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Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination
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The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation
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Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo
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eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma
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Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL
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Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies
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Triazine-Based Small Molecules: A Potential New Class of Compounds in the Antifungal Toolbox
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Therapeutic Potential of Targeting Prokineticin Receptors in Diseases
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The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA
Ann Kari Grindheim
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Article dans une revue
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Non-classical ferroptosis inhibition by a small molecule targeting PHB2
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Development of fluorizoline analogues as prohibitin ligands that modulate C-RAF signaling, p21 expression and melanogenesis
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Article dans une revue
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Flavaglines: Their Discovery from Plants Used in Traditional Chinese Medicine, Synthesis, and Drug Development Against Cancer and Immune Disorders
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Article dans une revue
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Development of prohibitin ligands against osteoporosis
Redouane Tabti
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Article dans une revue
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Fluorizoline Blocks the Interaction between Prohibitin-2 and γ -Glutamylcyclotransferase and Induces p21 Waf1/Cip1 Expression in MCF7 Breast Cancer Cells
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Updates on Anticancer Therapy-Mediated Vascular Toxicity and New Horizons in Therapeutic Strategies
Po-Yen Hsu
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Article dans une revue
hal-03373354
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Updates on Anticancer Therapy-Mediated Vascular Toxicity and New Horizons in Therapeutic Strategies
Po-Yen Hsu
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Aynura Mammadova
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Nadia Benkirane-Jessel
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Canan Nebigil
Article dans une revue
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Prohibitin Inactivation in Adipocytes Results in Reduced Lipid Metabolism and Adaptive Thermogenesis Impairment
Zhanguo Gao
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Article dans une revue
hal-03374098
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Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells
Tharcisio Citrangulo Tortelli
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Article dans une revue
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Recent Advances in the Synthesis of C2‐Functionalized Pyridines and Quinolines Using N ‐Oxide Chemistry
Dong Wang
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Gaoyu Li
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Mindong Huang
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Shixin Zheng
Article dans une revue
hal-03028714
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Development of prohibitin ligands against osteoporosis
Redouane Tabti
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Céline Charrier
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Benjamin Ory
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Dominique Heymann
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Article dans une revue
hal-03004271
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Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses
Canan G Nebigil
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Article dans une revue
hal-02996744
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Targeting GPCRs Against Cardiotoxicity Induced by Anticancer Treatments
Anais Audebrand
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Article dans une revue
hal-02996608
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The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis
Xin Jin
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Michael Zabolocki
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Article dans une revue
hal-03415943
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Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
Ezeddine Harmouch
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Article dans une revue
hal-03018022
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Discovery of 3,3′-pyrrolidinyl-spirooxindoles as cardioprotectant prohibitin ligands
Sabria Elderwish
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Canan G Nebigil
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Article dans une revue
hal-02996582
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SFPH proteins as therapeutic targets for a myriad of diseases
Dong Wang
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Sabria Elderwish
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Article dans une revue
hal-03092105
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A subset of flavaglines inhibits KRAS nanoclustering and activation
Hajime Yurugi
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Article dans une revue
hal-02996708
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Prokineticin signaling in heart-brain developmental axis: Therapeutic options for heart and brain injuries
Laurent Désaubry
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Canan G Nebigil
Article dans une revue
hal-03014835
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One-Pot Selective Saturation and Functionalization of Heteroaromatics Leading to Dihydropyridines and Dihydroquinolines
Dong Wang
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Yuanyang Jiang
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Linru Dong
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Article dans une revue
hal-02996680
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The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis
Xin Jin
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Jianling Xie
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Michael Zabolocki
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Xuemin Wang
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Tao Jiang
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Article dans une revue
hal-03413807
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Unexpected Inversion of Configuration During the Carbamoylation of 1-Azaflavaglines
Hussein Abou-Hamdan
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Laurent Désaubry
Article dans une revue
hal-03373324
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Recent advances in the synthesis of 2,3-dihydropyrroles
Dong Wang
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Yu Fan
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Peng Yu
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Laurent Désaubry
Article dans une revue
hal-02996692
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Accessing 1,8‐Naphthyridones by Metal‐Free Regioselective Amination of Pyridine N ‐oxides/Acid‐Mediated Cyclization
