Luc BUEE

Directeur de Recherche au CNRS - Directeur du laboratoire LilNCog Lille Neuroscience & Cognition Inserm U1172
212
Documents
Affiliation actuelle
  • Lille Neurosciences & Cognition - U 1172 (LilNCog)

Présentation

Luc Buée est directeur de recherche au CNRS et directeur du Centre de recherche Inserm Neurosciences & Cognition de Lille à l'Université de Lille, en France. Son laboratoire, situé sur le campus du centre hospitalo-universitaire de Lille, appartient au Centre d'excellence de Lille sur les troubles neurodégénératifs (LiCEND).

Luc Buée travaille sur la maladie d'Alzheimer et les troubles apparentés depuis plus de trente ans (>350 articles dans Pubmed). Il a commencé ses travaux sur le rôle des protéoglycanes dans la maladie d'Alzheimer pendant sa formation doctorale au Mount Sinai Medical Center, à New York. Il a réalisé certaines des observations neuropathologiques pionnières sur les anomalies microvasculaires dans les troubles neurodégénératifs. Il a participé à la caractérisation biochimique initiale des agrégats de tau dans certaines maladies neurodégénératives (le code-barre des tauopathies). Il a ensuite développé des modèles expérimentaux pour mieux comprendre le rôle des modifications post-traductionnelles dans l'agrégation et la sécrétion de la protéine tau. Ces modèles expérimentaux sont aujourd'hui largement utilisés pour évaluer les stratégies thérapeutiques contre les tauopathies (immunothérapie, petites molécules, thérapies non médicamenteuses...). Avec son équipe, il a également découvert de nombreuses fonctions non microtubulaires de la protéine tau. Il travaille actuellement sur les conséquences physiopathologiques de la dégénérescence neurofibrillaire et leurs liens avec la pathologie amyloïde et l'inflammation dans la maladie d'Alzheimer. Son groupe a participé/participe à différents consortiums nationaux & internationaux.

Domaines de recherche

Sciences du Vivant [q-bio]

Publications

Publications

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Protein kinase R induced by type I interferons is a main regulator of reactive microglia in Zika virus infection

Violaine Bortolin , Zeyni Mansuroglu , Laurine Conquet , Gaetano Calcagno , Fanny Lambert et al.

Glia, 2025, 73 (1), pp.80-104. ⟨10.1002/glia.24619⟩

Article dans une revue hal-04798761v1
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Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference

B. Frost , J. B. Rowe , R. O. Akinyemi , J. F. Abisambra , N. J. Ashton et al.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025, Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 21 (5), pp.e70078. ⟨10.1002/alz.70078⟩

Article dans une revue (article de synthèse) hal-05237376v1
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Inhibition of tau neuronal internalization using anti-tau single domain antibodies.

Clement Danis , Elian Dupre , Thomas Bouillet , M. Denéchaud , Camille Lefebvre et al.

Nature Communications, 2025, Nat Commun, 16, pp.3162. ⟨10.1038/s41467-025-58383-4⟩

Article dans une revue hal-05043654v1
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Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences

M. Ali , P. Garcia , L. P. Lunkes , A. Sciortino , M. H. Thomas et al.

Acta Neuropathologica Communications, 2025, Acta Neuropathol. Commun., 13, ⟨10.1186/s40478-025-02013-z⟩

Article dans une revue hal-05118196v1

Hampered AMPK-ULK1 cascade in Alzheimer's disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin

A. Mary , S. Barale , F. Eysert , A. Valverde , S. Lacas-Gervais et al.

Alzheimer's Research and Therapy, 2025, Alzheimer's Research and Therapy, 17 (127), ⟨10.1186/s13195-025-01772-0⟩

Article dans une revue hal-05248286v1
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Hippocampal Astrocyte Morphology Follows an Unexpected Trajectory With Age in a Transgenic Rodent Model of Tauopathy.

Emma Augustin , Tatiana Vinasco-Sandoval , Miriam Riquelme-Perez , Damien Plassard , Mylène Gaudin et al.

Glia, 2025, Glia, 73 (7), pp.1502-1519. ⟨10.1002/glia.70019⟩

Article dans une revue hal-05043661v1

Sex-dependent effects of maternal high-fat diet during lactation in the offspring of adult THY-Tau22 mice.

Thibaut Gauvrit , Hamza Benderradji , A. Pelletier , Kevin Carvalho , Soulaimane Aboulouard et al.

Brain : a journal of neurology, 2025, Brain, pp.awaf417. ⟨10.1093/brain/awaf417⟩

Article dans une revue hal-05383267v1

Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis.

Ariunjargal Nyamerdene , Nhi Thao Ngoc Le , Ouada Nebie , Emilie Faivre , L. Delila et al.

Biomaterials, 2025, Biomaterials, 328, pp.123838. ⟨10.1016/j.biomaterials.2025.123838⟩

Article dans une revue hal-05383375v1
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Upregulation of adenosine A<sub>2A</sub> receptor in astrocytes is sufficient to trigger hippocampal multicellular dysfunctions and memory deficits

Agathe Launay , Kevin Carvalho , Athénais Genin , Thibaut Gauvrit , Paola Nobili et al.

Molecular Psychiatry, In press, 30 (11), pp.5300-5314. ⟨10.1038/s41380-025-03115-9⟩

Article dans une revue hal-05213296v1
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Protein fingerprints of brain-derived extracellular vesicles predict types of tau pathology.

Jeanne Espourteille , A. Barve , V. Zufferey , Elodie Leroux , Romain Perbet et al.

Alzheimer's Research and Therapy, 2025, Alzheimer's Research and Therapy, 17, pp.223. ⟨10.1186/s13195-025-01865-w⟩

Article dans une revue hal-05372245v1
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Anti-tau VHH therapy against PHF6: a safe approach to slowing the phenotype of tau pathology

Raphaelle Caillierez , Clémence Leboullenger , Sarah Leclercq , Mélanie Besegher , Séverine Bégard et al.

Alzheimer's Research and Therapy, 2025, 17 (1), pp.221. ⟨10.1186/s13195-025-01823-6⟩

Article dans une revue hal-05349800v1
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Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer's disease: associations with Aβ, tau, synaptic proteins and APOE ε4.

Jana Nussbaumer , A. Barve , V. Zufferey , J. Espourteille , T. Kirabali et al.

Translational Neurodegeneration, 2025, Translational Neurodegeneration, 14, pp.48. ⟨10.1186/s40035-025-00508-2⟩

Article dans une revue hal-05315622v1
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Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment

S. Lehmann , Susanna Schraen , Jean-Sébastien Vidal , Constance Delaby , Luc Buee et al.

Journal of Neurology, Neurosurgery and Psychiatry, 2024, Journal of Neurology, Neurosurgery and Psychiatry, 95 (11), pp.1046-1053. ⟨10.1136/jnnp-2024-333467⟩

Article dans une revue hal-04686879v1
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Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

N. Basheer , Luc Buee , J. P. Brion , T. Smolek , M. K. Muhammadi et al.

Acta Neuropathologica Communications, 2024, Acta Neuropathologica Communications, 12 (1), pp.52. ⟨10.1186/s40478-024-01748-5⟩

Article dans une revue (article de synthèse) hal-04684931v1
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Tau, synapse loss and gliosis progress in an Alzheimer's mouse model after amyloid-β immunotherapy.

L. A. Welikovitch , A. Mate de Gerando , A. Khasnavis , H. Bhavsar , J. C. Meltzer et al.

Brain : a journal of neurology, 2024, Brain, ⟨10.1093/brain/awae345⟩

Article dans une revue hal-04977490v1
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Dysregulated expression of cholesterol biosynthetic genes in Alzheimer's disease alters epigenomic signatures of hippocampal neurons

Isabel Paiva , Jonathan Seguin , Iris Grgurina , Akash Kumar Singh , Brigitte Cosquer et al.

