Michel Khrestchatisky

117
Documents
Affiliation actuelle
  • Institut de neurophysiopathologie (INP)

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Publications

A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice

Lotfi Ferhat , Rabia Soussi , Maxime Masse , Grigorios Kyriatzis , Stéphane Girard et al.

eLife, 2025, 13, ⟨10.7554/eLife.100527⟩

Article dans une revue hal-05392802v1

A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice

Lotfi Ferhat , Rabia Soussi , Maxime Masse , Grigorios Kyriatzis , Stéphane Girard et al.

eLife, 2025, 13, ⟨10.7554/eLife.100527⟩

Article dans une revue hal-05047200v1
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Novel single-domain antibodies targeting a unique transferrin receptor 1 epitope for cross-species delivery of drugs in the central nervous system

Marion David , Romy Cohen , Diane Beuzelin , Géraldine Ferracci , Marina Cresci et al.

Journal of Controlled Release, 2025, 388, pp.114344. ⟨10.1016/j.jconrel.2025.114344⟩

Article dans une revue hal-05340484v1

A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice

Lotfi Ferhat , Rabia Soussi , Maxime Masse , Grigorios Kyriatzis , Stéphane Girard et al.

eLife, 2025, 13, ⟨10.7554/eLife.100527⟩

Article dans une revue hal-05392993v1

A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice

Lotfi Ferhat , Rabia Soussi , Maxime Masse , Grigorios Kyriatzis , Stéphane Girard et al.

eLife, 2025, 13, ⟨10.7554/eLife.100527⟩

Article dans une revue hal-05379842v1
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Suppression of MT5-MMP Reveals Early Modulation of Alzheimer’s Pathogenic Events in Primary Neuronal Cultures of 5xFAD Mice

Dominika Pilat , Jean-Michel Paumier , Laurence Louis , Christine Manrique , Laura García-González et al.

Biomolecules, 2024, 14 (12), pp.1645. ⟨10.3390/biom14121645⟩

Article dans une revue hal-04872662v1
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In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ, and Collagen IV in Endothelial Cells and Pericytes of the Blood–Brain Barrier

Grigorios Kyriatzis , Anne Bernard , Angélique Bôle , Michel Khrestchatisky , Lotfi Ferhat

International Journal of Molecular Sciences, 2024, 25 (3), pp.1693. ⟨10.3390/ijms25031693⟩

Article dans une revue hal-04453136v1
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LDLR-Mediated Targeting and Productive Uptake of siRNA-Peptide Ligand Conjugates In Vitro and In Vivo

Baptiste Broc , Karine Varini , Rose Sonnette , Belinda Pecqueux , Florian Benoist et al.

Pharmaceutics, 2024, 16 (4), pp.548. ⟨10.3390/pharmaceutics16040548⟩

Article dans une revue hal-04749729v1
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Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug Targets

Grigorios Kyriatzis , Michel Khrestchatisky , Lotfi Ferhat , Ekaterini Alexiou Chatzaki

Current Neuropharmacology, 2023, 22 (5), pp.916 - 934. ⟨10.2174/1570159X21666230803101629⟩

Article dans une revue (article de synthèse) hal-04300376v1
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Preparation and In Vitro Validation of a Cucurbit[7]uril-Peptide Conjugate Targeting the LDL Receptor

Xue Yang , Karine Varini , Magali Godard , Fanny Gassiot , Rose Sonnette et al.

Journal of Medicinal Chemistry, 2023, 66 (13), pp.8844-8857. ⟨10.1021/acs.jmedchem.3c00423⟩

Article dans une revue hal-04235717v1
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High and low permeability of human pluripotent stem cell–derived blood–brain barrier models depend on epithelial or endothelial features

Stéphane D Girard , Ingrid Julien-Gau , Yves Molino , Benjamin F Combes , Louise Greetham et al.

FASEB Journal, 2023, 37 (2), ⟨10.1096/fj.202201422R⟩

Article dans une revue (data paper) hal-04300615v1

The Helico Maze Detects Early Impairment of Reference Memory at Three Months of Age in the 5XFAD Mouse Model of Alzheimer’s Disease

Martine Migliorati , Christine Manrique , Melinda Rahrah , Guy Escoffier , Abdessadek El Ahmadi et al.

Journal of Alzheimer's Disease, 2022, 90 (1), pp.251-262. ⟨10.3233/JAD-220281⟩

Article dans une revue hal-03867273v1
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MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer's disease

Dominika Pilat , Jean-Michel Paumier , Laura García-González , Laurence Louis , Delphine Stephan et al.

