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Nathalie LE BRIS

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Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity

Fernando Ortega-Caballero , María L Santana-Armas , Conchita Tros de Ilarduya , Christophe Di Giorgio , Raphäel Tripier
Journal of materials chemistry‎ B, 2024, 12 (14), pp.3445-3452. ⟨10.1039/d3tb02889e⟩
Journal articles hal-04542122v1
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Preclinical Evaluation of a 64Cu-Based Theranostic Approach in a Murine Model of Multiple Myeloma

Cassandra Métivier , Patricia Le Saëc , Joëlle Gaschet , Catherine Chauvet , Séverine Marionneau-Lambot
Pharmaceutics, 2023, 15 (7), pp.1817. ⟨10.3390/pharmaceutics15071817⟩
Journal articles hal-04161269v1

Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable Cu-64-labelling and biodistribution

Julie Pineau , Luis M P Lima , M Le Roy , Séverine Marionneau-Lambot , Marie Cordier
Chemical Communications, 2023, 59 (7), pp.888-891. ⟨10.1039/d2cc06602e⟩
Journal articles hal-03969219v1

Highly inert Cu( ii ) complexes of C -aryl bifunctional cyclam-picolinates with remarkable 64 Cu-labelling and biodistribution

Julie Pineau , Luís Lima , Marie Le Roy , Séverine Marionneau-Lambot , Marie Cordier
Chemical Communications, 2023, 59 (7), pp.888-891. ⟨10.1039/D2CC06602E⟩
Journal articles hal-04545837v1
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Palladium(II) coordination with polyazacycloalkanes

Nathalie Le Bris , Julie Pineau , Luís M.P. Lima , Raphaël Tripier
Coordination Chemistry Reviews, 2022, 455, pp.214343. ⟨10.1016/j.ccr.2021.214343⟩
Journal articles hal-03583088v1
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Cyclam-Based Chelators Bearing Phosphonated Pyridine Pendants for 64 Cu-PET Imaging: Synthesis, Physicochemical Studies, Radiolabeling, and Bioimaging

Richard C Knighton , Thibault Troadec , Valérie Mazan , Patricia Le Saëc , Séverine Marionneau-Lambot
Inorganic Chemistry, 2021, 60 (4), pp.2634-2648. ⟨10.1021/acs.inorgchem.0c03492⟩
Journal articles hal-03123032v1
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In Vivo Albumin‐Binding of a C ‐Functionalized Cyclam Platform for 64 Cu‐PET/CT Imaging in Breast Cancer Model

Thomas Le Bihan , Cathryn Driver , Thomas Ebenhan , Nathalie Le Bris , Jan Rijn Zeevaart
ChemMedChem, 2020, ⟨10.1002/cmdc.202000800⟩
Journal articles hal-03079054v1

Reactivities of cyclam derivatives with metal–amyloid-β

Gunhee Kim , Evan Lelong , Juhye Kang , Jong-Min Suh , Nathalie Le Bris
Inorganic Chemistry Frontiers, 2020, ⟨10.1039/D0QI00791A⟩
Journal articles hal-02961463v1

Synthesis of Orthogonal N -Protected C -Functional Side-Bridged Cyclams to Give Access to Unsymmetrical Constrained BCAs

Thomas Le Bihan , Nathalie Le Bris , Hélène Bernard , Carlos Platas-Iglesias , Raphaël Tripier
European Journal of Organic Chemistry, 2019, ⟨10.1002/ejoc.201901013⟩
Journal articles hal-02270928v1
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TE1PA as innovating chelator for 64Cu immuno-TEP imaging: a comparative in vivo study with DOTA/NOTA by conjugation on 9E7.4 mAb in a syngeneic multiple myeloma model

Anne-Sophie Navarro , Thomas Le Bihan , Patricia Le Saec , Nathalie Le Bris , Clément Bailly
Bioconjugate Chemistry, 2019, ⟨10.1021/acs.bioconjchem.9b00510⟩
Journal articles inserm-02266369v1
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Synthesis of C-functionalized TE1PA and comparison with its analogues. An example of bioconjugation on 9E7.4 mAb for multiple myeloma 64 Cu-PET imaging

