Lucas TREPS

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Publications

In vitro models to mimic tumor endothelial cell-mediated immune cell reprogramming in lung adenocarcinoma

Morgane Krejbich , Emilie Navarro , Judith Fresquet , Marine Cotinat , Valentin Isen et al.

Journal of Experimental and Clinical Cancer Research, 2026, ⟨10.1186/s13046-025-03576-4⟩

Article dans une revue hal-05425299v1

scRNA-seq data of human lung multicellular tumor spheroid (MCTS)

Lucas Treps Article dans une revue hal-05335858v1
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MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer-associated fibroblasts

Chloé Lefebvre , Philippine Giowachini , Jennifer Derrien , Maxime Naour , Isabelle Corre et al.

Cell Death and Disease, 2025, 16 (1), pp.603. ⟨10.1038/s41419-025-07920-6⟩

Article dans une revue hal-05217632v1
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Secretomes From Non-Small Cell Lung Cancer Cells Induce Endothelial Plasticity Through a Partial Endothelial-to-Mesenchymal Transition

Clara Bourreau , Emilie Navarro , Marine Cotinat , Morgane Krejbich , François Guillonneau et al.

Cancer Medicine, 2025, ⟨10.1002/cam4.70707⟩

Article dans une revue hal-04978598v1
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Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition.

Mathilde Lebas , Giorgia Chinigò , Evan Courmont , Louay Bettaieb , Amani Machmouchi et al.

Science Advances , 2024, Sci Adv, 10 (32), eadp6182. ⟨10.1126/sciadv.adp6182⟩

Article dans une revue hal-04711617v1
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The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells

Pauline de Zeeuw , Lucas Treps , Melissa García-Caballero , Ulrike Harjes , Joanna Kalucka et al.

Communications Biology, 2024, 7 (1), pp.618. ⟨10.1038/s42003-024-06186-6⟩

Article dans une revue inserm-05169224v1
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Single‐cell RNA sequencing of cystic fibrosis liver disease explants reveals endothelial complement activation

Mathias Declercq , Lucas Treps , Vincent Geldhof , Nadine V Conchinha , Laura P M H de Rooij et al.

Liver International, 2024, 44 (9), pp.2382-2395. ⟨10.1111/liv.15963⟩

Article dans une revue inserm-05169218v1
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Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment

Camille Chatelain , Laurine Berland , Marion Grard , Nicolas Jouand , Judith Fresquet et al.

OncoImmunology, 2024, 13 (1), pp.2377830. ⟨10.1080/2162402x.2024.2377830⟩

Article dans une revue inserm-04652311v1
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Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy

Pauline Hulo , Sophie Deshayes , Judith Fresquet , Anne-Laure Chéné , Stéphanie Blandin et al.

Respiratory Research, 2024, 25 (1), pp.156. ⟨10.1186/s12931-024-02791-5⟩

Article dans une revue inserm-04537685v1

Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies

Clara Bourreau , Lucas Treps , Sébastien Faure , Delphine Fradin , Nicolas Clere

Pharmacology & Therapeutics, 2023, pp.108347. ⟨10.1016/j.pharmthera.2023.108347⟩

Article dans une revue hal-03944679v1
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Editorial: Tumor Vessels as Directors of the Tumor Microenvironment: New Findings, Current Challenges & Perspectives

Lucas Treps , Ann Ager , Kyoko Hida

Frontiers in Cell and Developmental Biology, 2022, 10, pp.885670. ⟨10.3389/fcell.2022.885670⟩

Article dans une revue inserm-05169236v1
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Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast

Vincent Geldhof , Laura P M H de Rooij , Liliana Sokol , Jacob Amersfoort , Maxim de Schepper et al.

Nature Communications, 2022, 13 (1), pp.5511. ⟨10.1038/s41467-022-33052-y⟩

Article dans une revue inserm-05169233v1
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Protocols for endothelial cell isolation from mouse tissues: small intestine, colon, heart, and liver

Liliana Sokol , Vincent Geldhof , Melissa García-Caballero , Nadine V Conchinha , Sébastien J Dumas et al.