Journal of Neuroinflammation, In press, ⟨10.1186/s12974-022-02407-z⟩

Article dans une revue hal-03570912v1

The Helico Maze Detects Early Impairment of Reference Memory at Three Months of Age in the 5XFAD Mouse Model of Alzheimer’s Disease

Martine Migliorati , Christine Manrique , Melinda Rahrah , Guy Escoffier , Abdessadek El Ahmadi et al.

Journal of Alzheimer's Disease, 2022, 90 (1), pp.251-262. ⟨10.3233/JAD-220281⟩

Article dans une revue hal-04235746v1
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MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer’s disease

Dominika Pilat , Jean-Michel Paumier , Laura García-González , Laurence Louis , Delphine Stephan et al.

Journal of Neuroinflammation, 2022, 19 (1), pp.65. ⟨10.1186/s12974-022-02407-z⟩

Article dans une revue hal-04235761v1
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MT5‐MMP controls APP and β‐CTF/C99 metabolism through proteolytic‐dependent and ‐independent mechanisms relevant for Alzheimer's disease

Laura García‐gonzález , Jean‐michel Paumier , Laurence Louis , Dominika Pilat , Anne Bernard et al.

FASEB Journal, 2021, 35 (7), ⟨10.1096/fj.202100593r⟩

Article dans une revue hal-03431629v1

LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma

Angélina Acier , Magali Godard , Fanny Gassiot , Pascal Finetti , Marion Rubis et al.

Communications Biology, 2021, 4 (1), pp.987. ⟨10.1038/s42003-021-02508-0⟩

Article dans une revue hal-04235770v1
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The actin binding protein α-actinin-2 expression is associated with dendritic spine plasticity and migrating granule cells in the rat dentate gyrus following pilocarpine-induced seizures

Oualid Sbai , Rabia Soussi , Angélique Bole , Michel Khrestchatisky , Monique Esclapez et al.

Experimental Neurology, 2021, 335, pp.113512. ⟨10.1016/j.expneurol.2020.113512⟩

Article dans une revue hal-03452685v1
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LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma.

Angélina Acier , Magali Godard , Fanny Gassiot , Pascal Finetti , Marion Rubis et al.

Communications Biology, 2021, 4 (1), pp.987. ⟨10.1038/s42003-021-02508-0⟩

Article dans une revue hal-03452855v1
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Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to neuroinflammation following pilocarpine‐induced seizures in rats

Grigorios Kyriatzis , Anne Bernard , Angélique Bôle , Guillaume Pflieger , Petros Chalas et al.

Glia, 2021, 69 (11), pp.2618 - 2643. ⟨10.1002/glia.24062⟩

Article dans une revue hal-03452666v1
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The Helico Maze allows testing of early learning and subcategories of long-term memory in mice

Guy Escoffier , Martine Migliorati , Melinda Rahrah , Charles S.M. Roman , Michel Khrestchatisky et al.

Behavioural Brain Research, 2021, 406, pp.113242. ⟨10.1016/j.bbr.2021.113242⟩

Article dans une revue hal-03436061v1
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High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis

Adil Maarouf , Delphine Stephan , Marie-Pierre Ranjeva , Jean-Philippe Ranjeva , Jean Pelletier et al.

Journal of Translational Medicine, 2019, 17 (1), ⟨10.1186/s12967-019-1789-3⟩

Article dans une revue hal-02059493v1

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking

Jean-Michel Paumier , Nathalie Py , Laura García-González , Anne Bernard , Delphine Stephan et al.

FASEB Journal, 2019, 33 (2), pp.2910-2927. ⟨10.1096/fj.201801076R⟩

Article dans une revue hal-02387988v1

Metalloproteinases and their tissue inhibitors in Alzheimer’s disease and other neurodegenerative disorders

Santiago Rivera , Laura García-González , Michel Khrestchatisky , Kevin Baranger

Cellular and Molecular Life Sciences, 2019, 76 (16), pp.3167-3191. ⟨10.1007/s00018-019-03178-2⟩

Article dans une revue hal-02407337v1
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Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer’s Disease Pathogenesis in a Transgenic Mouse Model

Kévin Baranger , Manuel van Gijsel-Bonnello , Delphine Stephan , Wassila Carpentier , Santiago Rivera et al.

Neurotherapeutics, 2019, ⟨10.1007/s13311-019-00754-z⟩

Article dans une revue hal-02339537v1

Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies

K. Varini , P. Lécorché , R. Sonnette , F. Gassiot , B. Broc et al.

Journal of Controlled Release, 2019, 314, pp.141-161. ⟨10.1016/j.jconrel.2019.10.033⟩

Article dans une revue hal-02348680v1
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gH625-liposomes as tool for pituitary adenylate cyclase-activating polypeptide brain delivery

Giuseppina Iachetta , Annarita Falanga , Yves Molino , Maxime Masse , Françoise Jabès et al.

Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-45137-8⟩

Article dans une revue hal-02416027v1
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Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos

Marion David , Pascaline Lecorché , Maxime Masse , Aude Faucon , Karima Abouzid et al.

PLoS ONE, 2018, 13 (2), pp.e0191052. ⟨10.1371/journal.pone.0191052⟩

Article dans une revue hal-01765841v1
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Isolation and characterization of olfactory ecto-mesenchymal stem cells from eight mammalian genera

Antoine Veron , Cécile Bienboire-Frosini , François Feron , Elisa Codecasa , Arnaud Deveze et al.

BMC Veterinary Research, 2018, 14 (1), ⟨10.1186/s12917-018-1342-2⟩

Article dans une revue hal-02282096v1
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Syngeneic Transplantation of Olfactory Ectomesenchymal Stem Cells Restores Learning and Memory Abilities in a Rat Model of Global Cerebral Ischemia

Antoine Veron , Cécile Bienboire-Frosini , Stephane D. Girard , Kevin Sadelli , Jean-Claude Stamegna et al.

Stem Cells International, 2018, 2018, pp.1-10. ⟨10.1155/2018/2683969⟩

Article dans une revue hal-02416043v1
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Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

John Greenwood , Margareta Hammarlund-Udenaes , Hazel C. Jones , Alan W. Stitt , Roosmarijn E. Vandenbroucke et al.

Fluids and Barriers of the CNS, 2018, 15 (1), pp.3. ⟨10.1186/s12987-017-0086-x⟩

Article dans une revue hal-01718178v1

Grafts of olfactory stem cells restore breathing and motor functions after a rat spinal cord injury

Jean-Claude Stamegna , Kevin Sadelli , Guy Escoffier , Stéphane D. Girard , Antoine D. Veron et al.

Journal of Neurotrauma, 2018, ⟨10.1089/neu.2017.5383⟩

Article dans une revue hal-01718177v1
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Isolation and characterization of olfactory ecto-mesenchymal stem cells from eight mammalian genera

Antoine Veron , Cécile Bienboire-Frosini , François Feron , Elisa Codecasa , Arnaud Deveze et al.

BMC Veterinary Research, 2018, 14, pp.17. ⟨10.1186/s12917-018-1342-2⟩

Article dans une revue hal-03888326v1
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Isolation and characterization of olfactory ecto-mesenchymal stem cells from eight mammalian genera

Antoine D. Veron , Cécile Bienboire-Frosini , François Feron , Elisa Codecasa , Arnaud Deveze et al.

BMC Veterinary Research, 2018, 14 (1), pp.17. ⟨10.1186/s12917-018-1342-2⟩

Article dans une revue hal-01718179v1
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Identification of LRP-1 as an endocytosis and recycling receptor for B1-integrin in thyroid cancer cells

Louis Theret , Albin Jeanne , Benoît Langlois , Cathy Hachet , Marion David et al.

Oncotarget, 2017, 8 (45), pp.78614-78632. ⟨10.18632/oncotarget.20201⟩

Article dans une revue hal-02184520v1
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Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine

Manuel Van Gijsel-Bonnello , Kévin Baranger , Philippe Benech , Santiago Rivera , Michel Khrestchatisky et al.

PLoS ONE, 2017, 12 (4), pp.e0175369. ⟨10.1371/journal.pone.0175369⟩

Article dans une revue hal-01718180v1
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From Blood to Lesioned Brain: An In Vitro Study on Migration Mechanisms of Human Nasal Olfactory Stem Cells

Stephane Girard , Isabelle Virard , Emmanuelle Lacassagne , Jean-Michel Paumier , Hanae Lahlou et al.

Stem Cells International, 2017, 2017, 1478606 (17 p.). ⟨10.1155/2017/1478606⟩

Article dans une revue hal-02282115v1
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Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease

Kévin Baranger , Patrizia Giannoni , Stéphane Girard , Sarah Girot , Florence Gaven et al.

Neuropharmacology, 2017, 126, pp.128-141. ⟨10.1016/j.neuropharm.2017.08.031⟩

Article dans une revue hal-01799428v1
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Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

John Greenwood , Margareta Hammarlund-Udenaes , Hazel C. Jones , Alan W. Stitt , Roosmarijn E. Vandenbroucke et al.

