Olivier Christophe

68
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Publications

Publications

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A fully humanized von Willebrand disease type 1 mouse model as unique platform to investigate novel therapeutic options

Geneviève Mccluskey , Marco Heestermans , Ivan Peyron , Eloise Pascal , Marie Clavel et al.
Haematologica, In press, ⟨10.3324/haematol.2024.286076⟩
Article dans une revue (data paper) hal-04871911 v1

Alternative AAV gene therapy for hemophilia A using expression of Bi8, a novel single-chain FVIII-mimetic antibody

Vincent Muczynski , Olivier Christophe , Lewis Tanner , Charlotte Vayssiere , Alice Guérin et al.
Article dans une revue hal-05299843 v1

Factor VIII restores bone parameters and modulates muscle proteo-metabolome in Factor VIII knockout male mice

Antoine Babuty , Javier Muñoz-Garcia , Olivier Christophe , Laurie Fradet , Manon Taupin et al.
Bone Research, In press
Article dans une revue hal-05319155 v1
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A bispecific nanobody for the treatment of von Willebrand disease type 1

Ivan Peyron , Caterina Casari , Geneviève Mccluskey , Stéphanie Roullet , Vincent Licari et al.
Article dans une revue hal-05263486 v1

Clinical, Phenotypic and Genotypic Characteristics of Von Willebrand Disease in Afro‐Caribbeans: Results From a Study in Martinique Island, French West Indies

Marie‐daniéla Dubois , Olivier Nicolas Pierre-Louis , Serge Pierre-Louis , Pierre Boisseau , Cécile Denis et al.
Haemophilia, 2025, 31 (3), pp.458-476. ⟨10.1111/hae.70003⟩
Article dans une revue hal-05306019 v1
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Differences in venous clot structures between hemophilic mice treated with emicizumab versus factor VIII or factor VIIIFc

Thibaud Sefiane , Hortense Maynadié , Carmen Escurola Ettingshausen , Vincent Muczynski , Xavier Heiligenstein et al.
Article dans une revue hal-04449388 v1
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Von Willebrand factor: how unique structural adaptations support and coordinate its complex function

Peter J. Lenting , Cécile Denis , Olivier Christophe
Blood, 2024, 144 (21), pp.2174-2184. ⟨10.1182/blood.2023023277⟩
Article dans une revue hal-04817254 v1
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Thrombin generation on vascular cells in the presence of factor VIII and/or emicizumab

Sénadé Atsou , Célia Schellenberg , Jeremy Lagrange , Patrick Lacolley , Peter Lenting et al.
Journal of Thrombosis and Haemostasis, 2024, 22 (1), pp.112-125. ⟨10.1016/j.jtha.2023.09.017⟩
Article dans une revue hal-04449373 v1
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Fitusiran reduces bleeding in factor X–deficient mice

Sebastien Verhenne , Geneviève Mccluskey , Hortense Maynadié , Frédéric Adam , Caterina Casari et al.
Blood, 2024, 144 (2), pp.227-236. ⟨10.1182/blood.2023023404⟩
Article dans une revue hal-04654300 v1
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Transplacental delivery of therapeutic proteins by engineered IgG: a step towards perinatal replacement therapy

Angelina Mimoun , Melissa Bou Jaoudeh , Sandrine Delignat , Victoria Daventure , Alejandra Reyes Ruiz et al.
Journal of Thrombosis and Haemostasis, In press, ⟨10.1016/j.jtha.2023.05.021⟩
Article dans une revue hal-04117814 v1

Angiopoietin-2 binds to multiple interactive sites within von Willebrand factor

Alexis Texier , Peter Lenting , Cécile Denis , Stéphanie Roullet , Olivier Christophe
Research and Practice in Thrombosis and Haemostasis, 2023, HITH, 7 (7), pp.102204. ⟨10.1016/j.rpth.2023.102204⟩
Article dans une revue (data paper) hal-04449394 v1
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A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD

Claire Kizlik-Masson , Ivan Peyron , Stéphane Gangnard , Gaelle Le Goff , Solen Lenoir et al.
Blood, 2023, 141 (12), pp.1457-1468. ⟨10.1182/blood.2022017569⟩
Article dans une revue inserm-04258451 v1
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Imlifidase, a new option to optimize the management of patients with hemophilia A on emicizumab

