Jouve , Roberta Lattanzi , Rossella Miele et al.
Pharmacological Reviews, 2023, 75 (6), pp.1167-1199. ⟨10.1124/pharmrev.122.000801⟩
Article dans une revue (article de synthèse) hal-04534273 v1
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Therapeutic Potential of Targeting Prokineticin Receptors in Diseases

Martina Vincenzi , Amin Kremić , Appoline Jouve , Roberta Lattanzi , Rossella Miele et al.
Pharmacological Reviews, 2023, 75 (6), pp.1167-1199. ⟨10.1124/pharmrev.122.000801⟩
Article dans une revue hal-04270268 v1
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The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA

Ann Kari Grindheim , Sudarshan S. Patil , Canan Nebigil , Laurent Désaubry , Anni Vedeler
Frontiers in Cell and Developmental Biology, 2023, 11, ⟨10.3389/fcell.2023.1094941⟩
Article dans une revue hal-04268976 v1
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Non-classical ferroptosis inhibition by a small molecule targeting PHB2

Wei Yang , Bo Mu , Jing You , Chenyu Tian , Huachao Bin et al.
Nature Communications, 2022, 13 (1), ⟨10.1038/s41467-022-35294-2⟩
Article dans une revue hal-03942198 v1
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Development of fluorizoline analogues as prohibitin ligands that modulate C-RAF signaling, p21 expression and melanogenesis

Nora Chouha , Hussein Abou Hamdan , Hajime Yurugi , Riku Yoshii , Hiromi Ii et al.
European Journal of Medicinal Chemistry, 2022, 242, pp.114635. ⟨10.1016/j.ejmech.2022.114635⟩
Article dans une revue hal-03806694 v1
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Flavaglines: Their Discovery from Plants Used in Traditional Chinese Medicine, Synthesis, and Drug Development Against Cancer and Immune Disorders

Dong Wang , Mustafa Ali Tezeren , Hussein Abou Hamdan , Peng Yu , Canan Nebigil-Désaubry et al.
Current Chinese Chemistry, 2022, 2 (2), ⟨10.2174/2666001601666211126091737⟩
Article dans une revue hal-03806707 v1
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Development of prohibitin ligands against osteoporosis

Redouane Tabti , François Lamoureux , Céline Charrier , Benjamin Ory , Dominique Heymann et al.
European Journal of Medicinal Chemistry, 2021, 210, pp.112961. ⟨10.1016/j.ejmech.2020.112961⟩
Article dans une revue hal-03420106 v1
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Fluorizoline Blocks the Interaction between Prohibitin-2 and γ -Glutamylcyclotransferase and Induces p21 Waf1/Cip1 Expression in MCF7 Breast Cancer Cells

Hiroko Takagi , Chiami Moyama , Keiko Taniguchi , Kota Ando , Ryohei Matsuda et al.
Molecular Pharmacology, 2021, 101 (2), pp.78-86. ⟨10.1124/molpharm.121.000334⟩
Article dans une revue hal-03809849 v1
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Updates on Anticancer Therapy-Mediated Vascular Toxicity and New Horizons in Therapeutic Strategies

Po-Yen Hsu , Aynura Mammadova , Nadia Benkirane-Jessel , Laurent Désaubry , Canan Nebigil
Frontiers in Cardiovascular Medicine, 2021, 8, ⟨10.3389/fcvm.2021.694711⟩
Article dans une revue hal-03373354 v1

Updates on Anticancer Therapy-Mediated Vascular Toxicity and New Horizons in Therapeutic Strategies

Po-Yen Hsu , Aynura Mammadova , Nadia Benkirane-Jessel , Laurent Désaubry , Canan Nebigil
Frontiers in Cardiovascular Medicine, 2021, 8, ⟨10.3389/fcvm.2021.694711⟩
Article dans une revue hal-03439172 v1
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Prohibitin Inactivation in Adipocytes Results in Reduced Lipid Metabolism and Adaptive Thermogenesis Impairment

Zhanguo Gao , Alexes C Daquinag , Cale Fussell , Amel Djehal , Laurent Désaubry et al.
Diabetes, 2021, 70 (10), pp.2204-2212. ⟨10.2337/db21-0094⟩
Article dans une revue hal-03374098 v1
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Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells

