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Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer's disease model
Valentin Travers--Lesage
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Lucie Crouzier
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Mirjana Antonijevic
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Alice Wang
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François-Xavier Toublet
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Article dans une revue
hal-05576481v1
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Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s Disease
Mireia Toledano-Pinedo
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Alicia Porro-Pérez
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Linda Schäker-Hübner
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Daniel Diez-Iriepa
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Isabel Iriepa
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Article dans une revue
hal-05577025v1
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Implication of Central β 2 Adrenergic Receptor for the Development of Novel Drugs Against Alzheimer's Disease
Alice Wang
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Marc Since
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Patrick Dallemagne
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Christophe Rochais
Article dans une revue
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Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential
Omar Khoumeri
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Sébastien Hutter
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Nicolas Primas
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Caroline Castera-Ducros
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Sandra Carvalho
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Article dans une revue
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Towards New Anti‐inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP‐BIR2
Marc Ragui Farag
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Nicolas Guedeney
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Florian Schwalen
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Aymeric Zadorovnyj
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Amelie Barczyk
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Article dans une revue
hal-04772005v1
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Disruption of PHF6 Peptide Aggregation from Tau Protein: Mechanisms of Palmatine Chloride in Preventing Early PHF6 Aggregation
Charline Fagnen
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Johanna Giovannini
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Thomas Vignol
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Marc Since
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Marco Catto
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Article dans une revue
hal-04847910v1
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Molecular glue degraders: exciting opportunities for novel drug discovery
Thomas Lemaitre
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Marie Cornu
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Florian Schwalen
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Marc Since
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Charline Kieffer
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Article dans une revue
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A biomimetic multiparametric assay to characterise anti-amyloid drugs
Willy Smeralda
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Marc Since
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Sophie Corvaisier
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Dimitri Fayoll
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Julien Cardin
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Article dans une revue
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Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy
Romain Mustière
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Prisca Lagardère
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Sébastien Hutter
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Viviana Dell’orco
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Nadia Amanzougaghene
et al.
Article dans une revue
hal-03737417v1
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Star-like poly(peptoid)s with selective antibacterial activity
Pedro Salas-Ambrosio
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Antoine Tronnet
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Mostafa Badreldin
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Luzangel Reyes
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Marc Since
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Article dans une revue
hal-03559890v1
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Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore
Romain Paoli-Lombardo
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Nicolas Primas
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Sandra Bourgeade-Delmas
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Sébastien Hutter
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Alix Sournia-Saquet
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Article dans une revue
hal-03755519v1
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A functional m 6 A‐RNA methylation pathway in the oyster Crassostrea gigas assumes epitranscriptomic regulation of lophotrochozoan development
Lorane Le Franc
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Benoit Bernay
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Bruno Petton
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Marc Since
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Pascal Favrel
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Article dans une revue
hal-02952460v1
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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease
François-Xavier Toublet
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Julien Lalut
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Bérénice Hatat
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Cédric Lecoutey
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Audrey Davis
et al.
Article dans une revue
hal-03082877v1
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β-Amyloid peptide interactions with biomimetic membranes: A multiparametric characterization
Willy Smeralda
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Marc Since
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Julien Cardin
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Sophie Corvaisier
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Sophie Lecomte
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Article dans une revue
hal-03187852v1
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Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones
Pedro Salas-Ambrosio
,
Antoine Tronnet
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Marc Since
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Sandra Bourgeade-Delmas
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Jean-Luc Stigliani
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Article dans une revue
hal-03173586v1
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Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancer
A.C. Groo
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S. Hedir
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M. Since
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E. Brotin
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L.-B. Weiswald
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Article dans une revue
hal-03492393v1
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New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi
Julien Pedron
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Clotilde Boudot
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Jean-Yves Brossas
,
Emilie Pinault
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Sandra Bourgeade-Delmas
et al.
Article dans une revue
hal-02476867v1
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Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment
Thomas Adnet
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Anne-Claire Groo
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Céline Picard
,
Audrey Davis
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Sophie Corvaisier
et al.
