Marie Morille

Associate Professor - Montpellier University (Pharmacy)/ICGM French Society Extracellular Vesicles (FSEV) treasurer IUF Junior member
59
Documents
Identifiants chercheurs

Présentation

Marie Morille is Associate Professor in Montpellier University (Pharmacy School, Pharmaceutical sciences and Biomaterials Department) and Institute Charles Gerhardt of Montpellier (ICGM) (ORCID; Google Scholar) since 2012. During her phD and post-doctoral research, she worked on formulation of nano/microcarriers (surface functionalization, nucleic acids/protein loading) with a special care on coordination between carriers physico-chemical properties and impact on biological behaviour (in vitro/in vivo). As a result, she developed a multidisciplinary expertise at the interface of physico-chemistry, galenics and biology, which is particularly stimulating and allows me to interact with very different scientific backgrounds. In ICGM, she focuses on the delivery of biomolecules (nucleic acids, proteins) for health applications (cancerology, tissue engineering) using nanocarriers (lipid/polymer based). Since 2016, she has developed a line of research based on pharmaceutical sciences applied to Mesenchymal Stromal Cells (MSC) derived extracellular vesicles (EV), to increase the therapeutic potential of these promising bio/nanomedicines using pharmaceutical and physico-chemical tools/processes (characterization, storage, EV surface modification, EV engineering for biomolecules loading).

Publications

Publications

Surface modification of extracellular vesicles with polyoxazolines to enhance their plasma stability and tumor accumulation

L. Simon , J. Constanzo , Claudia Terraza-Aguirre , Z. Ibn Elfekih , J. Berthelot et al.
Biomaterials, 2025, 313, pp.122748. ⟨10.1016/j.biomaterials.2024.122748⟩
Article dans une revue hal-04754669 v1

Polyoxazolines with Cholesterol Lipid Anchor for Fast Intracellular Delivery

Laurianne Simon , Liên Sabrina Reichel , Belkacem Tarek Benkhaled , Jean‐marie Devoisselle , Sylvain Catrouillet et al.
Macromolecular Bioscience, 2024, ⟨10.1002/mabi.202400148⟩
Article dans une revue hal-04748321 v1
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Antioxidant capacity of an ethanolic extract of Elaeagnus x submacrophylla Servett. leaves

Hélène Bisi , Michel Bonnard , Laurianne Simon , Marie Morille , Sylvie Bégu et al.
Heliyon, 2024, 10 (7), pp.e28067. ⟨10.1016/j.heliyon.2024.e28067⟩
Article dans une revue hal-04574698 v1

Exploring the role of polymers to overcome ongoing challenges in the field of extracellular vesicles

Laurianne Simon , Vincent Lapinte , Marie Morille
Journal of Extracellular Vesicles, 2023, 12 (12), pp.e12386. ⟨10.1002/jev2.12386⟩
Article dans une revue hal-04369573 v1
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Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

François Noverraz , Baptiste Robin , Solène Passemard , Bénédicte Fauvel , Jessy Presumey et al.
International Journal of Pharmaceutics, 2023, 630, pp.122463. ⟨10.1016/j.ijpharm.2022.122463⟩
Article dans une revue hal-03935985 v1

Size-tunable lipid vectors for controlled local delivery of siRNA from gene activated matrix

Jérémy Salvador , Jade Berthelot , Claire Bony , Baptiste Robin , Josephine Lai Kee Him et al.
Acta Biomaterialia, 2022, 153, pp.97-107. ⟨10.1016/j.actbio.2022.09.016⟩
Article dans une revue hal-03906280 v1
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Interest of extracellular vesicles in regards to lipid nanoparticle based systems for intracellular protein delivery

Sarah Le Saux , Anne Aubert-Pouëssel , Khaled Elhady Mohamed , Pierre Martineau , Laurence Guglielmi et al.
Advanced Drug Delivery Reviews, 2021, pp.113837. ⟨10.1016/j.addr.2021.113837⟩
Article dans une revue hal-03292014 v1
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Rapid communication: insights into the role of extracellular vesicles during Auger radioimmunotherapy

Jihad Karam , Julie Constanzo , Alexandre Pichard , Laurent Gros , Joël Chopineau et al.
International Journal of Radiation Biology, 2021, pp.1 - 10. ⟨10.1080/09553002.2021.1955999⟩
Article dans une revue hal-03367192 v1
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Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France”

