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Pascale MARCHOT

103
Documents
Current affiliations

Presentation

AFMB lab (AMU-CNRS) "Architecture et Fonction des Macromolécules Biologiques" laboratory

Publications

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Report from the 29th Meeting on Toxinology, “Toxins: From the Wild to the Lab”, Organized by the French Society of Toxinology on 30 November–1 December 2023

Pascale Marchot , Ziad Fajloun , Christian Legros , Évelyne Benoit , Sylvie Diochot
Toxins, 2024, 16 (3), pp.147. ⟨10.3390/toxins16030147⟩
Journal articles hal-04508917v1
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The Cyclic Imine Core Common to the Marine Macrocyclic Toxins Is Sufficient to Dictate Nicotinic Acetylcholine Receptor Antagonism

Yves Bourne , Gerlind Sulzenbacher , Laurent Chabaud , Rómulo Aráoz , Zoran Radić
Marine drugs, 2024, Marine Biotoxins 2.0, 22 (4), pp.149. ⟨10.3390/md22040149⟩
Journal articles hal-04542228v1
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The ESTHER database on alpha/beta hydrolase fold proteins - An overview of recent developments

Arnaud Chatonnet , Michel Perochon , Eric Velluet , Pascale Marchot
Chemico-Biological Interactions, 2023, 383, pp.110671. ⟨10.1016/j.cbi.2023.110671⟩
Journal articles hal-04195109v1
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Report from the 28th Meeting on Toxinology, “Toxins: What’s up, Doc?”, Organized by the French Society of Toxinology on 28–29 November 2022

Pascale Marchot , Évelyne Benoit , Ziad Fajloun , Sylvie Diochot
Toxins, 2023, 15 (126), pp.1-25. ⟨10.3390/toxins15020126⟩
Journal articles hal-03978955v1
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Obituary - Hervé Paul Marie Antoine ROCHAT 1937–2023

Marie-France Martin-Eauclaire , Pascale Marchot
Toxicon, 2023, 233, pp.107249. ⟨10.1016/j.toxicon.2023.107249⟩
Journal articles hal-04195329v1
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Report from the 27th (Virtual) Meeting on Toxinology, “Toxins: Mr Hyde or Dr Jekyll?”, Organized by the French Society of Toxinology, 9–10 December 2021

Daniel Ladant , Pascale Marchot , Sylvie Diochot , Gilles Prévost , Michel Popoff
Toxins, 2022, 14 (110), pp.1-32. ⟨10.3390/toxins14020110⟩
Journal articles hal-03551958v1
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Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1

Jorge Ramirez-Franco , Kévin Debreux , Johanna Extremet , Yves Maulet , Maya Belghazi
Brain - A Journal of Neurology , 2022, pp.awac218. ⟨10.1093/brain/awac218⟩
Journal articles hal-03701887v1
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Comparative mapping of selected structural determinants on the extracellular domains of cholinesterase-like cell-adhesion molecules.

Davide Comoletti , Laura Trobiani , Arnaud Chatonnet , Yves Bourne , Pascale Marchot
Neuropharmacology, 2021, 184, pp.108381. ⟨10.1016/j.neuropharm.2020.108381⟩
Journal articles hal-03021748v1
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The Ig-like domain of Punctin/MADD-4 is the primary determinant for interaction with the ectodomain of neuroligin NLG-1

Semeli Platsaki , Xin Zhou , Bérangère Pinan-Lucarré , Vincent Delauzun , Haijun Tu
Journal of Biological Chemistry, 2020, pp.16267-16279. ⟨10.1074/jbc.RA120.014591⟩
Journal articles hal-03021788v1
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The neuroligins and the synaptic pathway in Autism Spectrum Disorder.

Laura Trobiani , Maria Meringolo , Tamara Diamanti , Yves Bourne , Pascale Marchot
Neuroscience and Biobehavioral Reviews, 2020, 119, pp.37-51. ⟨10.1016/j.neubiorev.2020.09.017⟩
Journal articles hal-03021773v1
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Report from the 26th Meeting on Toxinology, Bioengineering of Toxins, Organized by the French Society of Toxinology (SFET) and Held in Paris, France, 4-5 December 2019

Pascale Marchot , Sylvie Diochot , Michel R Popoff , Evelyne Benoit
Toxins, 2020, 12 (E31), pp.1-30. ⟨10.3390/toxins12010031⟩
Journal articles hal-02441465v1
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An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes

Arnaud Chatonnet , Xavier Brazzolotto , Thierry Hotelier , Nicolas Lenfant , Pascale Marchot
Chemico-Biological Interactions, 2019, 308 (308), pp.179-184. ⟨10.1016/j.cbi.2019.05.016⟩
Journal articles hal-02269496v1
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Hot Spots for Protein Partnerships at the Surface of Cholinesterases and Related α/β Hydrolase Fold Proteins or Domains—A Structural Perspective

Yves Bourne , Pascale Marchot
Molecules, 2018, 23 (1), ⟨10.3390/molecules23010035⟩
Journal articles hal-01802955v1
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Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors

Jordi Molgó , Pascale Marchot , Rómulo Aráoz , Evelyne Benoit , Bogdan I Iorga
Journal of Neurochemistry, 2017, 142, pp.41 - 51. ⟨10.1111/jnc.13995⟩
Journal articles hal-01661784v1
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Natural genomic amplification of cholinesterase genes in animals

Arnaud Chatonnet , Nicolas Lenfant , Pascale Marchot , Murray E. Selkirk
Journal of Neurochemistry, 2017, Cholinergic Mechanisms, 142 (2), pp.73-81. ⟨10.1111/jnc.13990⟩
Journal articles hal-01608096v1

A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation

Olivier Thoumine , Pascale Marchot
Neuron, 2017, 95 (4), pp.729 - 732. ⟨10.1016/j.neuron.2017.08.001⟩
Journal articles hal-01802853v1

Preface: Cholinergic Mechanisms

Marco Prado , Pascale Marchot , Israel Silman , Marco A.M. Prado
Journal of Neurochemistry, 2017, 142, pp.3 - 6. ⟨10.1111/jnc.14027⟩
Journal articles hal-01802851v1

The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions

Pascal Kessler , Pascale Marchot , Marcela Silva , Denis Servent
Journal of Neurochemistry, 2017, 142, pp.7 - 18. ⟨10.1111/jnc.13975⟩
Journal articles hal-01802811v1

Relationships of human alpha/beta hydrolase fold proteins and other organophosphate-interacting proteins

Nicolas Lenfant , Yves Bourne , Pascale Marchot , Arnaud Chatonnet
Chemico-Biological Interactions, 2016, 259 (B, SI), pp.343-351. ⟨10.1016/j.cbi.2016.04.027⟩
Journal articles hal-01439103v1

Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase

Yves Bourne , K. Barry Sharpless , Palmer Taylor , Pascale Marchot
Journal of the American Chemical Society, 2016, 138 (5), pp.1611-1621. ⟨10.1021/jacs.5b11384⟩
Journal articles hal-01439081v1

Crystal Structure of Snake Venom Acetylcholinesterase in Complex with Inhibitory Antibody Fragment Fab410 Bound at the Peripheral Site EVIDENCE FOR OPEN AND CLOSED STATES OF A BACK DOOR CHANNEL

Yves Bourne , Ludovic Renault , Pascale Marchot
Journal of Biological Chemistry, 2015, 290 (3), pp.1522-1535. ⟨10.1074/jbc.M114.603902⟩
Journal articles hal-01439005v1
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Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α12βγδ nAChRs.

Yves Bourne , Gerlind Sulzenbacher , Zoran Radić , Rómulo Aráoz , Morgane Reynaud
Structure (London, England : 1993), 2015, 23 (6), pp.1106-15. ⟨10.1016/j.str.2015.04.009⟩
Journal articles hal-01178822v1
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The neuroligins and their neurexin ligands: from structure to function at the synapse

Yves Bourne , Pascale Marchot
Journal of Molecular Neuroscience, 2014, 53, pp.387-396. ⟨10.1007/s12031-014-0234-6⟩
Journal articles hal-03270068v1

Special Issue on “freshwater and marine toxins”

Evelyne Benoit , César Mattei , Julien Barbier , Pascale Marchot , Jordi Molgó
Toxicon, 2014, 91, pp.1-4. ⟨10.1016/j.toxicon.2014.11.217⟩
Journal articles hal-04215133v1
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Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins

Nicolas Lenfant , Thierry Hotelier , Yves Bourne , Pascale Marchot , Arnaud Chatonnet
Journal of Molecular Neuroscience, 2014, 53 (3), pp.362-369. ⟨10.1007/s12031-013-0194-2⟩
Journal articles hal-01190082v1
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Editorial : Special Issue on "freshwater and marine toxins".

