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Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies
Ahmad Najem
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Mohammad Krayem
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Serena Sabbah
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Matilde Pesetti
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Fabrice Journe
Article dans une revue
hal-04268975v1
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Triazine-Based Small Molecules: A Potential New Class of Compounds in the Antifungal Toolbox
Karen A. Conrad
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Hyunjeong Kim
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Mohammad Qasim
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Amel Djehal
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Aaron D. Hernday
Article dans une revue
hal-03942199v1
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eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma
Sara M. Steinmann
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Anabel Sánchez-Martín
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Elisabeth Tanzer
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Antonio Cigliano
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Giovanni M. Pes
Article dans une revue
hal-04268974v1
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Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo
Junmei Liu
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Ranran Zhang
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Tong Su
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Qianqian Zhou
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Lin Gao
Article dans une revue
hal-04268973v1
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Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL
Anne Largeot
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Vanessa Klapp
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Elodie Viry
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Susanne Gonder
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Iria Fernandez Botana
Article dans une revue
hal-04270267v1
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The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA
Ann Kari Grindheim
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Sudarshan S. Patil
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Canan Nebigil
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Laurent Désaubry
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Anni Vedeler
Article dans une revue
hal-04268976v1
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Therapeutic Potential of Targeting Prokineticin Receptors in Diseases
Martina Vincenzi
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Amin Kremić
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Appoline Jouve
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Roberta Lattanzi
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Rossella Miele
Article dans une revue
hal-04270268v1
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Development of fluorizoline analogues as prohibitin ligands that modulate C-RAF signaling, p21 expression and melanogenesis
Nora Chouha
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Hussein Abou Hamdan
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Hajime Yurugi
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Riku Yoshii
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Hiromi Ii
Article dans une revue
hal-03806694v1
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Non-classical ferroptosis inhibition by a small molecule targeting PHB2
Wei Yang
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Bo Mu
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Jing You
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Chenyu Tian
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Huachao Bin
Article dans une revue
hal-03942198v1
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Flavaglines: Their Discovery from Plants Used in Traditional Chinese Medicine, Synthesis, and Drug Development Against Cancer and Immune Disorders
Dong Wang
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Mustafa Ali Tezeren
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Hussein Abou Hamdan
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Peng Yu
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Canan Nebigil-Désaubry
Article dans une revue
hal-03806707v1
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Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells
Tharcisio Citrangulo Tortelli
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Rodrigo Esaki Tamura
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Mara de Souza Junqueira
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Janio da Silva Mororó
