Murielle Lombard

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Publications

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Structural Plasticity of Flavin-Dependent Thymidylate Synthase Controlled by the Enzyme Redox State

Ludovic Pecqueur , Murielle Lombard , Djemel Hamdane

Biomolecules, 2025, 15 (3), pp.318. ⟨10.3390/biom15030318⟩

Article dans une revue hal-05357083v1
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Functional redundancy in tRNA dihydrouridylation

Claudia Sudol , Lea-Marie Kilz , V. Marchand , Quentin Thullier , Vincent Guérineau et al.

Nucleic Acids Research, 2024, 52 (10), pp.5880-5894. ⟨10.1093/nar/gkae325⟩

Article dans une revue hal-04614743v1
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An organic O donor for biological hydroxylation reactions

Katayoun Kazemzadeh Ferizhendi , Philippe Simon , Ludovic Pelosi , Emmanuel Séchet , Roache Arulanandam et al.

Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (13), pp.e2321242121. ⟨10.1073/pnas.2321242121⟩

Article dans une revue pasteur-04665824v1
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Evolutionary Diversity of Dus2 Enzymes Reveals Novel Structural and Functional Features among Members of the RNA Dihydrouridine Synthases Family

Murielle Lombard , Colbie J Reed , Ludovic Pecqueur , Bruno Faivre , Sabrine Toubdji et al.

Biomolecules, 2022, 12 (12), pp.1760. ⟨10.3390/biom12121760⟩

Article dans une revue hal-04238858v1
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Dihydrouridine in the transcriptome: New life for this ancient RNA chemical modification

Damien Brégeon , Ludovic Pecqueur , Sabrine Toubdji , Claudia Sudol , Murielle Lombard et al.

ACS Chemical Biology, 2022, 17 (7), pp.1638-1657. ⟨10.1021/acschembio.2c00307⟩

Article dans une revue hal-03836746v1
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An enzymatic activation of formaldehyde for nucleotide methylation

Charles Bou-Nader , Frederick W Stull , Ludovic Pecqueur , Philippe Simon , Vincent Guérineau et al.

Nature Communications, 2021, 12, pp.4542. ⟨10.1038/s41467-021-24756-8⟩

Article dans une revue hal-03343627v1
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Ultrafast Dynamics of Fully Reduced Flavin in Catalytic Structures of Thymidylate Synthase ThyX

Nadia Dozova , Fabien Lacombat , Murielle Lombard , Djemel Hamdane , Pascal Plaza

Physical Chemistry Chemical Physics, 2021, 23, pp.22692-22702. ⟨10.1039/D1CP03379D⟩

Article dans une revue hal-03361405v1
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Dihydrouridine synthesis in tRNAs is under reductive evolution in Mollicutes

Bruno Faivre , Murielle Lombard , Soufyan Fakroun , Chau-Duy-Tam Vo , Catherine Goyenvalle et al.

RNA Biology, 2021, 18 (12), pp.2278 - 2289. ⟨10.1080/15476286.2021.1899653⟩

Article dans une revue hal-03837152v1
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The O2-independent pathway of ubiquinone biosynthesis is essential for denitrification in Pseudomonas aeruginosa

Chau-Duy-Tam Vo , Julie Michaud , Sylvie Elsen , Bruno Faivre , Emmanuelle Bouveret et al.

Journal of Biological Chemistry, 2020, 295 (27), pp.9021-9032. ⟨10.1074/jbc.RA120.013748⟩

Article dans une revue pasteur-02746713v1
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Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway

Ludovic Pelosi , Chau-Duy-Tam Vo , Sophie Saphia Abby , Laurent Loiseau , Bérengère Rascalou et al.

mBio, 2019, 10 (4), ⟨10.1128/mBio.01319-19⟩

Article dans une revue hal-02183791v1

Structural and Functional Characterization of 4‐Hydroxyphenylacetate 3‐Hydroxylase from Escherichia coli

Yifan Deng , Bruno Faivre , Olivier Back , Murielle Lombard , Ludovic Pecqueur et al.

ChemBioChem, 2019, 10 (4), ⟨10.1002/cbic.201900277⟩

Article dans une revue hal-02359262v1
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A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone

Mahmoud Hajj Chehade , Ludovic Pelosi , Cameron David Fyfe , Laurent Loiseau , Bérengère Rascalou et al.

Cell Chemical Biology, 2019, 26 (4), pp.482-492.e7. ⟨10.1016/j.chembiol.2018.12.001⟩

Article dans une revue hal-02071798v1

Power of protein/tRNA functional assembly against aberrant aggregation

Charles Bou-Nader , Ludovic Pecqueur , David Cornu , Murielle Lombard , Manuela Dezi et al.

Physical Chemistry Chemical Physics, 2017, ⟨10.1039/c7cp05599d⟩

Article dans une revue hal-02187768v1
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Flavin-dependent epitranscriptomic world

Murielle Lombard , Djemel Hamdane

Archives of Biochemistry and Biophysics, 2017, ⟨10.1016/j.abb.2017.06.011⟩

Article dans une revue hal-01542856v1

The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ

Laurent Loiseau , Cameron Fyfe , Laurent Aussel , Mahmoud Hajj Chehade , Sara B. Hernández et al.

