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Natalia de Isla

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Highly immunosuppressive myeloid cells correlate with early relapse after allogeneic stem cell transplantation

Anne-Béatrice Notarantonio , Allan Bertrand , Romain Piucco , Ghislain Fievet , Hervé Sartelet
Experimental Hematology & Oncology, 2024, 13 (1), pp.50. ⟨10.1186/s40164-024-00516-4⟩
Journal articles hal-04576863v1
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Scale-Up of Academic Mesenchymal Stromal Cell Production

Caroline Laroye , Mélanie Gauthier , Jessica Morello , Naceur Charif , Véronique Latger-Cannard
Journal of Clinical Medicine, 2023, 12 (13), pp.4414. ⟨10.3390/jcm12134414⟩
Journal articles hal-04503576v1
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Impact of microcarrier concentration on mesenchymal stem cell growth and death: Experiments and modeling

Charlotte Maillot , Natalia De Isla , Celine Loubiere , Dominique Toye , Eric Olmos
Biotechnology and Bioengineering, 2022, 119 (12), pp.3537 - 3548. ⟨10.1002/bit.28228⟩
Journal articles hal-04504478v1
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Secretome of Mesenchymal Stem Cells from Consecutive Hypoxic Cultures Promotes Resolution of Lung Inflammation by Reprogramming Anti-Inflammatory Macrophages

Zhihong Xu , Lulu Lin , Yuxuan Fan , Céline Huselstein , Natalia de Isla
International Journal of Molecular Sciences, 2022, 23 (8), pp.4333. ⟨10.3390/ijms23084333⟩
Journal articles hal-04504687v1
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Quality by design to define critical process parameters for mesenchymal stem cell expansion

Charlotte Maillot , Caroline Sion , Natalia de Isla , Dominique Toye , Eric Olmos
Biotechnology Advances, 2021, 50, pp.107765. ⟨10.1016/j.biotechadv.2021.107765⟩
Journal articles hal-03505285v1

Characterization of Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering

Xing Liu , Adrien Baldit , Emilie de Brosses , Frédéric Velard , Ghislaine Cauchois
Polymers, 2020, 12 (9), pp.2163. ⟨10.3390/polym12092163⟩
Journal articles hal-02973729v1
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Impact of the type of microcarrier and agitation modes on the expansion performances of mesenchymal stem cells derived from umbilical cord

Céline Loubière , Caroline Sion , Natalia de Isla , Loïc Reppel , Emmanuel Guedon
Biotechnology Progress, 2019, 35 (6), pp.e2887. ⟨10.1002/btpr.2887⟩
Journal articles hal-02968491v1
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Mesenchymal stem cell interacted with PLCL braided scaffold coated with poly- l -lysine/hyaluronic acid for ligament tissue engineering

Xing Liu , Cédric Laurent , Qiaoyue Du , Laurie Targa , Ghislaine Cauchois
Journal of Biomedical Materials Research Part A, 2018, 106 (12), pp.3042-3052. ⟨10.1002/jbm.a.36494⟩
Journal articles hal-02070806v1
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Laser photobiomodulation in pressure ulcer healing of human diabetic patients: gene expression analysis of inflammatory biochemical markers

Anelice Calixto Ruh , Lucio Frigo , Marcos Fernando Xisto Braga Cavalcanti , Paulo Svidnicki , Viviane Nogaroto Vicari
Lasers in Medical Science, 2018, 33 (1), pp.165 - 171. ⟨10.1007/s10103-017-2384-6⟩
Journal articles hal-01831939v1

Defining a scaffold for ligament tissue engineering: What has been done, and what still needs to be done

Cédric P. Laurent , Xing Liu , Natalia de Isla , Xiong Wang , Rachid Rahouadj
Journal of Cellular Immunotherapy, 2018, 4 (1), pp.4-9. ⟨10.1016/j.jocit.2018.09.002⟩
Journal articles hal-02070833v1
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Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold

Jessica Schiavi , Loïc Reppel , Naceur Charif , Natalia de Isla , Didier Mainard
Journal of Tissue Engineering and Regenerative Medicine, 2017, 12 (2), pp.360-369. ⟨10.1002/term.2461⟩
Journal articles hal-01715211v1

Stem cells and vascular regenerative medicine: A mini review

Jean-François Stoltz , Danièle Bensoussan , Natalia de Isla , L. Zhang , Z. Han
Clinical Hemorheology and Microcirculation, 2017, 64 (4), pp.613 - 633. ⟨10.3233/CH-168036⟩
Journal articles hal-01715476v1

Revisiting MSC expansion from critical quality attributes to critical culture process parameters