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Silvina Odete Bustos
Article dans une revue
hal-03400765v1
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Development of prohibitin ligands against osteoporosis
Redouane Tabti
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François Lamoureux
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Céline Charrier
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Benjamin Ory
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Dominique Heymann
Article dans une revue
hal-03420106v1
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Fluorizoline Blocks the Interaction between Prohibitin-2 and γ -Glutamylcyclotransferase and Induces p21 Waf1/Cip1 Expression in MCF7 Breast Cancer Cells
Hiroko Takagi
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Chiami Moyama
,
Keiko Taniguchi
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Kota Ando
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Ryohei Matsuda
Article dans une revue
hal-03809849v1
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Updates on Anticancer Therapy-Mediated Vascular Toxicity and New Horizons in Therapeutic Strategies
Po-Yen Hsu
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Aynura Mammadova
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Nadia Benkirane-Jessel
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Laurent Désaubry
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Canan Nebigil
Article dans une revue
hal-03373354v1
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Updates on Anticancer Therapy-Mediated Vascular Toxicity and New Horizons in Therapeutic Strategies
Po-Yen Hsu
,
Aynura Mammadova
,
Nadia Benkirane-Jessel
,
Laurent Désaubry
,
Canan Nebigil
Article dans une revue
hal-03439172v1
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Prohibitin Inactivation in Adipocytes Results in Reduced Lipid Metabolism and Adaptive Thermogenesis Impairment
Zhanguo Gao
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Alexes C Daquinag
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Cale Fussell
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Amel Djehal
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Laurent Désaubry
Article dans une revue
hal-03374098v1
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Discovery of 3,3′-pyrrolidinyl-spirooxindoles as cardioprotectant prohibitin ligands
Sabria Elderwish
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Anaïs Audebrand
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Canan G Nebigil
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Laurent Désaubry
Article dans une revue
hal-02996582v1
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Recent advances in the synthesis of 2,3-dihydropyrroles
Dong Wang
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Yu Fan
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Peng Yu
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Laurent Désaubry
Article dans une revue
hal-02996692v1
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Accessing 1,8‐Naphthyridones by Metal‐Free Regioselective Amination of Pyridine N ‐oxides/Acid‐Mediated Cyclization
Lianbo Zhao
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Lei Hao
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Yupeng Fu
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Yan Cheng
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Guojun Pan
Article dans une revue
hal-02996754v1
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One-Pot Selective Saturation and Functionalization of Heteroaromatics Leading to Dihydropyridines and Dihydroquinolines
Dong Wang
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Yuanyang Jiang
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Linru Dong
,
Gaoyu Li
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Baoying Sun
Article dans une revue
hal-02996680v1
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A subset of flavaglines inhibits KRAS nanoclustering and activation
Hajime Yurugi
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Yinyin Zhuang
,
Farid A Siddiqui
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Hong Liang
,
Sebastian Rosigkeit
Article dans une revue
hal-02996708v1
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Prokineticin signaling in heart-brain developmental axis: Therapeutic options for heart and brain injuries
Laurent Désaubry
,
Anumantha G Kanthasamy
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Canan G Nebigil
Article dans une revue
hal-03014835v1
|
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SFPH proteins as therapeutic targets for a myriad of diseases
Dong Wang
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Redouane Tabti
,
Sabria Elderwish
,
Amel Djehal
,
Nora Chouha
Article dans une revue
hal-03092105v1
