Nathalie Sibille

69%
Libre accès
49
Documents
Affiliations actuelles
  • Centre National de la Recherche Scientifique (CNRS)
  • Université de Montpellier (UM)

Présentation

Trained in Physics and expert in NMR spectroscopy for Structural Biology, my research interest is centred on Intrinsically Disordered Proteins (IDPs) and their functions. They are the targets of multiple post-translational modifications modulating interaction with physiological partners, in particular for modulation of signaling events in cells. My main project aim to study the molecular mechanism of interaction of GPCR and arrestin.

Domaines de recherche

Sciences du Vivant [q-bio]

Compétences

Integrative Structural Biology NMR spectroscopy SAXS Biophysics IDPs PTMs Signaling

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Publications

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Lipids modulate the dynamics of GPCR:β-arrestin interaction

Antoniel Gomes , Michela Di Michele , Rita Ann Roessner , Marjorie Damian , Paulo Bisch et al.
Nature Communications, 2025, 16 (1), pp.4982. ⟨10.1038/s41467-025-59842-8⟩
Article dans une revue hal-05094158 v1
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A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation

Juan Manuel Valverde , Geronimo Dubra , Michael Phillips , Austin Haider , Carlos A Elena-Real et al.
Nature Communications, 2023, 14 (1), pp.6316. ⟨10.1038/s41467-023-42049-0⟩
Article dans une revue hal-04239889 v1
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Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction

Myriam Guillien , Assia Mouhand , Amin Sagar , Aurélie Fournet , Frédéric Allemand et al.
Structure, 2023, 31 (11), pp.1394-1406.e7. ⟨10.1016/j.str.2023.08.011⟩
Article dans une revue hal-04235502 v1
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Structure–function relationships in protein homorepeats

Carlos Elena-Real , Pablo Mier , Nathalie Sibille , Miguel Andrade-Navarro , Pau Bernadó
Current Opinion in Structural Biology, 2023, 83, pp.102726. ⟨10.1016/j.sbi.2023.102726⟩
Article dans une revue hal-04269590 v1
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Structure of the vasopressin hormone–V2 receptor–β-arrestin1 ternary complex

Julien Bous , Aurélien Fouillen , Hélène Orcel , Stefano Trapani , Xiaojing Cong et al.
Science Advances , 2022, 8 (35), pp.eabo7761. ⟨10.1126/sciadv.abo7761⟩
Article dans une revue hal-03790728 v1
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eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1 and self-assembly

Belén Chaves-Arquero , Santiago Martínez-Lumbreras , Nathalie Sibille , Sergio Camero , Pau Bernadó et al.
Frontiers in Molecular Biosciences, 2022, ⟨10.3389/fmolb.2022.986121⟩
Article dans une revue hal-03763836 v1
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Structural Insights into the Intrinsically Disordered GPCR C:Terminal Region, Major Actor in Arrestin:GPCR Interaction

Myriam Guillien , Assia Mouhand , Aurelie Fournet , Amandine Gontier , Aleix Martí Navia et al.
Biomolecules, 2022, 12 (5), pp.617. ⟨10.3390/biom12050617⟩
Article dans une revue hal-03748408 v1
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The diversity of molecular interactions involving intrinsically disordered proteins: A molecular modeling perspective

Ilinka Clerc , Amin Sagar , Alessandro Barducci , Nathalie Sibille , Pau Bernadó et al.
Computational and Structural Biotechnology Journal, 2021, 19, pp.3817-3828. ⟨10.1016/j.csbj.2021.06.031⟩
Article dans une revue hal-03281983 v1
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Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells

Nikola Arsic , Tania Slatter , Gilles Gadea , Etienne Villain , Aurelie Fournet et al.
Nature Communications, 2021, 12 (1), pp.5463. ⟨10.1038/s41467-021-25550-2⟩
Article dans une revue hal-03346748 v1
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Structural insights into the cooperative interaction of the intrinsically disordered co-activator TIF2 with retinoic acid receptor heterodimer (RXR/RAR)