Thomas Le Bihan , Anne-Sophie Navarro , Nathalie Le Bris , Patricia Le Saec , Sébastien Gouard
Organic & Biomolecular Chemistry, 2018, Epub ahead of print. ⟨10.1039/c8ob00499d⟩
Journal articles inserm-01804657v1

Tuning the copper( ii ) coordination properties of cyclam by subtle chemical modifications

Nathalie Le Bris , Nathalie Camus , Selbi Nuryyeva , Matthieu Chessé , David Esteban-Gómez
Dalton Transactions, 2017, 46 (34), pp.11479 - 11490. ⟨10.1039/C7DT00750G⟩
Journal articles hal-01629506v1

Catching anions with coloured assemblies: binding of pH indicators by a giant-size polyammonium macrocycle for anion naked-eye recognition

Nathalie Le Bris , Francesco Bartoli , Andrea Bencini , Luca Conti , Claudia Giorgi
Organic & Biomolecular Chemistry, 2016, 14 (35), pp.8309 - 8321. ⟨10.1039/c6ob01474g⟩
Journal articles hal-01629492v1

A [two-step/one week] synthesis of C-functionalized homocyclens and cyclams. Application to the preparation of conjugable BCAs without chelating properties alteration

Nathalie Camus , Zakaria Halime , Nathalie Le Bris , Hélène Bernard , Maryline Beyler
RSC Advances, 2015, 5 (104), pp.85898 - 85910. ⟨10.1039/c5ra17133d⟩
Journal articles hal-01517785v1

Full Control of the Regiospecific N -Functionalization of C -Functionalized Cyclam Bisaminal Derivatives and Application to the Synthesis of their TETA, TE2A, and CB-TE2A Analogues

Nathalie Le Bris , Nathalie Camus , Zakaria Halime , Hélène Bernard , Carlos Platas-Iglesias
Journal of Organic Chemistry, 2014, 79 (5), pp.1885 - 1899. ⟨10.1021/jo4028566⟩
Journal articles hal-01629496v1

A new bis-tetraamine ligand with a chromophoric 4-(9-anthracenyl)-2,6-dimethylpyridinyl linker for glyphosate and ATP sensing

Jacky Pouessel , Nathalie Le Bris , Sabah Abada , Mourad Elhabiri , Loïc J. Charbonnière
Dalton Transactions, 2013, 42 (14), ⟨10.1039/c3dt32325k⟩
Journal articles hal-01629499v1

Glyphosate and ATP binding by mononuclear Zn(ii) complexes with non-symmetric ditopic polyamine ligands

Jacky Pouessel , Nathalie Le Bris , Andrea Bencini , Claudia Giorgi , Barbara Valtancoli
Dalton Transactions, 2012, 41 (35), ⟨10.1039/C2DT31110K⟩
Journal articles hal-01556793v1

Selective Binding of Glyphosate by a Ditopic Cyclic-Open-Chain Polyazaligand in Aqueous Solution

Nathalie Le Bris , Jacky Pouessel , Andrea Bencini , Claudia Giorgi , Henri Handel
European Journal of Organic Chemistry, 2011, 2011 (34), pp.6965 - 6973. ⟨10.1002/ejoc.201100972⟩
Journal articles hal-01629511v1

1,2,4-Triazine method of bipyridine ligand synthesis for the preparation of new luminescent Eu(III) complexes

Nathalie Le Bris , Anton Prokhorov , Valery N. Kozhevnikov , Dmitry S. Kopchuk , Hélène Bernard
Tetrahedron, 2011, 67 (3), pp.597 - 607. ⟨10.1016/j.tet.2010.11.058⟩
Journal articles hal-01629509v1

Exploring New Molecular Architectures for Anion Recognition: Synthesis and ATP Binding Properties of New Cyclam-Based Ditopic Polyammonium Receptors.