Tharcisio Citrangulo Tortelli , Rodrigo Esaki Tamura , Mara de Souza Junqueira , Janio da Silva Mororó , Silvina Odete Bustos et al.
Aging, 2021, 13 (18), pp.21914-21940. ⟨10.18632/aging.203528⟩
Article dans une revue hal-03400765 v1
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Recent Advances in the Synthesis of C2‐Functionalized Pyridines and Quinolines Using N ‐Oxide Chemistry

Dong Wang , Laurent Désaubry , Gaoyu Li , Mindong Huang , Shixin Zheng
Advanced Synthesis and Catalysis, In press, ⟨10.1002/adsc.202000910⟩
Article dans une revue hal-03028714 v1

Development of prohibitin ligands against osteoporosis

Redouane Tabti , François Lamoureux , Céline Charrier , Benjamin Ory , Dominique Heymann et al.
European Journal of Medicinal Chemistry, 2020, pp.112961. ⟨10.1016/j.ejmech.2020.112961⟩
Article dans une revue hal-03004271 v1
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Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Canan G Nebigil , Christiane Moog , Stéphan Vagner , Nadia Benkirane-Jessel , Duncan R Smith et al.
European Journal of Medicinal Chemistry, 2020, 203, pp.112653. ⟨10.1016/j.ejmech.2020.112653⟩
Article dans une revue hal-02996744 v1
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Targeting GPCRs Against Cardiotoxicity Induced by Anticancer Treatments

Anais Audebrand , Laurent Désaubry , Canan G Nebigil
Frontiers in Cardiovascular Medicine, 2020, 6, pp.194. ⟨10.3389/fcvm.2019.00194⟩
Article dans une revue hal-02996608 v1
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The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis

Xin Jin , Jianling Xie , Michael Zabolocki , Xuemin Wang , Tao Jiang et al.
Journal of Biological Chemistry, 2020, 295 (29), pp.9855 - 9867. ⟨10.1074/jbc.ra120.012979⟩
Article dans une revue hal-03415943 v1
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Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes

Ezeddine Harmouch , Joseph Seitlinger , Hassan Chaddad , Geneviève Ubeaud-Sequier , Jochen Barths et al.
Scientific Reports, 2020, 10 (1), pp.13750. ⟨10.1038/s41598-020-70820-6⟩
Article dans une revue hal-03018022 v1

Discovery of 3,3′-pyrrolidinyl-spirooxindoles as cardioprotectant prohibitin ligands

Sabria Elderwish , Anaïs Audebrand , Canan G Nebigil , Laurent Désaubry
European Journal of Medicinal Chemistry, 2020, 186, pp.111859. ⟨10.1016/j.ejmech.2019.111859⟩
Article dans une revue hal-02996582 v1
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SFPH proteins as therapeutic targets for a myriad of diseases

Dong Wang , Redouane Tabti , Sabria Elderwish , Amel Djehal , Nora Chouha et al.
Bioorganic and Medicinal Chemistry Letters, 2020, 30 (22), pp.127600. ⟨10.1016/j.bmcl.2020.127600⟩
Article dans une revue hal-03092105 v1
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A subset of flavaglines inhibits KRAS nanoclustering and activation

Hajime Yurugi , Yinyin Zhuang , Farid A Siddiqui , Hong Liang , Sebastian Rosigkeit et al.
Journal of Cell Science, 2020, 133 (12), pp.jcs244111. ⟨10.1242/jcs.244111⟩
Article dans une revue hal-02996708 v1
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Prokineticin signaling in heart-brain developmental axis: Therapeutic options for heart and brain injuries

Laurent Désaubry , Anumantha G Kanthasamy , Canan G Nebigil
Pharmacological Research, 2020, 160, pp.105190. ⟨10.1016/j.phrs.2020.105190⟩
Article dans une revue hal-03014835 v1
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One-Pot Selective Saturation and Functionalization of Heteroaromatics Leading to Dihydropyridines and Dihydroquinolines