Lucile Senicourt , Albane Le Maire , Frédéric Allemand , João E Carvalho , Laura Guee et al.
Journal of Molecular Biology, 2021, 433 (9), pp.166899. ⟨10.1016/j.jmb.2021.166899⟩
Article dans une revue hal-03047222 v2
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Predicting secondary structure propensities in IDPs using simple statistics from three-residue fragments

Alejandro N Estaña , Amélie Barozet , Assia Mouhand , Marc Vaisset , Christophe Zanon et al.
Journal of Molecular Biology, 2020, 342 (19), pp.5447-5459. ⟨10.1016/j.jmb.2020.07.026⟩
Article dans une revue hal-02920302 v1
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Evidence of the reduced abundance of proline cis conformation in protein poly-proline tracts

Annika N Urbanek , Matija Popovic , Carlos A Elena-Real , Anna Morató , Alejandro N Estaña et al.
Journal of the American Chemical Society, 2020, 142 (17), pp.7976-7986. ⟨10.1021/jacs.0c02263⟩
Article dans une revue hal-02545935 v1
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Robust Cell-Free Expression of Sub-Pathological and Pathological Huntingtin Exon-1 for NMR Studies. General Approaches for the Isotopic Labeling of Low-Complexity Proteins

Anna Morató , Carlos Elena-Real , Matija Popovic , Aurélie Fournet , Karen Zhang et al.
Biomolecules, 2020, 10 (10), pp.1458. ⟨10.3390/biom10101458⟩
Article dans une revue hal-03047216 v1
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IDPs and their complexes in GPCR and nuclear receptor signaling

Myriam Guillien , Albane E Le Maire , Assia Mouhand , Pau Bernadó , William Bourguet et al.
Progress in Molecular Biology and Translational Science, 2020, Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, 174, pp.105 - 155. ⟨10.1016/bs.pmbts.2020.05.001⟩
Article dans une revue hal-03749862 v1
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Flanking regions determine the structure of the poly-glutamine homo- repeat in huntingtin through mechanisms common among glutamine-rich human proteins

Annika N Urbanek , Matija Popovic , Anna Morató , Alejandro N Estaña , Carlos A Elena-Real et al.
Structure, 2020, 28 (7), pp.733-746.e5. ⟨10.1016/j.str.2020.04.008⟩
Article dans une revue hal-02893075 v1
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Site‐Specific Isotopic Labeling (SSIL) – Access to High‐Resolution Structural and Dynamic Information in Low Complexity Proteins

Annika N Urbanek , Carlos A Elena-Real , Matija Popovic , Anna Morató , Aurélie Fournet et al.
ChemBioChem, 2019, ⟨10.1002/cbic.201900583⟩
Article dans une revue hal-02359756 v1
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Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression

Tiago N Cordeiro , Nathalie Sibille , Pierre Germain , Philippe Barthe , Abdelhay Boulahtouf et al.
Structure, 2019, 27 (8), pp.1270-1285.e6. ⟨10.1016/j.str.2019.05.001⟩
Article dans une revue hal-03078485 v1
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Realistic Ensemble Models of Intrinsically Disordered Proteins Using a Structure-Encoding Coil Database

Alejandro N Estaña , Nathalie Sibille , Elise Delaforge , Marc Vaisset , Juan Cortés et al.
Structure, 2019, 27 (5), pp.381-391.e2. ⟨10.1016/j.str.2018.10.016⟩
Article dans une revue hal-01954977 v1
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A General Strategy to Access Structural Information at Atomic Resolution in Polyglutamine Homorepeats

Annika N Urbanek , Anna Morató , Frédéric Allemand , Elise Delaforge , Aurélie Fournet et al.
Angewandte Chemie International Edition, 2018, ⟨10.1002/anie.201711530⟩
Article dans une revue hal-01737188 v1
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Hybrid parallelization of a multi-tree path search algorithm: Application to highly-flexible biomolecules

Alejandro N Estaña , Kevin Molloy , Marc Vaisset , Nathalie Sibille , Thierry Simeon et al.
Parallel Computing, 2018, 77, pp.84-100. ⟨10.1016/j.parco.2018.06.005⟩
Article dans une revue hal-01823694 v2
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Structural Characterization of Highly Flexible Proteins by Small-Angle Scattering.

