Lionel Ulmann

Professeur de Biochimie - IUT de Laval
50
Documents
Affiliations actuelles
  • IUT de Laval
  • Biologie des Organismes, Stress, Santé, Environnement [Le Mans Université] (BiOSSE)
Contact

Présentation

Actuellement directeur adjoint du laboratoire BiOSSE - Biologie des Organismes, Stress, Santé, Environnement - à Le Mans Université, je co-anime l'axe de recherche MIMMA-Métabolisme et Ingénierie des Molécules des Microalgues et Applications.

J'ai obtenu un doctorat en Physiologie et Biochimie de la Nutrition à l'Université de Bourgogne en 1991. En 2018, j'ai présenté mon Habilitation à Diriger des Recherches en Biochimie et Biologie Moléculaire à Le Mans Université.

Mes activités de recherche se développent dans deux domaines :

  • la régulation du métabolisme des lipides et des acides gras polyinsaturés des microalgues marines;
  • l'utilisation des molécules bioactives des microalgues dans la santé et la prévention des maladies.

Le premier domaine de recherche est centré sur la réponse des diatomées marines soumises à un stress nutritif, afin de déterminer quels mécanismes cellulaires sont impliqués dans le transport, le stockage et l'utilisation des lipides. Le deuxième domaine de recherche est davantage une approche appliquée grâce à des collaborations avec des partenaires industriels pour la valorisation des molécules produites par les microalgues et leurs bénéfices pour la santé.

Domaines de recherche

Alimentation et Nutrition Biochimie, Biologie Moléculaire

Compétences

Métabolisme des microalgues - Molécules à activités biologiques - Nutrition et santé

Publications

Publications

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Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation

Victor Murison , Josiane Hérault , Justine Marchand , Lionel Ulmann
Biological Reviews, 2025, ⟨10.1111/brv.70006⟩
Article dans une revue hal-04987301 v1
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Combined Effects of Spirulina Liquid Extract and Endurance Training on Aerobic Performance and Muscle Metabolism Adaptation in Wistar Rats

Jordi Vignaud , Céline Loiseau , Martine Côme , Isabelle Martin , Rova Rasoanarivo et al.
Nutrients, 2025, 17 (2), pp.283. ⟨10.3390/nu17020283⟩
Article dans une revue hal-04887681 v1
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Neutral lipid and chrysolaminarin metabolic pathways during nitrogen starvation and recovery in the diatom Phaeodactylum tricornutum

Victor Murison , Josiane Hérault , Sabrina Guinio , Martine Côme , Céline Loiseau et al.
Algal Research - Biomass, Biofuels and Bioproducts, 2024, 82, pp.103621. ⟨10.1016/j.algal.2024.103621⟩
Article dans une revue hal-04675343 v1
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Bioinformatics-Based Screening Approach for the Identification and Characterization of Lipolytic Enzymes from the Marine Diatom Phaeodactylum tricornutum

Victor Murison , Josiane Hérault , Benoît Schoefs , Justine Marchand , Lionel Ulmann
Marine drugs, 2023, 21 (2), pp.125. ⟨10.3390/md21020125⟩
Article dans une revue hal-04092790 v1
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Comparison of two Phaeodactylum tricornutum ecotypes under nitrogen starvation and resupply reveals distinct lipid accumulation strategies but a common degradation process

Victor Murison , Josiane Hérault , Martine Côme , Sabrina Guinio , Alexis Lebon et al.
Frontiers in Plant Science, 2023, 14, ⟨10.3389/fpls.2023.1257500⟩
Article dans une revue (data paper) hal-04215015 v1
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Microalgae Produce Antioxidant Molecules with Potential Preventive Effects on Mitochondrial Functions and Skeletal Muscular Oxidative Stress

Jordi Vignaud , Céline Loiseau , Josiane Hérault , Claire Mayer , Martine Côme et al.
Antioxidants , 2023, 12 (5), pp.1050. ⟨10.3390/antiox12051050⟩
Article dans une revue hal-04092798 v1
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Lysophosphatidylcholine-DHA Specifically Induces Cytotoxic Effects of the MDA-MB-231 Human Breast Cancer Cell Line In Vitro—Comparative Effects with Other Lipids Containing DHA