Lianbo Zhao
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Lei Hao
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Yupeng Fu
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Yan Cheng
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Guojun Pan
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Article dans une revue
hal-02996754
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The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling
Dakota N Jackson
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Yaritza Delgado-Deida
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Redouane Tabti
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Kevin Turner
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Article dans une revue
hal-02996732
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Prohibitin, STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria
Carolin Ploeger
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Thorben Huth
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Raisatun Nisa Sugiyanto
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Stefan Pusch
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Benjamin Goeppert
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Article dans une revue
hal-03032751
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An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
Shensi Shen
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Sara Faouzi
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Amandine Bastide
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Sylvain Martineau
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Hélène Malka-Mahieu
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Article dans une revue
hal-02418638
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The role of GPCR signaling in cardiac Epithelial to Mesenchymal Transformation (EMT)
Canan G Nebigil
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Laurent Désaubry
Article dans une revue
hal-03014893
v1
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Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles
Dong Wang
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Xinyue Ma
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Linru Dong
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Hairong Feng
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Peng Yu
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Article dans une revue
hal-02996593
v1
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The synthetic flavagline FL3 spares normal human skin cells from its cytotoxic effect via an activation of Bad
Fathi Emhemmed
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Sarah Ali Azouaou
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Sarah Hassan
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Ray Lefevbre
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Laurent Desaubry
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Article dans une revue
hal-03033544
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Correction to: The mTOR-S6 kinase pathway promotes stress granule assembly
Aristeidis Sfakianos
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Laura Mellor
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Yoke Fei Pang
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Paraskevi Kritsiligkou
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Hope Needs
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Article dans une revue
hal-02361047
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An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
Shensi Shen
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Sara Faouzi
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Amandine Bastide
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Sylvain Martineau
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Hélène Malka-Mahieu
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Article dans une revue
hal-02996564
v1
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Prokineticin Receptor-1 Signaling Inhibits Dose- and Time-Dependent Anthracycline-Induced Cardiovascular Toxicity Via Myocardial and Vascular Protection
Adeline Gasser
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Yue-Wen Chen
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Anais Audebrand
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Ayhan Daglayan
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Marine Charavin
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Article dans une revue
hal-03092065
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PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis
Chaojun Yan
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Longlong Gong
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Li Chen
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Meng Xu
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Hussein Abou-Hamdan
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Article dans une revue
hal-02361056
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Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer
Marine F Garrido
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Nicolas J.-P. Martin
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Matthieu Bertrand
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Catherine Gaudin
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Frédéric Commo
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Article dans une revue
hal-03210950
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Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects
Hafidha Bentayeb
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Marine Aitamer
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Barbara Petit
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Lydie Dubanet
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Sabria Elderwish
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Article dans une revue
hal-02361081
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Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes
Matthew Neal
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Jie Luo
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Dilshan Harischandra
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Richard Gordon
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Souvarish Sarkar
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Article dans une revue
hal-02361086
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Updates in Anthracycline-Mediated Cardiotoxicity
Canan G Nebigil
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Laurent Désaubry
Article dans une revue
hal-01935306
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The synthetic flavagline FL3 protects against colitis-associated cancer via inhibition of wnt/beta-catenin signaling
Dn Jackson
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J Han
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Hussein Abou Hamdan
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Laurent Désaubry
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Xf Huo
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Gastroenterology, 2018, 154 (6)
Article dans une revue
hal-04835052
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Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells
Amel Djehal
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Mohammad Krayem
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Ahmad Najem
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Hassan Hammoud
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Thierry Cresteil
et al.