Fluids and Barriers of the CNS, 2017, 14 (1), pp.31. ⟨10.1186/s12987-017-0079-9⟩

Article dans une revue hal-01718184v1
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MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

Kévin Baranger , Amandine E Bonnet , Stéphane D Girard , Michel Paumier , Laura García-González et al.

Frontiers in Molecular Neuroscience, 2017, 9, pp.163. ⟨10.3389/fnmol.2016.00163⟩

Article dans une revue hal-01479008v1

Use of LDL receptor-targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier.

Yves Molino , Marion David , Karine Varini , Françoise Jabès , Nicolas Gaudin et al.

FASEB Journal, 2017

Article dans une revue hal-01478978v1

Global cerebral ischemia in rats leads to amnesia due to selective neuronal death followed by astroglial scar formation in the CA1 layer

Kevin Sadelli , Jean-Claude Stamegna , Stéphane D. Girard , Nathalie Baril , Guy Escoffier et al.

Neurobiology of Learning and Memory, 2017, 141, pp.168--178. ⟨10.1016/j.nlm.2017.04.004⟩

Article dans une revue hal-01718182v1

Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor

Guillaume Jacquot , Pascaline Lecorché , Jean-Daniel Malcor , Mathieu Laurencin , Maria Smirnova et al.

Molecular Pharmaceutics, 2016, 13 (12), pp.4094--4105. ⟨10.1021/acs.molpharmaceut.6b00687⟩

Article dans une revue hal-01474309v1
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Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders

François Feron , Bruno Gepner , Emmanuelle Lacassagne , Delphine Stephan , Bruce Mesnage et al.

Molecular Psychiatry, 2016, 21 (9), pp.1215-1224. ⟨10.1038/mp.2015.106⟩

Article dans une revue hal-01787249v1
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MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?

Kévin Baranger , Michel Khrestchatisky , Santiago Rivera

Journal of Neuroinflammation, 2016, 13, ⟨10.1186/s12974-016-0633-4⟩

Article dans une revue hal-01477833v1

The FVB/N mice: A well suited strain to study learning and memory ă processes using olfactory cues

Stephane D. Girard , Guy Escoffier , Michel Khrestchatisky , Francois S. Roman

Behavioural Brain Research, 2016, 296, pp.254-259. ⟨10.1016/j.bbr.2015.09.004⟩

Article dans une revue hal-01477821v1
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MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid ă pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease

Kévin Baranger , Yannick Marchalant , Amandine E. Bonnet , Nadine Crouzin , Alex Carrete et al.

Cellular and Molecular Life Sciences, 2016, 73 (1), pp.217-236. ⟨10.1007/s00018-015-1992-1⟩

Article dans une revue hal-01477822v1
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Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal ă cord-derived microvascular endothelial cells

Yves Molino , Francoise Jabes , Amandine Bonnet , Nicolas Gaudin , Anne Bernard et al.

Journal of Neuroinflammation, 2016, 13 (1), pp.290. ⟨10.1186/s12974-016-0749-6⟩

Article dans une revue hal-01477828v1

Pantethine alters lipid composition and cholesterol content of membrane rafts, with down-regulation of cxcl12-induced t cell migration

Manuel van Gijsel-Bonnello , Niyazi Acar , Yves Molino , Lionel Brétillon , Michel Khrestchatisky et al.

Journal of Cellular Physiology, 2015, 2015 (230), pp.2415-2425. ⟨10.1002/jcp.24971⟩

Article dans une revue istex hal-01208113v1

Cholecalciferol (vitamin D-3) improves functional recovery when delivered during the acute phase after a spinal cord trauma

Yatma Gueye , Tanguy Marqueste , Fanny Maurel , Michel Khrestchatisky , Patrick Decherchi et al.

Journal of Steroid Biochemistry and Molecular Biology, 2015, 154, pp.23-31. ⟨10.1016/j.jsbmb.2015.06.007⟩

Article dans une revue hal-01414098v1

Dynamic Expression of the Polysialyltransferase in Adult Rat Hippocampus Performing an Olfactory Associative Task

Christine Manrique , Martine Migliorati , Valerie Gilbert , Jean-Michel Brezun , Franck A. Chaillan et al.

Hippocampus, 2014, 24 (8), pp.979-989. ⟨10.1002/hipo.22284⟩

Article dans une revue istex hal-01384076v1
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Tissue inhibitor of matrix metalloproteinases-1 loaded poly(lactic-co-glycolic acid) nanoparticles for delivery across the blood-brain barrier

Mayank Chaturvedi , Yves Molino , Bojja Sreedhar , Michel Khrestchatisky , Leszek Kaczmarek

International Journal of Nanomedicine, 2014, 9, pp.575--588. ⟨10.2147/IJN.S54750⟩

Article dans une revue hal-01718188v1
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Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP

Nathalie A. Py , Amandine E. Bonnet , Anne Bernard , Yannick Marchalant , Eliane Charrat et al.

