Luca Grumolato

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MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)-dependent oncogenic driver in vitro and in humanized HGF knock-in mice.

Marie Fernandes , B. Hoggard , Philippe Jamme , Sonia Paget , Marie-Jose Truong et al.
Molecular Oncology, 2023, Molecular Oncology, 17 (11), p. 2257-2274. ⟨10.1002/1878-0261.13397⟩
Article dans une revue hal-04405493 v1

Mechanisms of Acquired Resistance and Tolerance to EGFR Targeted Therapy in Non-Small Cell Lung Cancer

Houssein Chhouri , David Alexandre , Luca Grumolato
Cancers, 2023, 15 (2), pp.504. ⟨10.3390/cancers15020504⟩
Article dans une revue hal-05043716 v1

High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer

Anita Rogic , Ila Pant , Luca Grumolato , Ruben Fernandez-Rodriguez , Andrew Edwards et al.
Nature Communications, 2021, 12 (1), pp.6889. ⟨10.1038/s41467-021-27108-8⟩
Article dans une revue hal-05043720 v1

ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation

María Victoria Castro , Gastón Alexis Barbero , María Belén Villanueva , Luca Grumolato , Jérémie Nsengimana et al.
Journal of Biomedical Science, 2021, 28 (1), pp.76. ⟨10.1186/s12929-021-00776-w⟩
Article dans une revue hal-05139244 v1
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XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma

Hadjer Miloudi , Elodie Bohers , François Guillonneau , Antoine Taly , Vincent Cabaud Gibouin et al.
Cancers, 2020, 12 (10), pp.2829. ⟨10.3390/cancers12102829⟩
Article dans une revue hal-02957363 v1

Tolerant/Persister Cancer Cells and the Path to Resistance to Targeted Therapy

Mirna Swayden , Houssein Chhouri , Youssef Anouar , Luca Grumolato
Cells, 2020, 9 (12), pp.2601. ⟨10.3390/cells9122601⟩
Article dans une revue hal-05043732 v1

CRISPR/Cas9 editing of the genome for cancer modeling

Alexis Guernet , Luca Grumolato
Methods, 2017, 121-122, pp.130-137. ⟨10.1016/j.ymeth.2017.03.007⟩
Article dans une revue hal-02017519 v1

Selenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion

Abdallah Hamieh , Dorthe Cartier , Houssni Abid , André Calas , Carole Burel et al.
EMBO Reports, 2017, 18 (11), pp.1935 - 1946. ⟨10.15252/embr.201643504⟩
Article dans une revue hal-01777667 v1

CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations

Alexis Guernet , Sathish kumar Mungamuri , Dorthe Cartier , Ravi Sachidanandam , Anitha Jayaprakash et al.
Molecular Cell, 2016, 63 (3), pp.526-538. ⟨10.1016/j.molcel.2016.06.017⟩
Article dans une revue hal-02376161 v1

Modeling intratumor heterogeneity through CRISPR-barcodes

Alexis Guernet , Stuart A. Aaronson , Youssef Anouar , Luca Grumolato
Molecular & Cellular Oncology, 2016, 3 (6), pp.e1227894. ⟨10.1080/23723556.2016.1227894⟩
Article dans une revue hal-02017522 v1

ROR1 contributes to melanoma cell growth and migration by regulating N‐cadherin expression via the PI3K/Akt pathway

Natalia Brenda Fernández , Daniela Lorenzo , María Elisa Picco , Gastón Barbero , Leonardo Sebastián Dergan-Dylon et al.
Molecular Carcinogenesis, 2015, 55 (11), pp.1772-1785. ⟨10.1002/mc.22426⟩
Article dans une revue hal-05043739 v1

Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Promotes Both Survival and Neuritogenesis in PC12 Cells through Activation of Nuclear Factor κB (NF-κB) Pathway

Destiny-Love Manecka , Sardar Faisal Mahmood , Luca Grumolato , Isabelle Lihrmann , Youssef Anouar
Journal of Biological Chemistry, 2013, 288 (21), pp.14936-14948. ⟨10.1074/jbc.M112.434597⟩
Article dans une revue hal-02427077 v1
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β-Catenin-Independent Activation of TCF1/LEF1 in Human Hematopoietic Tumor Cells through Interaction with ATF2 Transcription Factors

