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Carcinogenicity of atrazine, alachlor, and vinclozolin
Russell Cattley
,
Anneclaire de Roos
,
Daniele Mandrioli
,
Neil Pearce
,
Anjoeka Pronk
et al.
Article dans une revue
hal-05461597
v1
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In vitro hepatic metabolism and associated binding of enniatin B
Ludovic Le Hégarat
,
Estelle Dubreil
,
Nicolas Le Yondre
,
Solenne Martin
,
Françoise Brée
et al.
Article dans une revue
hal-05453769
v1
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Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health
Anne-Cathrin Behr
,
Christiane Kruse Fæste
,
Amaya Azqueta
,
Ana M Tavares
,
Anastasia Spyropoulou
et al.
Article dans une revue
anses-05080180
v1
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Hydrogen inhalation: in vivo rat genotoxicity tests
Cordélia Salomez-Ihl
,
Stéphane Tanguy
,
Jean-Pierre Alcaraz
,
Chloé Davin
,
Victor Pascal-Moussellard
et al.
Article dans une revue
hal-04813069
v1
|
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Chlordecone-induced hepatotoxicity and fibrosis are mediated by the proteasomal degradation of septins
Thibaut Léger
,
Sarah Alilat
,
Pierre-Jean Ferron
,
Léonie Dec
,
Tahar Bouceba
et al.
Article dans une revue
anses-04661415
v1
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Hydrogen inhalation: in vivo rat genotoxicity tests
Cordélia Salomez-Ihl
,
Stéphane Tanguy
,
Jean-Pierre Alcaraz
,
Chloé Davin
,
Victor Pascal-Moussellard
et al.
Article dans une revue
hal-04445635
v1
|
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Genotoxicity of beauvericin
Helle Katrine Knutsen
,
Agneta Åkesson
,
Vasileios Bampidis
,
Laurent Bodin
,
James Kevin Chipman
et al.
Article dans une revue
anses-04868059
v1
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P03-08 Metabolism of Enniatin B in primary mouse, rat and human hepatocytes
Estelle Dubreil
,
Lada Ivanova
,
Charlène Gendre
,
Mariam Mahdjoub
,
Valérie Fessard
et al.
Article dans une revue
anses-04701403
v1
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New methodological developments for testing the in vitro genotoxicity of nanomaterials: Comparison of 2D and 3D HepaRG liver cell models and classical and high throughput comet assay formats
Julia Varet
,
Audrey Barranger
,
Camille Crochet
,
Sylvie Huet
,
Kevin Hogeveen
et al.
Article dans une revue
anses-04550130
v1
|
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Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health
Henriqueta Louro
,
Ariane Vettorazzi
,
Adela López de Cerain
,
Anastasia Spyropoulou
,
Anita Solhaug
et al.
Article dans une revue
anses-04383220
v1
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Combined in silico and in vitro approaches to identify P‐glycoprotein‐inhibiting pesticides
Nelly Guéniche
,
Zeineb Lakehal
,
Denis Habauzit
,
Arnaud Bruyère
,
Olivier Fardel
et al.
Article dans une revue
anses-04311433
v1
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Modeling HepaRG metabolome responses to pyrrolizidine alkaloid exposure for insight into points of departure and modes of action
Estelle Dubreil
,
Keyvin Darney
,
Marie Laure Delignette-Muller
,
Audrey Barranger
,
Sylvie Huet
et al.
Article dans une revue
hal-04611387
v1
|
|
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An Evaluation of the Cytotoxic and Genotoxic Effects of the Marine Toxin C17-SAMT in Human TK6 and HepaRG Cell Lines
Zeineb Marzougui
,
Ludovic Le Hegarat
,
Kevin Hogeveen
,
Sylvie Huet
,
Riadh Kharrat
et al.
Article dans une revue
anses-04165449
v1
|
|
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Fate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics
Thibaut Léger
,
Patrick Balaguer
,
Ludovic Le Hégarat
,
Valérie Fessard
Article dans une revue
anses-03933720
v1
|
|
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In Vivo Genotoxicity Testing Strategies: Report from the 8th International Workshop on Genotoxicity Testing ( IWGT )
Carol Beevers
,
Yoshifumi Uno
,
Krista Meurer
,
Shuichi Hamada
,
Kiyohiro Hashimoto
et al.