Neurobiology of Disease, 2024, Neurobiology of Disease, 198, pp.106538. ⟨10.1016/j.nbd.2024.106538⟩

Article dans une revue hal-04686940v1

Reply to: Questioning the cycad theory of Kii ALS-PDC causation

K. Menšíková , R. Rosales , C. Colosimo , P. Spencer , A. Lannuzel et al.

Nature Reviews Neurology, 2024, Nature Reviews Neurology, 20, pp.195-196. ⟨10.1038/s41582-024-00938-y⟩

Article dans une revue hal-04684988v1
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A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

Justine Mortelecque , O. Zejneli , S. Bégard , M. C. Simões , Lea El Hajjar et al.

Journal of Biological Chemistry, 2024, Journal of Biological Chemistry, 300 (4), pp.107163. ⟨10.1016/j.jbc.2024.107163⟩

Article dans une revue hal-04684954v1
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Galectin-3 aggravates microglial activation and tau transmission in tauopathy.

Jian Jing Siew , Hui-Mei Chen , Feng-Lan Chiu , Chia-Wei Lee , Yao-Ming Chang et al.

The Journal of clinical investigation, 2024, The Journal of clinical investigation, 134, ⟨10.1172/JCI165523⟩

Article dans une revue hal-04835444v1
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Effects of the therapeutic correction of U1 snRNP complex on Alzheimer's disease

Caio Bruno Q. S. Leal , Camila G. M. Zimmer , Vanessa V. C. Sinatti , Ericks S. Soares , Britt Poppe et al.

Scientific Reports, 2024, Scientific Reports, 14, ⟨10.1038/s41598-024-81687-2⟩

Article dans une revue hal-04956606v1
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The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease

L. Vaillant-Beuchot , F. Eysert , B. Duval , P. F. Kinoshita , R. Pardossi-Piquard et al.

Cell Death and Disease, 2024, Cell Death and Disease, 15, pp.367. ⟨10.1038/s41419-024-06742-2⟩

Article dans une revue hal-04686736v1
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The free plasma amyloid Aβ1–42/Aβ1–40 ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma Aβ1–42/Aβ1–40 ratio. The BALTAZAR study

Susanna Schraen , Alain Duhamel , J. S. Vidal , Nassima Ramdane , L. Vaudran et al.

Neurobiology of Disease, 2024, Neurobiology of Disease, 193, pp.106459. ⟨10.1016/j.nbd.2024.106459⟩

Article dans une revue hal-04684814v1
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Dipyridamole Ameliorates Memory Impairment and Increases Hippocampal Calbindin Expression in Niemann Pick C1 Mice.

Lucia Gaddini , Valentina Chiodi , Andrea Matteucci , Zaira Boussadia , Luc Buee et al.

Journal of Neuroscience Research, 2024, Journal of Neuroscience Research, 102, pp.e70011. ⟨10.1002/jnr.70011⟩

Article dans une revue hal-04942797v1
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Proteomics of human platelet lysates and insight from animal studies on platelet protein diffusion to hippocampus upon intranasal administration.

N. T. N. Le , C. L. Han , L. Delila , Ouada Nebie , H. T. Chien et al.

APL Bioengineering, 2024, APL Bioengineering, 8, pp.026111. ⟨10.1063/5.0196553⟩

Article dans une revue hal-04595617v1
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Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

Victoria Gomez-Murcia , Agathe Launay , Kévin Carvalho , Anaëlle Burgard , Céline Meriaux et al.

Brain - A Journal of Neurology , 2024, Brain - A Journal of Neurology, 147 (8), pp.2691-2705. ⟨10.1093/brain/awae113⟩

Article dans une revue hal-04684882v1
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Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson's disease models.

Liling Delila , Ouada Nebie , Nhi Thao Ngoc Le , Kelly Timmerman , Deng-Yao Lee et al.

Journal of Biomedical Science, 2024, Journal of Biomedical Science, 31, ⟨10.1186/s12929-024-01072-z⟩

Article dans une revue hal-04976607v1
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Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease

Sylvain Lehmann , Susanna Schraen-Maschke , Luc Buée , Jean-Sébastien Vidal , Constance Delaby et al.

Molecular Neurodegeneration, 2024, 19 (1), pp.66. ⟨10.1186/s13024-024-00755-3⟩

Article dans une revue hal-04799669v1
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Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations.

M. Ali , P. Garcia , L. P. Lunkes , A. Sciortino , M. Thomas et al.

Cell Death Discovery, 2024, Cell Death Discovery, 10 (1), pp.119. ⟨10.1038/s41420-024-01885-9⟩

Article dans une revue hal-04595341v1
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Caffeine consumption outcomes on amyotrophic lateral sclerosis disease progression and cognition

Vincent Huin , David Blum , Violette Delforge , E. Cailliau , S. Djeziri et al.

Neurobiology of Disease, 2024, Neurobiology of Disease, 199, pp.106603. ⟨10.1016/j.nbd.2024.106603⟩

Article dans une revue hal-04684979v1
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Novel avenues of tau research

C. E. Sexton , G. Bitan , K. R. Bowles , M. Brys , Luc Buee et al.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024, Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 20 (3), pp.2240-2261. ⟨10.1002/alz.13533⟩

Article dans une revue (article de synthèse) hal-04684894v1
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Cell redistribution of G quadruplex-structured DNA is associated with morphological changes of nuclei and nucleoli in neurons during tau pathology progression

Thomas Comptdaer , Meryem Tardivel , Claire Schirmer , Luc Buee , Marie-Christine Galas

Brain Pathology, 2024, Brain Pathology, pp.e13262. ⟨10.1111/bpa.13262⟩

Article dans une revue hal-04685000v1
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FTLD-MAPT mutations and short 5′UTR Tau mRNAs increase Tau translation

Paulo J da Costa , Antoine Perret , Luc Buée , Malika Hamdane , Franck Martin

NAR Molecular Medicine, 2024, 1 (4), ⟨10.1093/narmme/ugae023⟩

Article dans une revue hal-04909340v1
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Aggregate-selective removal of pathological tau via clustering-activated degraders

Jonathan Benn , Shi Cheng , Sophie Keeling , Annabel Smith , Marina Vaysburd et al.

Science, 2024, 385 (6712), pp.1009-1016. ⟨10.1126/science.adp5186⟩

Article dans une revue hal-04745023v1
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Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology

T. J. Zwang , E. D. Sastre , N. Wolf , N. Ruiz-Uribe , B. Woost et al.

Cell Reports, 2024, Cell Reports, 43 (8), pp.114574. ⟨10.1016/j.celrep.2024.114574⟩

Article dans une revue hal-04687045v1
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Precision proteoform design for 4R tau isoform selective templated aggregation

A. P. Longhini , A. Dubose , S. Lobo , V. Vijayan , Y. Bai et al.

Proceedings of the National Academy of Sciences of the United States of America, 2024, Proceedings of the National Academy of Sciences of the United States of America, 121 (15), pp.e2320456121. ⟨10.1073/pnas.2320456121⟩

Article dans une revue hal-04684829v1
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Electropolymerization processing of side-chain engineered EDOT for high performance microelectrode arrays

Mahdi Ghazal , Anna Susloparova , Camille Lefebvre , Michel Daher Mansour , Najami Ghodhbane et al.

Biosensors and Bioelectronics, 2023, 237, pp.115538. ⟨10.1016/j.bios.2023.115538⟩

Article dans une revue hal-04182196v1

Endemic parkinsonism: clusters, biology and clinical features

K. Menšíková , J. C. Steele , R. Rosales , C. Colosimo , P. Spencer et al.

Nature Reviews Neurology, 2023, Nature Reviews Neurology, ⟨10.1038/s41582-023-00866-3⟩

Article dans une revue (article de synthèse) hal-04684401v1
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Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System

Romain Perbet , Valentin Zufferey , Elodie Leroux , Enea Parietti , Jeanne Espourteille et al.

Cells, 2023, 12 (7), pp.985. ⟨10.3390/cells12070985⟩

Article dans une revue inserm-04237877v1
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Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents

Thomas Rico , Marine Denecha , Raphaelle Caillierez , Thomas Comptdaer , Eric Adriaenssens et al.

