marc since

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Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer's disease model

Valentin Travers--Lesage , Lucie Crouzier , Mirjana Antonijevic , Alice Wang , François-Xavier Toublet et al.

European Journal of Medicinal Chemistry, 2026, 307, pp.118670. ⟨10.1016/j.ejmech.2026.118670⟩

Article dans une revue hal-05576481v1

Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s Disease

Mireia Toledano-Pinedo , Alicia Porro-Pérez , Linda Schäker-Hübner , Daniel Diez-Iriepa , Isabel Iriepa et al.

International Journal of Molecular Sciences, 2026, 27 (7), pp.3135. ⟨10.3390/ijms27073135⟩

Article dans une revue hal-05577025v1
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Implication of Central β 2 Adrenergic Receptor for the Development of Novel Drugs Against Alzheimer's Disease

Alice Wang , Marc Since , Patrick Dallemagne , Christophe Rochais

Archiv der Pharmazie / Chemistry in Life Sciences, 2025, 358 (4), ⟨10.1002/ardp.202400750⟩

Article dans une revue hal-05020271v1
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Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential

Omar Khoumeri , Sébastien Hutter , Nicolas Primas , Caroline Castera-Ducros , Sandra Carvalho et al.

Pharmaceuticals, 2024, 17 (7), pp.878. ⟨10.3390/ph17070878⟩

Article dans une revue hal-04635068v1

Towards New Anti‐inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP‐BIR2

Marc Ragui Farag , Nicolas Guedeney , Florian Schwalen , Aymeric Zadorovnyj , Amelie Barczyk et al.

ChemMedChem, 2024, pp.e202400567. ⟨10.1002/cmdc.202400567⟩

Article dans une revue hal-04772005v1

Disruption of PHF6 Peptide Aggregation from Tau Protein: Mechanisms of Palmatine Chloride in Preventing Early PHF6 Aggregation

Charline Fagnen , Johanna Giovannini , Thomas Vignol , Marc Since , Marco Catto et al.

ACS Chemical Neuroscience, 2024, 15 (21), pp.3981-3990. ⟨10.1021/acschemneuro.4c00353⟩

Article dans une revue hal-04847910v1

Molecular glue degraders: exciting opportunities for novel drug discovery

Thomas Lemaitre , Marie Cornu , Florian Schwalen , Marc Since , Charline Kieffer et al.

Expert Opinion on Drug Discovery, 2024, 19 (4), pp.433-449. ⟨10.1080/17460441.2024.2306845⟩

Article dans une revue hal-04711906v1
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A biomimetic multiparametric assay to characterise anti-amyloid drugs

Willy Smeralda , Marc Since , Sophie Corvaisier , Dimitri Fayoll , Julien Cardin et al.

International Journal of Molecular Sciences, 2023, 24 (23), pp.16982. ⟨10.3390/ijms242316982⟩

Article dans une revue hal-04315267v1

Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy

Romain Mustière , Prisca Lagardère , Sébastien Hutter , Viviana Dell’orco , Nadia Amanzougaghene et al.

European Journal of Medicinal Chemistry, 2022, 241, pp.114619. ⟨10.1016/j.ejmech.2022.114619⟩

Article dans une revue hal-03737417v1
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Star-like poly(peptoid)s with selective antibacterial activity

Pedro Salas-Ambrosio , Antoine Tronnet , Mostafa Badreldin , Luzangel Reyes , Marc Since et al.

Polymer Chemistry, 2022, 13 (5), pp.600-612. ⟨10.1039/D1PY01529J⟩

Article dans une revue hal-03559890v1
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Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore

Romain Paoli-Lombardo , Nicolas Primas , Sandra Bourgeade-Delmas , Sébastien Hutter , Alix Sournia-Saquet et al.

Pharmaceuticals, 2022, 15 (8), pp.998. ⟨10.3390/ph15080998⟩

Article dans une revue hal-03755519v1
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A functional m 6 A‐RNA methylation pathway in the oyster Crassostrea gigas assumes epitranscriptomic regulation of lophotrochozoan development

Lorane Le Franc , Benoit Bernay , Bruno Petton , Marc Since , Pascal Favrel et al.

FEBS Journal, 2021, 288 (5), pp.1696-1711. ⟨10.1111/febs.15500⟩

Article dans une revue hal-02952460v1
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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease

François-Xavier Toublet , Julien Lalut , Bérénice Hatat , Cédric Lecoutey , Audrey Davis et al.

European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩

Article dans une revue hal-03082877v1
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β-Amyloid peptide interactions with biomimetic membranes: A multiparametric characterization

Willy Smeralda , Marc Since , Julien Cardin , Sophie Corvaisier , Sophie Lecomte et al.

International Journal of Biological Macromolecules, 2021, 181, pp.769-777. ⟨10.1016/j.ijbiomac.2021.03.107⟩

Article dans une revue hal-03187852v1
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Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones

Pedro Salas-Ambrosio , Antoine Tronnet , Marc Since , Sandra Bourgeade-Delmas , Jean-Luc Stigliani et al.

Journal of the American Chemical Society, 2021, 143 (10), pp.3697-3702. ⟨10.1021/jacs.0c13231⟩

Article dans une revue hal-03173586v1
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Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancer

A.C. Groo , S. Hedir , M. Since , E. Brotin , L.-B. Weiswald et al.

International Journal of Pharmaceutics, 2020, 587, pp.119655 -. ⟨10.1016/j.ijpharm.2020.119655⟩

Article dans une revue hal-03492393v1
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New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi

Julien Pedron , Clotilde Boudot , Jean-Yves Brossas , Emilie Pinault , Sandra Bourgeade-Delmas et al.