Nathalie Le Bris , Jacky Pouessel , Carla Bazzicalupi , Andrea Bencini , Hélène Bernard
Chemistry - An Asian Journal, 2011, 6 (6), pp.1582 - 1594. ⟨10.1002/asia.201100046⟩
Journal articles hal-01629512v1

Synthesis of a New Linear-Cyclic Ditopic Polyazaligand with a Xylenyl Linker

Nathalie Le Bris , Hélène Bernard , Zein El Abidine Chamas , Henri Handel
Synthetic Communications, 2009, 39 (11), pp.1992 - 2000. ⟨10.1080/00397910802630203⟩
Journal articles hal-01629515v1

Selective mono-N-alkylation of triethylenetetraamine. A new versatile route to polylinear aza-ligands

Nathalie Le Bris , Anne-Sophie Delépine , Raphaël Tripier , Hélène Bernard , Henri Handel
Tetrahedron Letters, 2009, 50 (21), pp.2521 - 2524. ⟨10.1016/j.tetlet.2009.03.088⟩
Journal articles hal-01580187v1

Selective mono-N-alkylation of triethylenetetraamine. A new versatile route to polylinear aza-ligands

Nathalie Le Bris , Anne-Sophie Delépine , Raphaël Tripier , Hélène Bernard , Henri Handel
Tetrahedron Letters, 2009, 50 (21), pp.2521 - 2524. ⟨10.1016/j.tetlet.2009.03.088⟩
Journal articles hal-01629513v1

ATP and triphosphate anions complexation by bis-linear tetraamines: Strong interactions at neutral pH

Nathalie Le Bris , Anne-Sophie Delépine , Raphaël Tripier , Hélène Bernard , Aurelien Honraedt
Inorganica Chimica Acta Reviews, 2009, 362 (10), pp.3829 - 3834. ⟨10.1016/j.ica.2009.05.003⟩
Journal articles hal-01629518v1

Synthesis of a New Ditopic Ligand Possessing Linear and Cyclic Tetraaza Subunits

Nathalie Le Bris , Anton Prokhorov , Hélène Bernard , Nicolas Marquet , Henri Handel
Synthetic Communications, 2008, 38 (10), pp.1589 - 1600. ⟨10.1080/00397910801929481⟩
Journal articles hal-01629521v1

A potentiometric and NMR investigation of triphosphate recognition by linear and bismacrocyclic octaamines possessing a 1,4-xylenyl linker

Nathalie Le Bris , Hélène Bernard , Raphaël Tripier , Henri Handel
Inorganica Chimica Acta Reviews, 2007, 360 (9), pp.3026 - 3032. ⟨10.1016/j.ica.2007.02.041⟩
Journal articles hal-01629525v1

Cyclohexanedione Bisaminals as Intermediates for Cyclen, Homocyclen, and Cyclam Synthesis

Nathalie Le Bris , Anton Prokhorov , Hélène Bernard , Géraldine Claudon , Henri Handel
Synthetic Communications, 2006, 36 (21), pp.3271 - 3282. ⟨10.1080/00397910600910633⟩
Journal articles hal-01629526v1

PowerfulN-Monoalkylation of Linear Tetraamines via Bisaminal Intermediates

Géraldine Claudon , Nathalie Le Bris , Hélène Bernard , Henri Handel
European Journal of Organic Chemistry, 2004, 2004 (24), pp.5027 - 5030. ⟨10.1002/ejoc.200400459⟩
Journal articles hal-01629489v1

Rhodium Complexes of Bidentate and Potentially Hemilabile Phosphorus Ligands for Hydroformylation of Styrene at Low Temperature

Pascale Laurent , Nathalie Le Bris , Herve Des Abbayes
ChemInform, 2004, 35 (45), ⟨10.1002/chin.200445272⟩
Journal articles hal-04547457v1