Cancers, 2023, 15 (1), pp.116. ⟨10.3390/cancers15010116⟩

Article dans une revue inserm-03985380v1
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Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology

Iain Hartnell , Declan Woodhouse , William Jasper , Luke Mason , Pavan Marwaha et al.

Brain - A Journal of Neurology , 2023, pp.awad309. ⟨10.1093/brain/awad309⟩

Article dans une revue inserm-04237870v1
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A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APPSwe/PSEN1ΔE9 Mice Model of Amyloid Pathology

Marie Tautou , Florian Descamps , Paul-Emmanuel Larchanché , Luc Buée , Jamal El Bakali et al.

International Journal of Molecular Sciences, 2023, 24 (6), pp.5285. ⟨10.3390/ijms24065285⟩

Article dans une revue hal-04345588v1
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Precision of neuronal localization in 2D cell cultures by using high-performance electropolymerized microelectrode arrays correlated with optical imaging

Mahdi Ghazal , Corentin Scholaert , Corentin Dumortier , Camille Lefebvre , Nicolas Barois et al.

Biomedical Physics & Engineering Express, 2023, 9 (3), pp.035016. ⟨10.1088/2057-1976/acb93e⟩

Article dans une revue hal-03999001v1
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Plasma Amyloid Beta Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment: The BALTAZAR Study

Olivier Hanon , Jean-Sébastien Vidal , Sylvain Lehmann , Stéphanie Bombois , Bernadette Allinquant et al.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2022, 18, pp.2537-2550. ⟨10.1002/alz.12613⟩

Article dans une revue hal-03719721v1
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Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription

Isabel Paiva , Lucrezia Cellai , Céline Meriaux , Lauranne Poncelet , Ouada Nebie et al.

The Journal of clinical investigation, 2022, 132 (12), ⟨10.1172/JCI149371⟩

Article dans une revue hal-03855350v1
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Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men.

Hamza Benderradji , Anne-Laure Barbotin , M. Leroy-Billiard , J. Prasivoravong , F. Marcelli et al.

Journal of Clinical Endocrinology and Metabolism, 2022, The Journal of clinical endocrinology & metabolism, 107 (7), p. 1878-1887. ⟨10.1210/clinem/dgac218⟩

Article dans une revue hal-04450259v1
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Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer’s Disease

Shu-Mei Chen , Tsung-Chin Hsu , Chee-Ho Chew , Wan-Ting Huang , Amanda Lin Chen et al.

International Journal of Molecular Sciences, 2022, 23 (12), pp.6855. ⟨10.3390/ijms23126855⟩

Article dans une revue inserm-03704677v1
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Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats

Ludovic Arandel , Magdalena Matloka , Arnaud F Klein , Frédérique Rau , Alain Sureau et al.

Nature Biomedical Engineering, 2022, 6 (2), pp.207-220. ⟨10.1038/s41551-021-00838-2⟩

Article dans une revue hal-03830811v1
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Mammalian Brain Ca2+ Channel Activity Transplanted into Xenopus laevis Oocytes

Matthieu Rousset , Sandrine Humez , Cyril Laurent , Luc Buée , David Blum et al.

Membranes, 2022, 12 (5), pp.496. ⟨10.3390/membranes12050496⟩

Article dans une revue inserm-03699305v1
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Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration

Lee-Hsin Wang , Chien-Yu Lin , Yu-Mei Lin , Luc Buée , Nicolas Sergeant et al.

Journal of Neuroscience, 2022, pp.JN-RM-2006-21. ⟨10.1523/JNEUROSCI.2006-21.2022⟩

Article dans une revue inserm-03699311v1
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Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects

Edmone Dewaeles , Kévin Carvalho , Sandy Fellah , Jaewon Sim , Nihad Boukrout et al.

The Journal of clinical investigation, 2022, 132 (22), pp.e152924. ⟨10.1172/JCI152924⟩

Article dans une revue inserm-03865945v1

Efficacy of lanreotide 120 mg primary therapy on tumor shrinkage and ophthalmologic symptoms in acromegaly after one month.

Hamza Benderradji , E. Vernotte , Gustavo Soto-Ares , J. P. Woillez , Arnaud Jannin et al.

Clinical Endocrinology, 2022, Clinical Endocrinology, ⟨10.1111/cen.14748⟩

Article dans une revue hal-04430922v1
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Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey

Paulo da Costa , Malika Hamdane , Luc Buée , Franck Martin

Biomedicines, 2022, 10 (2), pp.241. ⟨10.3390/biomedicines10020241⟩

Article dans une revue hal-03599343v1
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Can the administration of platelet lysates to the brain help treat neurological disorders?

Ouada Nebie , Luc Buée , David Blum , Thierry Burnouf

Cellular and Molecular Life Sciences, 2022, 79 (7), pp.379. ⟨10.1007/s00018-022-04397-w⟩

Article dans une revue inserm-04237892v1
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Early-Life Environment Influence on Late-Onset Alzheimer’s Disease

Thibaut Gauvrit , Hamza Benderradji , Luc Buée , David Blum , Didier Vieau

Frontiers in Cell and Developmental Biology, 2022, 10, pp.834661. ⟨10.3389/fcell.2022.834661⟩

Article dans une revue inserm-03699318v1
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Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model

Hamza Benderradji , Sarra Kraiem , Emilie Courty , Sabiha Eddarkaoui , Cyril Bourouh et al.

Frontiers in Molecular Neuroscience, 2022, 15, pp.841892. ⟨10.3389/fnmol.2022.841892⟩

Article dans une revue inserm-03699324v1
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Impact of chronic doxycycline treatment in the APP/PS1 mouse model of Alzheimer's disease

Victoria Gomez-Murcia , Kevin Carvalho , Bryan Thiroux , Raphaëlle Caillierez , Melanie Besegher et al.

Neuropharmacology, 2022, 209, pp.108999. ⟨10.1016/j.neuropharm.2022.108999⟩

Article dans une revue inserm-03699325v1
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Cancers

Thomas Rico , Marine Denechaud , Raphaelle Caillierez , Thomas Comptdaer , Eric Adriaenssens et al.

Cancers, 2022, 15 (1), pp.116. ⟨10.3390/cancers15010116⟩

Article dans une revue hal-04488614v1
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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

Clément Danis , Elian Dupré , Orgeta Zejneli , Raphaëlle Caillierez , Alexis Arrial et al.

Molecular Therapy, 2022, ⟨10.1016/j.ymthe.2022.01.009⟩

Article dans une revue hal-03543108v1
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Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease.

Ilda Coku , Eugénie Mutez , Sabiha Eddarkaoui , Sébastien Carrier , Antoine Marchand et al.

Movement Disorders, 2022, ⟨10.1002/mds.29124⟩

Article dans une revue hal-03703786v1
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Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles

Christophe Mesangeau , Pascal Carato , Nicolas Renault , Mathilde Coevoet , Paul-Emmanuel Larchanché et al.

International Journal of Molecular Sciences, 2022, 23 (21), pp.13111. ⟨10.3390/ijms232113111⟩

Article dans une revue hal-04035715v1
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GnRH replacement rescues cognition in Down syndrome

Maria Manfredi-Lozano , Valerie Leysen , Michela Adamo , Isabel Paiva , Renaud Rovera et al.

Science, 2022, 377 (6610), pp.eabq4515. ⟨10.1126/science.abq4515⟩

Article dans une revue inserm-03841247v1
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IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease

Helena Brigas , Miguel Ribeiro , Joana Coelho , Rui Gomes , Victoria Gomez-Murcia et al.

Cell Reports, 2021, 36 (9), pp.109574. ⟨10.1016/j.celrep.2021.109574⟩

Article dans une revue inserm-03366653v1
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Tau Stabilizes Chromatin Compaction

Thomas Rico , Melissa Gilles , Alban Chauderlier , Thomas Comptdaer , Romain Magnez et al.