STAR Protocols, 2021, 2 (2), pp.100489. ⟨10.1016/j.xpro.2021.100489⟩

Article dans une revue inserm-05169282v1
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Comparative meta-analysis of cystic fibrosis cell models suggests partial endothelial-to-mesenchymal transition

Lucas Treps , Mathias Declercq , Siham Bousfia , Peter Carmeliet , Peter Witters

Journal of Cystic Fibrosis, 2021, pp.S1569-1993(21)00101-6. ⟨10.1016/j.jcf.2021.03.019⟩

Article dans une revue inserm-03349936v1
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Vasculogenic mimicry, a complex and devious process favoring tumorigenesis -Interest in making it a therapeutic target

Lucas Treps , Sébastien Faure , Nicolas Clere

Pharmacology & Therapeutics Part A Chemotherapy Toxicology and Metabolic Inhibitors, 2021, 223, pp.107805. ⟨10.1016/j.pharmthera.2021.107805⟩

Article dans une revue inserm-03349934v1
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Tumor vessel co-option probed by single-cell analysis

Laure-Anne Teuwen , Laura P M H de Rooij , Anne Cuypers , Katerina Rohlenova , Sébastien J Dumas et al.

Cell Reports, 2021, 35 (11), pp.109253. ⟨10.1016/j.celrep.2021.109253⟩

Article dans une revue inserm-05169278v1
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Endothelial CFTR dysfunction and its involvement in the pathogenesis of pulmonary arterial hypertension

Mathias Declercq , Lucas Treps , Siham Bousfia , Peter Carmeliet , Peter Witters

European Respiratory Journal, 2021, 58 (2), pp.2101645. ⟨10.1183/13993003.01645-2021⟩

Article dans une revue inserm-03349937v1
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Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle

Nadine V Conchinha , Liliana Sokol , Laure-Anne Teuwen , Koen Veys , Sébastien J Dumas et al.

STAR Protocols, 2021, 2 (3), pp.100508. ⟨10.1016/j.xpro.2021.100508⟩

Article dans une revue inserm-05169243v1
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Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype

Mathias Declercq , Pauline de Zeeuw , Nadine V Conchinha , Vincent Geldhof , Anabela S Ramalho et al.

European Respiratory Journal, 2021, 57 (4), pp.2000261. ⟨10.1183/13993003.00261-2020⟩

Article dans une revue inserm-05169290v1
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Protocols for endothelial cell isolation from mouse tissues: kidney, spleen, and testis

Sébastien J Dumas , Elda Meta , Nadine V Conchinha , Liliana Sokol , Rongyuan Chen et al.

STAR Protocols, 2021, 2 (3), pp.100523. ⟨10.1016/j.xpro.2021.100523⟩

Article dans une revue inserm-05169267v1
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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

Ulrike Bruning , Francisco Morales-Rodriguez , Joanna Kalucka , Jermaine Goveia , Federico Taverna et al.

Cell Metabolism, 2021, 28 (6), pp.866 - 880.e15. ⟨10.1016/j.cmet.2018.07.019⟩

Article dans une revue inserm-05169365v1
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Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

Katerina Rohlenova , Jermaine Goveia , Melissa García-Caballero , Abhishek Subramanian , Joanna Kalucka et al.

Cell Metabolism, 2020, 31 (4), pp.862-877. ⟨10.1016/j.cmet.2020.03.009⟩

Article dans une revue inserm-05169310v1
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BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization

Federico Taverna , Jermaine Goveia , Tobias K Karakach , Shawez Khan , Katerina Rohlenova et al.