Céline Martin , Eric Olmos , Marie-Laure Collignon , Natalia de Isla , Fabrice Blanchard
Process Biochemistry, 2017, 59, pp.231 - 243. ⟨10.1016/j.procbio.2016.04.017⟩
Journal articles hal-01921144v1

MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis

Francesca Diomede , Maria Zingariello , Marcos F.X.B. Cavalcanti , Ilaria Merciaro , Jacopo Pizzicannella
European Journal of Histochemistry, 2017, 61 (2), ⟨10.4081/ejh.2017.2791⟩
Journal articles hal-01831940v1

Comparative Study of the Physiotherapeutic and Drug Protocol and Low-Level Laser Irradiation in the Treatment of Pain Associated with Temporomandibular Dysfunction

Marcos Fernando Xisto Braga Cavalcanti , Uoston Holder Silva , Ernesto Cesar Pinto Leal-Junior , Rodrigo A.B. Lopes-Martins , Rodrigo Labat Marcos
Photomedicine and Laser Surgery, 2016, 34 (12), pp.652-656. ⟨10.1089/pho.2016.4195⟩
Journal articles hal-02973719v1

Stem cells and applications: A survey

Jean-François Stoltz , D. Bensoussan , L. Zhang , V. Decot , Natalia de Isla
Bio-Medical Materials and Engineering, 2015, 25 (1), pp.S3-S26. ⟨10.3233/BME-141225⟩
Journal articles hal-01452233v1
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Stem Cells and Regenerative Medicine

Jean-François Stoltz , Natalia de Isla , Y. P. Li, , Danièle Bensoussan , L. Zhang,
Stem Cells International, 2015, 2015, pp.734731. ⟨10.1155/2015/734731⟩
Journal articles hal-01465786v1

Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine.

Jessica Schiavi , Laetitia Keller , David-Nicolas Morand , Natalia De Isla , Olivier Huck
Nanomedicine, 2015, 10 (5), pp.753-63. ⟨10.2217/nnm.14.228⟩
Journal articles hal-01451383v1

Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes

Jun-Song Ye , Xiao-San Su , Jean-François Stoltz , Natalia de Isla , Lei Zhang
Cell Proliferation, 2015, 48 (2), pp.157-165. ⟨10.1111/cpr.12165⟩
Journal articles hal-01451903v1

Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor

Cédric Laurent , Cédryck Vaquette , Céline Martin , Emmanuel Guedon , Xiude Wu
Processes, 2014, 2 (1), pp.167. ⟨10.3390/pr2010167⟩
Journal articles hal-01424974v1

Donor's age dependent proliferation decrease of human bone marrow mesenchymal stem cells is linked to diminished clonogenicity

Natalia de Isla , Yueying Li , Naceur Charif , Didier Mainard , Danisle Bensoussan
Bio-Medical Materials and Engineering, 2014, 24 (1), pp.S47-S52. ⟨10.3233/BME-140973⟩
Journal articles hal-01453218v1

Research on stem cells as candidates to be differentiated into hepatocytes

Lei Zhang , Jun-Song Ye , Veronique Decot , Jean-François Stoltz , Natalia de Isla
Bio-Medical Materials and Engineering, 2012, 22 (1-3), pp.105-111. ⟨10.3233/BME-2012-0695⟩
Journal articles hal-02973708v1

Human Stem Cells and Articular Cartilage Tissue Engineering

J-F. Stoltz , Céline Huselstein , Jessica Schiavi , Y.Y. Li , Danièle Bensoussan
Current Pharmaceutical Biotechnology, 2012, 13 (15), pp.2682-2691. ⟨10.2174/138920112804724846⟩
Journal articles hal-03782970v1

Does Making Method of Alginate Hydrogel Influence the Chondrogenic Differentiation of Human Mesenchymal Stem Cells?

Jessica Schiavi , Naceur Charif , Natalia De Isla , Danièle Bensoussan , Jean-François Stoltz
Engineering, 2012, 04 (10), pp.110-113. ⟨10.4236/eng.2012.410B028⟩
Journal articles hal-03782979v1

Mechanical properties evolution of a PLGA-PLCL composite scaffold for ligament tissue engineering under static and cyclic traction-torsion in vitro culture conditions

Cyril Kahn , Kahina Ziani , Ye Min Zang , Jian Liu , Nguyen Tran
Journal of Biomaterials Science, Polymer Edition, 2012, 24 (8), pp.899-911. ⟨10.1080/09205063.2012.727265⟩
Journal articles hal-00867834v1

Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status

Leticia Basciano , Christophe Nemos , Bernard Foliguet , Natalia de Isla , Marcelo de Carvalho
BMC Cell Biology, 2011, 12 (1), pp.12. ⟨10.1186/1471-2121-12-12⟩
Journal articles hal-02973723v1

Collagenous extracellular matrix of cartilage submitted to mechanical forces studied by second harmonic generation microscopy.