Journal of Biological Chemistry, 2017, 292 (28), pp.11937 - 11950. ⟨10.1074/jbc.M117.789164⟩

Article dans une revue hal-01615493v1

A chemical chaperone induces inhomogeneous conformational changes in flexible proteins

Djemel Hamdane , Christophe Velours , David Cornu , Magali Nicaise , Murielle Lombard et al.

Physical Chemistry Chemical Physics, 2016, 18 (30), pp.20410--20421. ⟨10.1039/c6cp03635j⟩

Article dans une revue hal-02393836v1
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Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6

Alexandre Ismail , Vincent Leroux , Myriam Smadja , Lucie Gonzalez , Murielle Lombard et al.

PLoS Computational Biology, 2016, 12 (1), pp.e1004690. ⟨10.1371/journal.pcbi.1004690⟩

Article dans une revue hal-01424489v1

Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies.

Lionel Ducassou , Gabriella Jonasson , Laura Dhers , Nicolas Pietrancosta , Booma Ramassamy et al.

BBA - Biochimica et Biophysica Acta, 2015, 1850 (7), pp.1426-37. ⟨10.1016/j.bbagen.2015.03.014⟩

Article dans une revue hal-01449701v1
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Biosynthesis and physiology of coenzyme Q in bacteria.

Laurent Aussel , Fabien Pierrel , Laurent Loiseau , Murielle Lombard , Marc Fontecave et al.

Biochimica biophysica acta (BBA) - Bioenergetics, 2014, 1837 (7), pp.1004-1011. ⟨10.1016/j.bbabio.2014.01.015⟩

Article dans une revue hal-01077983v1
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A new gene involved in coenzyme Q biosynthesis in Escherichia coli: UbiI functions in aerobic C5-hydroxylation

Mahmoud Hajj Chehade , Laurent Loiseau , Murielle Lombard , Ludovic Pecqueur , Alexandre Ismail et al.

Journal of Biological Chemistry, 2013, 288 (27), pp.20085-92. ⟨10.1074/jbc.M113.480368⟩

Article dans une revue hal-00904907v1
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Intermolecular electron transfer in two-iron superoxide reductase: a putative role for the desulforedoxin center as an electron donor to the iron active site.

Florence Bonnot , Simon Duval , Murielle Lombard , Julien Valton , Chantal Houée-Levin et al.

Journal of Biological Inorganic Chemistry, 2011, 16 (6), pp.889-98. ⟨10.1007/s00775-011-0788-5⟩

Article dans une revue hal-01075287v1
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Superoxide reductase from Desulfoarculus baarsii: identification of protonation steps in the enzymatic mechanism.

Vincent Nivière , Marcel Asso , Claire O Weill , Murielle Lombard , Bruno Guigliarelli et al.

Biochemistry, 2004, 43, pp.808-18. ⟨10.1021/bi035698i⟩

Article dans une revue hal-01075794v1
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Identification of iron(III) peroxo species in the active site of the superoxide reductase SOR from Desulfoarculus baarsii.

Christelle Mathé , Tony A Mattioli , Olivier Horner , Murielle Lombard , Jean-Marc Latour et al.

Journal of the American Chemical Society, 2002, pp.4966-7

Article dans une revue hal-01075797v1
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Superoxide reductase from Desulfoarculus baarsii.

Vincent Nivière , Murielle Lombard

Methods in Enzymology, 2001, 349, pp.123-9

Article dans une revue hal-01075799v1
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Pulse radiolysis studies on superoxide reductase from Treponema pallidum.

V Nivière , M Lombard , M. Fontecave , C Houée-Levin

FEBS Letters, 2001, 497, pp.171-3. ⟨10.1016/S0014-5793(01)02468-1⟩

Article dans une revue hal-01075800v1
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Superoxide reductase from Desulfoarculus baarsii: reaction mechanism and role of glutamate 47 and lysine 48 in catalysis.

M Lombard , C Houée-Levin , D Touati , M. Fontecave , V Nivière

Biochemistry, 2001, pp.5032-40

Article dans une revue hal-01075802v1
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Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity.

M Lombard , M. Fontecave , D Touati , V Nivière

Journal of Biological Chemistry, 2000, 275, pp.115-21. ⟨10.1074/jbc.275.1.115⟩

Article dans une revue hal-01075803v1
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Superoxide reductase as a unique defense system against superoxide stress in the microaerophile Treponema pallidum.

M Lombard , D Touati , M. Fontecave , V Nivière

Journal of Biological Chemistry, 2000, 275 (35), pp.27021-6

Article dans une revue hal-01075805v1

Anaerobic ubiquinone biosynthetic pathway in Escherichia coli

Katayoun Kazemzadeh , Sophie Abby , Sophie-Carole Chobert , Mahmoud Hajj Chehade , M Lombard et al.

Société française de biochimie et biologie moléculaire, Jul 2022, Paris, France

Communication dans un congrès hal-04976976v1