Nucleic Acids Research, 2020, 48 (W1), pp.W385-W394. ⟨10.1093/nar/gkaa332⟩

Article dans une revue inserm-05169304v1
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Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers

Lyna Kara-Terki , Lucas Treps , Christophe Blanquart , Delphine Fradin

International Journal of Molecular Sciences, 2020, 21 (17), pp.6024. ⟨10.3390/ijms21176024⟩

Article dans une revue inserm-02946311v1
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Basic and Therapeutic Aspects of Angiogenesis Updated

Guy Eelen , Lucas Treps , Xuri Li , Peter Carmeliet

Circulation Research, 2020, 127 (2), pp.310-329. ⟨10.1161/CIRCRESAHA.120.316851⟩

Article dans une revue inserm-05169300v1
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Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Joanna Kalucka , Laura P M H de Rooij , Jermaine Goveia , Katerina Rohlenova , Sébastien J Dumas et al.

Cell, 2020, 180 (4), pp.764-779. ⟨10.1016/j.cell.2020.01.015⟩

Article dans une revue inserm-05169319v1
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An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Jermaine Goveia , Katerina Rohlenova , Federico Taverna , Lucas Treps , Lena-Christin Conradi et al.

Cancer Cell, 2020, 37 (1), pp.21-36. ⟨10.1016/j.ccell.2019.12.001⟩

Article dans une revue inserm-05169323v1
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BRAF, A gatekeeper controlling endothelial permeability

Mathias Declercq , Lucas Treps

FEBS Journal, 2019, 286 (12), pp.2273 - 2276. ⟨10.1111/febs.14861⟩

Article dans une revue inserm-05169328v1
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EndoDB: a database of endothelial cell transcriptomics data

Shawez Khan , Federico Taverna , Katerina Rohlenova , Lucas Treps , Vincent Geldhof et al.

Nucleic Acids Research, 2018, 47 (D1), pp.D736 - D744. ⟨10.1093/nar/gky997⟩

Article dans une revue inserm-05169336v1
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RAISEing VEGF-D’s importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients

P. Carmeliet , Xiaojian Li , Lucas Treps , L-C Conradi , S Loges

Annals of Oncology, 2018, 29 (3), pp.529-532. ⟨10.1093/annonc/mdy028⟩

Article dans une revue hal-02047270v1
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Endothelial Cell Metabolism

Guy Eelen , Pauline de Zeeuw , Lucas Treps , Ulrike Harjes , Brian Wong et al.

Physiological Reviews, 2018, 98 (1), pp.3-58. ⟨10.1152/physrev.00001.2017⟩

Article dans une revue inserm-05169374v1
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EnLIGHTenment of tumor vessel normalization and immunotherapy in glioblastoma

Lucas Treps

Journal of Pathology, 2018, 246 (1), pp.3 - 6. ⟨10.1002/path.5103⟩

Article dans une revue inserm-05169367v1
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Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

Joanna Kalucka , Laura Bierhansl , Nadine Vasconcelos Conchinha , Rindert Missiaen , Ilaria Elia et al.

Cell Metabolism, 2018, 28 (6), pp.881 - 894. ⟨10.1016/j.cmet.2018.07.016⟩

Article dans une revue inserm-05169358v1
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Endothelial cell metabolism in health and disease: impact of hypoxia

Brian W Wong , Elke Marsch , Lucas Treps , Myriam Baes , Peter Carmeliet

EMBO Journal, 2017, 36 (15), pp.2187 - 2203. ⟨10.15252/embj.201696150⟩

Article dans une revue inserm-05169389v1

Assaying the Action of Secreted Semaphorins on Vascular Permeability

Lucas Treps , Julie Gavard

Methods in Molecular Biology, 2017, ⟨10.1007/978-1-4939-6448-2_30⟩

Article dans une revue inserm-01662346v1
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Central Role of Metabolism in Endothelial Cell Function and Vascular Disease

Laura Bierhansl , Lena-Christin Conradi , Lucas Treps , Mieke Dewerchin , Peter Carmeliet

Physiology, 2017, 32 (2), pp.126 - 140. ⟨10.1152/physiol.00031.2016⟩

Article dans une revue inserm-05170115v1
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Glioblastoma stem‐like cells secrete the pro‐angiogenic VEGF‐A factor in extracellular vesicles