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Recent Advances in the Synthesis of C2‐Functionalized Pyridines and Quinolines Using N ‐Oxide Chemistry
Dong Wang
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Laurent Désaubry
,
Gaoyu Li
,
Mindong Huang
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Shixin Zheng
Article dans une revue
hal-03028714v1
|
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Development of prohibitin ligands against osteoporosis
Redouane Tabti
,
François Lamoureux
,
Céline Charrier
,
Benjamin Ory
,
Dominique Heymann
Article dans une revue
hal-03004271v1
|
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Targeting GPCRs Against Cardiotoxicity Induced by Anticancer Treatments
Anais Audebrand
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Laurent Désaubry
,
Canan G Nebigil
Article dans une revue
hal-02996608v1
|
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Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
Ezeddine Harmouch
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Joseph Seitlinger
,
Hassan Chaddad
,
Geneviève Ubeaud-Sequier
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Jochen Barths
Article dans une revue
hal-03018022v1
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Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses
Canan G Nebigil
,
Christiane Moog
,
Stéphan Vagner
,
Nadia Benkirane-Jessel
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Duncan R Smith
Article dans une revue
hal-02996744v1
|
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The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis
Xin Jin
,
Jianling Xie
,
Michael Zabolocki
,
Xuemin Wang
,
Tao Jiang
Article dans une revue
hal-03415943v1
|
|
Prohibitin, STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria
Carolin Ploeger
,
Thorben Huth
,
Raisatun Nisa Sugiyanto
,
Stefan Pusch
,
Benjamin Goeppert
Article dans une revue
hal-03032751v1
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The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling
Dakota N Jackson
,
Kibrom M Alula
,
Yaritza Delgado-Deida
,
Redouane Tabti
,
Kevin Turner
Article dans une revue
hal-02996732v1
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Unexpected Inversion of Configuration During the Carbamoylation of 1-Azaflavaglines
Hussein Abou-Hamdan
,
Laurent Désaubry
Article dans une revue
hal-03373324v1
|
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The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis
Xin Jin
,
Jianling Xie
,
Michael Zabolocki
,
Xuemin Wang
,
Tao Jiang
Article dans une revue
hal-03413807v1
|
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Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles
Dong Wang
,
Xinyue Ma
,
Linru Dong
,
Hairong Feng
,
Peng Yu
Article dans une revue
hal-02996593v1
|
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Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer
Marine F Garrido
,
Nicolas J.-P. Martin
,
Matthieu Bertrand
,
Catherine Gaudin
,
Frédéric Commo
Article dans une revue
hal-03210950v1
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Prokineticin Receptor-1 Signaling Inhibits Dose- and Time-Dependent Anthracycline-Induced Cardiovascular Toxicity Via Myocardial and Vascular Protection
Adeline Gasser
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Yue-Wen Chen
,
Anais Audebrand
,
Ayhan Daglayan
,
Marine Charavin
Article dans une revue
hal-03092065v1
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An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
Shensi Shen
,
Sara Faouzi
,
Amandine Bastide
,
Sylvain Martineau
,
Hélène Malka-Mahieu
Article dans une revue
hal-02418638v1
|
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The role of GPCR signaling in cardiac Epithelial to Mesenchymal Transformation (EMT)
Canan G Nebigil
,
Laurent Désaubry
Article dans une revue
hal-03014893v1
|
|
Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects
Hafidha Bentayeb
,
Marine Aitamer
,
Barbara Petit
,
Lydie Dubanet
,
Sabria Elderwish
Article dans une revue
hal-02361081v1
|
|
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis
Chaojun Yan
,
Longlong Gong
,
Li Chen
,
Meng Xu
,
Hussein Abou-Hamdan
Article dans une revue
hal-02361056v1
|
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The mTOR-S6 kinase pathway promotes stress granule assembly
Aristeidis Sfakianos
,
Laura Mellor
,
Yoke Fei Pang
,
Paraskevi Kritsiligkou
,
Hope Needs
Article dans une revue
hal-02361603v1
|
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The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model
Marina Wierz
,
Sandrine Pierson
,
Nora Chouha
,
Laurent Désaubry
,
Jean-Hugues François
Article dans une revue
hal-02361624v1
|
|
Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells
Amel Djehal
,
Mohammad Krayem
,
Ahmad Najem
,
Hassan Hammoud
,
Thierry Cresteil
Article dans une revue
hal-02361593v1
|
|
Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2