Amanda K.A. Silva , Marie Morille , Max Piffoux , Surendar Arumugam , Phlippe Mauduit et al.
Advanced Drug Delivery Reviews, 2021, 179, pp.114001. ⟨10.1016/j.addr.2021.114001⟩
Article dans une revue hal-03412034 v1

Melanotransferrin is efficiently sorted on the surface of exosomes secreted by melanoma cells

Anne Bonhoure , Laurent Henry , Marie Morille , Nesrine Aissaoui , Gaëtan Bellot et al.
Melanoma Research, 2021, 31 (4), pp.338-351. ⟨10.1097/CMR.0000000000000741⟩
Article dans une revue hal-03295843 v1
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Nanotechnologies for Intracellular Protein Delivery: Recent Progress in Inorganic and Organic Nanocarriers

Sarah Le Saux , Anne Aubert‐pouëssel , Lyria Ouchait , Khaled Elhady Mohamed , Pierre Martineau et al.
Advanced Therapeutics, 2021, pp.2100009. ⟨10.1002/adtp.202100009⟩
Article dans une revue hal-03210215 v1
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Polyoxazolines based lipid nanocapsules for topical delivery of antioxidants

L. Simon , V. Lapinte , L. Lionnard , N. Marcotte , M. Morille et al.
International Journal of Pharmaceutics, 2020, 579, pp.119126. ⟨10.1016/j.ijpharm.2020.119126⟩
Article dans une revue hal-03037735 v1
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Post-production modifications of murine mesenchymal stem cell (mMSC) derived extracellular vesicles (EVs) and impact on their cellular interaction

Sarah Le Saux , Hanna Aarrass , Josephine Lai Kee Him , Patrick Bron , Jean Armengaud et al.
Biomaterials, 2020, 231, pp.119675. ⟨10.1016/j.biomaterials.2019.119675⟩
Article dans une revue hal-02414428 v1
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Degradable double hydrophilic block copolymers and tripartite polyionic complex micelles thereof for small interfering ribonucleic acids (siRNA) delivery

Ayman El Jundi , Marie Morille , Nadir Bettache , Audrey Bethry , Jade Berthelot et al.
Journal of Colloid and Interface Science, 2020, 580, pp.449-459. ⟨10.1016/j.jcis.2020.07.057⟩
Article dans une revue hal-03025049 v1
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PySHS:A Python Open Source Software for Second Harmonic Scattering

Lotfi Boudjema , Hanna Aarrass , Marwa Assaf , Marie Morille , Gaelle Martin-Gassin et al.
Journal of Chemical Information and Modeling, 2020, 60 (12), pp.5912-5917. ⟨10.1021/acs.jcim.0c00789⟩
Article dans une revue hal-03092719 v1
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Polyoxazolines based mixed micelles as PEG free formulations for an effective quercetin antioxidant topical delivery

L. Simon , M. Vincent , S. Le Saux , V. Lapinte , N. Marcotte et al.
International Journal of Pharmaceutics, 2019, 570, pp.118516. ⟨10.1016/j.ijpharm.2019.118516⟩
Article dans une revue hal-03212233 v1

Liposomes, lipid nanocapsules and smartCrystals®: A comparative study for an effective quercetin delivery to the skin

T. Hatahet , M. Morille , A. Hommoss , J.M. Devoisselle , R.H. Müller et al.
International Journal of Pharmaceutics, 2018, 542 (1-2), pp.176 - 185. ⟨10.1016/j.ijpharm.2018.03.019⟩
Article dans une revue hal-01785066 v1

Fluorescent biosensor for detection of the R248Q aggregation‐prone mutant of p53

Morgan Pellerano , Delphine Naud-Martin , Florence Mahuteau-Betzer , Marie Morille , May Catherine Morris
ChemBioChem, 2018, Special Issue: Biosensing and Bioimaging, 20 (4), pp.605-613. ⟨10.1002/cbic.201800531⟩
Article dans une revue hal-02009856 v1
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Elaboration of Materials with Functionality Gradients by Assembly of Chitosan-Collagen Microspheres Produced by Microfluidics

