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Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure
Muhammad Imran
,
Frédéric Chalmel
,
Odile Sergent
,
Bertrand Evrard
,
Hélène Le Mentec
Article dans une revue
hal-03647402v1
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L’évaluation des risques des pesticides : entre savoir réglementaire et science académique
Laurence Huc
,
Jean-Noël Jouzel
Article dans une revue
halshs-03509565v1
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Short-Term and Long-Term Carcinogenic Effects of Food Contaminants (4-Hydroxynonenal and Pesticides) on Colorectal Human Cells: Involvement of Genotoxic and Non-Genomic Mechanisms
Liana C. Arnaud
,
Thierry Gauthier
,
Augustin Le Naour
,
Saleha Hashim
,
Nathalie Naud
Article dans une revue
hal-03343517v1
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Les xénobiotiques, quel impact sur les maladies métaboliques ?
Carolina Duarte-Hospital
,
Laurence Huc
,
Sylvie Bortoli
,
Xavier Coumoul
Article dans une revue
hal-02618196v1
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Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells
Paule Bénit
,
Agathe Kahn
,
Dominique Chretien
,
Sylvie Bortoli
,
Laurence Huc
Article dans une revue
inserm-02409310v1
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Disturbances in H dynamics during environmental carcinogenesis
Dominique Lagadic-Gossmann
,
Kévin Hardonnière
,
Baharia Mograbi
,
Odile Sergent
,
Laurence Huc
Article dans une revue
hal-02179386v1
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Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation
Océane Martin
,
Maïwenn Olier
,
Sandrine Ellero-Simatos
,
Nathalie Naud
,
Jacques Dupuy
Article dans une revue
hal-02170463v1
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Sur l’impact des pesticides, la recherche scientifique doit éclairer la décision publique
Marion Desquilbet
,
Laurence Huc
,
Jean Francois Humbert
,
Bernard Salles
,
Stefan Ambec
Le Monde, 2019, vendredi 17 mai, pp.1-23
Article dans une revue
hal-02285622v1
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Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene
Marie Liamin
,
Hélène Le Mentec
,
Bertrand Evrard
,
Laurence Huc
,
Frédéric Chalmel
Article dans une revue
hal-01940253v1
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Nrf2 and AhR in metabolic reprogramming after contaminant exposure
Sylvie Bortoli
,
Elisa Boutet-Robinet
,
Dominique Lagadic-Gossmann
,
Laurence Huc
Article dans une revue
hal-01699380v1
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DNA damage response upon environmental contaminants: an exhausting work for genomic integrity
Elisa Boutet-Robinet
,
Sylvie Bortoli
,
Laurence Huc
Article dans une revue
hal-02617932v1
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Validation of gelbond® high-throughput alkaline and fpg-modified comet assay using a linear mixed model
Hervé Perdry
,
Kristine B. Gutzkow
,
Marianne Chevalier
,
Laurence Huc
,
Gunnar Brunborg
Article dans une revue
hal-02621813v1
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Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype
Kévin Hardonnière
,
Morgane Fernier
,
Isabelle Gallais
,
Baharia Mograbi
,
Normand Podechard
Article dans une revue
hal-01518808v1
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Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism
Kévin Hardonniere
,
Laurence Huc
,
Odile Sergent
,
Jørn A Holme
,
Dominique Lagadic-Gossmann
Article dans une revue
hal-01531077v1
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Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
Elise Saunier
,
Samantha Antonio
,
Anne Regazzetti
,
Nicolas Auzeil
,
Olivier Laprévote
Article dans une revue
hal-01603368v1
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Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats
Reggie Surya
,
Cécile Héliès-Toussaint
,
Océane Martin
,
Thierry Gauthier
,
Françoise Guéraud
Article dans une revue
hal-01901462v1
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Genotoxicity of cytolethal distending toxin (cdt) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis
Vanessa Graillot
,
Inge Dormoy
,
Jacques Dupuy
,
Jerry W. Shay
,
Laurence Huc
Article dans une revue
hal-02635460v1
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The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival
Kevin Hardonnière
,
Elise Saunier
,
Anthony Lemarié
,
Morgane Fernier
,
Isabelle Gallais
Article dans une revue
hal-01359569v1
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Stefan Grimm, 1963-2014, a tragic loss for the scientific community Obituary
A-L Mahul-Mellier
,
Laurence Huc
,
A. Lemarié
,
S. Irshad
,
M. Hwang
Article dans une revue
hal-02629476v1
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Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential
Kevin Hardonnière
,
Laurence Huc
,
Normand Podechard
,
Morgane Fernier
,
Xavier Tekpli
Article dans une revue
hal-01163757v1
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Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice
Alice Marmugi
,
Frédéric Lasserre
,
Diane Beuzelin
,
Simon Ducheix
,
Laurence Huc
Article dans une revue
hal-02641668v1
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Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance
Sabine Dalleau
,
Maryse Baradat
,
Françoise Guéraud
,
Laurence Huc
Article dans une revue
hal-02650840v1
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Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.
.Carolina D. Garciarena
,
Yu-Ling Ma
,
Pawel Swietach
,
Richard D Vaughan-Jones
,
Laurence Huc
Article dans une revue
hal-02647708v1
|
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NHE-1 relocation outside cholesterol-rich membrane microdomains is associated with its benzo[a]pyrene-related apoptotic function.
Xavier Tekpli
,
Laurence Huc
,
Odile Sergent
,
Béatrice Dendelé
,
Marie-Thérèse Dimanche-Boitrel
Article dans une revue
inserm-00871487v1
|
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Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells
Laurence Huc
,
Anthony Lemarié
,
Françoise Guéraud
,
Cécile Héliès-Toussaint
Article dans une revue
hal-02940780v1
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Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.