Dong Wang , Yuanyang Jiang , Linru Dong , Gaoyu Li , Baoying Sun et al.
Journal of Organic Chemistry, 2020, 85 (7), pp.5027 - 5037. ⟨10.1021/acs.joc.0c00314⟩
Article dans une revue hal-02996680 v1
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The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis

Xin Jin , Jianling Xie , Michael Zabolocki , Xuemin Wang , Tao Jiang et al.
Journal of Biological Chemistry, 2020, 295 (29), pp.9855 - 9867. ⟨10.1074/jbc.ra120.012979⟩
Article dans une revue hal-03413807 v1
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Unexpected Inversion of Configuration During the Carbamoylation of 1-Azaflavaglines

Hussein Abou-Hamdan , Laurent Désaubry
SYNLETT, 2020, 31 (20), pp.2023-2026. ⟨10.1055/s-0040-1707277⟩
Article dans une revue hal-03373324 v1
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Recent advances in the synthesis of 2,3-dihydropyrroles

Dong Wang , Yu Fan , Peng Yu , Laurent Désaubry
Chemical Communications, 2020, 56 (42), pp.5584-5592. ⟨10.1039/D0CC02096F⟩
Article dans une revue hal-02996692 v1
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Accessing 1,8‐Naphthyridones by Metal‐Free Regioselective Amination of Pyridine N ‐oxides/Acid‐Mediated Cyclization

Lianbo Zhao , Lei Hao , Yupeng Fu , Yan Cheng , Guojun Pan et al.
Advanced Synthesis and Catalysis, 2020, 362 (18), pp.3841-3845. ⟨10.1002/adsc.202000769⟩
Article dans une revue hal-02996754 v1
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The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling

Dakota N Jackson , Kibrom M Alula , Yaritza Delgado-Deida , Redouane Tabti , Kevin Turner et al.
Cancer Research, 2020, 80 (17), pp.3519-3529. ⟨10.1158/0008-5472.CAN-20-0216⟩
Article dans une revue hal-02996732 v1
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Prohibitin, STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria

Carolin Ploeger , Thorben Huth , Raisatun Nisa Sugiyanto , Stefan Pusch , Benjamin Goeppert et al.
Cell Death and Disease, 2020, 11 (11), ⟨10.1038/s41419-020-03220-3⟩
Article dans une revue hal-03032751 v1
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An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

Shensi Shen , Sara Faouzi , Amandine Bastide , Sylvain Martineau , Hélène Malka-Mahieu et al.
Nature Communications, 2019, 10 (1), pp.5713. ⟨10.1038/s41467-019-13360-6⟩
Article dans une revue hal-02418638 v1
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The role of GPCR signaling in cardiac Epithelial to Mesenchymal Transformation (EMT)

Canan G Nebigil , Laurent Désaubry
Trends in Cardiovascular Medicine, 2019, 29 (4), pp.200-204. ⟨10.1016/j.tcm.2018.08.007⟩
Article dans une revue hal-03014893 v1
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Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles

Dong Wang , Xinyue Ma , Linru Dong , Hairong Feng , Peng Yu et al.
Frontiers in Chemistry, 2019, 7, ⟨10.3389/fchem.2019.00810⟩
Article dans une revue hal-02996593 v1
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The synthetic flavagline FL3 spares normal human skin cells from its cytotoxic effect via an activation of Bad

Fathi Emhemmed , Sarah Ali Azouaou , Sarah Hassan , Ray Lefevbre , Laurent Desaubry et al.
Toxicology in Vitro, 2019, 60, pp.27-35. ⟨10.1016/j.tiv.2019.04.025⟩
Article dans une revue hal-03033544 v1

Correction to: The mTOR-S6 kinase pathway promotes stress granule assembly

Aristeidis Sfakianos , Laura Mellor , Yoke Fei Pang , Paraskevi Kritsiligkou , Hope Needs et al.
Cell Death and Differentiation, 2019, ⟨10.1038/s41418-019-0438-y⟩
Article dans une revue hal-02361047 v1

An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

Shensi Shen , Sara Faouzi , Amandine Bastide , Sylvain Martineau , Hélène Malka-Mahieu et al.
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-13360-6⟩
Article dans une revue hal-02996564 v1
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Prokineticin Receptor-1 Signaling Inhibits Dose- and Time-Dependent Anthracycline-Induced Cardiovascular Toxicity Via Myocardial and Vascular Protection

