Lucy Glover

Head of Trypanosome Molecular Biology Unit
44
Documents

Domaines de recherche

Biologie moléculaire

Publications

Publications

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Division of labor in trypanosome RNA processing and export through expanded Mex67 paralogs

Samson Obado , Peter Fridy , Eva Hegedűsová , Trevor van Eeuwen , Milana Stein et al.

Nucleic Acids Research, In press, 54 (1), pp.gkaf1443. ⟨10.1093/nar/gkaf1443⟩

Article dans une revue hal-05447852v1
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A SHERLOCK toolbox for eco-epidemiological surveillance of African trypanosomes in domestic pigs from Western Africa

Roger Eloiflin , Elena Pérez-Antón , Aïssata Camara , Annick Dujeancourt-Henry , Salimatou Boiro et al.

eLife, 2025, 14, pp.RP106823. ⟨10.7554/eLife.106823⟩

Article dans une revue hal-05273604v2
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A CRISPR-based diagnostic tool to survey drug resistance in human African trypanosomiasis

Elena Pérez Antón , Annick Dujeancourt-Henry , Brice Rotureau , Lucy Glover

Antimicrobial Agents and Chemotherapy, In press, pp.e00933-25. ⟨10.1128/aac.00933-25⟩

Article dans une revue hal-05389986v1
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Phosphoproteomic analysis of the response to DNA damage in Trypanosoma brucei

Emilia Mclaughlin , Monica Gabriela Zavala Martinez , Annick Dujeancourt-Henry , Thibault Chaze , Quentin Giai Gianetto et al.

Journal of Biological Chemistry, 2024, 300 (9), pp.107657. ⟨10.1016/j.jbc.2024.107657⟩

Article dans une revue pasteur-04854518v1
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Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome

Monica Chandra , Sara Đaković , Konstantina Foti , Johan Zeelen , Monique van Straaten et al.

PLoS Neglected Tropical Diseases, 2023, 17 (2), pp.e0011093. ⟨10.1371/journal.pntd.0011093⟩

Article dans une revue hal-05273629v1
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Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

Emilia Jane Mclaughlin , Karinna Rubio-Pena , Annick Dujeancourt-Henry , Lucy Glover

mBio, 2022, 13 (2), pp.e0384721. ⟨10.1128/mbio.03847-21⟩

Article dans une revue pasteur-03647000v1
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VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei

Eliane Tihon , Karinna Rubio-Peña , Annick Dujeancourt-Henry , Aline Crouzols , Brice Rotureau et al.

Frontiers in Cell and Developmental Biology, 2022, 10, pp.851475. ⟨10.3389/fcell.2022.851475⟩

Article dans une revue pasteur-03646994v1
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SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis

Núria Sima , Annick Dujeancourt-Henry , Blanca Liliana Perlaza , Marie-Noelle Ungeheuer , Brice Rotureau et al.

EBioMedicine, 2022, 85, pp.104308. ⟨10.1016/j.ebiom.2022.104308⟩

Article dans une revue pasteur-04073409v1

Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

Joana Faria , Vanessa Luzak , Laura Müller , Benedikt Brink , Sebastian Hutchinson et al.

Nature Microbiology, 2021, 6 (3), pp.289-300. ⟨10.1038/s41564-020-00833-4⟩

Article dans une revue hal-05130106v1
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The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

Ann-Kathrin Mehnert , Marco Prorocic , Annick Dujeancourt-Henry , Sebastian Hutchinson , Richard Mcculloch et al.

Nucleic Acids Research, 2021, ⟨10.1093/nar/gkaa1265⟩

Article dans une revue pasteur-03112362v1
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DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice

Alix Thivolle , Ann-Kathrin Mehnert , Eliane Tihon , Emilia Mclaughlin , Annick Dujeancourt-Henry et al.

PLoS Pathogens, 2021, 17 (11), pp.e1010038. ⟨10.1371/journal.ppat.1010038⟩

Article dans une revue pasteur-04073401v1
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mSphere of Influence: Expanding the CRISPR Sphere with Single-Locus Proteomics

Lucy Glover

MSphere, 2020, 5 (1), ⟨10.1128/mSphere.00001-20⟩

Article dans une revue pasteur-03107138v1
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CRISPR in Parasitology: Not Exactly Cut and Dried!