Melissa Bou-Jaoudeh , Angelina Mimoun , Sandrine Delignat , Ivan Peyron , Ladislas Capdevila et al.
Journal of Thrombosis and Haemostasis, 2023, 21 (10), pp.2776-2783. ⟨10.1016/j.jtha.2023.06.038⟩
Article dans une revue hal-04217783 v1
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Over‐expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice

Guillaume Postic , Jean Solarz , Cécile Loubière , Janany Kandiah , Jaysen Sawmynaden et al.
Journal of Cellular and Molecular Medicine, 2023, 27 (15), pp.228-2238. ⟨10.1111/jcmm.17817⟩
Article dans une revue anses-04164790 v1
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Over‐expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice

Guillaume Postic , Jean Solarz , Cécile Loubière , Janany Kandiah , Jaysen Sawmynaden et al.
Journal of Cellular and Molecular Medicine, 2023, 27 (15), pp.2228-2238. ⟨10.1111/jcmm.17817⟩
Article dans une revue hal-04294741 v1

Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen

Chinaemerem Onyishi , Guillaume Desanti , Alex Wilkinson , Samuel Lara-Reyna , Eva-Maria Frickel et al.
Nature Communications, 2023, 14 (1), pp.4895. ⟨10.1038/s41467-023-40635-w⟩
Article dans une revue hal-04449439 v1
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Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in Von Willebrand disease murine models

Stéphanie Roullet , Norman Luc , Julie Rayes , Jean Solarz , Dante Disharoon et al.
Blood, 2023, 141 (23), pp.2891-2900. ⟨10.1182/blood.2022018956⟩
Article dans une revue inserm-04066466 v1

Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor

Elena Barbon , Charlotte Kawecki , Solenne Marmier , Aboud Sakkal , Fanny Collaud et al.
Gene Therapy, 2023, 30 (3-4), pp.245-254. ⟨10.1038/s41434-020-00218-6⟩
Article dans une revue hal-04455812 v1
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In vitro recovery of FIX clotting activity as a marker of highly functional hepatocytes in a hemophilia B iPSC model

Eléanor Luce , Clara Steichen , Mickaël Allouche , Antonietta Messina , Jean-Marie Heslan et al.
Hepatology, 2022, 75 (4), pp.866-880. ⟨10.1002/hep.32211⟩
Article dans une revue inserm-04251849 v1

Antithrombotic potential of a single‐domain antibody enhancing the activated protein C‐cofactor activity of protein S

Josepha Sedzro , Frédéric Adam , Claire Auditeau , Elsa Bianchini , Allan de Carvalho et al.
Journal of Thrombosis and Haemostasis, 2022, 20 (7), pp.1653-1664. ⟨10.1111/jth.15736⟩
Article dans une revue inserm-04455219 v1

Identification of von Willebrand factor D4 domain mutations in patients of Afro‐Caribbean descent: In vitro characterization

Marie‐daniéla Dubois , Ivan Peyron , Olivier‐nicolas Pierre-Louis , Serge Pierre-Louis , Johalène Rabout et al.
Research and Practice in Thrombosis and Haemostasis, 2022, 6 (4), pp.e12737. ⟨10.1002/rth2.12737⟩
Article dans une revue hal-05306074 v1
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Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor

Elena Barbon , Charlotte Kawecki , Solenne Marmier , Aboud Sakkal , Fanny Collaud et al.
Gene Therapy, 2021, 30 (3-4), pp.245-254. ⟨10.1038/s41434-020-00218-6⟩
Article dans une revue (data paper) hal-04324328 v1

A Combination of Two Variants p. (Val510 =) and p. (Pro2145Thrfs * 5), Responsible for von Willebrand Disease Type 3 in a Caribbean Patient

Marie Daniela Dubois , Serge Pierre-Louis , Johalène Rabout , Cécile Denis , Olivier Christophe et al.
TH Open : Companion Journal To Thrombosis and Haemostasis, 2020, 04 (04), pp.e318-e321. ⟨10.1055/s-0040-1718703⟩
Article dans une revue hal-04683162 v1

Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Ivan Peyron , Claire Kizlik-Masson , Marie-Daniéla Dubois , Sénadé Atsou , Stephen Ferrière et al.
Research and Practice in Thrombosis and Haemostasis, 2020, 4 (7), pp.1087-1100. ⟨10.1002/rth2.12420⟩
Article dans une revue hal-05320380 v1

A Combination of Two Variants p. (Val510 =) and p. (Pro2145Thrfs * 5), Responsible for von Willebrand Disease Type 3 in a Caribbean Patient

Marie Daniela Dubois , Serge Pierre-Louis , Johalène Rabout , Cécile Denis , Olivier Christophe et al.
TH Open : Companion Journal To Thrombosis and Haemostasis, 2020, 04 (04), pp.e318-e321. ⟨10.1055/s-0040-1718703⟩
Article dans une revue hal-05320384 v1

A Combination of Two Variants p. (Val510 =) and p. (Pro2145Thrfs * 5), Responsible for von Willebrand Disease Type 3 in a Caribbean Patient

Marie Daniela Dubois , Serge Pierre-Louis , Johalène Rabout , Cécile Denis , Olivier Christophe et al.
TH Open : Companion Journal To Thrombosis and Haemostasis, 2020, 04 (04), pp.e318-e321. ⟨10.1055/s-0040-1718703⟩
Article dans une revue hal-05306098 v1
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Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Ivan Peyron , Claire Kizlik‐masson , Marie‐daniéla Dubois , Sénadé Atsou , Stephen Ferrière et al.
Research and Practice in Thrombosis and Haemostasis, 2020, 4 (7), pp.1087-1110. ⟨10.1002/rth2.12420⟩
Article dans une revue hal-03116405 v1
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A Combination of Two Variants p. (Val510 =) and p. (Pro2145Thrfs * 5), Responsible for von Willebrand Disease Type 3 in a Caribbean Patient

Marie Daniela Dubois , Marie Daniela Dubois , Serge Pierre-Louis , Johalène Rabout , Cécile Denis et al.
TH Open, 2020, 04 (04), pp.e318-e321. ⟨10.1055/s-0040-1718703⟩
Article dans une revue hal-03121861 v1
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A single‐domain antibody that blocks factor VIIa activity in the absence but not presence of tissue factor

Stephen Ferrière , Charlotte Kawecki , Jean‐françois Ottavi , Cécile Denis , Alexandre Kauskot et al.
Journal of Thrombosis and Haemostasis, 2019, 17 (12), pp.2035-2046. ⟨10.1111/jth.14615⟩
Article dans une revue hal-04456634 v1
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Correction of bleeding in experimental severe hemophilia A by systemic delivery of factor VIII- encoding mRNA

Jules Russick , Sandrine Delignat , Peter Milanov , Olivier D. Christophe , Gábor Boros et al.
Haematologica, 2019, 105 (4), pp.1129-1137. ⟨10.3324/haematol.2018.210583⟩
Article dans une revue hal-02328193 v1
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Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor

Nikolett Wohner , Vincent Muczynski , Amel Mohamadi , Paulette Legendre , Valérie Proulle et al.
Haematologica, 2018, 103 (4), pp.728-737. ⟨10.3324/haematol.2017.175216⟩
Article dans une revue hal-04456818 v1

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

Amine Meliani , Florence Boisgerault , Romain Hardet , Solenne Marmier , Fanny Collaud et al.
Nature Communications, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Article dans une revue hal-04495633 v1

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

Amine Meliani , Florence Boisgerault , Romain Hardet , Solenne Marmier , Fanny Collaud et al.
Nature Communications, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Article dans une revue hal-04324439 v1

Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor

Nikolett Wohner , Vincent Muczynski , Amel Mohamadi , Paulette Legendre , Valérie Proulle et al.
Haematologica, 2018, 103 (4), pp.728-737. ⟨10.3324/haematol.2017.175216⟩
Article dans une revue pasteur-03209471 v1

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski , Caterina Casari , François Moreau , Gabriel Ayme , Charlotte Kawecki et al.
Blood, 2018, 132 (11), pp.1193-1197. ⟨10.1182/blood-2018-01-829523⟩
Article dans une revue pasteur-03209466 v1
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Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets

Caterina Casari , David Paul , Sophie Susen , Cécile Lavenu-Bombled , Annie Harroche et al.
Blood Advances, 2018, 2 (12), pp.1417-1428. ⟨10.1182/bloodadvances.2017014290⟩
Article dans une revue hal-04376230 v1
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A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski , Caterina Casari , François Moreau , Gabriel Aymé , Charlotte Kawecki et al.
Blood, 2018, 132 (11), pp.1193-1197. ⟨10.1182/blood-2018-01-829523⟩
Article dans une revue (data paper) hal-04456589 v1

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

Vincent Muczynski , Gabriel Aymé , Véronique Regnault , Marc Vasse , Delphine Borgel et al.
Blood, 2017, 129 (17), pp.2443-2454. ⟨10.1182/blood-2016-06-724351⟩
Article dans une revue hal-03567147 v1

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

Vincent Muczynski , Gabriel Ayme , Véronique Regnault , Marc Vasse , Delphine Borgel et al.
Blood, 2017, 129 (17), pp.2443-2454. ⟨10.1182/blood-2016-06-724351⟩
Article dans une revue pasteur-03209468 v1

Enhanced liver gene transfer and evasion of preexisting humoral immunity with exosome-enveloped AAV vectors

Amine Meliani , Florence Boisgerault , Zachary Fitzpatrick , Solenne Marmier , Christian Leborgne et al.
Blood Advances, 2017, 1 (23), pp.2019-2031. ⟨10.1182/bloodadvances.2017010181⟩
Article dans une revue hal-04324460 v1

A Novel Single-Domain Antibody Against von Willebrand Factor A1 Domain Resolves Leukocyte Recruitment and Vascular Leakage During Inflammation—Brief Report

Gabriel Ayme , Frédéric Adam , Paulette Legendre , Amine Bazaa , Valérie Proulle et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017, 37 (9), pp.1736-1740. ⟨10.1161/ATVBAHA.117.309319⟩
Article dans une revue pasteur-03209478 v1

Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis

Abdel-Majid Khatib , Rachid Lahlil , Martin Hagedorn , Claudine Delomenie , Olivier Christophe et al.
Oncotarget, 2016, 7 (11), pp.12102-12120. ⟨10.18632/oncotarget.7728⟩
Article dans une revue hal-03519971 v1

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B

Alexandre Kauskot , Sonia Poirault-Chassac , Frédéric Adam , Vincent Muczynski , Gabriel Ayme et al.
JCI Insight, 2016, 1 (16), pp.e88643. ⟨10.1172/jci.insight.88643⟩
Article dans une revue hal-03209475 v1

A consistent in vivo factor VIII-equivalence is unlikely to exist for non-factor therapies

Hortense Maynadié , Thibaud Sefiane , Genevieve Mccluskey , Marie Clavel , Ivan Peyron et al.
Congrès Français d'Hémostase, Société Française de Thrombose et d'Hémostase, Sep 2024, Lille, France
Communication dans un congrès hal-04701045 v1

L'angiopoïétine-2 se lie à de multiples sites interactifs au sein du facteur von Willebrand

Alexis Texier , Peter J. Lenting , Cécile Denis , Stéphanie Roullet , Olivier Christophe
44ème congrès de la Société Française d'Hématologie, Société Française d'Hématologie, Mar 2024, Paris, France. pp.P327, Abstract 18-03
Communication dans un congrès inserm-04541054 v1

L'angiopoïétine-2 se lie à de multiples sites interactifs au sein du facteur von Willebrand

Alexis Texier , Peter J. Lenting , Cécile Denis , Stéphanie Roullet , Olivier Christophe
44e congrès annuel de la Société Française d’Hématologie, Société Française d’Hématologie, Mar 2024, Paris, France. p 327, abstract 18-03
Communication dans un congrès hal-04654288 v1

Fitusiran-treatment modulates the ratio between alpha- and beta-antithrombin isoforms

Geneviève Mccluskey , Hortense Maynadié , Caterina Casari , Delphine Borgel , Laurent Frenzel et al.
Congrès Français d'Hémostase, Société Française de Thrombose et d'Hémostase, Sep 2024, Lille, France
Communication dans un congrès hal-04701035 v1

Fitusiran displays efficient pro-hemostatic activity in a mouse model of inducible factor X-deficiency