Lucas Treps , Raul Perret , Sébastien Edmond , Damien Ricard , Julie Gavard

Journal of Extracellular Vesicles, 2017, 6 (1), pp.1359479. ⟨10.1080/20013078.2017.1359479⟩

Article dans une revue hal-04963388v1
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Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities

Andreas Pircher , Lucas Treps , Natalia Bodrug , Peter Carmeliet

Atherosclerosis, 2016, 253, pp.247 - 257. ⟨10.1016/j.atherosclerosis.2016.08.011⟩

Article dans une revue inserm-05170187v1
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Manipulating Angiogenesis by Targeting Endothelial Metabolism: Hitting the Engine Rather than the Drivers—A New Perspective?

Lucas Treps , Lena-Christin Conradi , Ulrike Harjes , Peter Carmeliet

Pharmacological Reviews, 2016, 68 (3), pp.872 - 887. ⟨10.1124/pr.116.012492⟩

Article dans une revue inserm-05170192v1
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The E3 ubiquitin ligase MARCH3 controls the endothelial barrier

Héloïse M Leclair , Gwennan André-Grégoire , Lucas Treps , Sandy Azzi , Nicolas Bidère et al.

FEBS Letters, 2016, 590 (20), pp.3660-3668. ⟨10.1002/1873-3468.12417⟩

Article dans une revue inserm-01385212v1
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Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma

L Treps , S Edmond , E Harford-Wright , Em Galan-Moya , Anne Schmitt et al.

Oncogene, 2016, 35, pp.2615 - 2623. ⟨10.1038/onc.2015.317⟩

Article dans une revue inserm-01406334v1
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Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

Anna Rita Cantelmo , Lena-Christin Conradi , Aleksandra Brajic , Jermaine Goveia , Joanna Kalucka et al.

Cancer Cell, 2016, 30 (6), pp.968 - 985. ⟨10.1016/j.ccell.2016.10.006⟩

Article dans une revue inserm-05170152v1
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The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity

Julie Dwyer , Sandy Azzi , Héloïse M Leclair , Steven Georges , Agnès Carlotti et al.

Cell Communication and Signaling, 2015, 13 (1), pp.11. ⟨10.1186/s12964-015-0090-1⟩

Article dans une revue inserm-01264495v1
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L'angiogenèse tumorale Quand l'arbre de vie tourne mal

Lucas Treps , Julie Gavard

Médecine/Sciences, 2015, 31 (11), pp.989 - 995. ⟨10.1051/medsci/20153111013⟩

Article dans une revue inserm-01819799v1
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Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma

Sandy Azzi , Lucas Treps , Héloïse M. Leclair , Hai-Mi Ngo , Elizabeth Harford-Wright et al.

Frontiers in Pharmacology, 2015, ⟨10.3389/fphar.2015.00281⟩

Article dans une revue inserm-01247505v1
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Endothelial Secreted Factors Suppress Mitogen Deprivation-Induced Autophagy and Apoptosis in Glioblastoma Stem-Like Cells

Eva Maria Galan-Moya , Lucas Treps , Lisa Oliver , Hervé Chneiweiss , François M. Vallette et al.

PLoS ONE, 2014, pp.e93505. ⟨10.1371/journal.pone.0093505⟩

Article dans une revue inserm-01075054v1
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Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders

Sandra Blanco , Sabine Dietmann , Joana V Flores , Shobbir Hussain , Claudia Kutter et al.

EMBO Journal, 2014, 33 (18), pp.2020 - 2039. ⟨10.15252/embj.201489282⟩

Article dans une revue inserm-05170194v1

Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation

Armelle Le Guelte , Eva-Maria Galan-Moya , Julie Dwyer , Lucas Treps , Garance Kettler et al.

Journal of Cell Science, 2012, 125 (17), pp.4137-4146. ⟨10.1242/jcs.108282⟩

Article dans une revue hal-01541442v1