Article dans une revue
hal-03969997v1
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Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes
Martina de Pascale
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Domenico Iacopetta
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Marc Since
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Sophie Corvaisier
,
V. Vié
et al.
Article dans une revue
hal-02434628v1
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8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi
Cyril Fersing
,
Clotilde Boudot
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Caroline Castera-Ducros
,
Émilie Pinault
,
Sébastien Hutter
et al.
Article dans une revue
hal-02899751v1
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Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties
Cyril Fersing
,
Clotilde Boudot
,
Romain Paoli-Lombardo
,
Nicolas Primas
,
Emilie Pinault
et al.
Article dans une revue
hal-02920293v1
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Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease
François-Xavier Toublet
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Cédric Lecoutey
,
Julien Lalut
,
Bérénice Hatat
,
Audrey Davis
et al.
Article dans une revue
hal-02399906v1
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Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease
Caroline Lanthier
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Hugo Payan
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Irene Liparulo
,
Bérénice Hatat
,
Cédric Lecoutey
et al.
Article dans une revue
hal-02399942v1
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Microplate assay for lipophilicity determination using intrinsic fluorescence of drugs: Application to a promising anticancer lead, pyridoclax
Willy Smeralda
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Marc Since
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Sophie Corvaisier
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Rémi Legay
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Anne-Sophie Voisin-Chiret
et al.
Article dans une revue
hal-02168030v1
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Nongenotoxic 3-Nitroimidazo[1,2- a ]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity
Cyril Fersing
,
Louise Basmaciyan
,
Clotilde Boudot
,
Julien Pedron
,
Sébastien Hutter
et al.
Article dans une revue
hal-02478935v1
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Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment
Jean-Pierre Jourdan
,
Marc Since
,
Laïla El kihel
,
Cédric Lecoutey
,
Sophie Corvaisier
et al.
Article dans une revue
hal-02043731v1
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Comparison of 2 strategies to enhance pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis
Anne-Claire Groo
,
Martina de Pascale
,
Anne-Sophie Voisin-Chiret
,
Sophie Corvaisier
,
Marc Since
et al.
Article dans une revue
istex
hal-02160866v1
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Evaluation of the versatile character of a nanoemulsion formulation
Emilie Gué
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Marc Since
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S. Ropars
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R. Herbinet
,
L. Le Pluart
et al.
Article dans une revue
istex
hal-01847973v1
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Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
Jean-Pierre Jourdan
,
Marc Since
,
Laïla El Kihel
,
Cédric Lecoutey
,
Sophie Corvaisier
et al.
Article dans une revue
hal-02043765v1
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Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography
Julien Lalut
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Benjamin B. Tournier
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Thomas Cailly
,
Cédric Lecoutey
,
Sophie Corvaisier
et al.
Article dans une revue
hal-02011098v1
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
Cédric Lecoutey
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Damien Hedou
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Thomas Freret
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Patrizia Giannoni
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Florence Gaven
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Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Article dans une revue
hal-01800439v2
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Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.
David Genest
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Christophe Rochais
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Cédric Lecoutey
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Jana Sopkova-de Oliveira Santos
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Céline Ballandonne
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MedChemComm, 2013, 4, pp.925-931
Article dans une revue
hal-00840942v1
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New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation
Marc Since
,
Thomas Freret
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Gerald Nee
,
Thierry Terme
,
Patrice Vanelle
et al.
Article dans une revue
istex
hal-01460473v1
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First SNAr reaction using TDAE-initiated carbanions in quinazoline series
Marc Since
,
Omar Khoumeri
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Pierre Verhaeghe
,
Martine Maillard-Boyer
,
Thierry Terme
et al.
Article dans une revue
istex
hal-01460328v1
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Original TDAE strategy using α-halocarbonyl derivatives
Marc Since
,
Thierry Terme
,
Patrice Vanelle
Article dans une revue
istex
hal-05577598v1
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