Evelyne Benoit , César Mattei , Julien Barbier , Pascale Marchot , Jordi Molgó
Toxicon, 2014, 91, pp.1-4. ⟨10.1016/j.toxicon.2014.11.217⟩
Journal articles hal-01165542v1
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Molecular Characterization of Monoclonal Antibodies that Inhibit Acetylcholinesterase by Targeting the Peripheral Site and Backdoor Region

Yves Bourne , Ludovic Renault , Sosthène Essono , Grégoire Mondielli , Patricia Lamourette
PLoS ONE, 2013, 8, pp.e77226. ⟨10.1371/journal.pone.0077226⟩
Journal articles hal-01771534v1
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ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions

Nicolas Lenfant , Thierry Hotelier , Eric Velluet , Yves Bourne , Pascale Marchot
Nucleic Acids Research, 2013, 41, pp.423-429. ⟨10.1093/nar/gks1154⟩
Journal articles hal-01218998v1

Proteins with an alpha/beta hydrolase fold: Relationships between subfamilies in an ever-growing superfamily.

Nicolas Lenfant , Thierry Hotelier , Yves Bourne , Pascale Marchot , Arnaud Chatonnet
Chemico-Biological Interactions, 2013, 203 (1), pp.266-268. ⟨10.1016/j.cbi.2012.09.003⟩
Journal articles hal-01837554v1
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Editorial : Special issue on "toxins: from threats to benefits".

Marie-France Martin-Eauclaire , Evelyne Benoit , Pascale Marchot , Julien Barbier , Jordi Molgó
Toxicon, 2013, 75, pp.1-2. ⟨10.1016/j.toxicon.2013.08.001⟩
Journal articles hal-00919888v1

Hydrolase versus other functions of members of the alpha/beta-hydrolase fold superfamily of proteins.

Pascale Marchot , Arnaud Chatonnet
Protein and Peptide Letters, 2012, 19 (2), pp.130-131. ⟨10.2174/092986612799080239⟩
Journal articles hal-00755664v1
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Structural Insights into Antibody Sequestering and Neutralizing of Na+ Channel α-Type Modulator from Old World Scorpion Venom.

Igor P Fabrichny , Grégoire Mondielli , Sandrine Conrod , Marie-France Martin-Eauclaire , Yves Bourne
Journal of Biological Chemistry, 2012, 287 (17), pp.14136-48. ⟨10.1074/jbc.M111.315382⟩
Journal articles hal-00701162v1

Enzymatic activity and protein interactions in alpha/beta hydrolase fold proteins: moonlighting versus promiscuity.

Pascale Marchot , Arnaud Chatonnet
Protein and Peptide Letters, 2012, 19 (2), pp.132-143. ⟨10.2174/092986612799080284⟩
Journal articles hal-00755665v1

Structure-function relationships of the alpha/beta-hydrolase fold domain of neuroligin: A comparison with acetylcholinesterase.

Philippe Leone , Davide Comoletti , Palmer Taylor , Yves Bourne , Pascale Marchot
Chemico-Biological Interactions, 2010, epub ahead of print. ⟨10.1016/j.cbi.2010.01.030⟩
Journal articles hal-00482300v1

Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state.

Yves Bourne , Zoran Radić , Palmer Taylor , Pascale Marchot
Journal of the American Chemical Society, 2010, 132 (51), pp.18292-300. ⟨10.1021/ja106820e⟩
Journal articles hal-00625332v1

Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions.

Philippe Leone , Davide Comoletti , Géraldine Ferracci , Sandrine Conrod , Simon U Garcia
EMBO Journal, 2010, 29 (14), pp.2461-71. ⟨10.1038/emboj.2010.123⟩
Journal articles hal-00625337v1

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism.

Yves Bourne , Zoran Radic , Rómulo Aráoz , Todd T Talley , Evelyne Benoit
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (13), pp.6076-81. ⟨10.1073/pnas.0912372107⟩
Journal articles hal-00464306v1
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Insecticide resistance through mutations in cholinesterases or carboxylesterases : data mining in the ESTHER database

Thierry Hotelier , Vincent Negre , Pascale Marchot , Arnaud Chatonnet
Journal of Pesticide Science, 2010, 35 (3), pp.315-320. ⟨10.1584/jpestics.R10-10⟩
Journal articles hal-02661971v1

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

Ryan Hibbs , Gerlind Sulzenbacher , Jianxin Shi , Todd Talley , Sandrine Conrod
EMBO Journal, 2009, 28 (19), pp.3040 - 3051. ⟨10.1038/emboj.2009.227⟩
Journal articles hal-01809973v1

Structural Analysis of the Synaptic Protein Neuroligin and Its β-Neurexin Complex: Determinants for Folding and Cell Adhesion

Igor Fabrichny , Philippe Leone , Gerlind Sulzenbacher , Davide Comoletti , Meghan Miller
Neuron, 2007, 56 (6), pp.979-991. ⟨10.1016/j.neuron.2007.11.013⟩
Journal articles hal-02989328v1

Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding.