Frontiers in Cell and Developmental Biology, 2021, 9, pp.740550. ⟨10.3389/fcell.2021.740550⟩

Article dans une revue hal-03429442v1
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THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency

Audrey Vautheny , Charlotte Duwat , Gwennaëlle Aurégan , Charlène Joséphine , Anne-Sophie Hérard et al.

Neurobiology of Disease, 2021, 155, pp.105398. ⟨10.1016/j.nbd.2021.105398⟩

Article dans une revue inserm-03366724v1
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Extracellular vesicles: major actors of heterogeneity in tau spreading among human tauopathies

Elodie Leroux , Romain Perbet , Raphaëlle Caillerez , Kevin Richetin , Sarah Lieger et al.

Molecular Therapy, 2021, pp.S1525-0016(21)00475-5. ⟨10.1016/j.ymthe.2021.09.020⟩

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Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate

Suzanne Lam , Fanny Petit , Anne-Sophie Hérard , Susana Boluda , Sabiha Eddarkaoui et al.

Acta Neuropathologica Communications, 2021, 9 (1), pp.165. ⟨10.1186/s40478-021-01266-8⟩

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A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

Marie Tautou , Sabiha Eddarkaoui , Florian Descamps , Paul-Emmanuel Larchanché , Jamal El Bakali et al.

Frontiers in Pharmacology, 2021, 12, pp.679335. ⟨10.3389/fphar.2021.679335⟩

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P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy

Kevin Carvalho , Elodie Martin , Aurélia Ces , Nadège Sarrazin , Pauline Lagouge-Roussey et al.

Progress in Neurobiology, 2021, 206, pp.102139. ⟨10.1016/j.pneurobio.2021.102139⟩

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Les vésicules extracellulaires

Élodie Leroux , Romain Perbet , Luc Buée , Morvane Colin

Médecine/Sciences, 2021, 37 (12), pp.1133-1138. ⟨10.1051/medsci/2021205⟩

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Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

Ching-Pang Chang , Ya-Gin Chang , Pei-Yun Chuang , Thi Ngoc Anh Nguyen , Kuo-Chen Wu et al.

Acta Neuropathologica Communications, 2021, 9 (1), pp.112. ⟨10.1186/s40478-021-01213-7⟩

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Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment

Ouada Nebie , Kevin Carvalho , Lassina Barro , Liling Delila , Emilie Faivre et al.

Brain - A Journal of Neurology , 2021, pp.awab205. ⟨10.1093/brain/awab205⟩

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Current directions in tau research: Highlights from Tau 2020

Claire Sexton , Heather Snyder , Dirk Beher , Adam Boxer , Pat Brannelly et al.

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021, Online ahead of print. ⟨10.1002/alz.12452⟩

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Characterization and Chromatographic Isolation of Platelet Extracellular Vesicles from Human Platelet Lysates for Applications in Neuroregenerative Medicine

Ariunjargal Nyam-Erdene , Ouada Nebie , Liling Delila , Luc Buée , David Devos et al.

ACS Biomaterials Science and Engineering, 2021, 7 (12), pp.5823-5835. ⟨10.1021/acsbiomaterials.1c01226⟩

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Low impedance and highly transparent microelectrode arrays (MEA) for in vitro neuron electrical activity probing

Anna Susloparova , Sophie Halliez , Séverine Begard , Morvane Colin , Luc Buée et al.

Sensors and Actuators B: Chemical, 2021, 327, pp.128895. ⟨10.1016/j.snb.2020.128895⟩

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Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

Vincent Damotte , Sven J. van Der Lee , Vincent Chouraki , Benjamin Grenier-Boley , Jeannette Simino et al.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, In press, ⟨10.1002/alz.12333⟩

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A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms

Joke Verelst , Nick Geukens , Sabiha Eddarkaoui , Dorien Vliegen , Elien de Smidt et al.

Frontiers in Molecular Biosciences, 2020, 7, pp.48. ⟨10.3389/fmolb.2020.00048⟩

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Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Jin Zheng , Mansour Akbari , Claire Schirmer , Marie-Line Reynaert , Anne Loyens et al.

Acta Neuropathologica Communications, 2020, 8 (1), ⟨10.1186/s40478-020-00896-8⟩

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Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

Annerieke Sierksma , Ashley Lu , Renzo Mancuso , Nicola Fattorelli , Nicola Thrupp et al.

EMBO Molecular Medicine, 2020, pp.e10606. ⟨10.15252/emmm.201910606⟩

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Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

Kevin Richetin , Pascal Steullet , Mathieu Pachoud , Romain Perbet , Enea Parietti et al.

Nature Neuroscience, 2020, 23 (12), pp.1567-1579. ⟨10.1038/s41593-020-00728-x⟩

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Correction to: Gel Electrophoresis of Human Sperm: A Simple Method for Evaluating Sperm Protein Quality

Fanny Jumeau , Julien Sigala , Francisco-Jose Fernandez-Gomez , Sabiha Eddarkaoui , Sophie Duban-Deweer et al.

Basic and clinical andrology, 2020, 30, pp.4. ⟨10.1186/s12610-020-00102-8⟩

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Brain network remodelling reflects tau-related pathology prior to memory deficits in Thy-Tau22 mice

Laetitia Degiorgis , Meltem Karatas , Marion Sourty , Emilie Faivre , Julien Lamy et al.

Brain - A Journal of Neurology , 2020, ⟨10.1093/brain/awaa312⟩

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Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Jin Zheng , Mansour Akbari , Claire Schirmer , Marie-Line Reynaert , Anne Loyens et al.

Acta Neuropathologica Communications, 2020, 8 (1), pp.25. ⟨10.1186/s40478-020-00896-8⟩

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Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy

Victoria Gomez-Murcia , Ursula Sandau , Barbara Ferry , Sandrine Parrot , Cyril Laurent et al.

Neurobiology of Aging, 2020, 94, pp.265-270. ⟨10.1016/j.neurobiolaging.2020.06.004⟩

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The TMEM240 Protein, Mutated in SCA21, Is Expressed in Purkinje Cells and Synaptic Terminals

Mégane Homa , Anne Loyens , Sabiha Eddarkaoui , Emilie Faivre , Vincent Deramecourt et al.

The Cerebellum, In press, Ahead of print. ⟨10.1007/s12311-020-01112-y⟩

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Chronic Sodium Selenate Treatment Restores Deficits in Cognition and Synaptic Plasticity in a Murine Model of Tauopathy

Tariq Ahmed , Ann van Der Jeugd , Raphaëlle Caillierez , Luc Buée , David Blum et al.

Frontiers in Molecular Neuroscience, 2020, 13, pp.570223. ⟨10.3389/fnmol.2020.570223⟩

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Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains

Loan Vaillant-Beuchot , Arnaud Mary , Raphaëlle Pardossi-Piquard , Alexandre Bourgeois , Inger Lauritzen et al.

Acta Neuropathologica, 2020, ⟨10.1007/s00401-020-02234-7⟩

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Heat-treated human platelet pellet lysate modulates microglia activation, favors wound healing and promotes neuronal differentiation in vitro

Ouada Nebie , Lassina Barro , Yu-Wen Wu , Folke Knutson , Luc Buee et al.

Platelets, 2020, 1, pp.1-12. ⟨10.1080/09537104.2020.1732324⟩

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Tau hyperphosphorylation induced by the anesthetic agent ketamine/xylazine involved the calmodulin‐dependent protein kinase II

Audrey Hector , Christina Mcanulty , Maude‐éloïse Piché‐lemieux , Claire Alves‐pires , Valérie Buée‐scherrer et al.

FASEB Journal, 2020, 34 (2), pp.2968-2977. ⟨10.1096/fj.201902135R⟩

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Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model

Antoine Leboucher , Tariq Ahmed , Emilie Caron , Anne Tailleux , Sylvie Raison et al.