David Azria , Raluca Guermache , Sophie Raisin , Sébastien Blanquer , Frédéric Gobeaux et al.
Journal of Renewable Materials, 2018, 6 (3), pp.314-324. ⟨10.7569/JRM.2017.634186⟩
Article dans une revue cea-01695847 v1

Dermal quercetin lipid nanocapsules: Influence of the formulation on antioxidant activity and cellular protection against hydrogen peroxide

T. Hatahet , Marie Morille , A. Shamseddin , A. Aubert-Pouëssel , J.M. Devoisselle et al.
International Journal of Pharmaceutics, 2017, 518 (1-2), pp.167-176. ⟨10.1016/j.ijpharm.2016.12.043⟩
Article dans une revue hal-03212222 v1

Tripartite polyionic complex (PIC) micelles as non-viral vectors for mesenchymal stem cell siRNA transfection

Sophie Raisin , Marie Morille , Claire Bony , Danièle Noël , Jean-Marie Devoisselle et al.
Biomaterials Science, 2017, 5 (9), pp.1910 - 1921. ⟨10.1039/c7bm00384f⟩
Article dans une revue hal-01834627 v1

Quercetin topical application, from conventional dosage forms to nanodosage forms

T. Hatahet , Marie Morille , A. Hommoss , J.M. Devoisselle , R.H. Müller et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2016, 108, pp.41-53. ⟨10.1016/j.ejpb.2016.08.011⟩
Article dans une revue hal-03212219 v1

Dermal quercetin smartCrystals®: Formulation development, antioxidant activity and cellular safety

T. Hatahet , Marie Morille , A. Hommoss , C. Dorandeu , R.H. Müller et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2016, 102, pp.51-63. ⟨10.1016/j.ejpb.2016.03.004⟩
Article dans une revue hal-03212217 v1

Non-viral gene activated matrices for mesenchymal stem cells based tissue engineering of bone and cartilage

Sophie Raisin , Emmanuel Belamie , Marie Morille
Biomaterials, 2016, 104, pp.223-237. ⟨10.1016/j.biomaterials.2016.07.017⟩
Article dans une revue hal-03212220 v1

PLGA-based microcarriers induce mesenchymal stem cell chondrogenesis and stimulate cartilage repair in osteoarthritis

Marie Morille , Karine Toupet , Claudia Montero-Menei , Christian Jorgensen , Danièle Noël
Biomaterials, 2016, 88, pp.60 - 69. ⟨10.1016/j.biomaterials.2016.02.022⟩
Article dans une revue hal-01834277 v1

Scaffolds for controlled release of cartilage growth factors

Marie Morille , Marie-Claire Venier-Julienne , Claudia Montero-Menei
Methods in Molecular Biology, 2015, 1340, pp.171-180. ⟨10.1007/978-1-4939-2938-2_12⟩
Article dans une revue hal-01392462 v1
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DNA nanocarriers for systemic administration: characterization and in vivo bioimaging in healthy mice.

Stephanie David , Catherine Passirani , Jean-Pierre Benoit , Nathalie Carmoy , Marie Morille et al.
Molecular Therapy - Nucleic Acids, 2013, 2, pp.e64. ⟨10.1038/mtna.2012.56⟩
Article dans une revue inserm-00786437 v1

New PLGA-P188-PLGA matrix enhances TGF-β3 release from pharmacologically active microcarriers and promotes chondrogenesis of mesenchymal stem cells

Marie Morille , Tran Van-Thanh , Xavier Garric , Jérôme Cayon , Jean Coudane et al.
Journal of Controlled Release, 2013, 170 (1), pp.99-110. ⟨10.1016/j.jconrel.2013.04.017⟩
Article dans une revue istex hal-00881128 v1

Transferrin adsorption onto PLGA nanoparticles govern their interaction with biological systems from blood circulation to brain cancer cells.

