NS

Nathalie Sans

Directrice de Recherche Inserm
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Documents

Présentation

Cursus Académique

1996 - Doctorat de l'Université Montpellier II, Montpellier.

2014 Habilitation à diriger des recherches, Université de Bordeaux Segalen

Carrière

1997-2002 : Post-Doc National Institutes of Health, USA

2003-2005: Senior Research Fellow, NIH, MD, USA

2007 : Chargée de recherche Inserm

2014 : Directrice de recherche Inserm

Fonctions

2015-2021 Directrice Adjointe de l’UMR U1215 INSERM-UM et Responsable équipe "planar Polarity and Plasticity"

2016-2019 Directrice Adjointe du département SVS de l'Univ. de Bordeaux

2019-2021 Directrice du département Bordeaux Neurocampus de l'Univ. de Bordeaux

2022-2026 Vice -présidente en charge de la recherche, Univ. de Bordeaux

Domaines de recherche

Neurosciences [q-bio.NC]

Compétences

neurobiologie biologie cellulaire et moleculaire comportement synapse AIS

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Publications

The correct connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling

Noémie Depret , Marie Gleizes , Maïté Marie Moreau , Sonia Poirault-Chassac , Anne Quiedeville et al.
Progress in Neurobiology, 2025, pp.102728. ⟨10.1016/j.pneurobio.2025.102728⟩
Article dans une revue hal-04960513 v1
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MuSK cysteine-rich domain antibodies are pathogenic in a mouse model of autoimmune myasthenia gravis

Marius Halliez , Steve Cottin , Axel You , Céline Buon , Antony Grondin et al.
The Journal of clinical investigation, 2025, 135, ⟨10.1172/jci173308⟩
Article dans une revue hal-05344474 v1

The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling

Ana Dorrego-Rivas , Jerome Ezan , Maïté Moreau , Sonia Poirault-Chassac , Nathalie Aubailly et al.
Science Advances , 2022, 8 (36), ⟨10.1126/sciadv.abo6333⟩
Article dans une revue hal-03856056 v1
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Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway

Maite M. Moreau , Susanna Pietropaolo , Jerome Ezan , Benjamin J. A. Robert , Sylvain Miraux et al.
Cells, 2022, 11 (10), pp.1601. ⟨10.3390/cells11101601⟩
Article dans une revue hal-03709848 v1
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The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK

Myriam Boëx , Steve Cottin , Marius Halliez , Stéphanie Bauché , Céline Buon et al.
Science Signaling, 2022, 15 (734), pp.eabg4982. ⟨10.1126/scisignal.abg4982⟩
Article dans une revue inserm-03768653 v1
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Neuron-Specific Deletion of in Mice Leads to Neuroanatomical and Locomotor Deficits.

Jerome Ezan , Maite Moreau , Tamrat M Mamo , Miki Shimbo , Maureen Decroo et al.
Frontiers in Genetics, 2022, 13, pp.872700. ⟨10.3389/fgene.2022.872700⟩
Article dans une revue hal-03709715 v1

The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK

Myriam Boëx , Steve Cottin , Marius Halliez , Stéphanie Bauché , Céline Buon et al.
Science Signaling, 2022, 15 (734), ⟨10.1126/scisignal.abg4982⟩
Article dans une revue cea-04460528 v1
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Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity

Jerome Ezan , Maite M. Moreau , Tamrat M. Mamo , Miki Shimbo , Maureen Decroo et al.
Scientific Reports, 2021, 11, pp.9106. ⟨10.1038/s41598-021-88147-1⟩
Article dans une revue hal-03424316 v1
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Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion

Benjamin J.A. Robert , Maïté M Moreau , Steve dos Santos Carvalho , Gael Barthet , Claudia Racca et al.
Cell Reports, 2020, 31 (10), pp.107743. ⟨10.1016/j.celrep.2020.107743⟩
Article dans une revue hal-03402580 v1
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Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth

Steve Dos-Santos Carvalho , Maite Moreau , Yeri Esther Hien , Mikael Garcia , Nathalie Aubailly et al.
Article dans une revue hal-02996265 v1

Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion

Benjamin J.A. Robert , Maïté Moreau , Steve dos Santos Carvalho , Gael Barthet , Claudia Racca et al.
Cell Reports, 2020, 31 (10), pp.107743. ⟨10.1016/j.celrep.2020.107743⟩
Article dans une revue hal-03367473 v1