Phosphonolipids as non-viral vectors for gene therapy

V. Floch , G. Le Bolc'H , C. Gable-Guillaume , Nathalie Le Bris , J.-J. Yaouanc
European Journal of Medicinal Chemistry, 1998, 33, pp.923--934. ⟨10.1016/S0223-5234(99)80017-8⟩
Journal articles hal-01770726v1
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Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA

Julie Pineau , Luís Lima , Carlos Platas-Iglesias , Jan Rijn Zeevaart , Cathryn Driver
Chemistry - A European Journal, 0202, ⟨10.1002/chem.202200942⟩
Journal articles hal-03697874v1

A competitive chelating agent for the development of radiopharmaceuticals in personalized nuclear medicine

Julie Pineau , Nathalie Le Bris , Raphaël Tripier
SECO, May 2024, Pornichet, France
Conference papers hal-04547260v1

Optimisation d’un Agent Chélatant Avancé pour la Production de Radiopharmaceutiques en Médecine Nucléaire Personnalisée

Julie Pineau , Nathalie Le Bris , Raphaël Tripier
Journée IBSAM, Mar 2024, Brest, France
Conference papers hal-04547231v1

New CuAAC-based method to reach bifunctional cyclam derivatives application in cancer imaging and therapy

Cédric Ollier , Nathalie Le Bris , Raphaël Tripier
SCF Western section, Jun 2024, Logonna-Daoulas, France
Conference papers hal-04547240v1

Functionalization of TE1PA derivatives via CuAAC for cancer imaging and therapy

Cédric Ollier , Nathalie Le Bris , Raphaël Tripier
SECO, May 2023, Arëches-Beaufort, France
Conference papers hal-04547205v1

Cyclam as Relevant Platform to Design 99mTc, 64Cu, or 109Pd Radiopharmaceuticals in Nuclear Medicine

Maher Hojorat , Nathalie Le Bris , Raphaël Tripier
ISMEC, Jun 2023, Urbino, Italy
Conference papers hal-04547213v1

Vers de nouveaux radiopharmaceutiques au cuivre pour l’imagerie TEP et la thérapie des cancers

Cédric Ollier , Nathalie Le Bris , Raphaël Tripier
Journée IBSAM, Nov 2023, Brest, France
Conference papers hal-04547221v1

In vivo albumin-binding of a cyclam-based platform for imaging and therapy of cancers

Julie Pineau , Nathalie Le Bris , Raphaël Tripier
GECOM Mini, Jul 2021, Webinaire, France
Conference papers hal-04547156v1

Novel 64Cu/109Pd theranostic pair for a TE1PA-based trifunctional chelating agent

Julie Pineau , Nathalie Le Bris , Raphaël Tripier
SCF western section, Sep 2021, Rennes, France
Conference papers hal-04547167v1

Développement de radiopharmaceutiques à base de cyclam pour l'imagerie TEP au cuivre-64 et la thérapie des cancers

Nathalie Le Bris , Julie Pineau , Raphaël Tripier
Journée de l'Ecole Doctorale 3M, May 2021, Webinaire, France
Conference papers hal-04547151v1

64Cu/*Pd-GluCAB: an in vivo albumin-binding theranostic radiopharmaceutical for dual active and passive targeting of breast cancer

Nathalie Le Bris , Raphaël Tripier
International Symposium on Trends in Radiopharmaceuticals, Apr 2023, Vienna, Austria
Conference poster hal-04547303v1

Neutral Copper(II) TE1PA-based chelate for 64Cu-PET imaging: when an additional carboxyl group makes the difference

Julie Pineau , Nathalie Le Bris , Raphaël Tripier
New Modalities in Cancer Imaging and Therapy. Cancéropôle Grand-Ouest, Oct 2022, Erquy, France
Conference poster hal-04547281v1

Relevance of palladium to radiopharmaceutical development considering enhanced.

Julie Pineau , Nathalie Le Bris , Raphaël Tripier
New Modalities in Cancer Imaging and Therapy. Cancéropôle Grand Ouest, Oct 2022, Erquy, France
Conference poster hal-04547294v1