Frontiers in Aging Neuroscience, 2014, 6, pp.247. ⟨10.3389/fnagi.2014.00247⟩

Article dans une revue hal-01718189v1
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Setting-up an in vitro model of rat blood-brain barrier (BBB): a focus on BBB impermeability and receptor-mediated transport

Yves Molino , Françoise Jabès , Emmanuelle Lacassagne , Nicolas Gaudin , Michel Khrestchatisky

Journal of visualized experiments : JoVE, 2014, 88 (88), pp.e51278. ⟨10.3791/51278⟩

Article dans une revue hal-01718193v1
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Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities

Jessica Thevenard , Laurie Verzeaux , Jerôme Devy , Nicolas Etique , Albin Jeanne et al.

PLoS ONE, 2014, 9 (7), pp.e103839. ⟨10.1371/journal.pone.0103839⟩

Article dans une revue hal-01718192v1
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Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

Landel Véréna , Baranger Kévin , Virard Isabelle , Loriod Béatrice , Michel Khrestchatisky et al.

Molecular Neurodegeneration, 2014, 9, pp.33. ⟨10.1186/1750-1326-9-33⟩

Article dans une revue inserm-01071449v1

Endogenous and synthetic MMP inhibitors in CNS physiopathology

Kévin Baranger , Santiago Rivera , Fabian D. Liechti , Denis Grandgirard , Judit Bigas et al.

Progress in brain research, 2014, 214, pp.313--351. ⟨10.1016/B978-0-444-63486-3.00014-1⟩

Article dans une revue hal-01718187v1

A unique method for the isolation of nasal olfactory stem cells in living rats

Jean-Claude Stamegna , Stéphane D. Girard , Antoine Veron , Gilles Sicard , Michel Khrestchatisky et al.

Stem Cell Research, 2014, 12 (3), pp.673--679. ⟨10.1016/j.scr.2014.02.010⟩

Article dans une revue hal-01718191v1

Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease

Stéphane D. Girard , Marlyse Jacquet , Kévin Baranger , Martine Migliorati , Guy Escoffier et al.

Hippocampus, 2014, 24 (7), pp.762--772. ⟨10.1002/hipo.22267⟩

Article dans une revue istex hal-01718190v1
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Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus

Nadine Crouzin , Kevin Baranger , Mélanie Cavalier , Yannick Marchalant , Catherine Cohen-Solal et al.

PLoS ONE, 2013, 8 (9), pp.e74667. ⟨10.1371/journal.pone.0074667⟩

Article dans une revue hal-00868441v1

Evidence for early cognitive impairment related to frontal cortex in the 5XFAD mouse model of Alzheimer's disease

Stéphane D. Girard , Kévin Baranger , Cyrielle Gauthier , Marlyse Jacquet , Anne Bernard et al.

Journal of Alzheimer's Disease, 2013, 33 (3), pp.781--796. ⟨10.3233/JAD-2012-120982⟩

Article dans une revue hal-01718194v1

Medicinal chemistry based approaches and nanotechnology-based systems to improve CNS drug targeting and delivery

Patrick Vlieghe , Michel Khrestchatisky

Medicinal Research Reviews, 2013, 33 (3), pp.457--516. ⟨10.1002/med.21252⟩

Article dans une revue istex hal-01718195v1
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Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury

Jean-Francois Chabas , Delphine Stephan , Tanguy Marqueste , Stephane Garcia , Marie-Noelle Lavaut et al.

PLoS ONE, 2013, 8 (5), pp.e65034. ⟨10.1371/journal.pone.0065034⟩

Article dans une revue hal-01718197v1
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TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier.

Delphine Stephan , Oualid Sbai , Jing Wen , Pierre-Olivier Couraud , Chaim Putterman et al.

Journal of Neuroinflammation, 2013, 10 (1), pp.9. ⟨10.1186/1742-2094-10-9⟩

Article dans une revue inserm-00787290v1

Role of Matrix Metalloproteinases in Migration and Neurotrophic Properties of Nasal Olfactory Stem and Ensheathing Cells

Adlane Ould-Yahoui , Oualid Sbai , Kevin Baranger , Anne Bernard , Yatma Gueye et al.

