Nicolas FLOQUET

Documents

Publications

	Sodium is a negative allosteric regulator of the ghrelin receptor Guillaume Ferré , Antoniel A.S. Gomes , Maxime Louet , Marjorie Damian , Paulo Bisch Cell Reports, 2023, 42 (4), pp.112320. ⟨10.1016/j.celrep.2023.112320⟩ Journal articles hal-04265315v1
	MDexciteR: Enhanced Sampling Molecular Dynamics by Excited Normal Modes or Principal Components Obtained from Experiments Mauricio Costa , Paulo R Batista , Antoniel Gomes , Leonardo S Bastos , Maxime Louet Journal of Chemical Theory and Computation, 2023, 19 (2), pp.412-425. ⟨10.1021/acs.jctc.2c00599⟩ Journal articles hal-04277555v1
	Allosteric modulation of ghrelin receptor signaling by lipids Marjorie Damian , Maxime Louet , Antoniel Augusto Severo Gomes , Céline M’kadmi , Séverine Denoyelle Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩ Journal articles hal-03407522v1
	Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex Julien Bous , Hélène Orcel , Nicolas Floquet , Cédric Leyrat , Josephine Lai Kee Him Science Advances , 2021, 7 (21), pp.eabg5628. ⟨10.1126/sciadv.abg5628⟩ Journal articles hal-03240488v1
	Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor Maxime Louet , Marina Casiraghi , Marjorie Damian , Mauricio Gs Costa , Pedro Renault eLife, 2021, 10, pp.e63201. ⟨10.7554/elife.63201⟩ Journal articles hal-03407524v1
	Allosteric modulation of ghrelin receptor signaling by lipids Marjorie Damian , Maxime Louet , Antoniel Augusto Severo Gomes , Céline M’kadmi , Séverine Denoyelle Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩ Journal articles hal-03852471v1
	Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2a Receptor by a Mini-G Protein Pedro Renault , Maxime Louet , Jacky Marie , Gilles Labesse , Nicolas Floquet Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-41980-x⟩ Journal articles hal-02322127v1
	Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain Guillaume Ferré , Maxime Louet , Oliver Saurel , Bartholomé Delort , Georges Czaplicki Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (35), pp.17525-17530. ⟨10.1073/pnas.1905105116⟩ Journal articles hal-02322092v1
	GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation Marjorie Damian , Véronique Pons , Pedro Renault , Céline M’kadmi , Bartholomé Delort Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (17), pp.4501-4506. ⟨10.1073/pnas.1712725115⟩ Journal articles hal-02322168v1
	Crystal structure and functional domains of the Mambaquaretin-1, a vasopressin type 2 receptor peptide inhibitor for kidney cysts treatment Laura Droctové , Justyna Ciolek , Manon Lancien , Enrico Stura , Laura Vera Toxicon, 2018, 149, pp.91-92. ⟨10.1016/j.toxicon.2017.12.021⟩ Journal articles hal-03572739v1
	Structure and Dynamics of the Receptor-Bound Ghrelin Lipopeptide Guillaume Ferré , Marjorie Damian , Céline M'Kadmi , Olivier Saurel , Georges Czaplicki Biophysical Journal, 2018, 114 (3), pp.235a. ⟨10.1016/J.BPJ.2017.11.1308⟩ Journal articles hal-02405941v1
	Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues Roberto Fanelli , Nicolas Floquet , Élie Besserer-Offroy , Bartholomé Delort , Mélanie Vivancos Journal of Medicinal Chemistry, 2017, 60 (8), pp.3303-3313. ⟨10.1021/acs.jmedchem.6b01848⟩ Journal articles hal-02322191v1
	Coarse-Grained Prediction of Peptide Binding to G-Protein Coupled Receptors Bartholomé Delort , Pedro Renault , Landry Charlier , Florent Raussin , Jean Martinez Journal of Chemical Information and Modeling, 2017, 57 (3), pp.562-571. ⟨10.1021/acs.jcim.6b00503⟩ Journal articles hal-02322212v1
	Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein Peter Mercredi , Nadine Bucca , Burk Loeliger , Christy Gaines , Mansi Mehta Journal of Molecular Biology, 2016, 428 (8), pp.1637-1655. ⟨10.1016/j.jmb.2016.03.005⟩ Journal articles hal-02322236v1
	Identification of TAX2 peptide as a new unpredicted anti-cancer agent Albin Jeanne , Emilie Sick , Jerôme Devy , Nicolas Floquet , N. Belloy Oncotarget, 2015, 6, pp.17981-18000. ⟨10.18632/oncotarget.4025⟩ Journal articles hal-01280451v1