Adeline Gasser , Yue-Wen Chen , Anais Audebrand , Ayhan Daglayan , Marine Charavin et al.
JACC: CardioOncology, 2019, 1 (1), pp.84-102. ⟨10.1016/j.jaccao.2019.06.003⟩
Article dans une revue hal-03092065 v1

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

Chaojun Yan , Longlong Gong , Li Chen , Meng Xu , Hussein Abou-Hamdan et al.
Autophagy, 2019, pp.1-16. ⟨10.1080/15548627.2019.1628520⟩
Article dans une revue hal-02361056 v1
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Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer

Marine F Garrido , Nicolas J.-P. Martin , Matthieu Bertrand , Catherine Gaudin , Frédéric Commo et al.
Clinical Cancer Research, 2019, 25 (2), pp.710-723. ⟨10.1158/1078-0432.CCR-18-0704⟩
Article dans une revue hal-03210950 v1
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Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects

Hafidha Bentayeb , Marine Aitamer , Barbara Petit , Lydie Dubanet , Sabria Elderwish et al.
Journal of experimental & clinical cancer research, 2019, 38 (1), ⟨10.1186/s13046-019-1440-4⟩
Article dans une revue hal-02361081 v1

Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes

Matthew Neal , Jie Luo , Dilshan Harischandra , Richard Gordon , Souvarish Sarkar et al.
Glia, 2018, 66 (10), pp.2137-2157. ⟨10.1002/glia.23467⟩
Article dans une revue hal-02361086 v1
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Updates in Anthracycline-Mediated Cardiotoxicity

Canan G Nebigil , Laurent Désaubry
Frontiers in Pharmacology, 2018, 9, pp.1262. ⟨10.3389/fphar.2018.01262⟩
Article dans une revue hal-01935306 v1

The synthetic flavagline FL3 protects against colitis-associated cancer via inhibition of wnt/beta-catenin signaling

Dn Jackson , J Han , Hussein Abou Hamdan , Laurent Désaubry , Xf Huo et al.
Gastroenterology, 2018, 154 (6)
Article dans une revue hal-04835052 v1

Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells

Amel Djehal , Mohammad Krayem , Ahmad Najem , Hassan Hammoud , Thierry Cresteil et al.
European Journal of Medicinal Chemistry, 2018, 155, pp.880-888. ⟨10.1016/j.ejmech.2018.06.052⟩
Article dans une revue hal-02361593 v1
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The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model

Marina Wierz , Sandrine Pierson , Nora Chouha , Laurent Désaubry , Jean-Hugues François et al.
Haematologica, 2018, 103 (4), pp.e154-e157. ⟨10.3324/haematol.2017.175349⟩
Article dans une revue hal-02361624 v1
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The mTOR-S6 kinase pathway promotes stress granule assembly

Aristeidis Sfakianos , Laura Mellor , Yoke Fei Pang , Paraskevi Kritsiligkou , Hope Needs et al.
Cell Death and Differentiation, 2018, 25 (10), pp.1766-1780. ⟨10.1038/s41418-018-0076-9⟩
Article dans une revue hal-02361603 v1

Targeting a Gpcr, Prokineticin Receptor-1, Protects Heart Against Doxorubicin-Mediated Cardiotoxicity

Canan G Nebigil , Adeline Gasser , Marine Charavin , Brigitte Escoubet , Anais Audebrand et al.
Circulation, 2018, 138
Article dans une revue hal-04835044 v1

Emergence of cardio-oncology

Canan G Nebigil , L. Desaubry
Annales Pharmaceutiques Françaises, 2018, 76 (6), pp.504-506. ⟨10.1016/j.pharma.2018.06.003⟩
Article dans une revue hal-02361588 v1

Translational control of tumor immune escape via the eIF4F–STAT1–PD-L1 axis in melanoma