Béatrice Dendelé
,
Xavier Tekpli
,
Odile Sergent
,
Marie-Thérèse Dimanche-Boitrel
,
Jørn A. Holme
Article dans une revue
hal-00682104v1
|
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4-Hydroxy-2(E)-nonenal metabolism differs in apc(+/+) cells and in apc(Min/+) cells: it may explain colon cancer promotion by heme iron
Maryse Baradat
,
Isabelle Jouanin
,
Sabine Dalleau
,
Sylviane Taché
,
Mathilde Gieules
Article dans une revue
hal-02644375v1
|
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Membrane remodeling, an early event in benzo a pyrene-induced apoptosis
X. Tekpli
,
M. Rissel
,
Laurence Huc
,
Daniel D. Catheline
,
O. Sergent
Journal of Organometallic Chemistry, 2010, 248, 2 p
Article dans une revue
hal-00729575v1
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Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis.
X. Tekpli
,
M. Rissel
,
Laurence Huc
,
Daniel D. Catheline
,
O. Sergent
Article dans une revue
hal-00729574v1
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Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis.
Xavier Tekpli
,
Mary Rissel
,
Laurence Huc
,
Daniel D. Catheline
,
Odile Sergent
Article dans une revue
hal-00660136v1
|
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Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining
Fabien Jourdan
,
Ludovic Cottret
,
Laurence Huc
,
David Wildridge
,
Richard Scheltema
Article dans une revue
hal-02662801v1
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Chemistry and biochemistry of lipid peroxidation products
Françoise Guéraud
,
M. Atalay
,
N. Bresgen
,
A. Cipak
,
P.M. Eckl
Article dans une revue
hal-02667036v1
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Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction
Stefan Grimm
,
Anthony Lemarie
,
Laurence Huc
,
Evangelos Pazarentzos
,
Anne-Laure Mahul-Mellier
Article dans une revue
hal-00565452v1
|
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Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks.
Jérôme Lacroix
,
Mallorie Poët
,
Laurence Huc
,
Vincent Morello
,
Nadir Djerbi
Article dans une revue
hal-00674405v1
|
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Regulation of Na+/H+ exchanger 1 allosteric balance by its localization in cholesterol- and caveolin-rich membrane microdomains.
Xavier Tekpli
,
Laurence Huc
,
Jérôme Lacroix
,
Mary Rissel
,
Mallorie Poët
Article dans une revue
hal-00696172v1
|
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A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells.
Morgane Gorria
,
Xavier Tekpli
,
Mary Rissel
,
Odile Sergent
,
Laurence Huc
Article dans une revue
hal-00674390v1
|
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Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells.
Jørn A. Holme
,
Morgane Gorria
,
Volker M. Arlt
,
Steinar Ovrebø
,
Anita Solhaug
Article dans une revue
hal-00690306v1
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c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis.
Laurence Huc
,
Xavier Tekpli
,
Jørn A. Holme
,
Mary Rissel
,
Anita Solhaug
Article dans une revue
hal-00690320v1
|
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TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions.
Olivier Meurette
,
Amélie Rébillard
,
Laurence Huc
,
Gwenaëlle Le Moigne
,
Delphine Merino
Article dans une revue
hal-00690349v1
|
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Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells.
Laurence Huc
,
Mary Rissel
,
Anita Solhaug
,
Xavier Tekpli
,
Morgane Gorria
Article dans une revue
inserm-00130324v1
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Membrane fluidity changes are associated with benzo[a]pyrene-induced apoptosis in F258 cells: protection by exogenous cholesterol.
Morgane Gorria
,
Xavier Tekpli
,
Odile Sergent
,
Laurence Huc
,
François Gaboriau
Article dans une revue
hal-00699948v1
|
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Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transport.
Morgane Gorria
,
Laurence Huc
,
Odile Sergent
,
Amélie Rébillard
,
François Gaboriau
Article dans une revue
hal-00699820v1
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TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH.
Olivier Meurette
,
Laurence Huc
,
Amelie Rebillard
,
Gwénaelle Le Moigne
,
Dominique Lagadic-Gossmann
Article dans une revue
hal-02683522v1
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Role for membrane fluidity in ethanol-induced oxidative stress of primary rat hepatocytes.
Odile Sergent
,
Manuella Pereira
,
Corinne Belhomme
,
Martine Chevanne
,
Laurence Huc
Article dans une revue
hal-02677113v1
|
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Alterations of intracellular pH homeostasis in apoptosis: origins and roles
D Lagadic-Gossmann
,
Laurence Huc
,
V. Lecureur
Article dans une revue
hal-02683409v1
|
|
Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.
Lydie Sparfel
,
Laurence Huc
,
Marc Le Vée
,
Mireille Desille
,
Dominique Lagadic-Gossmann
Article dans une revue
hal-02681620v1
|
|
Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons.
Laurence Huc
,
Lydie Sparfel
,
Mary Rissel
,
Marie-Thérèse Dimanche-Boitre
,
André Guillouzo
Article dans une revue
hal-02678074v1
|
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Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.
Laurence Huc
,
David Gilot
,
Claire Gardyn
,
Mary Rissel
,
Marie-Thérèse Dimanche-Boitrel
Annals of the New York Academy of Sciences, 2003, 1010, pp.167-70
Article dans une revue
hal-02681880v1
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Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells.
Lydie Sparfel
,
Maud Loewert
,
Laurence Huc
,
Léa Payen
,
André Guillouzo
Toxicology Letters, 2002, 129 (3), pp.245-54
Article dans une revue
hal-02673286v1
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