	Conformational Equilibrium of CDK/Cyclin Complexes by Molecular Dynamics with Excited Normal Modes Nicolas Floquet , Mauricio g.S. Costa , Paulo r. Batista , Pedro Renault , Paulo m. Bisch Biophysical Journal, 2015, 109 (6), pp.1179-1189. ⟨10.1016/j.bpj.2015.07.003⟩ Journal articles hal-02322259v1
	Coarse-Grained Simulations of the HIV-1 Matrix Protein Anchoring: Revisiting Its Assembly on Membrane Domains. Landry Charlier , Maxime Louet , Laurent Chaloin , Patrick Fuchs , Jean Martinez Biophysical Journal, 2014, 106 (3), pp.577-585. ⟨10.1016/j.bpj.2013.12.019⟩ Journal articles hal-01105330v1
	Design of thrombospondin-binding peptides exhibiting strong anti- angiogenesis and anti-tumor properties A. Jeanne , E. Sick , C. Schneider , Nicolas Floquet , J. Devy FEBS Journal, 2013, 280 (S1), pp.307-307. ⟨10.1111/febs.12340⟩ Journal articles hal-03574560v1
	Conformational restriction of G-proteins Coupled Receptors (GPCRs) upon complexation to G-proteins: A putative activation mode of GPCRs? Maxime Louet , Esra Karakas , Alexandre Perret , David Perahia , Jean Martinez FEBS Letters, 2013, 587 (16), pp.2656-2661. ⟨10.1016/j.febslet.2013.06.052⟩ Journal articles hal-01107226v1
	Interaction between the Elastin Peptide VGVAPG and Human Elastin Binding Protein Charlotte Blanchevoye , Nicolas Floquet , Amandine Scandolera , Stéphanie Baud , Pascal Maurice Journal of Biological Chemistry, 2013, 288 (2), pp.1317-1328. ⟨10.1074/jbc.M112.419929⟩ Journal articles hal-02347668v1
	Interaction between the elastin peptide VGVAPG and human elastin binding protein. Charlotte Blanchevoye , Nicolas Floquet , Amandine Scandolera , Stéphanie Baud , Pascal Maurice Journal of Biological Chemistry, 2013, 288 (2), pp.1317-1328. ⟨10.1074/jbc.M112.419929⟩ Journal articles hal-01109325v1
	Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor. Sophie Mary , Marjorie Damian , Maxime Louet , Nicolas Floquet , Jean-Alain Fehrentz Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (21), pp.8304-9. ⟨10.1073/pnas.1119881109⟩ Journal articles hal-00713574v1
	Dissociation of Membrane-Anchored Heterotrimeric G-Protein Induced by Gα Subunit Binding to GTP. Maxime Louet , Landry Charlier , Jean Martinez , Nicolas Floquet Journal of Chemical Information and Modeling, 2012, 52 (11), pp.3022-3027. ⟨10.1021/ci3003717⟩ Journal articles hal-01109335v1
	Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting. Jean-Daniel Malcor , Nadine Payrot , Marion David , Aude Faucon , Karima Abouzid Journal of Medicinal Chemistry, 2012, 55 (5), pp.2227-41. ⟨10.1021/jm2014919⟩ Journal articles hal-00839126v1
	GDP release preferentially occurs on the phosphate side in heterotrimeric G-proteins. Maxime Louet , Jean Martinez , Nicolas Floquet PLoS Computational Biology, 2012, 8 (7), pp.e1002595. ⟨10.1371/journal.pcbi.1002595⟩ Journal articles hal-01109342v1
	A Concerted Mechanism for Opening the GDP Binding Pocket and Release of the Nucleotide in Hetero-Trimeric G-Proteins Maxime Louet , David Perahia , Jean Martinez , Nicolas Floquet Journal of Molecular Biology, 2011, 411, pp.296-312. ⟨10.1016/j.jmb.2011.05.034⟩ Journal articles hal-00771168v1
	L-Arginine Binding to Human Inducible Nitric Oxide Synthase: An Antisymmetric Funnel Route toward Isoform-Specific Inhibitors? Nicolas Floquet , Jean-François Hernandez , Jean-Luc Boucher , Jean Martinez Journal of Chemical Information and Modeling, 2011, 51, pp.1325-1335. ⟨10.1021/ci100422v⟩ Journal articles hal-00770855v1
	The YSNSG cyclopeptide derived from tumstatin inhibits tumor angiogenesis by down-regulating endothelial cell migration. Jessica Thevenard , Laurent Ramont , Jérome Devy , Bertrand Brassart , Aurélie Dupont-Deshorgue International Journal of Cancer Supplement, 2010, 126 (5), pp.1055-1066. ⟨10.1002/ijc.24688⟩ Journal articles hal-01109849v1