Tiago N Cordeiro , Fatima Herranz-Trillo , Annika N Urbanek , Alejandro N Estaña , Juan Cortés et al.
Advances in Experimental Medicine and Biology, 2017, pp.PP.107-129. ⟨10.1007/978-981-10-6038-0_7⟩
Article dans une revue hal-01664316 v1
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Disentangling polydispersity in the PCNA−p15PAF complex, a disordered, transient and multivalent macromolecular assembly

Tiago N Cordeiro , Po-Chia Chen , Alfredo De biasio , Nathalie Sibille , Francisco Blanco et al.
Nucleic Acids Research, 2017, 45 (3), pp.1501-1515. ⟨10.1093/nar/gkw1183⟩
Article dans une revue hal-02348011 v1

p15(PAF) Is an Intrinsically Disordered Protein with Nonrandom Structural Preferences at Sites of Interaction with Other Proteins.

Alfredo de Biasio , Alain Ibáñez de Opakua , Tiago N Cordeiro , Maider Villate , Nekane Merino et al.
Biophysical Journal, 2014, 106 (4), pp.865-874. ⟨10.1016/j.bpj.2013.12.046⟩
Article dans une revue hal-00967481 v1
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Measuring residual dipolar couplings at high hydrostatic pressure: robustness of alignment media to high pressure

Nathalie Sibille , Mariano Dellarole , Catherine A. Royer , Christian Roumestand
Journal of Biomolecular NMR, 2014, 58 (1), pp.9-16. ⟨10.1007/s10858-013-9798-7⟩
Article dans une revue hal-02347973 v1

Structural characterization of intrinsically disordered proteins by the combined use of NMR and SAXS

Nathalie Sibille , Pau Bernadó
Biochemical Society Transactions, 2012, 40 (5), pp.955-962. ⟨10.1042/BST20120149⟩
Article dans une revue hal-02347934 v1

Low concentration of a Gd-chelate increases the signal-to-noise ratio in fast pulsing BEST experiments

Nathalie Sibille , Gaëtan Bellot , Jing Wang , Hélène Déméné
Journal of Magnetic Resonance, 2012, 224, pp.32-37. ⟨10.1016/j.jmr.2012.07.022⟩
Article dans une revue istex hal-02347955 v1

Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein.

Nathalie Sibille , Isabelle Huvent , Caroline Fauquant , Dries Verdegem , Laziza Amniai et al.
Proteins - Structure, Function and Bioinformatics, 2011, epub ahead of print. ⟨10.1002/prot.23210⟩
Article dans une revue istex hal-00713027 v1

Oleuropein and derivatives from olives as Tau aggregation inhibitors.

Anthony Daccache , Cedric Lion , Nathalie Sibille , Melanie Gerard , Christian Slomianny et al.
Neurochemistry International, 2011, 58 (6), pp.700-7. ⟨10.1016/j.neuint.2011.02.010⟩
Article dans une revue istex hal-00586934 v1

Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.

Isabelle Landrieu , Xavier Hanoulle , Fanny Bonachera , Arnaud Hamel , Nathalie Sibille et al.
Biochemistry, 2010, 49 (22), pp.4679-86. ⟨10.1021/bi1003266⟩
Article dans une revue hal-00508817 v1

NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease.

Isabelle Landrieu , Arnaud Leroy , Caroline Smet-Nocca , Isabelle Huvent , Laziza Amniai et al.
Biochemical Society Transactions, 2010, 38 (4), pp.1006-11. ⟨10.1042/BST0381006⟩
Article dans une revue hal-00586933 v1

Selective backbone labelling of ILV methyl labelled proteins.

Nathalie Sibille , Xavier Hanoulle , Fanny Bonachera , Dries Verdegem , Isabelle Landrieu et al.
Journal of Biomolecular NMR, 2009, 43 (4), pp.219-27. ⟨10.1007/s10858-009-9307-1⟩
Article dans une revue istex hal-00373458 v1

Tau aggregation in Alzheimer's disease : what role for phosphorylation ?