Genevieve Mccluskey , Sebastien Verhenne , Hortense Maynadié , Cécile Denis , Olivier Christophe et al.
World Federation of Hemophilia, World Federation of Hemophilia, Apr 2024, Madrid, Spain
Communication dans un congrès hal-04654270 v1

A single-domain antibody enhancing protein S activity reduces vaso-occlusion in two murine models of sickle cell disease

Claire Auditeau , Thiago Maciel , Josepha Sedzro , Camille Roussel , Aurélie Fricot-Monsinjon et al.
European Congress on Thrombosis and Haemostasis, Sep 2023, Valence (Espagne), Spain
Communication dans un congrès hal-04501174 v1

Llama-derived single-domain antibodies blocking tissue factor pathway inhibitor and increasing thrombin generation in FVIII- and FX-deficient plasma

Francois Saller , Ivan Peyron , Andrea Ruty , Saenjamsai P , Claire Auditeau et al.
European Congress on Thrombosis and Haemostasis, Sep 2023, Valence (Espagne), Spain
Communication dans un congrès hal-04501177 v1

A FVIII-Mimetic Bispecific Antibody with an Embedded Self-Regulation Mechanism Reduces the Risk of Prothrombotic Events for the Treatment of Haemophilia a

Vincent Muczynski , Angel Smith , Thibaud Sefiane , Olivier Christophe , Peter J. Lenting et al.
ASH abstracts, Nov 2022, San Diego (CA), United States. pp.677-678, ⟨10.1182/blood-2022-169482⟩
Communication dans un congrès hal-04501469 v1

Transplacental Delivery of Maternal FVIII for Induction of FVIII-specific Immune Tolerance

Angelina Mimoun , Melissa Bou Jaoudeh , Ivan Peyron , Victoria Daventure , Sandrine Delignat et al.
Hybrid Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2021, Philadelphia (Pennsylvania), United States. pp.Abstract OC 14.1
Communication dans un congrès hal-04501088 v1

Antithrombotic Potential of a Single-domain Antibody Enhancing the Anticoagulant Activity of Protein S

Josepha Sedzro , Frédéric Adam , Allan De Carvalho , Elsa P Bianchini , Ivan Peyron et al.
Hybrid Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2021, Philadelphia (Pennsylvania), United States. pp.Abstract OC 60.2
Communication dans un congrès hal-04501112 v1

Caractérisation d’une nanobody qui potentialize l’activité cofacteur de la protéine C active de la protéine S

Sedzro Jc , Francois Saller , Frédéric Adam , De Carvalho , Sophie Gandrille et al.
40ème congrès de la Société Française d’Hématologie, Société Française d’Hématologie, Sep 2020, Paris, France. pp.Page 39, Abstract 04-01
Communication dans un congrès hal-04501074 v1

p.(Pro2145Thrfs*5) et p.(Cys2216Phefs*9), deux Nouvelles mutations identifiées dans le domaine D4 du facteur von Willebrand chez des patientes d’origine afro-caribéenne

Marie Daniela Dubois , Serge Pierre-Louis , Johalène Rabout , Cécile Denis , Olivier Christophe et al.
40ème congrès de la Société Française d’Hématologie, Société Française d’Hématologie, Sep 2020, Paris, France. p 50, Abstract 05-07
Communication dans un congrès hal-04501081 v1

A inducible mouse model of Factor X deficiency to test novel FX therapeutics

Sebastien Verhenne , Loubiere C , Cécile Denis , Peter J. Lenting , Olivier Christophe
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia. pp.Abstract OC 28.4
Communication dans un congrès hal-04499851 v1

Von Willebrand factor induces human vascular smooth muscle cells proliferation through low density lipoprotein-related receptor 4 and alphavbeta3 integrin

Morel Worou , Melusine Didelot , Vincent Muczynski , Raoul A , Paulette Legendre et al.
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia
Communication dans un congrès hal-04498513 v1

Développement d’un modèle de souris avec un déficit inductible en facteur X

Sebastien Verhenne , Loubière Cécile , Elena Barbon , F Mingozzi , Cécile Denis et al.
39th Congress of the Société Française d’Hématologie, Société Française d’Hématologie, Mar 2019, Paris, France. pp.Abstract 12-29
Communication dans un congrès hal-04498403 v1

Targeting Protease Nexin-1, a natural anticoagulant to control bleeding in hemophilia A

Karen Aymonnier , Charlotte Kawecki , Laurence Venisse , Emmanuelle de Raucourt , Olivier Christophe et al.
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia. pp.Abstract OC 75.3
Communication dans un congrès hal-04498448 v1

La Protéase Nexine-1, un inhibiteur physiologique de la thrombine, cible potentielle dans le traitement de l’hémophilie.