Hussein Abou-Hamdan
,
Laurent Désaubry
Article dans une revue
hal-01830554v1
|
|
Translational control of tumor immune escape via the eIF4F–STAT1–PD-L1 axis in melanoma
Michael Cerezo
,
Ramdane Guemiri
,
Sabine Druillennec
,
Isabelle Girault
,
Hélène Malka-Mahieu
Article dans une revue
hal-02361063v1
|
|
Updates in Anthracycline-Mediated Cardiotoxicity
Canan G Nebigil
,
Laurent Désaubry
Article dans une revue
hal-01935306v1
|
|
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts
Ricardos Tabet
,
Laure Schaeffer
,
Fernande Freyermuth
,
Melanie Jambeau
,
Michael Workman
Article dans une revue
hal-02361614v1
|
|
Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes
Matthew Neal
,
Jie Luo
,
Dilshan Harischandra
,
Richard Gordon
,
Souvarish Sarkar
Article dans une revue
hal-02361086v1
|
|
Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway
Gangjun Yuan
,
Xin Chen
,
Zhuowei Liu
,
Wensu Wei
,
Qinghai Shu
Article dans une revue
hal-02361608v1
|
|
Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles
Dong Wang
,
Linna Li
,
Hairong Feng
,
Hua Sun
,
Fabrice Almeida-Veloso
Article dans une revue
hal-01829592v1
|
|
Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment
Hélène Malka-Mahieu
,
Michelle Newman
,
Laurent Désaubry
,
Caroline Robert
,
Stéphan Vagner
Article dans une revue
hal-03533702v1
|
|
Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells
Fathi Emhemmed
,
Sarah Ali Azouaou
,
Qian Zhao
,
Aline Appert-Collin
,
Amar Bennasroune
Article dans une revue
hal-02106909v1
|
|
Bioisosteric modification of flavaglines
Qian Zhao
,
Annemilaï Tijeras-Raballand
,
Armand de Gramont
,
Eric Raymond
,
Laurent Désaubry
Article dans une revue
hal-03533709v1
|
|
A General and Efficient Synthesis of 2-Pyridones, 2-Quinolinones, and 1-Isoquinolinones from Azine N -Oxides
Dong Wang
,
Junjie Zhao
,
Yuxi Wang
,
Jianyong Hu
,
Linna Li
Article dans une revue
hal-03536473v1
|
|
Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines
Hélène Malka-Mahieu
,
Isabelle Girault
,
Margot Rubington
,
Melissa Leriche
,
Caroline Welsch
Article dans une revue
hal-03536458v1
|
|
Flavaglines Ameliorate Experimental Colitis and Protect Against Intestinal Epithelial Cell Apoptosis and Mitochondrial Dysfunction:
Jie Han
,
Qian Zhao
,
Christine Basmadjian
,
Laurent Désaubry
,
Arianne L. Theiss
Article dans une revue
hal-03536459v1
|
|
Synthesis of hydroxybenzofurans by condensation of quinones with benzoylacetone: revised structure of the adducts
Hassan Hammoud
,
Qian Zhao
,
Laurent Désaubry
Article dans une revue
hal-03536456v1
|
|
Recent Advances in the Synthesis of Flavaglines, a Family of Potent Bioactive Natural Compounds Originating from Traditional Chinese Medicine
Qian Zhao
,
Hussein Abou Hamdan
,
Laurent Désaubry
Article dans une revue
hal-03533707v1
|
|
Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1
Adeline Gasser
,
Simone Brogi
,
Kyoji Urayama
,
Toshishide Nishi
,
Hitoshi Kurose
Article dans une revue
hal-02391041v1
|
|
FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity
Rehana Qureshi
,
Onur Yildirim
,
Adeline Gasser
,
Christine Basmadjian
,
Qian Zhao
Article dans une revue
hal-02391039v1
|
|
Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway
Christian D. Muller
,
Fathi Emhemmed
,
Sarah Ali Azouaou
,
Frédéric Thuaud
,
Valerie Schini-Kerth
Article dans une revue
hal-02106955v1
|
|
Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential
Frédéric Thuaud
,
Nigel Ribeiro
,
Canan G Nebigil
,
Laurent Désaubry
Article dans une revue
hal-02391060v1
|
|
N -[3a-(4-Bromophenyl)-8b-hydroxy-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1 H -cyclopenta[ b ]benzofuran-1-yl]formamide monohydrate
Emmanuel Aubert
,
Frédéric Thuaud
,
Nigel Ribeiro
,
Laurent Désaubry
,
Enrique Espinosa
Article dans une revue
hal-01521958v1
|
|
Recent advances in the biology and chemistry of the flavaglines
Nigel Ribeiro
,
Frédéric Thuaud
,
Canan G Nebigil
,
Laurent Désaubry
Article dans une revue
hal-02391066v1
|
|
Flavaglines as potent anticancer and cytoprotective agents.
Nigel Ribeiro
,
Frédéric Thuaud
,
Yohann Bernard
,
Christian Gaiddon
,
Thierry Cresteil
Article dans une revue
hal-00765387v1
|
|
Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27
Yohann Bernard
,
Nigel Ribeiro
,
Frédéric Thuaud
,
Gülen Türkeri
,
Ronan Dirr
Article dans une revue
hal-02391070v1
|
|
Synthesis of 3-O-methylviridicatin analogues with improved anti-TNF-α properties
Nigel Ribeiro
,
Helena Tabaka
,
Jean Peluso
,
Ludivine Fetzer
,
Canan G Nebigil
Article dans une revue
hal-02391115v1
|
|
Future alchemy: account of the ESYOP experiment
Philippe Compain
,
Valérie Desvergnes
,
Cyril Ollivier
,
Frédéric Robert
,
Franck Suzenet
Article dans une revue
hal-00158010v1
|
|
Looking forward : a glance into the future of organic chemistry
Philippe Compain
,
Valérie Desvergnes
,
Cyril Ollivier
,
Frédéric Robert
,
Franck Suzenet
Article dans une revue
hal-00158370v1
|