Cell Transplantation, 2013, 22 (6), pp.993--1010. ⟨10.3727/096368912X657468⟩

Article dans une revue hal-01460477v1
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Is TWEAK a Biomarker for Autoimmune/Chronic Inflammatory Diseases?

Daniel Bertin , Delphine Stephan , Michel Khrestchatisky , Sophie Desplat-Jégo

Frontiers in Immunology, 2013, 4, pp.489. ⟨10.3389/fimmu.2013.00489⟩

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Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention?

Yannick Marchalant , Kevin Baranger , Gary L. Wenk , Michel Khrestchatisky , Santiago Rivera

Journal of Neuroinflammation, 2012, 9, pp.10. ⟨10.1186/1742-2094-9-10⟩

Article dans une revue hal-01718199v1

Drebrin A expression is altered after pilocarpine-induced seizures: time course of changes is consistent for a role in the integrity and stability of dendritic spines of hippocampal granule cells

Oualid Sbai , Michel Khrestchatisky , Monique Esclapez , Lotfi Ferhat

Hippocampus, 2012, 22 (3), pp.477--493. ⟨10.1002/hipo.20914⟩

Article dans une revue istex hal-01718198v1

Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting.

Jean-Daniel Malcor , Nadine Payrot , Marion David , Aude Faucon , Karima Abouzid et al.

Journal of Medicinal Chemistry, 2012, 55 (5), pp.2227-41. ⟨10.1021/jm2014919⟩

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LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion.

G. Perrot , B. Langlois , J. Devy , A. Jeanne , L. Verzeaux et al.

Molecular and Cellular Biology, 2012, 32 (16), pp.3293-3307

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Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions.

Emmanuel Nivet , Michel Vignes , Stéphane D Girard , Caroline Pierrisnard , Nathalie Baril et al.

Journal of Clinical Investigation, 2011, 121 (7), pp.2808-20. ⟨10.1172/JCI44489⟩

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Developmental vitamin D deficiency alters learning in C57Bl/6J mice

Diana Andrea Fernandes De Abreu , Emmanuel Nivet , Nathalie Baril , Michel Khrestchatisky , François Roman et al.

Behavioural Brain Research, 2010, 208 (2), pp.603--608. ⟨10.1016/j.bbr.2010.01.005⟩

Article dans une revue istex hal-01736211v1

The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties

Bruno Delorme , Emmanuel Nivet , Julien Gaillard , Thomas Häupl , Jochen Ringe et al.

Stem Cells and Development, 2010, 19 (6), pp.853--866. ⟨10.1089/scd.2009.0267⟩

Article dans une revue hal-01736210v1

Mapping of domains on HIV envelope protein mediating association with calnexin and protein-disulfide isomerase.

Marie-Jeanne Papandréou , Rym Barbouche , Régis Guieu , Santiago Rivera , Jacques Fantini et al.

Journal of Biological Chemistry, 2010, 285 (18), pp.13788-96. ⟨10.1074/jbc.M109.066670⟩

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Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.

Emilie Cornille , Mhamad Abou-Hamdan , Michel Khrestchatisky , André Nieoullon , Max de Reggi et al.

BMC Neuroscience, 2010, 11, pp.51. ⟨10.1186/1471-2202-11-51⟩

Article dans une revue hal-00848881v1
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Olfactory Stem Cells, a New Cellular Model for Studying Molecular Mechanisms Underlying Familial Dysautonomia

Nathalie Boone , Béatrice B. Loriod , Aurélie Bergon , Oualid Sbai , Christine Formisano-Tréziny et al.

PLoS ONE, 2010, 5 (12), pp.e15590. ⟨10.1371/journal.pone.0015590⟩

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TWEAK is expressed at the cell surface of monocytes during multiple sclerosis.

Sophie Desplat-Jégo , Lionel Feuillet , Rita Creidy , Irina Malikova , Roselyne Rance et al.

Journal of Leukocyte Biology, 2009, 85 (1), pp.132-5. ⟨10.1189/jlb.0608347⟩

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Vesicular trafficking and secretion of matrix metalloproteinases-2, -9 and tissue inhibitor of metalloproteinases-1 in neuronal cells.

Oualid Sbai , Lotfi Ferhat , Anne Bernard , Yatma Gueye , Adlane Ould-Yahoui et al.

Molecular and Cellular Neuroscience, 2008, 39 (4), pp.549-68. ⟨10.1016/j.mcn.2008.08.004⟩

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Vesicular Trafficking and Secretion of Matrix Metalloproteinases-2, -9 and Tissue Inhibitor of Metalloproteinases-1 in Neuronal Cells

Oualid Sbai , Lotfi Ferhat , Anne Bernard , Yatma Gueye , Adlane Ould-Yahoui et al.