Guy Lippens , Alain Sillen , Isabelle Landrieu , Laziza Amniai , Nathalie Sibille et al.
Prion, 2007, 1 (1), pp.21-25
Article dans une revue hal-00161158 v1

Structural and functional characterisation of the interaction between cyclophilin B and A heparin derived oligosaccharide.

Xavier Hanoulle , Aurélie Melchior , Nathalie Sibille , Benjamin Parent , Agnès Denys et al.
Journal of Biological Chemistry, 2007, epub ahead of print. ⟨10.1074/jbc.M706353200⟩
Article dans une revue hal-00175485 v1

Structural Impact of Heparin Binding to Full-Length Tau As Studied by NMR Spectroscopy.

Nathalie Sibille , Alain Sillen , Arnaud Leroy , Jean-Michel Wieruszeski , Barbara Mulloy et al.
Biochemistry, 2006, 45, pp.12560-12572
Article dans une revue hal-00108261 v1

Comparative NMR study on the impact of point mutations on protein stability of Pseudomonas mendocina lipase

Nathalie Sibille , Adrien Favier , Ana Azuaga , Grant Ganshaw , Richard Bott et al.
Protein Science, 2006, 15 (8), pp.1915-1927. ⟨10.1110/ps.062213706⟩
Article dans une revue hal-02347920 v1

NMR analysis of a Tau phosphorylation pattern.

Isabelle Landrieu I , Ludovic Lacosse , Arnaud Leroy , Jean-Michel Wieruszeski , Xavier Trivelli et al.
Journal of the American Chemical Society, 2006, 128, pp.3575-3583
Article dans une revue hal-00085610 v1

Solution Structure of the Sulfite Reductase Flavodoxin-like Domain from Escherichia coli † , ‡

Nathalie Sibille , Martin Blackledge , Bernhard Brutscher , Jacques Covès , Beate Bersch
Biochemistry, 2005, 44 (25), pp.9086-9095. ⟨10.1021/bi050437p⟩
Article dans une revue istex hal-02347867 v1

Side Chain Orientation from Methyl 1 H− 1 H Residual Dipolar Couplings Measured in Highly Deuterated Proteins

Nathalie Sibille , Beate Bersch , Jacques Covès , Martin Blackledge , Bernhard Brutscher
Journal of the American Chemical Society, 2002, 124 (49), pp.14616-14625. ⟨10.1021/ja020888m⟩
Article dans une revue istex hal-02347862 v1

Reactivity, Secondary Structure, and Molecular Topology of the Escherichia coli Sulfite Reductase Flavodoxin-like Domain †

Nathalie Sibille , Ludovic Champier , Beate Bersch , Bernhard Brutscher , Martin Blackledge et al.
Biochemistry, 2002, 41 (11), pp.3770-3780. ⟨10.1021/bi016008i⟩
Article dans une revue istex hal-02347845 v1

Refinement of Local and Long-Range Structural Order in Theophylline-Binding RNA Using 13 C− 1 H Residual Dipolar Couplings and Restrained Molecular Dynamics

Nathalie Sibille , Arthur Pardi , Jean-Pierre Simorre , Martin Blackledge
Journal of the American Chemical Society, 2001, 123 (49), pp.12135-12146. ⟨10.1021/ja011646+⟩
Article dans une revue hal-02347823 v1

1H, 13C and 15N assignment of the flavodoxin-like domain of the Escherichia coli sulfite reductase

Nathalie Sibille , Jacques Covès , Dominique Marion , Bernhard Brutscher , Beate Bersch
Journal of Biomolecular NMR, 2001, 21 (1), pp.71-72. ⟨10.1023/a:1011985803535⟩
Article dans une revue istex hal-02347783 v1
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Conformational Characterization of Intrinsically Disordered Proteins and Its Biological Significance

Elise Delaforge , Tiago N Cordeiro , Pau Bernadó , Nathalie Sibille
Graham A. Webb. Modern Magnetic Resonance, Springer International Publishing, pp.381-399, 2018, 978-3-319-28387-6. ⟨10.1007/978-3-319-28388-3_52⟩
Chapitre d'ouvrage hal-02348118 v1