Yves Bourne , Zoran Radic , Gerlind Sulzenbacher , Esther Kim , Palmer Taylor
Journal of Biological Chemistry, 2006, 281 (39), pp.29256-67. ⟨10.1074/jbc.M603018200⟩
Journal articles hal-00134313v1

Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica.

Scott B Hansen , Gerlind Sulzenbacher , Tom Huxford , Pascale Marchot , Yves Bourne
Journal of Molecular Neuroscience, 2006, 30 (1-2), pp.101-2
Journal articles hal-00134314v1

Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein.

Yves Bourne , Scott B Hansen , Gerlind Sulzenbacher , Todd T Talley , Tom Huxford
Journal of Molecular Neuroscience, 2006, 30 (1-2), pp.103-4
Journal articles hal-00134316v1

A. niger protein “EstA”, perhaps a new electrotactin, defines a new class of fungal esterases within the α/β hydrolase fold superfamily

Yves Bourne , Alinda Hasper , Henri Chahinian , Ludovic Renault , Marianick Juin
Chemico-Biological Interactions, 2005, 157-158, pp.395-396. ⟨10.1016/j.cbi.2005.10.072⟩
Journal articles hal-03263187v1

Structural insights into AChE inhibition by monoclonal antibodies

Ludovic Renault , Sosthène Essono , Marianick Juin , Didier Boquet , Jacques Grassi
Chemico-Biological Interactions, 2005, 157-158, pp.397-400. ⟨10.1016/j.cbi.2005.10.073⟩
Journal articles hal-03263196v1

Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE, Chem Biol Interact. 157-158, 159-65.

Yves Bourne , Z. Radic , Kolb H. C. , Sharpless K. B. , P. Taylor
Chemico-Biological Interactions, 2005, 157-158, pp.159-65
Journal articles hal-00018799v1

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

Scott B Hansen , Gerlind Sulzenbacher , Tom Huxford , Pascale Marchot , Palmer Taylor
EMBO Journal, 2005, 24 (20), pp.3635-3646. ⟨10.1038/sj.emboj.7600828⟩
Journal articles hal-03160548v1

Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors,

Yves Bourne , T. T. Talley , Hansen S. B. , P. Taylor , Pascale Marchot
EMBO Journal, 2005, 24, pp.1512-1522
Journal articles hal-00021395v1

New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins,

L. Renault , V. Negre , T. Hotelier , Xavier Cousin , Pascale Marchot
Chemico-Biological Interactions, 2005, 157-158, pp.339-43
Journal articles hal-00018798v1

Expression of the standard scorpion alpha-toxin AaH II and AaH II mutants leading to the identification of some key bioactive elements

C. Legros , B. Ceard , H. Vacher , Pascale Marchot , Bougis P. E.
BBA - Biochimica et Biophysica Acta, 2005, 1723, pp.91 99
Journal articles hal-00021020v1

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

Y. Bourne , H. Kolb , Z. Radic , K. Sharpless , P. Taylor
Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (6), pp.1449-1454. ⟨10.1073/pnas.0308206100⟩
Journal articles hal-03263174v1

Aspergillus niger Protein EstA Defines a New Class of Fungal Esterases within the α/β Hydrolase Fold Superfamily of Proteins

Yves Bourne , Alinda A Hasper , Henri Chahinian , Marianick Juin , Leo H de Graaff
Structure, 2004, 12, pp.677 - 687. ⟨10.1016/j.str.2004.03.005⟩
Journal articles hal-03263177v1
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ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins

Thierry Hotelier , Ludovic Renault , Xavier Cousin , Vincent Negre , Pascale Marchot
Nucleic Acids Research, 2004, 32, pp.D145-D147. ⟨10.1093/nar/gkh141⟩
Journal articles hal-02679326v1