	The YSNSG cyclopeptide derived from tumstatin inhibits tumor angiogenesis by down-regulating endothelial cell migration Jessica Thévenard , Laurent Ramont , Bertrand Brassart , Aurélie Dupont-Deshorgue , Nicolas Floquet International Journal of Cancer, 2010, 126 (5), pp.1055-1066 Journal articles hal-00771934v1
	Involvement of tryptophan W276 and of two surrounding amino acid residues in the high constitutive activity of the ghrelin receptor GHS-R1a C. Goze , Gilbert Berge , Celine M\'Kadmi , Nicolas Floquet , Didier Gagne European Journal of Pharmacology Molecular Pharmacology, 2010, 643 (2-3), pp.153-161. ⟨10.1016/j.ejphar.2010.06.018⟩ Journal articles hal-00583009v1
	Activation of the Ghrelin Receptor is Described by a Privileged Collective Motion: A Model for Constitutive and Agonist-induced Activation of a Sub-class A G-Protein Coupled Receptor (GPCR) Nicolas Floquet , C. Mikadmi , D. Perahia , Didier Gagne , Gilbert Berge Journal of Molecular Biology, 2010, 395 (4), pp.769-784. ⟨10.1016/j.jmb.2009.09.051⟩ Journal articles hal-00485751v1
	The spirocyclopropyl moiety as a methyl surrogate in the structure of L-fucosidase and L-rhamnosidase inhibitors Morwenna Pearson , Nicolas Floquet , Claudia Bello , Pierre Vogel , Richard Plantier-Royon Bioorganic and Medicinal Chemistry, 2009, 17 (23), pp.8020-8026. ⟨10.1016/j.bmc.2009.10.010⟩ Journal articles hal-00439568v1
	The role of aspartyl-rich pentapeptides in comparative complexation of actinide(IV) and iron(III). Part 1 Aurélie Jeanson , Claude Berthon , S. Coantic , Christophe den Auwer , Nicolas Floquet New Journal of Chemistry, 2009, 33 (5), pp.976-985. ⟨10.1039/B813523A⟩ Journal articles hal-00583012v1
	Collective motions in glucosamine-6-phosphate synthase: influence of ligand binding and role in ammonia channelling and opening of the fructose-6-phosphate binding site. Nicolas Floquet , Philippe Durand , Bernard Maigret , Bernard Badet , Marie-Ange Badet-Denisot Journal of Molecular Biology, 2009, 385 (2), pp.653-664. ⟨10.1016/j.jmb.2008.10.032⟩ Journal articles hal-00365799v1
	Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP. Anthony R. Martin , Kishor Mohanan , Delphine Luvino , Nicolas Floquet , Carine Baraguey Organic & Biomolecular Chemistry, 2009, 7 (21), pp.4369-4377. ⟨10.1039/b912616c⟩ Journal articles hal-01109915v1
	Human thrombospondin’s (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: A molecular modeling study Nicolas Floquet , Stéphane Dedieu , Laurent Martiny , Manuel Dauchez , David Perahia Archives of Biochemistry and Biophysics, 2008, 478 (1), pp.103-109. ⟨10.1016/j.abb.2008.07.015⟩ Journal articles hal-01109933v1
	Expression and purification of active human internal His6-tagged l-glutamine: d-Fructose-6P amidotransferase I Celine Richez , Joachim Boetzel , Nicolas Floquet , Kinnera Koteshwar , Julie Stevens Protein Expression and Purification, 2007, 54 (1), pp.45-53. ⟨10.1016/j.pep.2007.01.015⟩ Journal articles hal-02144676v1
	Ammonia channeling in bacterial glucosamine-6-phosphate synthase (Glms): Molecular dynamics simulations and kinetic studies of protein mutants. Nicolas Floquet , Stéphane Mouilleron , Rasha Daher , Bernard Maigret , Bernard Badet FEBS Letters, 2007, 581 (16), pp.2981-7. ⟨10.1016/j.febslet.2007.05.068⟩ Journal articles hal-00161331v1
	Discovery new inhibitors of bacterial glucosamine-6P synthase (GlmS) by docking simulations Nicolas Floquet , C. Richez , P. Durand , Bernard Maigret , B. Badet Bioorganic and Medicinal Chemistry Letters, 2007, 17 (7), pp.1966-1970. ⟨10.1016/j.bmcl.2007.01.052⟩ Journal articles hal-00146254v1
	Structural and antitumor properties of the YSNSG cyclopeptide derived from Tumstatin Jessica Thévenard , Nicolas Floquet , Laurent Ramont , Elise Prost , Jean-Marc Nuzillard Chemistry & biology, 2006, 13, pp.1307-1315 Journal articles hal-00134047v1
	Elastin as a matrikine Laurent Duca , Nicolas Floquet , Alain J.P Alix , Bernard Haye , Laurent Debelle Critical Reviews in Oncology/Hematology, 2004, 49 (3), pp.235-244. ⟨10.1016/j.critrevonc.2003.09.007⟩ Journal articles hal-02330586v1