Article dans une revue
hal-02361593
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The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model
Marina Wierz
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Sandrine Pierson
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Nora Chouha
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Laurent Désaubry
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Jean-Hugues François
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Article dans une revue
hal-02361624
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The mTOR-S6 kinase pathway promotes stress granule assembly
Aristeidis Sfakianos
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Laura Mellor
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Yoke Fei Pang
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Paraskevi Kritsiligkou
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Hope Needs
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Article dans une revue
hal-02361603
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Targeting a Gpcr, Prokineticin Receptor-1, Protects Heart Against Doxorubicin-Mediated Cardiotoxicity
Canan G Nebigil
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Adeline Gasser
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Marine Charavin
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Brigitte Escoubet
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Anais Audebrand
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Circulation, 2018, 138
Article dans une revue
hal-04835044
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Emergence of cardio-oncology
Canan G Nebigil
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L. Desaubry
Article dans une revue
hal-02361588
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Translational control of tumor immune escape via the eIF4F–STAT1–PD-L1 axis in melanoma
Michael Cerezo
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Ramdane Guemiri
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Sabine Druillennec
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Isabelle Girault
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Hélène Malka-Mahieu
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Article dans une revue
hal-02361063
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CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts
Ricardos Tabet
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Fernande Freyermuth
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Melanie Jambeau
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Michael Workman
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Article dans une revue
hal-02361614
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Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2
Hussein Abou-Hamdan
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Laurent Désaubry
Article dans une revue
hal-01830554
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Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway
Gangjun Yuan
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Xin Chen
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Zhuowei Liu
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Wensu Wei
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Qinghai Shu
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Article dans une revue
hal-02361608
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Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles
Dong Wang
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Linna Li
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Hairong Feng
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Hua Sun
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Fabrice Almeida-Veloso
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Article dans une revue
hal-01829592
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Abstract IA29: Role of eIF4F in anticancer drug resistance
Galina Boldina
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Maricarmen Vallejos
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Delphine Allard
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Isabelle Girault
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Article dans une revue
hal-04833132
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Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment
Hélène Malka-Mahieu
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Michelle Newman
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Laurent Désaubry
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Caroline Robert
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Stéphan Vagner
Article dans une revue
hal-03533702
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Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells
Fathi Emhemmed
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Sarah Ali Azouaou
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Qian Zhao
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Aline Appert-Collin
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Amar Bennasroune
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Article dans une revue
hal-02106909
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Flavaglines Ameliorate Experimental Colitis and Protect Against Intestinal Epithelial Cell Apoptosis and Mitochondrial Dysfunction:
Jie Han
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Qian Zhao
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Christine Basmadjian
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Laurent Désaubry
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Arianne L. Theiss
Article dans une revue
hal-03536459
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Bioisosteric modification of flavaglines
Qian Zhao
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Annemilaï Tijeras-Raballand
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Armand de Gramont
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Eric Raymond
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Laurent Désaubry
Article dans une revue
hal-03533709
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Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines
Hélène Malka-Mahieu
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Margot Rubington
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Melissa Leriche
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Caroline Welsch
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Article dans une revue
hal-03536458
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A General and Efficient Synthesis of 2-Pyridones, 2-Quinolinones, and 1-Isoquinolinones from Azine N -Oxides
Dong Wang
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Junjie Zhao
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Yuxi Wang
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Jianyong Hu
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Linna Li
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Article dans une revue
istex
hal-03536473
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Recent Advances in the Synthesis of Flavaglines, a Family of Potent Bioactive Natural Compounds Originating from Traditional Chinese Medicine
Qian Zhao
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Hussein Abou Hamdan
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Laurent Désaubry
Article dans une revue
istex
hal-03533707
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Synthesis of hydroxybenzofurans by condensation of quinones with benzoylacetone: revised structure of the adducts
Hassan Hammoud
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Qian Zhao
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Laurent Désaubry
Article dans une revue
hal-03536456
v1
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FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity
Rehana Qureshi
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Adeline Gasser
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Christine Basmadjian
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Qian Zhao
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Article dans une revue
hal-02391039
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Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1
Adeline Gasser
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Simone Brogi
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Kyoji Urayama
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Toshishide Nishi
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Hitoshi Kurose
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Article dans une revue
hal-02391041
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Cancer wars: natural products strike back
Christine Basmadjian
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Qian Zhao
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Embarek Bentouhami
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Amel Djehal
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Article dans une revue
hal-02391047
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Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway
Fathi Emhemmed
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Sarah Ali Azouaou
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Frédéric Thuaud
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Valerie Schini-Kerth
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Laurent Désaubry
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Article dans une revue
hal-02106955
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Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.