Michael Cerezo , Ramdane Guemiri , Sabine Druillennec , Isabelle Girault , Hélène Malka-Mahieu et al.
Nature Medicine, 2018, 24 (12), pp.1877-1886. ⟨10.1038/s41591-018-0217-1⟩
Article dans une revue hal-02361063 v1
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CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts

Ricardos Tabet , Laure Schaeffer , Fernande Freyermuth , Melanie Jambeau , Michael Workman et al.
Nature Communications, 2018, 9 (1), pp.152. ⟨10.1038/s41467-017-02643-5⟩
Article dans une revue hal-02361614 v1
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Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2

Hussein Abou-Hamdan , Laurent Désaubry
Journal of Organic Chemistry, 2018, 83 (5), pp.2954-2958. ⟨10.1021/acs.joc.7b03009⟩
Article dans une revue hal-01830554 v1
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Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway

Gangjun Yuan , Xin Chen , Zhuowei Liu , Wensu Wei , Qinghai Shu et al.
Journal of experimental & clinical cancer research, 2018, 37 (1), ⟨10.1186/s13046-018-0695-5⟩
Article dans une revue hal-02361608 v1
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Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles

Dong Wang , Linna Li , Hairong Feng , Hua Sun , Fabrice Almeida-Veloso et al.
Green Chemistry, 2018, 20 (12), pp.2775-2780. ⟨10.1039/C8GC00987B⟩
Article dans une revue hal-01829592 v1

Abstract IA29: Role of eIF4F in anticancer drug resistance

Galina Boldina , Maricarmen Vallejos , Delphine Allard , Isabelle Girault , Hélène Malka-Mahieu et al.
Cancer Research, 2017, 77 (6_Supplement), pp.IA29-IA29. ⟨10.1158/1538-7445.Transcontrol16-IA29⟩
Article dans une revue hal-04833132 v1

Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment

Hélène Malka-Mahieu , Michelle Newman , Laurent Désaubry , Caroline Robert , Stéphan Vagner
Clinical Cancer Research, 2017, 23 (1), pp.21-25. ⟨10.1158/1078-0432.CCR-14-2362⟩
Article dans une revue hal-03533702 v1

Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells

Fathi Emhemmed , Sarah Ali Azouaou , Qian Zhao , Aline Appert-Collin , Amar Bennasroune et al.
Cell Biology and Toxicology, 2017, 33 (3), pp.295-306. ⟨10.1007/s10565-016-9375-4⟩
Article dans une revue hal-02106909 v1

Flavaglines Ameliorate Experimental Colitis and Protect Against Intestinal Epithelial Cell Apoptosis and Mitochondrial Dysfunction:

Jie Han , Qian Zhao , Christine Basmadjian , Laurent Désaubry , Arianne L. Theiss
Inflammatory Bowel Diseases, 2016, 22 (1), pp.55-67. ⟨10.1097/MIB.0000000000000592⟩
Article dans une revue hal-03536459 v1

Bioisosteric modification of flavaglines

Qian Zhao , Annemilaï Tijeras-Raballand , Armand de Gramont , Eric Raymond , Laurent Désaubry
Tetrahedron Letters, 2016, 57 (26), pp.2943-2944. ⟨10.1016/j.tetlet.2016.05.089⟩
Article dans une revue hal-03533709 v1

Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines

Hélène Malka-Mahieu , Isabelle Girault , Margot Rubington , Melissa Leriche , Caroline Welsch et al.
Cell Cycle, 2016, 15 (18), pp.2405-2409. ⟨10.1080/15384101.2016.1208862⟩
Article dans une revue hal-03536458 v1

A General and Efficient Synthesis of 2-Pyridones, 2-Quinolinones, and 1-Isoquinolinones from Azine N -Oxides

Dong Wang , Junjie Zhao , Yuxi Wang , Jianyong Hu , Linna Li et al.
Asian Journal of Organic Chemistry, 2016, 5 (12), pp.1442-1446. ⟨10.1002/ajoc.201600430⟩
Article dans une revue istex hal-03536473 v1

Recent Advances in the Synthesis of Flavaglines, a Family of Potent Bioactive Natural Compounds Originating from Traditional Chinese Medicine