Elisabeth Werkmeister , Natalia de Isla , Patrick Netter , Jean-François Stoltz , Dominique Dumas
Photochemistry and Photobiology, 2010, 86 (2), pp.302-10. ⟨10.1111/j.1751-1097.2009.00648.x⟩
Journal articles hal-00558986v1
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Designing a three-dimensional alginate hydrogel by spraying method for cartilage tissue engineering

Jessica Tritz , Rachid Rahouadj , Natalia de Isla , Naceur Charif , Astrid Pinzano
Soft Matter, 2010, 6 (20), pp.5165-5174. ⟨10.1039/c000790k⟩
Journal articles hal-03697373v1

Original approach for cartilage tissue engineering with mesenchymal stem cells

Jessica Tritz-Schiavi , Naceur Charif , Christel Henrionnet , Natalia de Isla , Danièle Bensoussan
Bio-Medical Materials and Engineering, 2010, 20 (3-4), pp.167-174. ⟨10.3233/BME-2010-0628⟩
Journal articles hal-03782996v1

Interest of multimodal imaging in tissue engineering.

Elisabeth Werkmeister , Dominique Dumas , Natalia de Isla , Luc Marchal , Jean-François Stoltz
Bio-Medical Materials and Engineering, 2008, 18 (4-5), pp.329-33. ⟨10.3233/BME-2008-0548⟩
Journal articles hal-00559018v1

Evaluation of human MSCs cell cycle, viability and differentiation in micromass culture.

Jing-Wei Yang , Natalia De Isla , Céline Huselstein , Marie-Nathalie Sarda-Kolopp , Na Li
Biorheology, 2006, 43 (3,4), pp.489-96
Journal articles hal-01981088v1

Replicative senescent bone marrow mesenchymal stem cells spotting by surface protein expression

Laurie Targa , Naceur Charif , G. Cauchois , Jean‐françois Stoltz , Jean-Baptiste Vincourt
ICSA Conference "The ins and outs of cellular senescence, May 2017, Paris, France
Conference poster hal-02974106v1

Differences in the expression of cell surface proteins between young and replicative senescent bone marrow mesenchymal stromal / stem cells

Laurie Targa , Naceur Charif , Ghislaine Cauchois , Jean François Stoltz , Jean-Baptiste Vincourt
6th International Symposium Europe-China Mesenchymal Stem Cells and Regenerative Medicine "Molecular, cellular and tissue engineering, and clinical applications”, Jul 2016, Vandoeuvre-Lès-Nancy, France
Conference poster hal-02974097v1

Relationship between bone marrow mesenchymal stromal cells (MSCs) senescence and clinical evolution of AML and MDS patients after hematopoietic stem cells (HSC) transplantation

Meriem El Ouafy , Naceur Charif , Laura Boulanger , Romain Perouf , Allan Bertrand
International Cell Senescence Association 2020 Conference (ICSA2020), Dec 2021, Osaka, Japan
Conference papers hal-03626470v1
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The Mechanoadaptation Concept of Cells

Jean François Stoltz , Yves Rémond , Daniel George , Jacques Magdalou , Yinping Li
9th International Europe-China Symposium on Stem Cells and Regenerative Medicine, Université de Strasbourg; Association Bioingénierie, Oct 2019, Strasbourg, France. pp.47-59, ⟨10.3233/BHR210010⟩
Conference papers hal-03245667v1

Impact of in vitro expansion on immunomodulation properties of mesenchymal stromal cells

Naceur Charif , Meriem El Ouafy , Dima Ghannoum , Anne-Béatrice Notarantonio , Yinping Li
9th International Symposium Europe China on Stem Cells and Regenerative Medicine, Oct 2019, Strasbourg, France
Conference papers hal-02973617v1

Senescence of mesenchymal stroma cells and clinical applications

Dima Ghannoum , Laurie Targa , Naceur Charif , Meriem El Ouafy , Ghislaine Cauchois
9th International Symposium Europe China on Stem Cells and Regenerative Medicine, Jun 2018, Strasbourg, France
Conference papers hal-03629665v1

Mesenchymal stem cells heterogeneity considering surface markers and senescence

Laurie Targa , Naceur Charif , Xing Liu , Audrey Fortunat Zeh Eto'O , Mayssa Kacem
8th InternationalSymposium China-Europe Stem cells and regenerative medicine, Jun 2018, Wuhan, China
Conference papers hal-02973642v1