ACS Medicinal Chemistry Letters, 2020, 11 (4), pp.464-472. ⟨10.1021/acsmedchemlett.9b00566⟩

Article dans une revue hal-02476867v1
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Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment

Thomas Adnet , Anne-Claire Groo , Céline Picard , Audrey Davis , Sophie Corvaisier et al.

Pharmaceutics, 2020, 12 (3), pp.251. ⟨10.3390/pharmaceutics12030251⟩

Article dans une revue hal-03969997v1
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Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes

Martina de Pascale , Domenico Iacopetta , Marc Since , Sophie Corvaisier , V. Vié et al.

ChemMedChem, 2020, 15 (1), pp.136-154. ⟨10.1002/cmdc.201900542⟩

Article dans une revue hal-02434628v1
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8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi

Cyril Fersing , Clotilde Boudot , Caroline Castera-Ducros , Émilie Pinault , Sébastien Hutter et al.

European Journal of Medicinal Chemistry, 2020, 202, pp.112558. ⟨10.1016/j.ejmech.2020.112558⟩

Article dans une revue hal-02899751v1
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Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties

Cyril Fersing , Clotilde Boudot , Romain Paoli-Lombardo , Nicolas Primas , Emilie Pinault et al.

European Journal of Medicinal Chemistry, 2020, 206, pp.112668. ⟨10.1016/j.ejmech.2020.112668⟩

Article dans une revue hal-02920293v1
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Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease

François-Xavier Toublet , Cédric Lecoutey , Julien Lalut , Bérénice Hatat , Audrey Davis et al.

Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩

Article dans une revue hal-02399906v1
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Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

Caroline Lanthier , Hugo Payan , Irene Liparulo , Bérénice Hatat , Cédric Lecoutey et al.

European Journal of Medicinal Chemistry, 2019, 182, pp.111596. ⟨10.1016/j.ejmech.2019.111596⟩

Article dans une revue hal-02399942v1
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Microplate assay for lipophilicity determination using intrinsic fluorescence of drugs: Application to a promising anticancer lead, pyridoclax

Willy Smeralda , Marc Since , Sophie Corvaisier , Rémi Legay , Anne-Sophie Voisin-Chiret et al.

European Journal of Pharmaceutical Sciences, 2019, 131, pp.75-83. ⟨10.1016/j.ejps.2019.02.010⟩

Article dans une revue hal-02168030v1
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Nongenotoxic 3-Nitroimidazo[1,2- a ]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

Cyril Fersing , Louise Basmaciyan , Clotilde Boudot , Julien Pedron , Sébastien Hutter et al.

ACS Medicinal Chemistry Letters, 2019, 10 (1), pp.34-39. ⟨10.1021/acsmedchemlett.8b00347⟩

Article dans une revue hal-02478935v1

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment

Jean-Pierre Jourdan , Marc Since , Laïla El kihel , Cédric Lecoutey , Sophie Corvaisier et al.

ChemMedChem, 2017, 12 (12), pp.913-916. ⟨10.1002/cmdc.201700102⟩

Article dans une revue hal-02043731v1

Comparison of 2 strategies to enhance pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis

Anne-Claire Groo , Martina de Pascale , Anne-Sophie Voisin-Chiret , Sophie Corvaisier , Marc Since et al.

European Journal of Pharmaceutical Sciences, 2017, 97, pp.218-226. ⟨10.1016/j.ejps.2016.11.025⟩

Article dans une revue istex hal-02160866v1

Evaluation of the versatile character of a nanoemulsion formulation

Emilie Gué , Marc Since , S. Ropars , R. Herbinet , L. Le Pluart et al.

International Journal of Pharmaceutics, 2016, 498 (1-2), pp.49-65. ⟨10.1016/j.ijpharm.2015.12.010⟩

Article dans une revue istex hal-01847973v1

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

Jean-Pierre Jourdan , Marc Since , Laïla El Kihel , Cédric Lecoutey , Sophie Corvaisier et al.

European Journal of Medicinal Chemistry, 2016, 114, pp.365-379. ⟨10.1016/j.ejmech.2016.03.023⟩

Article dans une revue hal-02043765v1

Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography

Julien Lalut , Benjamin B. Tournier , Thomas Cailly , Cédric Lecoutey , Sophie Corvaisier et al.

European Journal of Medicinal Chemistry, 2016, 116, pp.90-101. ⟨10.1016/j.ejmech.2016.03.059⟩

Article dans une revue hal-02011098v1
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Cédric Lecoutey , Damien Hedou , Thomas Freret , Patrizia Giannoni , Florence Gaven et al.

Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩

Article dans une revue hal-01800439v2

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.

David Genest , Christophe Rochais , Cédric Lecoutey , Jana Sopkova-de Oliveira Santos , Céline Ballandonne et al.

MedChemComm, 2013, 4, pp.925-931

Article dans une revue hal-00840942v1

New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation

Marc Since , Thomas Freret , Gerald Nee , Thierry Terme , Patrice Vanelle et al.

European Journal of Medicinal Chemistry, 2013, 69, pp.728--734. ⟨10.1016/j.ejmech.2013.08.041⟩

Article dans une revue istex hal-01460473v1

First SNAr reaction using TDAE-initiated carbanions in quinazoline series

Marc Since , Omar Khoumeri , Pierre Verhaeghe , Martine Maillard-Boyer , Thierry Terme et al.

Tetrahedron Letters, 2011, 52 (29), pp.3810--3813. ⟨10.1016/j.tetlet.2011.05.060⟩

Article dans une revue istex hal-01460328v1

Original TDAE strategy using α-halocarbonyl derivatives

Marc Since , Thierry Terme , Patrice Vanelle

Tetrahedron, 2009, 65 (31), pp.6128-6134. ⟨10.1016/j.tet.2009.05.036⟩

Article dans une revue istex hal-05577598v1