Luca Grumolato , Guizhong Liu , Tomomi Haremaki , Sathish Kumar Mungamuri , Phyllus Mong et al.
PLoS Genetics, 2013, 9 (8), pp.e1003603. ⟨10.1371/journal.pgen.1003603⟩
Article dans une revue hal-02017513 v1

Wnk kinases are positive regulators of canonical Wnt/β‐catenin signalling

Ekatherina Serysheva , Hebist Berhane , Luca Grumolato , Kubilay Demir , Sophie Balmer et al.
EMBO Reports, 2013, 14 (8), pp.718-725. ⟨10.1038/embor.2013.88⟩
Article dans une revue hal-05043746 v1

Chromatin Modifications Sequentially Enhance ErbB2 Expression in ErbB2-Positive Breast Cancers

Sathish Kumar Mungamuri , William Murk , Luca Grumolato , Emily Bernstein , Stuart Aaronson et al.
Cell Reports, 2013, 5 (2), pp.302-313. ⟨10.1016/j.celrep.2013.09.009⟩
Article dans une revue hal-05043743 v1

A New Piece to the Unsolved Planar Cell Polarity Puzzle

Luca Grumolato , Ursula Weber , Marek Mlodzik
Developmental Cell, 2011, 20 (2), pp.146-147. ⟨10.1016/j.devcel.2011.01.013⟩
Article dans une revue hal-05043754 v1

High-Frequency Canonical Wnt Activation in Multiple Sarcoma Subtypes Drives Proliferation through a TCF/β-Catenin Target Gene, CDC25A

Sapna Vijayakumar , Guizhong Liu , Ioana Rus , Shen Yao , Yan Chen et al.
Cancer Cell, 2011, 19 (5), pp.601-612. ⟨10.1016/j.ccr.2011.03.010⟩
Article dans une revue hal-05043750 v1

Maternal Perinatal Undernutrition has Long-Term Consequences on Morphology, Function and Gene Expression of the Adrenal Medulla in the Adult Male Rat

C. Laborie , O. Molendi-Coste , C. Breton , V. Montel , F. Vandenbulcke et al.
Journal of Neuroendocrinology, 2011, 23 (8), pp.711-724. ⟨10.1111/j.1365-2826.2011.02159.x⟩
Article dans une revue hal-05043752 v1

Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation

Jaskirat Singh , Wang Yanfeng , Luca Grumolato , Stuart Aaronson , Marek Mlodzik
Genes and Development, 2010, 24 (19), pp.2157-2168. ⟨10.1101/gad.1961010⟩
Article dans une revue hal-05043762 v1

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

Luca Grumolato , Guizhong Liu , Phyllus Mong , Raksha Mudbhary , Romi Biswas et al.
Genes and Development, 2010, 24 (22), pp.2517-2530. ⟨10.1101/gad.1957710⟩
Article dans une revue hal-05043757 v1

Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells

S Asciutti , G Akiri , Luca Grumolato , S Vijayakumar , S Aaronson
Oncogene, 2010, 30 (8), pp.956-966. ⟨10.1038/onc.2010.475⟩
Article dans une revue hal-05043760 v1

Pharmacological profile of serotonergic receptors in the adrenal gland

Catherine Delarue , Vincent Contesse , Herve Lefebvre , Sebastien Lenglet , Luca Grumolato et al.
Endocrine Research, 2009, 24 (3-4), pp.687-694. ⟨10.3109/07435809809032670⟩
Article dans une revue hal-05043799 v1

Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells

Guizhong Liu , Sapna Vijayakumar , Luca Grumolato , Randy Arroyave , Huifang Qiao et al.
Journal of Cell Biology, 2009, 185 (1), pp.67-75. ⟨10.1083/jcb.200810137⟩
Article dans une revue hal-05043763 v1

Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca 2+ mobilization and neuroendocrine secretion

Luca Grumolato , Hafida Ghzili , Maite Montero-Hadjadje , Stephane Gasman , Jean J. Lesage et al.
FASEB Journal, 2008, 22 (6), pp.1756-1768. ⟨10.1096/fj.06-075820⟩
Article dans une revue hal-01962747 v1