Dalal Mohamad Ali , Kevin Hogeveen , Rose-Marie Orhant , Tiphaine Le Gal de Kerangal , Françoise Ergan et al.
Nutrients, 2023, 15 (9), pp.2137. ⟨10.3390/nu15092137⟩
Article dans une revue hal-04092785 v1
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Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors

Mostefa Fodil , Vincent Blanckaert , Lionel Ulmann , Virginie Mimouni , Benoît Chénais
International Journal of Environmental Research and Public Health, 2022, 19 (13), pp.7936. ⟨10.3390/ijerph19137936⟩
Article dans une revue hal-03710879 v1
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The Potential of the Marine Microalga Diacronema lutheri in the Prevention of Obesity and Metabolic Syndrome in High-Fat-Fed Wistar Rats

Claire Mayer , Martine Côme , Lionel Ulmann , Isabelle Martin , Graziella Chini Zittelli et al.
Molecules, 2022, 27 (13), pp.4246. ⟨10.3390/molecules27134246⟩
Article dans une revue hal-03710874 v1
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The Marine Microalga, Tisochrysis lutea, Protects against Metabolic Disorders Associated with Metabolic Syndrome and Obesity

Claire Mayer , Léo Richard , Martine Côme , Lionel Ulmann , Hassan Nazih et al.
Nutrients, 2021, 13 (2), pp.1-17. ⟨10.3390/nu13020430⟩
Article dans une revue hal-03124337 v1
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Protective Action of Ostreococcus tauri and Phaeodactylum tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

Manon Le Goff , Antoine Delbrut , Marie Quinton , Rémi Pradelles , Maelle Bescher et al.
Marine drugs, 2019, 18 (1), pp.3. ⟨10.3390/md18010003⟩
Article dans une revue hal-02441226 v1
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Nitrogen and phosphorus limitations induce carbon partitioning and membrane lipid remodelling in the marine diatom Phaeodactylum tricornutum

Bing Huang , Justine Marchand , Vincent Blanckaert , Ewa Lukomska , Lionel Ulmann et al.
European Journal of Phycology, 2019, 54 (3), pp.342-358. ⟨10.1080/09670262.2019.1567823⟩
Article dans une revue hal-02302335 v1
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Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in human health and disease prevention

Manon Le Goff , E. Le Ferrec , Claire Mayer , Virginie Mimouni , Dominique Lagadic-Gossmann et al.
Biochimie, 2019, 167, pp.106-118. ⟨10.1016/j.biochi.2019.09.012⟩
Article dans une revue hal-02302332 v1

A comparative study on the effect of argan oil versus fish oil on risk factors for cardio-vascular disease in high-fat-fed rats

Adil Haimeur , Nadia Meskini , Virginie Mimouni , Lionel Ulmann , Hafida Messaouri et al.
Nutrition, 2019, 57, pp.32-39. ⟨10.1016/j.nut.2018.05.027⟩
Article dans une revue hal-02302338 v1
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PAHs increase the production of extracellular vesicles both in vitro in endothelial cells and in vivo in urines from rats

Manon Le Goff , Dominique Lagadic-Gossmann , Remi Latour , Normand Podechard , Nathalie Grova et al.
Environmental Pollution, 2019, 255, pp.113171. ⟨10.1016/j.envpol.2019.113171⟩
Article dans une revue hal-02302334 v1
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Preventive Effects of the Marine Microalga Phaeodactylum tricornutum, Used as a Food Supplement, on Risk Factors Associated with Metabolic Syndrome in Wistar Rats

Claire Mayer , Martine Côme , Lionel Ulmann , Graziella Chini Zittelli , Cecilia Faraloni et al.
Nutrients, 2019, 11 (5), pp.1069. ⟨10.3390/nu11051069⟩
Article dans une revue hal-02495591 v1

Microalgal Fatty Acids and Their Implication in Health and Disease

Lionel Ulmann , Vincent Blanckaert , Virginie Mimouni , Mats Andersson , Benoît Schoefs et al.
Mini-Reviews in Medicinal Chemistry, 2017, 17 (12), ⟨10.2174/1389557516666160722132736⟩
Article dans une revue istex hal-01901146 v1
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Modulation of lipid biosynthesis by stress in diatoms