Karen Aymonnier , Charlotte Kawecki , Laurence Venisse , Emmanuelle de Raucourt , Olivier Christophe et al.
38th Congress of the Société Française d’Hématologie, Société Française d’Hématologie, Mar 2018, PARIS, France. p 133, Abstract 12-59
Communication dans un congrès hal-04457483 v1

The potential use of nanobodies delivered via AAV vectors in the treatment of hemophilia

Elena Barbon , Gabriel Ayme , Amel Mohamadi , Cécile Denis , Olivier Christophe et al.
21st Annual Meeting of the American Society of Gene and Cell Therapy, American Society of Gene and Cell Therapy, May 2018, CHICAGO, United States
Communication dans un congrès hal-04457494 v1

Targeting Protease Nexin-1, a natural anticoagulant to control bleeding in hemophilia A

Karen Aymonnier , Charlotte Kawecki , Laurence Venisse , Emmanuelle de Raucourt , Olivier Christophe et al.
2nd European Congress on Thrombosis and Haemostasis, Oct 2018, Marseille, France
Communication dans un congrès hal-04457505 v1

Protein engineering in FLT210, a Potent Next Generation AAV-hFVIII Vector Candidate

Tihomir Dodev , Petya Kalcheva , Azadeh Kia , Samantha Correia , Caterina Casari et al.
Protein Engineering Summit PEGS, Aug 2020, Boston - online, United States
Poster de conférence hal-04461544 v1

Transplacental delivery of maternal factor VIII for induction of immune tolerance to therapeutic factor VIII

Angelina Mimoun , Melissa Bou Jaoudeh , Ivan Peyron , Daventure V , Sandrine Delignat et al.
Virtual Congress of the International Society on Thrombosis and Haemostasis, Jul 2020, Milan (Virtual), Italy. Res. Pract. Thromb. Haemost, 4 (Suppl. 1), pp.Abstract PB0177, 2020
Poster de conférence hal-04501045 v1

Development of single domain antibodies targeting protease nexin-1 as a strategy for hemophilia treatment

Charlotte Kawecki , Karen Aymonnier , Laurence Venisse , Véronique Arocas , Olivier Christophe et al.
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia. Res. Pract. Thromb. Haemost, 3 (Suppl. 1), pp.Abstract PB0316, 2019
Poster de conférence hal-04499858 v1

Modulation of the platelet count by Romiplostim and inhibitors of LIM kinase in genetically-engineered von Willebrand disease type 2B mice: in vivo evaluation of haemostatic efficiency.

Mathilde Cheptou , Frédéric Adam , Olivier Christophe , Peter Lenting , Cécile Denis et al.
ECTH, 2018, Oct 2018, Marseille, France
Poster de conférence hal-04455308 v1

Design and Characterization of FLT210, a Potent Next Generation AAV-hFVIII Vector Candidate

Azadeh Kia , Fabrizio Comper , Samantha Correia , Caterina Casari , Segen Negash et al.
61 ASH Annual Meeting, Blood, 134 (Supplement_1), pp.4638-4638, 2019, ⟨10.1182/blood-2019-128490⟩
Proceedings/Recueil des communications hal-04461585 v1

Thrombin-mediated activation of factor VIII is insufficient to produce all necessary cofactor activity in vivo

Charlotte Kawecki , Ivan Peyron , Amine Bazaa , Vincent Muczynski , Stephen Ferrière et al.
Congress of the International Society of Thrombosis and Haemostasis, Research and Practice in Thrombosis and Haemostasis, 3, pp.1-891, 2019, ⟨10.1002/rth2.12229⟩
Proceedings/Recueil des communications hal-04461945 v1