Qian Zhao , Hussein Abou Hamdan , Laurent Désaubry
European Journal of Organic Chemistry, 2016, 2016 (36), pp.5908-5916. ⟨10.1002/ejoc.201600437⟩
Article dans une revue istex hal-03533707 v1

Synthesis of hydroxybenzofurans by condensation of quinones with benzoylacetone: revised structure of the adducts

Hassan Hammoud , Qian Zhao , Laurent Désaubry
Tetrahedron Letters, 2016, 57 (36), pp.4044-4045. ⟨10.1016/j.tetlet.2016.07.074⟩
Article dans une revue hal-03536456 v1
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FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity

Rehana Qureshi , Onur Yildirim , Adeline Gasser , Christine Basmadjian , Qian Zhao et al.
PLoS ONE, 2015, 10 (11), pp.e0141826. ⟨10.1371/journal.pone.0141826⟩
Article dans une revue hal-02391039 v1

Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1

Adeline Gasser , Simone Brogi , Kyoji Urayama , Toshishide Nishi , Hitoshi Kurose et al.
PLoS ONE, 2015, 10 (4), pp.e0121027. ⟨10.1371/journal.pone.0121027⟩
Article dans une revue hal-02391041 v1

Cancer wars: natural products strike back

Christine Basmadjian , Qian Zhao , Embarek Bentouhami , Amel Djehal , Canan G Nebigil et al.
Frontiers in Chemistry, 2014, 2, ⟨10.3389/fchem.2014.00020⟩
Article dans une revue hal-02391047 v1

Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway

Fathi Emhemmed , Sarah Ali Azouaou , Frédéric Thuaud , Valerie Schini-Kerth , Laurent Désaubry et al.
Biochemical Pharmacology, 2014, 89 (2), pp.185-196. ⟨10.1016/j.bcp.2014.02.020⟩
Article dans une revue hal-02106955 v1

Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.

F. Emhemmed , S. Ali Azouaou , F. Thuand , V. Schini-Kerth , L. Desaubry et al.
Biochemical Pharmacology, 2014, 89, pp.185-196
Article dans une revue hal-01065063 v1

N -[3a-(4-Bromophenyl)-8b-hydroxy-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1 H -cyclopenta[ b ]benzofuran-1-yl]formamide monohydrate

Emmanuel Aubert , Frédéric Thuaud , Nigel Ribeiro , Laurent Désaubry , Enrique Espinosa
Acta Crystallographica Section E : Structure Reports Online [2001-2014], 2013, 69 (1), pp.o52 - o53. ⟨10.1107/S1600536812049641⟩
Article dans une revue hal-01521958 v1

Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential

Frédéric Thuaud , Nigel Ribeiro , Canan G Nebigil , Laurent Désaubry
Chemistry & biology, 2013, 20 (3), pp.316-331. ⟨10.1016/j.chembiol.2013.02.006⟩
Article dans une revue hal-02391060 v1

Recent advances in the biology and chemistry of the flavaglines

Nigel Ribeiro , Frédéric Thuaud , Canan G Nebigil , Laurent Désaubry
Bioorganic and Medicinal Chemistry Letters, 2012, 20 (6), pp.1857-1864. ⟨10.1016/j.bmc.2011.10.048⟩
Article dans une revue istex hal-02391066 v1

Flavaglines as potent anticancer and cytoprotective agents.

Nigel Ribeiro , Frédéric Thuaud , Yohann Bernard , Christian Gaiddon , Thierry Cresteil et al.
Journal of Medicinal Chemistry, 2012, 55 (22), pp.10064-73. ⟨10.1021/jm301201z⟩
Article dans une revue hal-00765387 v1
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Cytochromes P450 CYP94C1 and CYP94B3 catalyze two successive oxidation steps of the plant hormone jasmonoyl-isoleucine for catabolic turnover

T. Heitz , E. Widemann , R. Lugan , L. Miesch , P. Ullmann et al.
Journal of Biological Chemistry, 2012, 287 (9), pp.6296-6306. ⟨10.1074/jbc.M111.316364⟩
Article dans une revue hal-00680337 v1

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27

Yohann Bernard , Nigel Ribeiro , Frédéric Thuaud , Gülen Türkeri , Ronan Dirr et al.
PLoS ONE, 2011, 6 (10), pp.e25302. ⟨10.1371/journal.pone.0025302⟩
Article dans une revue hal-02391070 v1

Novel Flavaglines Displaying Improved Cytotoxicity.