Olga Sayanova , Virginie Mimouni , Lionel Ulmann , Annick Morant-Manceau , Virginie Pasquet et al.
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017, 372 (1728), pp.20160407. ⟨10.1098/rstb.2016.0407⟩
Article dans une revue hal-02001096 v1

Proximate Analysis, Lipid Profile, Microbiological and Pigment Characterization of Chlorella Dry Powder Produced in a 20 L Agitated Photobioreactor

Luis Torres , Luis Corzo , Virginie Mimouni , Lionel Ulmann
Asian Journal of Biotechnology and Bioresource Technology, 2017, 2 (2), pp.1-10. ⟨10.9734/AJB2T/2017/38220⟩
Article dans une revue hal-02303544 v1

Fish Oil and Microalga Omega-3 as Dietary Supplements: A Comparative Study on Cardiovascular Risk Factors in High-Fat Fed Rats

Adil Haimeur , Virginie Mimouni , Lionel Ulmann , Anne-Sophie Martineau , Hafida Messaouri et al.
Lipids, 2016, 51, pp.1037-1049. ⟨10.1007/s11745-016-4177-2⟩
Article dans une revue hal-02001042 v1

Light Intensity Regulates LC-PUFA Incorporation into Lipids of Pavlova lutheri and the Final Desaturase and Elongase Activities Involved in Their Biosynthesis

Freddy Guihéneuf , Virginie Mimouni , Gérard Tremblin , Lionel Ulmann
Journal of Agricultural and Food Chemistry, 2015, 63 (4), pp.1261-1267. ⟨10.1021/jf504863u⟩
Article dans une revue hal-02047476 v1
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Marine microalgae used as food supplements and their implication in preventing cardiovascular diseases

Virginie Mimouni , Lionel Ulmann , Adil Haimeur , Frédérique Guéno , Nadia Meskini et al.
OCL Oilseeds and fats crops and lipids, 2015, 22 (4), pp.D409. ⟨10.1051/ocl/2015015⟩
Article dans une revue hal-02001045 v1

Fatty acids profile and temperature in the cultured marine diatom Odontella aurita

Virginie Pasquet , Lionel Ulmann , Virginie Mimouni , Freddy Guihéneuf , Boris Jacquette et al.
Journal of Applied Phycology, 2014, 26 (6), pp.2265-2271. ⟨10.1007/s10811-014-0252-3⟩
Article dans une revue hal-02001057 v1

Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning

Fatima Kasbi-Chadli , Clair-Yves Boquien , Gilles Simard , Lionel Ulmann , Virginie Mimouni et al.
Journal of Nutritional Biochemistry, 2014, 25 (7), pp.726-733. ⟨10.1016/j.jnutbio.2014.03.003⟩
Article dans une revue hal-02636983 v1

Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri

Freddy Guihéneuf , Lionel Ulmann , Virginie Mimouni , Gérard Tremblin
Phytochemistry, 2013, 90, pp.43-49. ⟨10.1016/j.phytochem.2013.02.014⟩
Article dans une revue istex hal-02001060 v1
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Argan oil prevents prothrombotic complications by lowering lipid levels and platelet aggregation, enhancing oxidative status in dyslipidemic patients from the area of Rabat (Morocco)

Adil Haimeur , Hafida Messaouri , Lionel Ulmann , Virginie Mimouni , Azelarab Masrar et al.
Lipids in Health and Disease, 2013, 12 (1), pp.107. ⟨10.1186/1476-511X-12-107⟩
Article dans une revue hal-02303556 v1
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Plastids of Marine Phytoplankton Produce Bioactive Pigments and Lipids

Parisa Heydarizadeh , Isabelle Poirier , Damien Loizeau , Lionel Ulmann , Virginie Mimouni et al.
Marine drugs, 2013, 11 (9), pp.3425-3471. ⟨10.3390/md11093425⟩
Article dans une revue hal-02304112 v1
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The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest

Virginie Mimouni , Lionel Ulmann , Virginie Pasquet , Marie Mathieu , Laurent Picot et al.
Current Pharmaceutical Biotechnology, 2012, 13 (15), pp.2733-2750. ⟨10.2174/138920112804724828⟩
Article dans une revue hal-01248050 v1
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The role of Odontella aurita, a marine diatom rich in EPA, as a dietary supplement in dyslipidemia, platelet function and oxidative stress in high-fat fed rats