Neurobiology of Disease, 2019, 125, pp.14-22. ⟨10.1016/j.nbd.2019.01.008⟩

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Clustering of Tau fibrils impairs the synaptic composition of $\alpha$3‐Na$^+$/K$^+$‐ATP ase and AMPA receptors

Amulya Nidhi Shrivastava , Virginie Redeker , Laura Pieri , Luc Bousset , Marianne Renner et al.

EMBO Journal, 2019, 38 (3), pp.e99871. ⟨10.15252/embj.201899871⟩

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Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models

Enrico Faldini , Tariq Ahmed , Luc Buée , David Blum , Detlef Balschun

Acta Neuropathologica Communications, 2019, 7 (1), pp.202. ⟨10.1186/s40478-019-0813-4⟩

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NLRP3 inflammasome activation drives tau pathology

Christina Ising , Carmen Venegas , Shuangshuang Zhang , Hannah Scheiblich , Susanne Schmidt et al.

Nature, 2019, 575 (7784), pp.669-673. ⟨10.1038/s41586-019-1769-z⟩

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Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies

Elian Dupré , Clément Danis , Alexis Arrial , Xavier Hanoulle , Mégane Homa et al.

ACS Chemical Neuroscience, 2019, 10 (9), pp.3997-4006. ⟨10.1021/acschemneuro.9b00217⟩

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A walk through tau therapeutic strategies

Santosh Jadhav , Jesus Avila , Michael Schöll , Gabor Kovacs , Enikö Kövari et al.

Acta Neuropathologica Communications, 2019, 7 (1), pp.22. ⟨10.1186/s40478-019-0664-z⟩

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Encephalopathy induced by Alzheimer brain inoculation in a non-human primate

Charlotte Gary , Suzanne Lam , Anne-Sophie Herard , James E Koch , Fanny Petit et al.

Acta Neuropathologica Communications, 2019, 7 (1), ⟨10.1186/s40478-019-0771-x⟩

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Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process

Manon Domise , Florent Sauvé , Sébastien Didier , Raphaëlle Caillerez , Séverine Bégard et al.

Cell Death and Disease, 2019, 10 (3), pp.221. ⟨10.1038/s41419-019-1464-x⟩

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The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates

Ouada Nebie , David Devos , Valérie Vingtdeux , Lassina Barro , Jean-Christophe Devedjian et al.

Journal of Biomedical Science, 2019, 26 (1), pp.89. ⟨10.1186/s12929-019-0579-9⟩

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From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

Morvane Colin , Simon Dujardin , Susanna Schraen-Maschke , Guy Meno-Tetang , Charles Duyckaerts et al.

Acta Neuropathologica, 2019, Epub ahead of print. ⟨10.1007/s00401-019-02087-9⟩

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Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Kevin Carvalho , Emilie Faivre , Marie Pietrowski , Xavier Marques , Victoria Gomez-Murcia et al.

Brain - A Journal of Neurology , 2019, 142 (11), pp.3636-3654. ⟨10.1093/brain/awz288⟩

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Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases

Vincent Huin , Claire-Marie Dhaenens , Mégane Homa , Kévin Carvalho , Luc Buée et al.

Journal of Caffeine and Adenosine Research, 2019, 9 (3), pp.73-88. ⟨10.1089/caff.2019.0011⟩

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Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy

Stefania Zappettini , Emilie Faivre , Antoine Ghestem , Sébastien Carrier , Luc Buee et al.

Frontiers in Cellular Neuroscience, 2019, 13, pp.438. ⟨10.3389/fncel.2019.00438⟩

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A2A R‐induced transcriptional deregulation in astrocytes: An in vitro study

Isabel Paiva , Kévin Carvalho , Patricia R. Santos , Lucrezia Cellai , Maria Angeliki S. Pavlou et al.

Glia, 2019, 67 (12), pp.2329-2342. ⟨10.1002/glia.23688⟩

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The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

Yann Fichou , Youssra K Al-Hilaly , François Devred , Caroline Smet-Nocca , Philipp O Tsvetkov et al.

Acta Neuropathologica Communications, 2019, 7 (1), ⟨10.1186/s40478-019-0682-x⟩

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New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

Nicolas Sergeant , Valérie Vingtdeux , Sabiha Eddarkaoui , Marion Gay , Caroline Evrard et al.

Neurobiology of Disease, 2019, 129, p.217-233. ⟨10.1016/j.nbd.2019.03.028⟩

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Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model

Antoine Leboucher , Tariq Ahmed , Emilie Caron , Anne Tailleux , Sylvie Raison et al.

Neurobiology of Disease, 2019, 125, pp.14-22. ⟨10.1016/j.nbd.2019.01.008⟩

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Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody

Marie Albert , Georges Mairet-Coello , Clément Danis , Sarah Lieger , Raphaëlle Caillierez et al.

Brain - A Journal of Neurology , 2019, 142 (6), pp.1736-1750. ⟨10.1093/brain/awz100⟩

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Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy

Stefania Zappettini , Emilie Faivre , Antoine Ghestem , Sébastien Carrier , Luc Buee et al.

Frontiers in Cellular Neuroscience, 2019, 13, pp.438. ⟨10.3389/fncel.2019.00438⟩

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New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

Marion Gay , Pascal Carato , Mathilde Coevoet , Nicolas Renault , Paul-Emmanuel Larchanché et al.

Bioorganic and Medicinal Chemistry, 2018, 26 (8), pp.2151-2164. ⟨10.1016/j.bmc.2018.03.016⟩

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Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

Annerieke Sierksma , Ashley Lu , Evgenia Salta , Elke Vanden Eynden , Zsuzsanna Callaerts-Vegh et al.

Molecular Neurodegeneration, 2018, 13 (1), pp.54. ⟨10.1186/s13024-018-0285-1⟩

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Relation mutuelle entre Tau et signalisation centrale de l’insuline

Aurélie Joly-Amado , Maud Gratuze , Hamza Benderradji , Didier D. Vieau , Luc Buée et al.

Médecine/Sciences, 2018, 34 (11), pp.929-935. ⟨10.1051/medsci/2018238⟩

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Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

Chia-Chia Lee , Ching-Pang Chang , Chun-Jung Lin , Hsing-Lin Lai , Yu-Han Kao et al.

Molecular Neurobiology, 2018, ⟨10.1007/s12035-018-1030-z⟩

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Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions

Houda Benhelli-Mokrani , Zeyni Mansuroglu , Alban Chauderlier , Benoit Albaud , David Gentien et al.

Nucleic Acids Research, 2018, ⟨10.1093/nar/gky929⟩

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[Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies]

Aurélie Joly-Amado , Maud Gratuze , Hamza Benderradji , Didier D. Vieau , Luc Buee et al.

Médecine/Sciences, 2018, 34 (11), pp.929-935. ⟨10.1051/medsci/2018238⟩

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Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers

Olivier Hanon , Jean-Sébastien Vidal , Sylvain Lehmann , Stéphanie Bombois , Bernadette Allinquant et al.

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018, 14 (7), pp.858-868. ⟨10.1016/j.jalz.2018.01.004⟩

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Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

Mariana Ferreira , Diana Ferreira , Vânia Batalha , Inês Marques-Morgado , Joana Coelho et al.

Molecular Psychiatry, 2018, 25 (8), pp.1876-1900. ⟨10.1038/s41380-018-0110-9⟩

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Amp-activated protein kinase controls immediate early genes expression following synaptic activation through the pka/creb pathway

Sebastien Didier , Florent Sauve , Manon Domise , Luc Buee , Claudia Marinangeli et al.

International Journal of Molecular Sciences, 2018, 19 (2), pp.3716. ⟨10.3390/ijms19123716⟩

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Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

Emilie Faivre , Joana Coelho , Katja Zornbach , Enas Malik , Younis Baqi et al.

Frontiers in Molecular Neuroscience, 2018, 11, pp.235. ⟨10.3389/fnmol.2018.00235⟩

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Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aβ1–42 and Tau Proteins in Elderly Patients With Mild Cognitive Impairment

Emmanuelle Duron , Jean-Sébastien Vidal , Dominique Grousselle , Audrey Gabelle , Sylvain Lehmann et al.