Alpha technology: A powerful tool to detect mouse brain intracellular signaling events

Marion Zanese , Giovanni Tomaselli , Valérie Roullot-Lacarrière , Maïté Moreau , Luigi Bellocchio et al.
Journal of Neuroscience Methods, 2020, 332, pp.108543. ⟨10.1016/j.jneumeth.2019.108543⟩
Article dans une revue hal-02990027 v1
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Age‐related impairment of declarative memory: linking memorization of temporal associations to GluN2B redistribution in dorsal CA1

Alice Shaam Al Abed , Azza Sellami , Mylene Potier , Eva‐gunnel Ducourneau , Pauline Gerbeaud‐lassau et al.
Aging Cell, 2020, 19 (10), pp.e13243. ⟨10.1111/acel.13243⟩
Article dans une revue hal-02960264 v1
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Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways

Julien Messéant , Jérôme Ezan , Perrine Delers , Konstantin Glebov , Carmen Marchiol et al.
Development (Cambridge, England), 2017, 144 (9), pp.1712 - 1724. ⟨10.1242/dev.146167⟩
Article dans une revue hal-01542853 v1
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Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome

Stephanie A. Mauriac , Yeri E. Hien , Jonathan E. Bird , Steve dos Santos Carvalho , Ronan Peyroutou et al.
Nature Communications, 2017, 8, pp.14907. ⟨10.1038/ncomms14907⟩
Article dans une revue hal-03724003 v1
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Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse

Muna L Hilal , Maité M Moreau , Claudia Racca , Vera L Pinheiro , Nicolas H Piguel et al.
Cerebral Cortex, 2017, 27 (12), pp.5635-5651. ⟨10.1093/cercor/bhw333⟩
Article dans une revue hal-01789668 v1
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Nutritional omega-3 deficiency alters glucocorticoid receptor-signaling pathway and neuronal morphology in regionally distinct brain structures associated with emotional deficits

Thomas Larrieu , Muna L. Hilal , Veronique de Smedt-Peyrusse , Nathalie Sans , Sophie Layé
Neural plasticity, 2016, pp.1-9. ⟨10.1155/2016/8574830⟩
Article dans une revue hal-02631971 v1
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Scribble1/AP2 Complex Coordinates NMDA Receptor Endocytic Recycling

Nicolas H Piguel , Sabine Fievre , Jean-Michel Blanc , Mario Carta , Maïté M Moreau et al.
Cell Reports, 2014, 9 (2), pp.712 - 727. ⟨10.1016/j.celrep.2014.09.017⟩
Article dans une revue hal-04675011 v1
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Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling

Nicolas H. Piguel , Sabine Fievre , Jean-Michel Blanc , Mario Carta , Maïté M. Moreau et al.
Cell Reports, 2014, 9 (2), pp.712--27. ⟨10.1016/j.celrep.2014.09.017⟩
Article dans une revue hal-01944934 v1

Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1 −/y mice

Yu Zhang , Audrey Bonnan , Guillaume Bony , Isabelle Ferezou , Susanna Pietropaolo et al.
Nature Neuroscience, 2014, 17 (12), pp.1701-1709. ⟨10.1038/nn.3864⟩
Article dans une revue hal-02064702 v1

Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton.

Jerome Ezan , Léa Lasvaux , Aysegul Gezer , Ana Novakovic , Helen May-Simera et al.
Nature Cell Biology, 2013, 15 (9), pp.1107-15. ⟨10.1038/ncb2819⟩
Article dans une revue hal-00862161 v1
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Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear

Arnaud P. Giese , Jerome Ezan , Lingyan Wang , Lea Lasvaux , Frederique Lembo et al.
Development (Cambridge, England), 2012, 139 (20), pp.3775-3785. ⟨10.1242/dev.074229⟩
Article dans une revue hal-03710271 v1
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SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

Nathalie Sans , Christelle M Durand , Julie Perroy , Francois Loll , David Perrais et al.
Molecular Psychiatry, 2011, ⟨10.1038/mp.2011.57⟩
Article dans une revue hal-00644264 v1

The Planar Polarity Protein Scribble1 Is Essential for Neuronal Plasticity and Brain Function

Maïté M Moreau , Nicolas Piguel , Thomas Papouin , Muriel Koehl , Christelle M Durand et al.
Journal of Neuroscience, 2010, 30 (29), pp.9738-9752. ⟨10.1523/JNEUROSCI.6007-09.2010⟩
Article dans une revue hal-02326134 v1