Article dans une revue
anses-04283415
v1
|
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New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project
Marc Audebert
,
Ann-Sophie Assmann
,
Amaya Azqueta
,
Pavel Babica
,
Emilio Benfenati
et al.
Article dans une revue
hal-04178861
v1
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In vitro genotoxicity potential investigation of 7 oxy‐PAHs
Adeline Clergé
,
Jérémie Le Goff
,
Emilie Brotin
,
Edwige Abeillard
,
Isabelle Vaudorne
et al.
Article dans une revue
hal-04169777
v1
|
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Measuring DNA modifications with the comet assay: a compendium of protocols
Andrew Collins
,
Peter Møller
,
Goran Gajski
,
Soňa Vodenková
,
Abdulhadi Abdulwahed
et al.
Article dans une revue
hal-03997215
v1
|
|
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Towards better prediction of xenobiotic genotoxicity: CometChip technology coupled with a 3D model of HepaRG human liver cells
Audrey Barranger
,
Ludovic Le Hégarat
Article dans une revue
anses-03665810
v1
|
|
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Investigation of the Genotoxic Potential of the Marine Toxin C17-SAMT Using the In Vivo Comet and Micronucleus Assays
Zeineb Marzougui
,
Sylvie Huet
,
Anne-Louise Blier
,
Ludovic Le Hégarat
,
Haïfa Tounsi-Kettiti
et al.
Article dans une revue
anses-03931234
v1
|
|
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Comparative in silico prediction of P-glycoprotein-mediated transport for 2010-2020 US FDA-approved drugs using six Web-tools
Nelly Gueniche
,
Antoine Huguet
,
Arnaud Bruyere
,
Denis Habauzit
,
Ludovic Le Hegarat
et al.
Article dans une revue
hal-03341369
v1
|
|
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Genotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral Exposure
Pégah Jalili
,
Sylvie Huet
,
Rachelle Lanceleur
,
Gérard Jarry
,
Ludovic Le Hégarat
et al.
Article dans une revue
anses-02870263
v1
|
|
|
Preface to the Special Issue dedicated to the 47th annual conference of the European Environmental Mutagen and Genomics Society (EEMGS)
Helga Stopper
,
Lisbeth Knudsen
,
Ludovic Le Hégarat
Article dans une revue
anses-02862250
v1
|
|
|
Differential interactions of carbamate pesticides with drug transporters
Nelly Gueniche
,
Arnaud Bruyère
,
Mélanie Ringeval
,
Elodie Jouan
,
Antoine Huguet
et al.
Article dans une revue
anses-02626126
v1
|
|
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Benchmark dose analyses of γH2AX and pH3 endpoints for quantitative comparison of in vitro genotoxicity potential of lipophilic phycotoxins
Ludovic Le Hégarat
,
Alain-Claude Roudot
,
Valérie Fessard
Article dans une revue
anses-02861907
v1
|
|
|
Synergic toxic effects of food contaminant mixtures in human cells
Benjamin Kopp
,
Pascal Sanders
,
Imourana Alassane-Kpembi
,
Valérie Fessard
,
Daniel Zalko
et al.
Article dans une revue
hal-02927206
v1
|
|
|
Differential toxic effects of food contaminant mixtures in HepaRG cells after single or repeated treatments
Benjamin Kopp
,
Ludovic Le Hegarat
,
Marc Audebert
Article dans une revue
hal-02613900
v1
|
|
|
Impact of solvents on the in vitro genotoxicity of TMPTA in human HepG2 cells
Ludovic Le Hegarat
,
Sylvie Huet
,
Elodie Pasquier
,
Sandrine Charles
Article dans une revue
anses-02958734
v1
|
|
|
Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models
Jimmy H Alarcan
,
Estelle Dubreil-Cheneau
,
Antoine H Huguet
,
Romulo Araoz
,
Françoise Brée
et al.
Article dans une revue
anses-02083152
v1
|
|
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Combined effects of okadaic acid and pectenotoxin-2, 13-desmethylspirolide C or yessotoxin in human intestinal Caco-2 cells
Jimmy H Alarcan
,
Sabrina Barbé
,
Benjamin Kopp
,
Stefanie Hessel-Pras
,
Albert Braeuning
et al.