Selenoprotein T is a novel target for PACAP signaling discovered via functionally coupled transcriptome array and gene silencing

Youssef Anouar , Hafida Ghzili , Luca Grumolato , Maite Montero-Hadjadje , Stéphane Gasman et al.
Journal of Molecular Neuroscience, 2007, 33 (3)
Article dans une revue hal-04847275 v1
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Identification of Potential Gene Markers and Insights into the Pathophysiology of Pheochromocytoma Malignancy

Erwan Thouennon , Abdel G. Elkahloun , Johann Guillemot , Anne-Paule Gimenez-Roqueplo , Jérôme Bertherat et al.
Journal of Clinical Endocrinology and Metabolism, 2007, 92 (12), pp.4865 - 4872. ⟨10.1210/jc.2007-1253⟩
Article dans une revue hal-01706427 v1

Pituitary Adenylate Cyclase‐Activating Polypeptide Regulates Neuroendocrine Markers and Transcription Factors in Differentiating Pheochromocytoma Cells

Luca Grumolato , D. Alexandre , V. Turquier , D. Ait-Ali , A. Fournier et al.
Annals of the New York Academy of Sciences, 2006, 971 (1), pp.467-470. ⟨10.1111/j.1749-6632.2002.tb04510.x⟩
Article dans une revue hal-05043786 v1

Proinflammatory Cytokines TNF‐α and IL‐1α Stimulate Neuropeptide Gene Expression in Adrenochromaffin Cells

V. Turquier , H. Vaudry , L. Yon , C-M Hsu , D. Ait-Ali et al.
Annals of the New York Academy of Sciences, 2006, 971 (1), pp.45-48. ⟨10.1111/j.1749-6632.2002.tb04431.x⟩
Article dans une revue hal-05043788 v1

Maternal Perinatal Undernutrition Alters Neuronal and Neuroendocrine Differentiation in the Rat Adrenal Medulla at Weaning

Olivier Molendi-Coste , Luca Grumolato , Christine Laborie , Jean Lesage , Eric Maubert et al.
Endocrinology, 2006, 147 (6), pp.3050-3059. ⟨10.1210/en.2005-1331⟩
Article dans une revue hal-05043774 v1

Possible implication of the transcriptional regulator Id3 in PACAP-induced pro-survival signaling during PC12 cell differentiation

Hafida Ghzili , Luca Grumolato , Erwan Thouënnon , Hubert Vaudry , Youssef Anouar
Regulatory Peptides, 2006, 137 (1-2), pp.89-94. ⟨10.1016/j.regpep.2006.06.015⟩
Article dans une revue hal-05043771 v1
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Circulating EM66 is a highly sensitive marker for the diagnosis and follow-up of pheochromocytoma

Johann Guillemot , Youssef Anouar , Maïté Montero-Hadjadje , Eric Grouzmann , Luca Grumolato et al.
International Journal of Cancer, 2006, 118 (8), pp.2003 - 2012. ⟨10.1002/ijc.21571⟩
Article dans une revue hal-01706431 v1

The Proinflammatory Cytokines Tumor Necrosis Factor-α and Interleukin-1 Stimulate Neuropeptide Gene Transcription and Secretion in Adrenochromaffin Cells via Activation of Extracellularly Regulated Kinase 1/2 and p38 Protein Kinases, and Activator Protein-1 Transcription Factors

Djida Aït-Ali , Valérie Turquier , Luca Grumolato , Laurent Yon , Matthieu Jourdain et al.
Molecular Endocrinology -Baltimore-, 2004, 18 (7), pp.1721-1739. ⟨10.1210/me.2003-0129⟩
Article dans une revue hal-02334636 v1

PACAP and NGF regulate common and distinct traits of the sympathoadrenal lineage: effects on electrical properties, gene markers and transcription factors in differentiating PC12 cells

Luca Grumolato , Estelle Louiset , David Alexandre , Djida Aït-Ali , Valérie Turquier et al.
European Journal of Neuroscience, 2003, 17 (1), pp.71-82. ⟨10.1046/j.1460-9568.2003.02426.x⟩
Article dans une revue hal-05043781 v1