	Lipids modulate the dynamics of gpcr:β-arrestin interaction Antoniel Gomes , Michela Di Michele , Rita Ann Roessner , Marjorie Damian , Paulo M Bisch 2024 Preprints, Working Papers, ... hal-04790648v1
	Structure of the antidiuretic hormone vasopressin receptor signalling complex. Julien Bous , Hélène Orcel , Nicolas Floquet , Cedric Leyrat , Josephine Lai-Kee-Him 2020 Preprints, Working Papers, ... hal-03088027v1

	Elastin in silico. Alain J.P. Alix , Brigida Bochicchio , Manuel Dauchez , Laurent Debelle , Philippe Derreumaux Second European Symposium ELASTIN 2002, Jul 2002, Acquafredda di Maratea, Italy Conference papers hal-02333204v1

	Nos récepteurs déroulent leur mécanique ! Maxime Louet , Landry Charlier , Jean Martinez , Nicolas Floquet 2013, pp.380:26 Other publications hal-01105310v1

	Structure-function relationships of elastin-derived peptides: determination of a structural motif involved in the peptides-receptor(s) interactions. Nicolas Floquet , Laurent Duca , Stéphanie Héry-Hyunh , Gauthier Moroy , Manuel Dauchez Elastin 2002, 2003 Book sections hal-02333101v1