Frontiers in Aging Neuroscience, 2018, 10, pp.297. ⟨10.3389/fnagi.2018.00297⟩

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Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

Annerieke Sierksma , Ashley Lu , Evgenia Salta , Elke Vanden Eynden , Zsuzsanna Callaerts-Vegh et al.

Molecular Neurodegeneration, 2018, 13 (1), pp.54. ⟨10.1186/s13024-018-0285-1⟩

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Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat

Marie D’orange , Gwenaëlle Auregan , Dimitri Cheramy , Mylène Gaudin-Guérif , Sarah Lieger et al.

Brain - A Journal of Neurology , 2018, 141 (2), pp.535-549. ⟨10.1093/brain/awx342⟩

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Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

Caroline Evrard , Pascal Kieulen-Campard , Mathilde Coevoet , Rémi Opsomer , Bernadette Tasiaux et al.

Frontiers in Cellular Neuroscience, 2018, 12, pp.435. ⟨10.3389/fncel.2018.00435⟩

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Relevance of Follow-Up in Patients with Core Clinical Criteria for Alzheimer Disease and Normal CSF Biomarkers

Olivier Vercruysse , Claire Paquet , Audrey Gabelle , Xavier Delbeuck , Frédéric Blanc et al.

Current Alzheimer Research, 2018, 15 (7), pp.691-700. ⟨10.2174/1567205015666180110113238⟩

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The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease

Lucrezia Cellai , Kevin Carvalho , Emilie Faivre , Aude Deleau , Didier D. Vieau et al.

Frontiers in Neuroscience, 2018, 12, pp.520. ⟨10.3389/fnins.2018.00520⟩

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Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

Cyril Laurent , Luc Buée , David Blum

Biomedical journal, 2018, 41 (1), pp.21 - 33. ⟨10.1016/j.bj.2018.01.003⟩

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Tau/DDX6 interaction increases microRNA activity

Alban Chauderlier , Melissa Gilles , Andrea Spolcova , Raphaëlle Caillierez , Maggy Chwastyniak et al.

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2018, 1861 (8), pp.762-772. ⟨10.1016/j.bbagrm.2018.06.006⟩

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A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors

Marion Gay , Caroline Evrard , Florian Descamps , Pascal Carato , Nicolas Renault et al.

European Journal of Medicinal Chemistry, 2018, 159, pp.104-125. ⟨10.1016/j.ejmech.2018.08.092⟩

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Relevance of Follow-Up in Patients with Core Clinical Criteria for Alzheimer Disease and Normal CSF Biomarkers

Olivier Vercruysse , Claire Paquet , Eloi Gabelle , Xavier Delbeuck , Frédéric Blanc et al.

Current Alzheimer Research, 2018, 15 (7), pp.691 - 700. ⟨10.2174/1567205015666180110113238⟩

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Different tau species lead to heterogeneous tau pathology propagation and misfolding

Simon Dujardin , Séverine Bégard , Raphaëlle Caillierez , Cédrick Lachaud , Sébastien Carrier et al.

Acta Neuropathologica Communications, 2018, 6 (1), pp.132. ⟨10.1186/s40478-018-0637-7⟩

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The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease

David Blum , Yijuang Chern , Maria Rosaria Domenici , Luc Buée , Chien-Yu Lin et al.

Journal of Caffeine and Adenosine Research, 2018, 8 (2), pp.43 - 58. ⟨10.1089/caff.2018.0006⟩

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Mutual relationship between Tau and central insulin signalling: consequences for AD and Tauopathies ?

Maud Gratuze , Aurélie Joly-Amado , Didier Vieau , Luc Buée , David Blum

Neuroendocrinology, 2018, ⟨10.1159/000487641⟩

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Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

Snehajyoti Chatterjee , Raphaelle Cassel , Anne Schneider‐anthony , Karine Mérienne , Brigitte Cosquer et al.

EMBO Molecular Medicine, 2018, 10 (11), pp.e8587. ⟨10.15252/emmm.201708587⟩

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Fabrication of new transparent MEAs made from pure PEDOT:PSS and their optical/electrical properties for neurons' activity assessment in the frame of Alzheimer disease case study

Anna Susloparova , Yannick Coffinier , F. Alibart , V. Thomy , S. Arscott et al.

Frontiers in Cellular Neuroscience, 2018, 12, ⟨10.3389/conf.fncel.2018.38.00035⟩

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The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease

Luc Cellai , Kevin Carvalho , Emilie Faivre , Aude Deleau , Didier Vieau et al.

Frontiers in Neuroscience, 2018, 12, pp.520. ⟨10.3389/fnins.2018.00520⟩

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Defining the human sperm microtubulome: an integrated genomics approach

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Biology of Reproduction, 2017, 96 (1), pp.93-106. ⟨10.1095/biolreprod.116.143479⟩

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Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

Cyril Laurent , Guillaume Dorothee , Stéphane Hunot , Elodie Martin , Yann Monnet et al.

Brain - A Journal of Neurology , 2017, 140 (1), pp.184 - 200. ⟨10.1093/brain/aww270⟩

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Tau deletion promotes brain insulin resistance

Elodie Marciniak , Antoine Leboucher , Emilie Caron , Tariq Ahmed , Anne Tailleux et al.

Journal of Experimental Medicine, 2017, 214 (8), pp.2257 - 2269. ⟨10.1084/jem.20161731⟩

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Alternative promoter usage generates novel shorter MAPT mRNA transcripts in Alzheimer’s disease and progressive supranuclear palsy brains

Vincent Huin , Vincent Deramecourt , Dominique Caparros-Lefebvre , Claude Alain Maurage , Charles Duyckaerts et al.

Scientific Reports, 2017, 7 (1), pp.12589. ⟨10.1038/s41598-017-12955-7⟩

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Tau et troubles cognitifs

Cyril Laurent , Guillaume Dorothee , Stéphane Hunot , Elodie Martin , Cecile Delarasse et al.

Médecine/Sciences, 2017, 33 (10), pp.817 - 819. ⟨10.1051/medsci/20173310002⟩

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Atypical, non-standard functions of the microtubule associated Tau protein

Ioannis Sotiropoulos , Marie-Christine Galas , Joana Silva , Efthimios Skoulakis , Susanne Wegmann et al.

Acta Neuropathologica Communications, 2017, 5 (1), ⟨10.1186/s40478-017-0489-6⟩

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Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly

Tatyana Shelkovnikova , Pasquale Dimasi , Michail Kukharsky , Haiyan An , Annamaria Quintiero et al.

Cell Death and Disease, 2017, 8 (5), pp.e2788. ⟨10.1038/cddis.2017.199⟩

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Atypical, non-standard functions of the microtubule associated Tau protein

Ioannis Sotiropoulos , Marie-Christine Galas , Joana Silva , Efthimios Skoulakis , Susanne Wegmann et al.

Acta Neuropathologica Communications, 2017, 5 (1), ⟨10.1186/s40478-017-0489-6⟩

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Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies

Nicolas Barthélemy , Audrey Gabelle , Christophe Hirtz , François Fenaille , Nicolas Sergeant et al.

Journal of Alzheimer's Disease, 2016, 51 (4), pp.1033 - 1043. ⟨10.3233/JAD-150962⟩

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Increased tauopathy drives microglia-mediated clearance of beta-amyloid

Wesley Chen , Edsel Abud , Stephen Yeung , Anita Lakatos , Trevor Nassi et al.

Acta Neuropathologica Communications, 2016, 4 (1), ⟨10.1186/s40478-016-0336-1⟩

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EuroTau: towing scientists to tau without tautology

Amrit Mudher , Jean-Pierre Brion , Jesus Avila , Miguel Medina , Luc Buée

Acta Neuropathologica Communications, 2016, 5 (1), pp.90. ⟨10.1186/s40478-017-0491-z⟩

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Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin

Zeyni Mansuroglu , Houda Benhelli-Mokrani , Vasco Marcato , Audrey Sultan , Marie Violet et al.