Frédéric Thuaud , Nigel Ribeiro , Christian Gaiddon , Thierry Cresteil , Laurent Désaubry
Journal of Medicinal Chemistry, 2010, 54 (1), pp.411-415. ⟨10.1021/jm101318b⟩
Article dans une revue hal-00572526 v1

Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12

Frédéric Thuaud , Yohann Bernard , Gülen Türkeri , Ronan Dirr , Geneviève Aubert et al.
Journal of Medicinal Chemistry, 2009, 52 (16), pp.5176-5187. ⟨10.1021/jm900365v⟩
Article dans une revue hal-02391094 v1

Synthesis and biological evaluation of PEG-tirofiban conjugates

Laurent Désaubry , Stéphanie Riché , Patricia Laeuffer , Jean-Pierre Cazenave
Bioorganic and Medicinal Chemistry Letters, 2008, 18 (6), pp.2028-2031. ⟨10.1016/j.bmcl.2008.01.118⟩
Article dans une revue istex hal-04724806 v1

Synthesis of 3-O-methylviridicatin analogues with improved anti-TNF-α properties

Nigel Ribeiro , Helena Tabaka , Jean Peluso , Ludivine Fetzer , Canan G Nebigil et al.
Bioorganic and Medicinal Chemistry Letters, 2007, 17 (20), pp.5523-5524. ⟨10.1016/j.bmcl.2007.08.036⟩
Article dans une revue istex hal-02391115 v1

Reinforcing effect of bi- and tri-cyclopolyprenols on ‘primitive' membranes made of polyprenyl phosphates.

N. Ribeiro , S. Streiff , D. Heissler , M. Elhabiri , A.M. Albrecht-Gary et al.
Tetrahedron, 2007, 63, pp.3395-3407
Article dans une revue hal-00139371 v1

Looking forward : a glance into the future of organic chemistry

Philippe Compain , Valérie Desvergnes , Cyril Ollivier , Frédéric Robert , Franck Suzenet et al.
New Journal of Chemistry, 2006, 30 (6), pp.823-831. ⟨10.1039/B601837H⟩
Article dans une revue istex hal-00158370 v1

Future alchemy: account of the ESYOP experiment

Philippe Compain , Valérie Desvergnes , Cyril Ollivier , Frédéric Robert , Franck Suzenet et al.
Comptes Rendus. Chimie, 2006, 9, pp.127-140. ⟨10.1016/j.crci.2005.09.004⟩
Article dans une revue istex hal-00158010 v1

Palladium catelysed arylation of 6,8-dimethoxybenzofuranone.

A. Sani Souna Sido , L. Boulenger , L. Desaubry
Tetrahedron Letters, 2005, 46, pp.8017-8018
Article dans une revue hal-00129976 v1

Concise synthesis and voltammetric studies of dielsiquinone, a cytotoxic azaanthraquinone.

A. Brisach-Wittmeyer , A. Sani Souna Sido , P. Guilini , L. Desaubry
Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.3609-3610
Article dans une revue hal-00129824 v1

Unexpected cleavage of tetrahydrofuran by catalytic reductive lithiation

S. Streiff , N. Ribeiro , L. Desaubry
Chemical Communications, 2004, pp.346-347
Article dans une revue hal-00167410 v1

Synthesis of allylsilanes by reductive lithiation of thioethers.

S. Streiff , N. Ribeiro , L. Desaubry
Journal of Organic Chemistry, 2004, 69, pp.7592-7598
Article dans une revue hal-00167414 v1

Cardioprotective effect of non-peptidic pkr1 agonist against anthracycline-cardiotoxicity

Adeline Gasser , Marine Charavin , Brigitte Escoubet , Nadia Messaddeq , Laurent Désaubry et al.
Heart Failure 2017 and the 4th World Congress on Acute Heart Failure, Paris, France, 29 April – 2 May 2017, May 2017, Paris, France. pp.511-511
Communication dans un congrès hal-04837835 v1