Molecular and Cellular Neuroscience, 2008, in press

Article dans une revue hal-00321014v1

Vitamin D2 potentiates axon regeneration.

Jean-François Chabas , Olivier Alluin , Michel Khrestchatisky , François Féron , G. Rao et al.

Journal of Neurotrauma, 2008, 25 (10), pp.1247-56. ⟨10.1089/neu.2008.0593⟩

Article dans une revue hal-00320785v1

Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins

C. Ogier , A. Bernard , Chollet Am , Le Diguardher T , S. Hanessian et al.

Glia, 2006, 54(4), pp.274-284

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Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice.

Chaillan Fa , S. Rivera , E. Marchetti , J. Jourquin , Z. Werb et al.

Behavioural Brain Research, 2006, 173(2), pp.191-198

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Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice.

Franck A. Chaillan , Santiago Rivera , Evelyne Marchetti , Jérôme Jourquin , Zena Werb et al.

Behavioural Brain Research, 2006, 173, pp.191-8. ⟨10.1016/j.bbr.2006.06.020⟩

Article dans une revue inserm-00092843v1

Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory.

J. Jourquin , E. Tremblay , A. Bernard , G. Charton , Chaillan Fa et al.

European Journal of Neuroscience, 2005, 22(10), pp.2569-78

Article dans une revue hal-00092830v1
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Astrocyte reactivity to Fas activation is attenuated in TIMP-1 deficient mice, an in vitro study

Crystel Ogier , Rita Creidy , José Boucraut , Paul D Soloway , Michel Khrestchatisky et al.

BMC Neuroscience, 2005, 6 (1), pp.68. ⟨10.1186/1471-2202-6-68⟩

Article dans une revue hal-00092828v1

Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8.

Munkeby Bh , Borke Wb , K. Bjornland , Sikkeland Li , Borge Gi et al.

Pediatric Research, 2005, 58, pp.542-548

Article dans une revue hal-00094385v1

Induction of infertility in adult male bonnet monkeys by immunization with phage-expressed peptides of the extracellular domain of FSH receptor

Michel Khrestchatisky , Rao Aj , Ramachandra Sg , V. Ramesh , L. Abdennebi et al.

Reproductive BioMedicine Online, 2004, 4, pp.385-391

Article dans une revue hal-00093408v1

The MMP/TIMP system in the nervous system.

S. Rivera , J. Jourquin , C. Ogier , A. Bernard , G. Charton et al.

Médecine/Sciences, 2004, 20 (1), pp.55-60

Article dans une revue hal-00094381v1
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Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

Serge Timsit , Santiago Rivera , Philippe Ouaghi , Frédérique Guischard , Evelyne Tremblay et al.

European Journal of Neuroscience, 1999, 11 (1), pp.263-78

Article dans une revue inserm-00486281v1
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Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation.

Anne Bernard , Lotfi Ferhat , Frédéric Dessi , Gérard Charton , Alfonso Represa et al.

European Journal of Neuroscience, 1999, 11 (2), pp.604-16

Article dans une revue inserm-00487253v1
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Glutamate receptors in dysplasic cortex: an in situ hybridization and immunohistochemistry study in rats with prenatal treatment with methylazoxymethanol

Amina Rafiki , Nicolas Chevassus-Au-Louis , Yehezkel Ben-Ari , Michel Khrestchatisky , Alfonso Represa

Brain Research, 1998, 782 (1-2), pp.142-52

Article dans une revue inserm-00487313v1
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MAP2d mRNA is expressed in identified neuronal populations in the developing and adult rat brain and its subcellular distribution differs from that of MAP2b in hippocampal neurones.

Lotfi Ferhat , Alfonso Represa , Walid Ferhat , Yezekiel Ben-Ari , Michel Khrestchatisky

European Journal of Neuroscience, 1998, 10 (1), pp.161-71

Article dans une revue inserm-00522435v1
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Long-lasting enhanced expression in the rat hippocampus of NMDAR1 splice variants in a kainate model of epilepsy.

Amina Rafiki , Yezekiel Ben-Ari , Michel Khrestchatisky , Alfonso Represa

European Journal of Neuroscience, 1998, 10 (2), pp.497-507

Article dans une revue inserm-00522431v1

Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.

M Cardoso , S Timsit , L Villard , Michel Khrestchatisky , M Fontès et al.

Human Molecular Genetics, 1998, 7 (4), pp.679-84

Article dans une revue hal-02090196v1
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Mutations in specific MT5-MMP domains prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in cell models of Alzheimer’s disease

Pedro Belio-Mairal , Athina Kamitsou , Delphine Stephan , Nicolas Jullien , Diarra Thiane et al.