Scientific Reports, 2016, 6 (1), pp.33047. ⟨10.1038/srep33047⟩

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Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

Meryem Tardivel , Séverine Bégard , Luc Bousset , Simon Dujardin , Audrey Coens et al.

Acta Neuropathologica Communications, 2016, 4 (1), pp.117. ⟨10.1186/s40478-016-0386-4⟩

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Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity

Nicolas Barthélemy , François Fenaille , Christophe Hirtz , Nicolas Sergeant , Susanna Schraen-Maschke et al.

Journal of Proteome Research, 2016, 15 (2), pp.667 - 676. ⟨10.1021/acs.jproteome.5b01001⟩

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Omics analysis of mouse brain models of human diseases

Véronique Paban , Béatrice Loriod , Claude Villard , Luc Buee , David Blum et al.

Gene, 2016, 600, pp.90 - 100. ⟨10.1016/j.gene.2016.11.022⟩

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The MAPT gene is differentially methylated in the progressive supranuclear palsy brain

Vincent Huin , Vincent Deramecourt , Dominique Caparros-Lefebvre , Claude-Alain Maurage , Charles Duyckaerts et al.

Movement Disorders, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩

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Atypical, non-standard functions of the microtubule associated Tau protein

Ioannis Sotiropoulos , Marie-Christine Galas , Joana M. Silva , Efthimios Skoulakis , Susanne Wegmann et al.

Acta Neuropathologica Communications, 2016, 5 (1), pp.91. ⟨10.1186/s40478-017-0489-6⟩

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The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Vânia Batalha , Diana Ferreira , Joana Coelho , Jorge Valadas , Rui Gomes et al.

Scientific Reports, 2016, 6, pp.31493. ⟨10.1038/srep31493⟩

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mRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance

Vânia Batalha , Diana Ferreira , Joana Coelho , Jorge Valadas , Rui Gomes et al.

Journal of Molecular Neuroscience, 2016, 58 (4), pp.411-415. ⟨10.1007/s12031-015-0699-y⟩

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Association of plasma β-amyloid with MRI markers of structural brain aging the 3-City Dijon study.

Sara Kaffashian , Christophe Tzourio , Aïcha Soumaré , Carole Dufouil , Bernard Mazoyer et al.

Neurobiology of Aging, 2015, 36 (10), pp.2663-70. ⟨10.1016/j.neurobiolaging.2015.03.016⟩

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Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles

Gerhard Multhaup , Otmar Huber , Luc Buée , Marie-Christine Galas

Journal of Biological Chemistry, 2015, 290 (39), pp.23515-23522. ⟨10.1074/jbc.R115.677211⟩

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Chloroquine and Chloroquinoline Derivatives as Models for the Design of Modulators of Amyloid Peptide Precursor Metabolism

Patricia Melnyk , Valérie Vingtdeux , Stéphane Burlet , Sabiha Eddarkaoui , Marie-Eve Grosjean et al.

ACS Chemical Neuroscience, 2015, 6 (4), pp.559-569. ⟨10.1021/cn5003013⟩

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Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

Sophie Ayciriex , Marie-Anne Burlot , Jérome Braudeau , Kristin Michaelsen-Preusse , Brigitte Potier et al.

Human Molecular Genetics, 2015, 24 (21), pp.5965 - 5976. ⟨10.1093/hmg/ddv268⟩

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Plasma β-amyloid 40 levels are positively associated with mortality risks in the elderly.

Audrey Gabelle , Susanna Schraen , Laure-Anne Gutierrez , Cecile Pays , Olivier Rouaud et al.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2015, 11 (6), pp.672-80. ⟨10.1016/j.jalz.2014.04.515⟩

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Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

Valeria Moas Heloire , Nicolas Renault , Vânia Batalha , Angela Rincon Arias , Mathieu Marchivie et al.

European Journal of Medicinal Chemistry, 2015, 106, pp.15-25. ⟨10.1016/j.ejmech.2015.10.030⟩

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Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

Maxime Derisbourg , Coline Leghay , Giovanni Chiappetta , Francisco-Jose Fernandez-Gomez , Cyril Laurent et al.

Scientific Reports, 2015, 5 (1), ⟨10.1038/srep09659⟩

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A geographical cluster of progressive supranuclear palsy in northern France

Dominique Caparros-Lefebvre , Lawrence I Golbe , Vincent Deramecourt , Claude-Alain Maurage , Vincent Huin et al.

Neurology, 2015, 85 (15), pp.1293-1300. ⟨10.1212/WNL.0000000000001997⟩

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Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation

Anthony Papegaey , Sabiha Eddarkaoui , Vincent Deramecourt , Francisco-Jose Fernandez-Gomez , Pierre Pantano et al.

Acta Neuropathologica Communications, 2015, 4 (1), pp.74. ⟨10.1186/s40478-016-0345-0⟩

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Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation.

Haoling Qi , François-Xavier Cantrelle , Houda Benhelli-Mokrani , Caroline Smet-Nocca , Luc Buée et al.

Biochemistry, 2015, 54 (7), pp.1525-33

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Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Marie Violet , Alban Chauderlier , Lucie Delattre , Meryem Tardivel , Meliza Sendid Chouala et al.

Neurobiology of Disease, 2015, 82, pp.540-551. ⟨10.1016/j.nbd.2015.09.003⟩

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Central Nervous System and Peripheral Inflammatory Processes in Alzheimer’s Disease: Biomarker Profiling Approach

Constance Delaby , Audrey Gabelle , Susanna Schraen-Maschke , Amandine Moulinier , Justine Boulanghien et al.

Frontiers in Neurology, 2015, 6, ⟨10.3389/fneur.2015.00181⟩

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Tau Monoclonal Antibody Generation Based on Humanized Yeast Models: IMPACT ON TAU OLIGOMERIZATION AND DIAGNOSTICS

Joëlle Rosseels , Jeff van den Brande , Marie-Luce Violet , Dirk Jacobs , Pierre Grognet et al.

Journal of Biological Chemistry, 2015, 290 (7), pp.4059-4074. ⟨10.1074/jbc.M114.627919⟩

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Dementia beyond 2025: knowledge and uncertainties

Paul-Ariel Kenigsberg , Jean-Pierre Aquino , Alain Berard , Fabrice Gzil , Sandrine Andrieu et al.

Dementia, 2015

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The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior.

Julien Giustiniani , Kevin Guillemeau , Omar Dounane , Elodie Sardin , Isabelle Huvent et al.

FASEB Journal, 2015, Epub ahead of print

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A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

Marie Violet , Lucie Delattre , Meryem Tardivel , Audrey Sultan , Alban Chauderlier et al.

Frontiers in Cellular Neuroscience, 2014, 8 (2), pp.350-358. ⟨10.3389/fncel.2014.00084⟩

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Plasma β-amyloid and MRI markers of cerebral small vessel disease: Three-City Dijon study.

Sara Kaffashian , Christophe Tzourio , Aïcha Soumaré , Carole Dufouil , Yicheng Zhu et al.

Neurology, 2014, 83 (22), pp.2038-45. ⟨10.1212/WNL.0000000000001038⟩

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PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer's disease in the hippocampus and spatial memory impairments.

Amina Chaalal , Roseline Poirier , David Blum , Brigitte Gillet , Pascale Le Blanc et al.

Hippocampus, 2014, 24 (11), pp.1381-93. ⟨10.1002/hipo.22319⟩

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Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: Relevance to sporadic tauopathies.

Simon Dujardin , Katia Lécolle , Raphaëlle Caillierez , Séverine Bégard , Nadège Zommer et al.

Acta Neuropathologica Communications, 2014, 2 (1), pp.14. ⟨10.1186/2051-5960-2-14⟩

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TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment

Jérôme Delplanque , David Devos , Vincent Huin , Alexandre Genet , Olivier Sand et al.

Brain - A Journal of Neurology , 2014, 137 (10), pp.2657-2663. ⟨10.1093/brain/awu202⟩

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Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.