Article dans une revue
anses-02114281
v1
|
|
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Identification of key pathways involved in the toxic response of the cyanobacterial toxin cylindrospermopsin in human hepatic HepaRG cells
Antoine Huguet
,
Rachelle Lanceleur
,
Hélène Quenault
,
Ludovic Le Hegarat
,
Valérie Fessard
Article dans une revue
anses-02100344
v1
|
|
|
Three-dimensional HepaRG spheroids as a liver model to study human genotoxicity in vitro with the single cell gel electrophoresis assay
Marion Mandon
,
Sylvie Huet
,
Estelle Dubreil-Chéneau
,
Valérie Fessard
,
Ludovic Le Hegarat
Article dans une revue
anses-02347230
v1
|
|
|
Genotoxicity and mutagenicity assessment of food contaminant mixtures present in the French diet
Benjamin Kopp
,
Julien Vignard
,
Gladys Mirey
,
Valérie Fessard
,
Daniel Zalko
et al.
Article dans une revue
anses-01880114
v1
|
|
|
Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment
Jimmy H Alarcan
,
Ronel Biré
,
Ludovic Le Hegarat
,
Valérie Fessard
Article dans une revue
anses-01790013
v1
|
|
|
Genotoxic effects of food contact recycled paperboard extracts on two human hepatic cell lines.
Emilie Souton
,
Isabelle Séverin
,
Ludovic Le Hegarat
,
Kevin Hogeveen
,
Abdulhadi Aljawish
et al.
Article dans une revue
hal-01625970
v1
|
|
|
Metabolism of the Marine Phycotoxin PTX-2 and Its Effects on Hepatic Xenobiotic Metabolism: Activation of Nuclear Receptors and Modulation of the Phase I Cytochrome P450
Jimmy H Alarcan
,
Estelle Dubreil-Chéneau
,
Antoine H Huguet
,
Dominique Hurtaud-Pessel
,
Stefanie Hessel-Pras
et al.
Article dans une revue
anses-01570019
v1
|
|
|
Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AalphaC) in Primary Human Hepatocytes
Medjda Bellamri
,
Ludovic Le Hegarat
,
Robert J. Turesky
,
Sophie Langouët
Article dans une revue
anses-01419468
v1
|
|
|
Metabolism and bioactivation of 2-amino-9H-pyrido[2,3-b]indole, a tobacco carcinogen, in human hepatocytes
Medjda Bellamri
,
Ludovic Le Hegarat
,
Robert Turesky
,
Sophie Langouët
Drug Metabolism Reviews, 2016, 48, pp.125--126
Article dans une revue
hal-01485263
v1
|
|
|
Modulation of CYP3A4 activity alters the cytotoxicity of lipophilic phycotoxins in human hepatic HepaRG cells
Pierre-Jean Ferron
,
Kevin Hogeveen
,
Georges de Sousa
,
Roger Rahmani
,
Estelle Dubreil-Cheneau
et al.
Article dans une revue
istex
anses-01340742
v1
|
|
|
Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts
Medjda Bellamri
,
Ludovic Le Hegarat
,
Laurent Vernhet
,
Georges Baffet
,
Robert J. Turesky
et al.
Article dans une revue
hal-01400486
v1
|
|
|
Comparative Analysis of the Cytotoxic Effects of Okadaic Acid-Group Toxins on Human Intestinal Cell Lines
Pierre-Jean Ferron
,
Kevin Hogeveen
,
Valérie Fessard
,
Ludovic Le Hégarat
Article dans une revue
hal-01082583
v1
|
|
|
Développement de séquences d’événements aboutissant à l’hépatotoxicité et modèles in vitro associés
C Gallian
,
L Bodin
,
B Enriquez
,
Ludovic Le Hégarat
,
C Rousselle
Article dans une revue
hal-01102277
v1
|
|
|
Toxicity of the diarrhetic marine phycotoxins okadaic acid and its analogues dinophysistoxin-1 and-2 in the human hepatic heparg cell line
Pierre-Jean Ferron
,
Kevin Hogeveen
,
Roger Rahmani
,
Georges de Sousa
,
Ludovic Le Hégarat
et al.