Nicolas FLOQUET

Publications

Sodium is a negative allosteric regulator of the ghrelin receptor

MDexciteR: Enhanced Sampling Molecular Dynamics by Excited Normal Modes or Principal Components Obtained from Experiments

Allosteric modulation of ghrelin receptor signaling by lipids

Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex

Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

Allosteric modulation of ghrelin receptor signaling by lipids

Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2a Receptor by a Mini-G Protein

Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

Crystal structure and functional domains of the Mambaquaretin-1, a vasopressin type 2 receptor peptide inhibitor for kidney cysts treatment

Structure and Dynamics of the Receptor-Bound Ghrelin Lipopeptide

Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues

Coarse-Grained Prediction of Peptide Binding to G-Protein Coupled Receptors

Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein

Identification of TAX2 peptide as a new unpredicted anti-cancer agent

Conformational Equilibrium of CDK/Cyclin Complexes by Molecular Dynamics with Excited Normal Modes

Coarse-Grained Simulations of the HIV-1 Matrix Protein Anchoring: Revisiting Its Assembly on Membrane Domains.

Design of thrombospondin-binding peptides exhibiting strong anti- angiogenesis and anti-tumor properties

Conformational restriction of G-proteins Coupled Receptors (GPCRs) upon complexation to G-proteins: A putative activation mode of GPCRs?

Interaction between the Elastin Peptide VGVAPG and Human Elastin Binding Protein

Interaction between the elastin peptide VGVAPG and human elastin binding protein.

Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor.

Dissociation of Membrane-Anchored Heterotrimeric G-Protein Induced by Gα Subunit Binding to GTP.

Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting.

GDP release preferentially occurs on the phosphate side in heterotrimeric G-proteins.

A Concerted Mechanism for Opening the GDP Binding Pocket and Release of the Nucleotide in Hetero-Trimeric G-Proteins

L-Arginine Binding to Human Inducible Nitric Oxide Synthase: An Antisymmetric Funnel Route toward Isoform-Specific Inhibitors?

The YSNSG cyclopeptide derived from tumstatin inhibits tumor angiogenesis by down-regulating endothelial cell migration.

The YSNSG cyclopeptide derived from tumstatin inhibits tumor angiogenesis by down-regulating endothelial cell migration

Involvement of tryptophan W276 and of two surrounding amino acid residues in the high constitutive activity of the ghrelin receptor GHS-R1a

Activation of the Ghrelin Receptor is Described by a Privileged Collective Motion: A Model for Constitutive and Agonist-induced Activation of a Sub-class A G-Protein Coupled Receptor (GPCR)

The spirocyclopropyl moiety as a methyl surrogate in the structure of L-fucosidase and L-rhamnosidase inhibitors

The role of aspartyl-rich pentapeptides in comparative complexation of actinide(IV) and iron(III). Part 1

Collective motions in glucosamine-6-phosphate synthase: influence of ligand binding and role in ammonia channelling and opening of the fructose-6-phosphate binding site.

Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP.

Human thrombospondin’s (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: A molecular modeling study

Expression and purification of active human internal His6-tagged l-glutamine: d-Fructose-6P amidotransferase I

Ammonia channeling in bacterial glucosamine-6-phosphate synthase (Glms): Molecular dynamics simulations and kinetic studies of protein mutants.

Discovery new inhibitors of bacterial glucosamine-6P synthase (GlmS) by docking simulations

Structural and antitumor properties of the YSNSG cyclopeptide derived from Tumstatin

Elastin as a matrikine

Lipids modulate the dynamics of gpcr:β-arrestin interaction

Structure of the antidiuretic hormone vasopressin receptor signalling complex.

Elastin in silico.

Nos récepteurs déroulent leur mécanique !

Structure-function relationships of elastin-derived peptides: determination of a structural motif involved in the peptides-receptor(s) interactions.