Adil Haimeur , Lionel Ulmann , Virginie Mimouni , Frédérique Guéno , Fabienne Pineau-Vincent et al.
Lipids in Health and Disease, 2012, 11, pp.147. ⟨10.1186/1476-511X-11-147⟩
Article dans une revue hal-02303557 v1

Light-dependent utilization of two radiolabelled carbon sources, sodium bicarbonate and sodium acetate, and relationships with long chain polyunsaturated fatty acid synthesis in the microalga Pavlova lutheri (Haptophyta)

Freddy Guihéneuf , Lionel Ulmann , Gerard Tremblin , Virginie Mimouni
European Journal of Phycology, 2011, 46 (2), pp.143-152. ⟨10.1080/09670262.2011.577912⟩
Article dans une revue hal-02001099 v1

No altered blood pressure and serum markers of oxidative stress after a long time dietary fish oil in the genetically 9 month-old type-2 diabetes Zucker rat

Sompadthana Tricot , Virginie Mimouni , Sonia Rompion , Christelle Froger , Pierre Lacroix et al.
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2010, 83 (4-6), pp.211-218. ⟨10.1016/j.plefa.2010.08.005⟩
Article dans une revue istex hal-02001103 v1

Effect of UV stress on the fatty acid and lipid class composition in two marine microalgae Pavlova lutheri (Pavlovophyceae) and Odontella aurita (Bacillariophyceae)

Freddy Guihéneuf , Manuela Fouqueray , Virginie Mimouni , Lionel Ulmann , Boris Jacquette et al.
Journal of Applied Phycology, 2010, 22 (5), pp.629-638. ⟨10.1007/s10811-010-9503-0⟩
Article dans une revue istex hal-02001107 v1

Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231

Vincent Blanckaert , Lionel Ulmann , Virginie Mimouni , Antol Johann , Lucile Brancquart et al.
International Journal of Oncology, 2010, 36 (3)
Article dans une revue hal-02001122 v1

Combined effects of irradiance level and carbon source on fatty acid and lipid class composition in the microalga Pavlova lutheri commonly used in mariculture

Freddy Guihéneuf , Virginie Mimouni , Lionel Ulmann , Gérard Tremblin
Journal of Experimental Marine Biology and Ecology, 2009, 369 (2), pp.136-143. ⟨10.1016/j.jembe.2008.11.009⟩
Article dans une revue istex hal-02001124 v1

ENVIRONMENTAL FACTORS AFFECTING GROWTH AND OMEGA 3 FATTY ACID COMPOSITION IN SKELETONEMA COSTATUM. THE INFLUENCES OF IRRADIANCE AND CARBON SOURCE

Freddy Guihéneuf , Virginie Mimouni , Lionel Ulmann , Gerard Tremblin
Diatom Research, 2008, 23 (1), pp.93-103. ⟨10.1080/0269249X.2008.9705739⟩
Article dans une revue hal-02303567 v1

Brain and hippocampus fatty acid composition in phospholipid classes of aged-relative cognitive deficit rats

Lionel Ulmann , Virginie Mimouni , S. Roux , R. Porsolt , J.-P. Poisson
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2001, 64 (3), pp.189-195. ⟨10.1054/plef.2001.0260⟩
Article dans une revue istex hal-02001128 v1

Age-related changes in antioxidant defence mechanisms and peroxidation in isolated hepatocytes from spontaneously hypertensive and normotensive rats

Evelyne Véricel , Michel Narce , Lionel Ulmann , Jean-Pierre Poisson , Michel Lagarde
Molecular and Cellular Biochemistry, 1994, 132 (1), pp.25-29. ⟨10.1007/bf00925671⟩
Article dans une revue istex hal-02303570 v1

Incorporation of Δ6- and Δ5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n − 6 or n − 3 fatty acids

Lionel Ulmann , Jean Paul Blond , Jean Pierre Poisson , Jean Bézard
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1994, 1214 (1), pp.73-78. ⟨10.1016/0005-2760(94)90011-6⟩
Article dans une revue istex hal-02303578 v1

Age-related changes in Δ6 and Δ5 desaturase activities in rat liver microsomes

C. Maniongul , J. Blond , Lionel Ulmann , Geoffroy Durand , J. Poisson et al.
Lipids, 1993, 28 (4), pp.291-297. ⟨10.1007/BF02536313⟩
Article dans une revue istex hal-02303581 v1