Kunie Ando , Pierre Dourlen , Anne-Véronique Sambo , Alexis Bretteville , Karim Bélarbi et al.

Neurobiol Aging, 2013, 34 (3), pp.757-69. ⟨10.1016/j.neurobiolaging.2012.08.004⟩

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Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.

Oscar Hernández-Hernández , Céline Guiraud-Dogan , Géraldine Sicot , Aline Huguet , Sabrina Luilier et al.

Brain - A Journal of Neurology , 2013, 136 (Pt 3), pp.957-70. ⟨10.1093/brain/aws367⟩

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Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

Simon Dujardin , Séverine Bégard , Raphaëlle Caillierez , Cédrick Lachaud , Lucie Delattre et al.

PLoS ONE, 2013, 9 (6), pp.e100760. ⟨10.1371/journal.pone.0100760⟩

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MBNL1 gene variants as modifiers of disease severity in myotonic dystrophy type 1

Vincent Huin , Francis Vasseur , Susanna Schraen-Maschke , Claire-Marie Dhaenens , Patrick Devos et al.

Journal of Neurology, 2013, 260 (4), pp.998-1003. ⟨10.1007/s00415-012-6740-y⟩

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Plasma Amyloid-β Levels and Prognosis in Incident Dementia Cases of the 3-City Study.

Audrey Gabelle , Florence Richard , Laure-Anne Gutierrez , Susanna Schraen , Fleur Delva et al.

Journal of Alzheimer's Disease, 2013, 33 (2), pp.381-91. ⟨10.3233/JAD-2012-121147⟩

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Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.

Laëticia Troquier , Raphaëlle Caillierez , Sylvie Burnouf , Francisco J. Fernandez-Gomez , Marie-Eve Grosjean et al.

Curr Alzheimer Res, 2012, 9 (4), pp.397-405

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Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.

Jean-Charles Lambert , Benjamin Grenier-Boley , Denise Harold , Diana Zelenika , Vincent Chouraki et al.

Molecular Psychiatry, 2012, 18, pp.521-521. ⟨10.1038/mp.2012.75⟩

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Analysis of Exonic Regions Involved in Nuclear Localization, Splicing Activity, and Dimerization of Muscleblind-like-1 Isoforms

Helene Tran , Nathalie Gourrier , Camille Lemercier-Neuillet , Claire-Marie Dhaenens , Audrey Vautrin et al.

Journal of Biological Chemistry, 2011, 286 (18), pp.16435 - 16446. ⟨10.1074/jbc.M110.194928⟩

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Mis-splicing of Tau exon 10 in myotonic dystrophy type I is reproduced by overexpression of CELF2 but not by MBNL1 silencing

C.M. Dhaenens , H. Tran , M.-L. Frandemiche , C. Carpentier , S. Schraen-Maschke et al.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2011, ⟨10.1016/j.bbadis.2011.03.010⟩

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Association between IgM Anti-Herpes Simplex Virus and Plasma Amyloid-Beta Levels.

Catherine Féart , Catherine Helmer , Hervé Fleury , Yannick Béjot , Karen Ritchie et al.

PLoS ONE, 2011, 6 (12), pp.e29480. ⟨10.1371/journal.pone.0029480⟩

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Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains

Sébastien Feuillette , Vincent Deramecourt , Annie Laquérriere , Charles Duyckaerts , Marie-Bernadette Delisle et al.

Brain Research, 2010, 1345, pp.182-189. ⟨10.1016/j.brainres.2010.05.007⟩

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NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease.

Isabelle Landrieu , Arnaud Leroy , Caroline Smet-Nocca , Isabelle Huvent , Laziza Amniai et al.

Biochemical Society Transactions, 2010, 38 (4), pp.1006-11. ⟨10.1042/BST0381006⟩

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Comment les acteurs moléculaires de la pathologie Alzheimer permettent de comprendre la démence ? Quelles conséquences diagnostiques et thérapeutiques ?

Luc Buée , David Blum , Stephanie Bombois , Valérie Buée-Scherrer , Marie-Laure Caillet-Boudin et al.

Alternative and Complementary Therapies, 2010, 65 (5), pp.401-407. ⟨10.2515/therapie/2010054⟩

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Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.

Karim Belarbi , Katharina Schindowski , Sylvie Burnouf , Raphaëlle Caillierez , Marie-Eve Grosjean et al.

Current Alzheimer Research, 2009, 6 (2), pp.152-7

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[Fundamental data on the pathologies amyloid and Tau in Alzheimer's disease: which therapeutic perspectives?]

F. Checler , Luc Buée

Annales Pharmaceutiques Françaises, 2009, 67 (2), pp.136-53. ⟨10.1016/j.pharma.2009.01.002⟩

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Tau as a biomarker of neurodegenerative diseases.

Susanna Schraen-Maschke , Nicolas Sergeant , Claire-Marie Dhaenens , Stephanie Bombois , Vincent Deramecourt et al.

Biomarkers in Medicine, 2008, 2 (4), pp.363-84. ⟨10.2217/17520363.2.4.363⟩

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Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats

Claire-Marie Dhaenens , Susanna Schraen-Maschke , Ha Tran , Valérie Vingtdeux , Dana Ghanem et al.

Experimental Neurology, 2008, 210 (2), pp.467-478. ⟨10.1016/j.expneurol.2007.11.020⟩

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Pin1 allows for differential Tau dephosphorylation in neuronal cells.

Malika Hamdane , Pierre Dourlen , Alexis Bretteville , Anne-Véronique Sambo , Stéphanie Ferreira et al.

Molecular and Cellular Neuroscience, 2006, 32, pp.155-160

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Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy.

Guy Lippens , Alain Sillen , Caroline Smet , Jean-Michel Wieruszeski , Arnaud Leroy et al.

Protein and Peptide Letters, 2006, 13, pp.235-246

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Exploring the Molecular Function of PIN1 by Nuclear Magnetic Resonance.

Isabelle Landrieu , Caroline Smet , Jean-Michel Wieruszeski , Anne-Véronique Sambo , René Wintjens et al.

Current Protein and Peptide Science, 2006, 7, pp.179-194

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Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.

Valérie Vingtdeux , Malika Hamdane , Marie Gompel , Severine Begard , Hervé Drobecq et al.

Neurobiology of Disease, 2005, 20, pp.625-37

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Translational exploration of dynamic functional connectivity changes in Alzheimer’s disease patients and Thy-Tau22 mice at the prodromal stage

Laëtitia Degiorgis , Eléna Chabran , Marion Sourty , Luc Buée , Frédéric Blanc et al.

Joint Annual Meeting ISMRM-ESMRMB and ISMRT 31st Annual Meeting, May 2022, Londres, United Kingdom

Communication dans un congrès hal-03799540v1

Prodromal changes in hippocampal functional connectivity in AD patients and Thy-tau22 mice: a translational exploration

Laëtitia Degiorgis , Eléna Chabran , Marion Sourty , Meltem Karatas , David Blum et al.

Alzheimer's disease and Parkinson's disease conference, Mar 2021, En ligne, France

Communication dans un congrès hal-03799537v1

P1‐129: CSF AD BIOMARKERS IN MEMORY CLINIC PATIENTS: THE EP.L.M.FR STUDY

Audrey Gabelle , Julien Dumurgier , Stephanie Bombois , David Wallon , Frédéric Blanc et al.

2014 Alzheimer's Imaging Consortium (IC): IC-02: Preclinical Alzheimer's Disease and Biomarkers, Jul 2014, Copenhagen, Denmark. ⟨10.1016/j.jalz.2014.05.366⟩

Communication dans un congrès istex hal-05348160v1
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Maladie d'Alzheimer : enjeux scientifiques, médicaux et sociétaux

Hélène Amieva , Sandrine Andrieu , Claudine Berr , Luc Buée , Frédéric Checler et al.

[Rapport de recherche] Institut national de la santé et de la recherche médicale(INSERM). 2007, XV - 654 p., illustrations, figures

Rapport (rapport de recherche) hal-01570630v1