Microarray and Suppression Subtractive Hybridization Analyses of Gene Expression in Pheochromocytoma Cells Reveal Pleiotropic Effects of Pituitary Adenylate Cyclase-Activating Polypeptide on Cell Proliferation, Survival, and Adhesion

Luca Grumolato , Abdel G. Elkahloun , Hafida Ghzili , David Alexandre , Cédric Coulouarn et al.
Endocrinology, 2003, 144 (6), pp.2368-2379. ⟨10.1210/en.2002-0106⟩
Article dans une revue hal-02334705 v1
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Identification of the Secretogranin II-Derived Peptide EM66 in Pheochromocytomas as a Potential Marker for Discriminating Benign Versus Malignant Tumors

Laurent Yon , Johann Guillemot , Maite Montero-Hadjadje , Luca Grumolato , Jérôme Leprince et al.
Journal of Clinical Endocrinology and Metabolism, 2003, 88 (6), pp.2579-2585. ⟨10.1210/jc.2002-021748⟩
Article dans une revue hal-01706414 v1

Novel Splice Variants of Type I Pituitary Adenylate Cyclase-Activating Polypeptide Receptor in Frog Exhibit Altered Adenylate Cyclase Stimulation and Differential Relative Abundance

David Alexandre , Hubert Vaudry , Luca Grumolato , Valérie Turquier , Alain Fournier et al.
Endocrinology, 2002, 143 (7), pp.2680-2692. ⟨10.1210/endo.143.7.8880⟩
Article dans une revue hal-05043790 v1

Pituiray adnylate cylcase-activating polypeptide stimulates secretoneurin release ans secretogranin II gene transcription in bovine adrenochromaffin cells

Valérie Turquier , Laurent Yon , Luca Grumolato , D. Alexandre , Alain Fournier et al.
Annals of the New York Academy of Sciences, 2002, 971 (1), pp.471-473. ⟨10.1111/j.1749-6632.2002.tb04511.x⟩
Article dans une revue istex hal-02334634 v1

Molecular characterization of frog chromogranin B reveals conservation of selective sequences encoding potential novel regulatory peptides 1

Djida Aït-Ali , Valérie Turquier , David Alexandre , Luca Grumolato , Sylvie Jégou et al.
FEBS Letters, 2001, 511 (1-3), pp.127-132. ⟨10.1016/s0014-5793(01)03296-3⟩
Article dans une revue hal-05043793 v1

Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Secretoneurin Release and Secretogranin II Gene Transcription in Bovine Adrenochromaffin Cells through Multiple Signaling Pathways and Increased Binding of Pre-Existing Activator Protein-1-Like Transcription Factors

Valérie Turquier , Laurent Yon , Luca Grumolato , David Alexandre , Alain Fournier et al.
Molecular Pharmacology, 2001, 60 (1), pp.42-52. ⟨10.1124/mol.60.1.42⟩
Article dans une revue hal-02334699 v1

Pharmacological and Molecular Characterization of 5-Hydroxytryptamine 7 Receptors in the Rat Adrenal Gland

Vincent Contesse , Sebastien Lenglet , Luca Grumolato , Youssef Anouar , Isabelle Lihrmann et al.
Molecular Pharmacology, 1999, 56 (3), pp.552-561. ⟨10.1124/mol.56.3.552⟩
Article dans une revue hal-02427287 v1

Résistance du cancer bronchique à la thérapie ciblée : nouveaux modèles d'étude in vitro et in vivo

Luca Grumolato
Journée de l'axe 1 du Cancéropôle Nord-Ouest, Nov 2022, Paris, France
Communication dans un congrès hal-05157033 v1

Targeting Tumor Evolution to Prevent Drug Resistance: A New Strategy to Prolong Lung Cancer Response to EGFR Inhibition

Luca Grumolato
Institute of Biological and Chemical Systems – Functional Molecular Systems, Jan 2020, Karlsruhe, Germany
Communication dans un congrès hal-05156995 v1

Preventing Acquired Resistance to Therapy by Targeting Tumor Evolution: A New Strategy to Prolong Lung Cancer Response to EGFR Inhibition

Luca Grumolato
Toulouse Onco Week, Feb 2020, Toulouse, France
Communication dans un congrès hal-05156994 v1