Jessica Bryant , Sebastian Baumgarten , Lucy Glover , Sebastian Hutchinson , Najma Rachidi

Trends in Parasitology, 2019, 35 (6), pp.409-422. ⟨10.1016/j.pt.2019.03.004⟩

Article dans une revue pasteur-02874588v1
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Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

Lucy Glover , Catarina Marques , Olga Suska , David Horn

mBio, 2019, 10 (4), pp.e01252-19. ⟨10.1128/mBio.01252-19⟩

Article dans une revue pasteur-03107118v1
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A post-transcriptional respiratome regulon in trypanosomes

Anna Trenaman , Lucy Glover , Sebastian Hutchinson , David Horn

Nucleic Acids Research, 2019, 47 (13), pp.7063-7077. ⟨10.1093/nar/gkz455⟩

Article dans une revue pasteur-03107129v1
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Escaping the immune system by DNA repair and recombination in African trypanosomes

Núria Sima , Emilia Jane Mclaughlin , Sebastian Hutchinson , Lucy Glover

Open Biology, 2019, 9 (11), pp.190182. ⟨10.1098/rsob.190182⟩

Article dans une revue pasteur-03107126v1
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Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Joana Faria , Lucy Glover , Sebastian Hutchinson , Cordula Boehm , Mark Field et al.

Nature Communications, 2019, 10 (1), pp.3023. ⟨10.1038/s41467-019-10823-8⟩

Article dans une revue pasteur-03107015v1
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Insights into antitrypanosomal drug mode-of-action from cytology-based profiling

James Thomas , Nicola Baker , Sebastian Hutchinson , Caia Dominicus , Anna Trenaman et al.

PLoS Neglected Tropical Diseases, 2018, 12 (11), pp.e0006980. ⟨10.1371/journal.pntd.0006980⟩

Article dans une revue pasteur-03107158v1
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Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei

Eva Rico , Alasdair Ivens , Lucy Glover , David Horn , Keith Matthews

PLoS Pathogens, 2017, 13 (3), pp.e1006279. ⟨10.1371/journal.ppat.1006279⟩

Article dans une revue pasteur-03107156v1

VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

Lucy Glover , Sebastian Hutchinson , Sam Alsford , David Horn

Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (26), pp.7225-7230. ⟨10.1073/pnas.1600344113⟩

Article dans une revue pasteur-03107112v1
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High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes

Sebastian Hutchinson , Lucy Glover , David Horn

BMC Genomics, 2016, 17 (1), pp.806. ⟨10.1186/s12864-016-3154-8⟩

Article dans une revue pasteur-03107120v1

The nuclear envelope and gene organization in parasitic protozoa: Specializations associated with disease

Samson Obado , Lucy Glover , Kirk Deitsch

Molecular and Biochemical Parasitology, 2016, 209 (1-2), pp.104-113. ⟨10.1016/j.molbiopara.2016.07.008⟩

Article dans une revue pasteur-03107121v1

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

Lucy Glover , Sam Alsford , Nicola Baker , Daniel Turner , Alejandro Sanchez-Flores et al.

Nature Protocols, 2015, 10 (1), pp.106-133. ⟨10.1038/nprot.2015.005⟩

Article dans une revue pasteur-03107102v1
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Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

Jane Munday , Anthonius Eze , Nicola Baker , Lucy Glover , Caroline Clucas et al.

Journal of Antimicrobial Chemotherapy, 2014, 69 (3), pp.651-663. ⟨10.1093/jac/dkt442⟩

Article dans une revue pasteur-03107152v1
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Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome

Lucy Glover , David Horn

Nucleic Acids Research, 2014, 42 (20), pp.12600-12613. ⟨10.1093/nar/gku900⟩

Article dans une revue pasteur-03107111v1
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Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

Lucy Glover , Sebastian Hutchinson , Sam Alsford , Richard Mcculloch , Mark Field et al.

Cellular Microbiology, 2013, 15 (12), pp.1984-1993. ⟨10.1111/cmi.12215⟩

Article dans une revue pasteur-03107113v1
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DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

Lucy Glover , Sam Alsford , David Horn

PLoS Pathogens, 2013, 9 (3), pp.e1003260. ⟨10.1371/journal.ppat.1003260⟩

Article dans une revue pasteur-03107107v1
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PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome

Sean Rudd , Lucy Glover , Stanislaw Jozwiakowski , David Horn , Aidan J Doherty

Molecular Cell, 2013, 52 (4), pp.554-565. ⟨10.1016/j.molcel.2013.10.034⟩

Article dans une revue pasteur-03107124v1

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

Nicola Baker , Lucy Glover , Jane Munday , David Aguinaga Andres , Michael P Barrett et al.

Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (27), pp.10996-11001. ⟨10.1073/pnas.1202885109⟩

Article dans une revue pasteur-03107134v1
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Trypanosomal histone γH2A and the DNA damage response

Lucy Glover , David Horn

Molecular and Biochemical Parasitology, 2012, 183 (1), pp.78-83. ⟨10.1016/j.molbiopara.2012.01.008⟩

Article dans une revue pasteur-03107110v1
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Microhomology-mediated deletion and gene conversion in African trypanosomes

Lucy Glover , Junho Jun , David Horn

Nucleic Acids Research, 2011, 39 (4), pp.1372-1380. ⟨10.1093/nar/gkq981⟩

Article dans une revue pasteur-03107115v1

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

Sam Alsford , Daniel Turner , Samson Obado , Alejandro Sanchez-Flores , Lucy Glover et al.

Genome Research, 2011, 21 (6), pp.915-924. ⟨10.1101/gr.115089.110⟩

Article dans une revue pasteur-03107133v1

DNA breaks as triggers for antigenic variation in African trypanosomes

Sam Alsford , David Horn , Lucy Glover

Genome Biology, 2009, 10 (6), pp.223. ⟨10.1186/gb-2009-10-6-223⟩

Article dans une revue pasteur-03107131v1
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Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei

Lucy Glover , David Horn

Molecular and Biochemical Parasitology, 2009, 166 (2), pp.194-197. ⟨10.1016/j.molbiopara.2009.03.010⟩

Article dans une revue pasteur-03107140v1
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Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes

Lucy Glover , Richard Mcculloch , David Horn

Nucleic Acids Research, 2008, 36 (8), pp.2608-2618. ⟨10.1093/nar/gkn104⟩

Article dans une revue pasteur-03107119v1
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Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest

Lucy Glover , Sam Alsford , Caroline Beattie , David Horn

Nucleic Acids Research, 2007, 35 (3), pp.872-880. ⟨10.1093/nar/gkl1100⟩

Article dans une revue pasteur-03107105v1

Repression of polymerase I‐mediated gene expression at Trypanosoma brucei telomeres

Lucy Glover , David Horn

EMBO Reports, 2006, 7 (1), pp.93-99. ⟨10.1038/sj.embor.7400575⟩

Article dans une revue pasteur-03107108v1

Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects

Sam Alsford , Taemi Kawahara , Lucy Glover , David Horn

Molecular and Biochemical Parasitology, 2005, 144 (2), pp.142-148. ⟨10.1016/j.molbiopara.2005.08.009⟩

Article dans une revue pasteur-03107132v1

Multiplex analysis of RNA interference defects in Trypanosoma brucei

Sam Alsford , Lucy Glover , David Horn

Molecular and Biochemical Parasitology, 2005, 139 (1), pp.129-132. ⟨10.1016/j.molbiopara.2004.11.001⟩

Article dans une revue pasteur-03107009v1
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SHERLOCK4AAT, a new molecular method for highly sensitive and specific detection of animal African trypanosomes

Roger Junior Eloiflin , Elena Perez Anton , Aïssata Camara , Annick Dujeancourt Henry , Jean Mathieu Bart et al.

Pasteur Network Annual Meeting, Pasteur Network, Oct 2025, Ho chi Minh city, Vietnam

Communication dans un congrès hal-05415525v1

SHERLOCK4HAT: A CRISPR based toolkit for diagnosis of Human African Trypanosomiasis

Lucy Glover

INSTITUT PASTEUR/UCSF QBI THIRD ANNUAL SYMPOSIUM ON INFECTIOUS DISEASES, Drs. Carla Saleh and Nevan Krogan,, Apr 2023, Paris, France

Communication dans un congrès hal-05392418v1
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SHERLOCK4AAT, a new molecular method for highly sensitive and specific detection of animal African trypanosomes

Aïssata Camara , Elena Perez Anton , Roger Junior Eloiflin , Annick Dujeancourt Henry , Martial Kassi N'Djetchi et al.

SHERLOCK4AAT, a new molecular method for highly sensitive and specific detection of animal African trypanosomes, Oct 2024, Conakry, Guinea

Poster de conférence hal-05415549v1

Development of a molecular diagnostic toolbox for the detection of trypanosomatid parasites by SHERLOCK

Elena Pérez Antón , Lucy Glover , Brice Rotureau , Jean-Mathieu Bart , Aïssata Camara et al.

Ninth Kinetoplastid Molecular Cell Biology Meeting, Sep 2022, Woods Hole, Massachusetts, USA, United States

Poster de conférence hal-05407247v1

Forward Genetics in African Trypanosomes

Sebastian Hutchinson , Lucy Glover

Trypanosomatids, 2116, pp.339-352, 2020, Methods in Molecular biology, 978-1-0716-0294-2 (online) ; 978-1-0716-0293-5 (print). ⟨10.1007/978-1-0716-0294-2_21⟩

Chapitre d'ouvrage pasteur-03107149v1