F. Emhemmed
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S. Ali Azouaou
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F. Thuand
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V. Schini-Kerth
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L. Desaubry
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Biochemical Pharmacology, 2014, 89, pp.185-196
Article dans une revue
hal-01065063
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N -[3a-(4-Bromophenyl)-8b-hydroxy-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1 H -cyclopenta[ b ]benzofuran-1-yl]formamide monohydrate
Emmanuel Aubert
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Frédéric Thuaud
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Nigel Ribeiro
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Laurent Désaubry
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Enrique Espinosa
Article dans une revue
hal-01521958
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Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential
Frédéric Thuaud
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Nigel Ribeiro
,
Canan G Nebigil
,
Laurent Désaubry
Article dans une revue
hal-02391060
v1
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Recent advances in the biology and chemistry of the flavaglines
Nigel Ribeiro
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Frédéric Thuaud
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Canan G Nebigil
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Laurent Désaubry
Article dans une revue
istex
hal-02391066
v1
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Flavaglines as potent anticancer and cytoprotective agents.
Nigel Ribeiro
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Frédéric Thuaud
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Yohann Bernard
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Christian Gaiddon
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Thierry Cresteil
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Article dans une revue
hal-00765387
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Cytochromes P450 CYP94C1 and CYP94B3 catalyze two successive oxidation steps of the plant hormone jasmonoyl-isoleucine for catabolic turnover
T. Heitz
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R. Lugan
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L. Miesch
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P. Ullmann
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Article dans une revue
hal-00680337
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Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27
Yohann Bernard
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Nigel Ribeiro
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Frédéric Thuaud
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Gülen Türkeri
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Ronan Dirr
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Article dans une revue
hal-02391070
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Novel Flavaglines Displaying Improved Cytotoxicity.
Frédéric Thuaud
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Nigel Ribeiro
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Christian Gaiddon
,
Thierry Cresteil
,
Laurent Désaubry
Article dans une revue
hal-00572526
v1
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Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12
Frédéric Thuaud
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Yohann Bernard
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Gülen Türkeri
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Ronan Dirr
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Geneviève Aubert
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Article dans une revue
hal-02391094
v1
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Synthesis and biological evaluation of PEG-tirofiban conjugates
Laurent Désaubry
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Stéphanie Riché
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Patricia Laeuffer
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Jean-Pierre Cazenave
Article dans une revue
istex
hal-04724806
v1
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Synthesis of 3-O-methylviridicatin analogues with improved anti-TNF-α properties
Nigel Ribeiro
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Helena Tabaka
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Jean Peluso
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Reinforcing effect of bi- and tri-cyclopolyprenols on ‘primitive' membranes made of polyprenyl phosphates.
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Tetrahedron, 2007, 63, pp.3395-3407
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Looking forward : a glance into the future of organic chemistry
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Palladium catelysed arylation of 6,8-dimethoxybenzofuranone.
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Tetrahedron Letters, 2005, 46, pp.8017-8018
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Concise synthesis and voltammetric studies of dielsiquinone, a cytotoxic azaanthraquinone.
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Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.3609-3610
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Unexpected cleavage of tetrahydrofuran by catalytic reductive lithiation
S. Streiff
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Chemical Communications, 2004, pp.346-347
Article dans une revue
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Synthesis of allylsilanes by reductive lithiation of thioethers.
S. Streiff
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Journal of Organic Chemistry, 2004, 69, pp.7592-7598
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