Relationship between rat liver microsomal Δ6 and Δ5 desaturase activities and fatty acid composition: comparative effects of coconut and salmon oils during protein restriction

Lionel Ulmann , Mahmoud Bouziane , Virginie Mimouni , Jacques Belleville , Jean Pierre Poisson
The Journal of Nutritional Biochemistry, 1992, 3 (4), pp.188-193. ⟨10.1016/0955-2863(92)90115-Y⟩
Article dans une revue istex hal-02303584 v1

Elongation and desaturation of arachidonic and eicosapentaenoic acids in rat liver. Effect of clofibrate feeding

Virginie Mimouni , Erling Christiansen , Jean Paul Blond , Lionel Ulmann , Jean-Pierre Poisson et al.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991, 1086 (3), pp.349-353. ⟨10.1016/0005-2760(91)90180-P⟩
Article dans une revue istex hal-02303586 v1

Effects of age and dietary fatty acids on desaturase activities and on fatty acid composition on liver microsomal phospholipids of adult rats

L. Ulmann , J.P. Blond , C. Maniongui , J.P. Poisson , G. Durand et al.
Lipids, 1991, 26 (1), pp.127-133
Article dans une revue hal-02712734 v1

Effects of age and dietary essential fatty acids on desaturase activities and on fatty acid composition of liver microsomal phospholipids of adult rats

Lionel Ulmann , J. Blond , C. Maniongui , J. Poisson , Geoffroy Durand et al.
Lipids, 1991, 26 (2), pp.127-133. ⟨10.1007/BF02544006⟩
Article dans une revue istex hal-02303592 v1

Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of Δ6 and Δ9 desaturation, γ-linolenic and oleic acids: effect of age and of blackcurrant seed oil

Lionel Ulmann , Jean-Pierre Poisson , Jean Paul Blond , Jean Bézard
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991, 1086 (2), pp.230-236. ⟨10.1016/0005-2760(91)90012-7⟩
Article dans une revue istex hal-02303589 v1

The effect of dietary α-bromopalmitate on blood lipids in the rat

Tor-Arne Hagve , Michel Narce , Morten Grønn , Erik Christensen , Lionel Ulmann et al.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989, 1004 (1), pp.143-146. ⟨10.1016/0005-2760(89)90225-7⟩
Article dans une revue istex hal-02303594 v1

Lipids From Microalgae

Virginie Mimouni , Aurélie Couzinet-Mossion , Lionel Ulmann , Gaëtane Wielgosz-Collin
Microalgae in Health and Disease Prevention, Elsevier, pp.109-131, 2018, ⟨10.1016/B978-0-12-811405-6.00005-0⟩
Chapitre d'ouvrage hal-02303530 v1
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The polyunsaturated fatty acids from microalgae as potential sources for health and disease

Lionel Ulmann , Virginie Mimouni , Vincent Blanckaert , Virginie Pasquet , Benoît Schoefs et al.
Angel Català. Polyunsaturated Fatty Acids: Sources, Antioxidant Properties and Health Benefits, Nova Science Publishers, 2013, 978-1-62948-151-7
Chapitre d'ouvrage hal-01906200 v1

Effects of age and dietary 18-3 omega-6 and 18-4 omega-3 on the delta 6-desaturations in rat liver microsomes

J.P. Blond , Philippe Guesnet , L. Ulmann , C. Maniongui , J. Bezard et al.
2. International Conference on the Health Effects of omega-3 Polyunsaturated Fatty Acids, Mar 1990, Washington DC, United States
Communication dans un congrès hal-02775576 v1

Effet de l'age sur la capacite du foie a desaturer les acides gras chez le rat

C. Maniongui , J.P. Blond , L. Ulmann , G. Durand , J. Bezard
5. Symposium sur Nutrition, Lipides, Lipoproteines, Mar 1991, Creteil, France
Communication dans un congrès hal-02777764 v1

Acides gras polyinsatures alimentaires et desaturations microsomales chez le rat.

J.P. Blond , G. Durand , L. Ulmann , M.P. Lonjaret , J.P. Poisson et al.
Congres International. 1. Congres Eurolipid, Jun 1989, Angers, France
Communication dans un congrès hal-02783543 v1