2025

Pré-publication, Document de travail hal-05409460v1

Identification and optimization of trans-species reactive TfR1-binding VHH as tools for drug delivery across the blood-brain barrier

Marion David , Romy Cohen , Diane Beuzelin , Géraldine Ferracci , Marina Cresci et al.

2025

Pré-publication, Document de travail hal-05088982v1
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A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice

Lotfi Ferhat , Rabia Soussi , Maxime Masse , Grigorios Kyriatzis , Stephane Girard et al.

2024

Pré-publication, Document de travail hal-04752312v1
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Suppression of MT5-MMP reveals early modulation of Alzheimer’s pathogenic events in primary neuronal cultures of 5xFAD mice

Dominika Pilat , Jean-Michel Paumier , Laurence Louis , Christine Manrique , Laura García-González et al.

2024

Pré-publication, Document de travail hal-04788130v1
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Mutations in specific domains of MT5-MMP prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in human in vitro models of Alzheimer's disease

Pedro Belio-Mairal , Athina Kamitsou , Delphine Stephan , Nicolas Jullien , Diarra Thiane et al.

2024

Pré-publication, Document de travail hal-04642476v1
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LDLR-mediated targeting and productive uptake of siRNA-peptide ligand conjugates in vitro and in vivo

Broc B , Varini K , Sonnette R , Pecqueux B , Benoist F et al.

2023

Pré-publication, Document de travail (preprint/prepublication) hal-04300755v1
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Pilocarpine-Induced Status Epilepticus in the Rat Hippocampus is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ and Collagen IV in Endothelial Cells and Pericytes of the Blood Brain Barrier

Grigorios Kyriatzis , Anne Bernard , Angélique Bôle , Michel Khrestchatisky , Lotfi Ferhat

2023

Pré-publication, Document de travail (preprint/prepublication) hal-04301907v1

High and low permeability of human pluripotent stem cell-derived Blood Brain barrier models depend on epithelial or endothelial features

Stéphane Girard , Ingrid Julien-Gau , Yves Molino , Benjamin Combes , Louise Greetham et al.

2022

Pré-publication, Document de travail hal-03866313v1
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MT5-MMP controls APP and β-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer’s disease

Laura García-González , Jean-Michel Paumier , Laurence Louis , Dominika Pilat , Anne Bernard et al.

2020

Pré-publication, Document de travail hal-03064994v1
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Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to status epilepticus and neuroinflammation following pilocarpine administration in rats

Kyriatzis Grigorios , Bernard Anne , Bôle Angélique , Pflieger Guillaume , Chalas Petros et al.

2020

Pré-publication, Document de travail hal-03073954v1

Utilisation de dérivés peptidiques (peptides et pseudo-peptides), qui présentent une affinité pour des récepteurs/transporteurs cellulaires, des types cellulaires particuliers et/ou qui passent les membranes cellulaires notamment celles des barrières physiologiques du cerveau telle que la barrière hémato-encéphalique (BHE), comme vecteurs de molécules d'intérêt thérapeutique ou d'agents d'imagerie ou de diagnostic ou de toute autre molécule comme une sonde moléculaire

Michel Khrestchatisky , Société Vect-Horus

N° de brevet: En cours. 2009

Brevet hal-00321258v1

Dérivés peptidiques et leur utilistion comme vecteurs de molécules sous forme de conjugués

Michel Khrestchatisky , Marion David , Yves Molino , Anne Fourtoul , Patrick Vlieghe

France, Patent n° : FR 08 57159. 2008

Brevet hal-00342607v1

Licence exclusive de transfert de Savoir Faire

Michel Khrestchatisky , Société Vect-Horus

N° de brevet: L07087. 2007

Brevet hal-00321266v1

Method of treating and preventing acute neural lesions with substances that modulate the expression or function of a protein involved in the cell cycle and pharmaceutical preparations containing such substances

Timsit Serge , Cavelier Pauline , Ben-Ari Yehezkel , Michel Khrestchatisky , Meijer Laurent

United States, Patent n° : 20030060397. 2003

Brevet hal-00095537v1

Utilisation de substances modulatrices de l'expression ou de la fonction d'une protéine impliquée dans le cycle cellulaire pour le traitement ou la prévention des lésions neurales aiguës

S. Timsit , P. Cavelier , Y. Ben-Ari , Michel Khrestchatisky , L. Meijer

France, N° de brevet: FR00/03673. 2000

Brevet hal-00095538v1