J. Chang , A. Paillard-Giteau , Catherine Passirani-Malleret , Marie Morille , Jean-Pierre Benoit et al.
Pharmaceutical Research, 2012, 29 (6), pp.1495-505
Article dans une revue hal-03165450 v1

Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells

Isabelle Passagne , Marie Morille , Marine Rousset , Igor Pujalté , Béatrice L’azou
Toxicology, 2012, 299 (2-3), pp.112-124. ⟨10.1016/j.tox.2012.05.010⟩
Article dans une revue istex hal-03212200 v1

Stealth properties of poly(ethylene oxide)-based triblock copolymer micelles: A prerequisite for a pH-triggered targeting system

K. van Butsele , Marie Morille , Catherine Passirani-Malleret , Pierre Legras , Jean-Pierre Benoît et al.
Acta Biomaterialia, 2011, 7 (10), pp.3700-3707. ⟨10.1016/j.actbio.2011.06.014⟩
Article dans une revue istex hal-03134788 v1

Tumor transfection after systemic injection of DNA lipid nanocapsules

Marie Morille , Catherine Passirani , Sandrine Dufort , Guillaume Bastiat , Bruno Pitard et al.
Biomaterials, 2011, 32 (9), pp.2327-2333. ⟨10.1016/j.biomaterials.2010.11.063⟩
Article dans une revue istex hal-02514303 v1

Treatment of 9L Gliosarcoma in Rats by Ferrociphenol-Loaded Lipid Nanocapsules Based on a Passive Targeting Strategy via the EPR Effect

Ngoc Trinh Huynh , Marie Morille , Jérôme Bejaud , Pierre Legras , Anne Vessières et al.
Pharmaceutical Research, 2011, 28 (12), pp.3189-3198. ⟨10.1007/s11095-011-0501-y⟩
Article dans une revue istex hal-03134633 v1
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Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting.

Marie Morille , Tristan Montier , Pierre Legras , Nathalie Carmoy , Priscille Brodin et al.
Biomaterials, 2010, 31 (2), pp.321-9. ⟨10.1016/j.biomaterials.2009.09.044⟩
Article dans une revue inserm-00491402 v1

Galactosylated DNA lipid nanocapsules for efficient hepatocyte targeting

Marie Morille , Catherine Passirani-Malleret , E. Letrou-Bonneval , Jean-Pierre Benoît , Bruno Pitard
International Journal of Pharmaceutics, 2009, 379 (2), pp.293-300. ⟨10.1016/j.ijpharm.2009.05.065⟩
Article dans une revue istex hal-03171792 v1
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Progress in developing cationic vectors for non-viral systemic gene therapy against cancer.

Marie Morille , Catherine Passirani , Arnaud Vonarbourg , Anne Clavreul , Jean-Pierre Benoit
Biomaterials, 2008, 29 (24-25), pp.3477-96. ⟨10.1016/j.biomaterials.2008.04.036⟩
Article dans une revue inserm-00353462 v1

Progress in developing cationic vectors for non-viral systemic gene therapy against cancer

Marie Morille , Catherine Passirani , Arnaud Vonarbourg , Anne Clavreul , Jean-Pierre Benoit
Biomaterials, 2008, 29 (24-25), pp.3477-3496. ⟨10.1016/j.biomaterials.2008.04.036⟩
Article dans une revue hal-03210109 v1

When polymers meet EVs: interest of EVs’ surface modification with PEG alternatives for in vivo administration

Marie Morille
ISEV Early Career Researchers network webinar, Feb 2025, Montpellier online, France
Communication dans un congrès hal-04970930 v1

Les vecteurs non viraux dans les thérapies innovantes

Marie Morille
Journée thématique « Thérapies innovantes », Filière de Santé Maladies Rares Neuromusculaire Filnemus, Paris, 12 Décembre 2024, Feb 2025, Paris, France
Communication dans un congrès hal-04970917 v1

EV engineering : what about numbers?!

Marie Morille
ISEV (International Society of Extracellular Vesicles) 2024 annual Meeting – Education Day, May 2024, Melbourne (AUS), Australia
Communication dans un congrès hal-04970912 v1

Biochemical Approach using Lipid Anchors to Associate Proteins to Extracellular Vesicles for Intracellular Drug Delivery

Antonin Marquant , Anne Aubert Pouëssel , Claudia Muracciole-Bich , Guillaume Cazals , Jade Berthelot et al.
SFNano Annual Meeting (French Society for Nanomedicine) Dec 2023, Montpellier, France., Dec 2023, Montpellier, France
Communication dans un congrès hal-04970899 v1

Biochemical Association of Proteins to Extracellular Vesicles for intracellular delivery