Impact of culture conditions on the behavior of mesenchymal stem cells: choosing critical parameters related to cell quality

Naceur Charif , Meriem El Ouafy , Laurie Targa , Xing Liu , Audrey Fortunat Zeh Eto'O
8th InternationalSymposium China-Europe Stem cells and regenerative medicine, Jun 2018, Wuhan, China
Conference papers hal-02973631v1

Senescence of mesenchymal stem cells and its impact on clinical applications

Natalia De Isla , Laurie Targa , Naceur Charif , Émilie Roeder , Ghislaine Cauchois
8th InternationalSymposium China-Europe Stem cells and regenerative medicine, Jun 2018, Wuhan, China
Conference papers hal-02973662v1

Higher Proliferative Potential of Human Mesenchymal Stromal Cells from Wharton's Jelly Compared to Bone Marrow Is Linked to Decreased Senescence

Naceur Charif , Yueying Li , Laurie Targa , Lei Zhang , Yinping Li
2nd International Meeting of the GDRI CNRS 851 CeSMeR “Mesenchymal Stem Cells and Regenerative Medicine”, Oct 2017, Shangrao, China. ⟨10.3233/BHR190019⟩
Conference papers hal-02973117v1

New advanced therapy medicinal product for cartilage defect treatment with extemporaneous association of a scaffold and Wharton's jelly mesenchymal stromal cells

Loïc Reppel , Céline Huselstein , Natalia de Isla , Nathalie Rouas-Freiss , Philippe Moreau
7th international symposium Europe-China Stem cells and Médecine Regenerative, Oct 2017, Shangrao, China
Conference papers hal-03612827v1

Comprendre l'hétérogénéité des CSM pour des produits de thérapie cellulaire personnalisés

Laurie Targa , Yueying Li , Naceur Charif , Mainard Didier , Danièle Bensoussan
FR CNRS-UL 3209 Bioingénierie Moléculaire Cellulaire & Thérapeutique "La médecine personnalisée", Dec 2016, Nancy, France
Conference papers hal-02974089v1

RNM as MCS aging biomarkers : pertinence for regenerative medicine

Naceur Charif , Li, Yy , T Kaoma, , Vallar, L , Li, Yp
6th International Symposium Europe-China, Jul 2016, Nancy, France
Conference papers hal-03033120v1

Research progress in liver tissue engineering

Lei Zhang , Zheng Guan , Jun-Song Ye , Yan-Feng Yin , Jean-François Stoltz
6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Jul 2016, Nancy, France. pp.S113-S119, ⟨10.3233/BME-171632⟩
Conference papers hal-02973692v1

Rat BMSC infusion was unable to ameliorate inflammatory injuries in tissues of mice with LPS-induced endotoxemia

Xiaolin Xie , Hanhan Liu , Jinhua Wu , Yun Chen , Zhui Yu
6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Oct 2016, Nancy, France. pp.S129-S138, ⟨10.3233/BME-171634⟩
Conference papers hal-02973711v1

Surface markers expressed differently according to MSC source and aging reflects MCS heterogeneity and define MSC subset

Laurie Targa , Li, Y , Ye, J , Naceur Charif , Du, W
6th International Symposium Europe-China, Jul 2016, Nancy, France
Conference papers hal-03033148v1

The importance of mesenchymal stem cell donor’s age for cartilage engineering

Yueying Li , Naceur Charif , Didier Mainard , Jean-Francois Stoltz , Natalia De Isla
2014 World Congress on Osteoarthritis, Osteoarthritis Research Society International (OARSI) Apr 2014, Paris, France. pp.S61
Conference papers hal-01532044v1

Changes in chondrogenesis differentiation potential of bone marrow mesenchymal stem cells according to donor age

Yueying Li , Naceur Charif , Didier Mainard , Natalia De Isla , Jean-Francois Stoltz
2013 Osteoarthritis Research Society International (OARSI) World Congress, Apr 2013, Philadelphie, United States. pp.S283
Conference papers hal-01511185v1

Multimodality of Microscopy Imaging Applied to Cartilage Tissue Engineering.

Dominique Dd Dumas , Bibiana Riquelme , Elisabeth Werkmeister , Natalia de Isla , Jean François Stoltz
J. Buckwalter, M. Lotz and J.-.Stoltz. Osteoarthritis, Inflammation and Degradation : A Continuum., IOS Press, pp.254-266, 2011, Biomedical and Health Research
Book sections hal-00559042v1