Drug Metabolism Reviews, 2014, 45, pp.159-159
Article dans une revue
hal-02630807
v1
|
|
|
Absence of in vitro genotoxicity potential of the mycotoxin deoxynivalenol in bacteria and in human TK6 and HepaRG cell lines.
Natsuko Takakura
,
Fabrice Nesslany
,
Valérie Fessard
,
Ludovic Le Hegarat
Article dans une revue
istex
hal-00949838
v1
|
|
|
Performance of Comet and Micronucleus Assays in Metabolic Competent Heparg Cells to Predict In Vivo Genotoxicity.
Ludovic Le Hegarat
,
Annick Mourot
,
Sylvie Huet
,
Lucie Vasseur
,
Sandrine Camus
et al.
Article dans une revue
hal-00935637
v1
|
|
|
The PERICLES research program: An integrated approach to characterize the combined effects of mixtures of pesticide residues to which the French population is exposed.
A. Crépet
,
F. Héraud
,
C. Béchaux
,
M. E. Gouze
,
S. Pierlot
et al.
Article dans une revue
istex
hal-00872111
v1
|
|
|
A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes.
Fatiha Aliche-Djoudi
,
Normand Podechard
,
Aurore Collin
,
Martine Chevanne
,
Emilie Provost
et al.
Article dans une revue
hal-00860153
v1
|
|
|
Genotoxicity of pesticide mixtures present in the diet of the French population
Vanessa Graillot
,
Natsuko Takakura
,
Ludovic Le Hégarat
,
Valérie Fessard
,
Marc Audebert
et al.
Article dans une revue
istex
hal-00666161
v1
|
|
|
Cytotoxic and genotoxic effects of cylindrospermopsin in mice treated by gavage or intraperitoneal injection.
Emmanuelle Bazin
,
Sylvie Huet
,
Gérard Jarry
,
Ludovic Le Hégarat
,
John S Munday
et al.
Article dans une revue
hal-00692410
v1
|
|
|
In vitro combined cytotoxic effects of pesticide cocktails simultaneously found in the French diet.
Natsuko Takakura
,
Pascal Sanders
,
Valérie Fessard
,
Ludovic Le Hégarat
Article dans une revue
istex
hal-00766599
v1
|
|
|
A co-culture system of human intestinal Caco-2 cells and lymphoblastoid TK6 cells for investigating the genotoxicity of oral compounds.
Ludovic Le Hégarat
,
Sylvie Huet
,
Valérie Fessard
Article dans une revue
hal-00763257
v1
|
|
|
In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop.
Stefan Pfuhler
,
Mick Fellows
,
Jan van Benthem
,
Raffaella Corvi
,
Rodger Curren
et al.
Article dans une revue
istex
hal-00595074
v1
|
|
|
A strategy to study genotoxicity: application to aquatic toxins, limits and solutions.
Valérie Fessard
,
Ludovic Le Hégarat
Article dans une revue
istex
hal-00487785
v1
|
|
|
Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays.
Ludovic Le Hegarat
,
Julie Dumont
,
Rozenn Josse
,
Sylvie Huet
,
Rachelle Lanceleur
et al.
Article dans une revue
hal-00533767
v1
|
|
|
Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells.
Julie Dumont
,
Rozenn Jossé
,
Carine Lambert
,
Sébastien Anthérieu
,
Ludovic Le Hegarat
et al.
Article dans une revue
istex
hal-00533754
v1
|
|
|
In vivo genotoxic potential of microcystin-LR: a cyanobacterial toxin, investigated both by the unscheduled DNA synthesis (UDS) and the comet assays after intravenous administration.
Julien Gaudin
,
Ludovic Le Hegarat
,
Fabrice Nesslany
,
Daniel Marzin
,
Valérie Fessard
Article dans une revue
istex
hal-00405465
v1
|
|
|
Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.
Isabelle Valentin-Severin
,
Ludovic Le Hegarat
,
Jean-Claude Lhuguenot
,
Anne-Marie Le Bon
,
Marie-Christine Chagnon
Article dans une revue
istex
hal-01981654
v1
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