Antonin Marquant , Claudia Bich-Muracciole , Guillaume Cazals , Jade Berthelot , J. Constanzo et al.
EVOCC scientific day 2023, Montpellier, Jun 2023, Montpellier, France
Communication dans un congrès hal-04970854 v1

Enhancing the therapeutic potential of natural vesicles using pharmaceutical & chemical engineering

Marie Morille
Inserm Workshop. Advances in therapeutic applications of extracellular vesicles, Jun 2023, Bordeaux, France
Communication dans un congrès hal-04970863 v1

Design of peptide-based and responsive biomaterials

Jules Simonin Garcia , Emmanuel Belamie , Marie Morille , Ahmad Mehdi , Brice Sorli et al.
23e Rassemblement du Groupe Français des Peptides et Protéines, GFPP, 2023, Fournols, France
Communication dans un congrès hal-04852354 v1

Use of Lipid Anchors to Associate Proteins and Extracellular Vesicles for Intracellular Drug Delivery

Antonin Marquant , Anne Aubert Pouëssel , Claudia Bich-Muracciole , Jade Berthelot , Marie Morille
French Society of Extracellular Vesicles (FSEV 2023) annual meeting, Nov 2023, Paris, France
Communication dans un congrès hal-04970885 v1

Extracellular vesicle pharmaceutical development to increase extracellular therapeutic potential

Marie Morille
18èmes Journées Annuelles du Cancéropôle GSO – 2022, Nov 2022, La Grande Motte - Montpellier, France
Communication dans un congrès hal-04970829 v1

Pharmaceutical development to enhance small Extracellular Vesicles (sEV) therapeutic potential

Marie Morille
Bioregate forum 2022, September, Louvain-la neuve, Sep 2022, Louvain -la-Neuve, Belgium
Communication dans un congrès hal-04970814 v1

Différents profils de miRNA sécrétés par le tissu adipeux viscéral de patients obèses présentant différents statuts métaboliques

Jonas Laget , Florence Galtier , Agathe Nouvel , Marie Morille , Philippe Géraud et al.
Congrès annuel 2022 de la Société Francophone du Diabète (SFD 2022), Société Francophone du Diabète (SFD), Mar 2022, Nice, France
Communication dans un congrès hal-05056500 v1

Surface modifications of mesenchymal stem cells derived extracellular vesicles for plasma stabilization

Laurianne Simon , Vincent Lapinte , Ghita Erraji , B.T Benkhaled , Jade Berthelot et al.
SFNano Annual Meeting, 2021, Angers, Dec 2021, Angers, France
Communication dans un congrès hal-04970794 v1

Spatio-temporal control of cellular differentiation for cartilage tissue engineering

Jules Simonin Garcia , Cécile Echalier , Emmanuel Belamie , Marie Morille , Gilles Subra
European Peptide Society. 37th European Peptide Symposium (37th EPS) & 14th International Peptide Symposium (14th IPS), Aug 2024, Florence, Italy. Wiley, Journal of Peptide Science, 30 (S2), pp.170-171, 2024
Poster de conférence hal-04811378 v1

Differential release of miRNAs by visceral adipose tissue from obese patients with various metabolic status

Jonas Laget , Florence Galtier , Agathe Nouvel , Marie Morille , Philippe Géraud et al.
56th Annual Meeting of the European Association for the Study of Diabetes (EASD 2020), Sep 2020, Vienne, Austria. Springer, Diabetologia, 63 (suppl. 1), pp.527, 2020
Poster de conférence hal-05056458 v1

Development of pharmacologically active microcarriers transporting stem cells and releasing growth factors integrated in a thermosensitive injectable hydrogel for an efficient tissue engineering strategy

Jean-Pierre Karam , Marie Morille , Guillaume Bastiat , D. Noël , Marie-Claire Venier-Julienne et al.
Annual Meeting Tissue Engineering & Regenerative Medicine (TERMIS), 2011, Houston, United States. 2011
Poster de conférence hal-03184060 v1

Systemic treatment of ferrocenyl-based drug loaded lipid nanocapsules on a subcutaneous 9L glioma model in rats

Ngoc Trinh Huynh , Catherine Passirani-Malleret , Marie Morille , Emilie Allard-Vannier , Anne Vessières et al.
7th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2010, Valletta, Malte. 2010
Poster de conférence hal-03179509 v1