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

Yves Bourne , Palmer Taylor , Zoran Radic , Pascale Marchot
EMBO Journal, 2003, 22 (1), pp.1-12. ⟨10.1093/emboj/cdg005⟩
Journal articles hal-03263169v1

Use of a purified and functional recombinant calcium-channel β4 subunit in surface-plasmon resonance studies

Sandrine Geib , Guillaume Sandoz , Kamel Mabrouk , Alessandra Matavel , Pascale Marchot
Biochemical Journal, 2002, 364 (1), pp.285-292. ⟨10.1042/bj3640285⟩
Journal articles hal-03263160v1

Mechanism of Acetylcholinesterase Inhibition by Fasciculin: A 5-ns Molecular Dynamics Simulation

Kaihsu Tai , Tongye Shen , Richard Henchman , Yves Bourne , Pascale Marchot
Journal of the American Chemical Society, 2002, 124 (21), pp.6153-6161. ⟨10.1021/ja017310h⟩
Journal articles hal-03263152v1

On the kaliotoxin and dendrotoxin binding sites on rat brain synaptosomes

N Tricaud , Pascale Marchot , M.F Martin-Eauclaire
Toxicon, 2000, 38 (12), pp.1749-1758. ⟨10.1016/s0041-0101(00)00104-5⟩
Journal articles hal-03262596v1
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Immunocytochemical Localization and Crystal Structure of Human Frequenin (Neuronal Calcium Sensor 1)

Yves Bourne , Jens Dannenberg , Verena Pollmann , Pascale Marchot , Olaf Pongs
Journal of Biological Chemistry, 2000, 276, pp.11949 - 11955. ⟨10.1074/jbc.m009373200⟩
Journal articles hal-03263149v1

Electron paramagnetic resonance reveals altered topography of the active center gorge of acetylcholinesterase after binding of fasciculin to the peripheral site

Marjeta Šentjurc , Slavko Pečar , Jure Stojan , Pascale Marchot , Zoran Radić
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1999, 1430 (2), pp.349-358. ⟨10.1016/s0167-4838(99)00018-7⟩
Journal articles hal-03262546v1
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Crystal Structure of Mouse Acetylcholinesterase

Yves Bourne , Palmer Taylor , Pierre E Bougis , Pascale Marchot
Journal of Biological Chemistry, 1999, 274 (5), pp.2963-2970. ⟨10.1074/jbc.274.5.2963⟩
Journal articles hal-03262510v1
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Conformational Flexibility of the Acetylcholinesterase Tetramer Suggested by X-ray Crystallography*

Yves Bourne , Jacques Grassi , Pierre E Bougis , Pascale Marchot
Journal of Biological Chemistry, 1999, 274 (43), pp.30370-30376
Journal articles hal-03262571v1

L’interaction fasciculine-acétylcholinestérase

Pascale Marchot
Journal de la Société de Biologie, 1999, 193 (6), pp.505-508. ⟨10.1051/jbio/1999193060505⟩
Journal articles hal-03363691v1

Residues at the Subunit Interfaces of the Nicotinic Acetylcholine Receptor That Contribute to α-Conotoxin M1 Binding

Naoya Sugiyama , Pascale Marchot , Chiaki Kawanishi , Hitoshi Osaka , Brian Molles
Molecular Pharmacology, 1998, 53 (4), pp.787-794. ⟨10.1124/mol.53.4.787⟩
Journal articles hal-03262437v1

Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure

Palmer Taylor , Hitoshi Osaka , Brian Molles , Naoya Sugiyama , Pascale Marchot
Journal of Physiology - Paris, 1998, 92 (2), pp.79-83. ⟨10.1016/S0928-4257(98)80142-3⟩
Journal articles hal-03262491v1

Inhibition of mouse acetylcholinesterase by fasciculin: Crystal structure of the complex and mutagenesis of fasciculin

Pascale Marchot , Yves Bourne , Claudine Prowse , Pierre Bougis , Palmer Taylor
Toxicon, 1998, 36 (11), pp.1613-1622. ⟨10.1016/s0041-0101(98)00154-8⟩
Journal articles hal-03262468v1
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Expression and Activity of Mutants of Fasciculin, a Peptidic Acetylcholinesterase Inhibitor from Mamba Venom*

Pascale Marchot , Claudine N Prowse , Joan Kanter , Shelley Camp , Elizabeth J Ackermann
Journal of Biological Chemistry, 1997, 272 (6), pp.3502-3510
Journal articles hal-03262147v1

Soluble monomeric acetylcholinesterase from mouse: Expression, purification, and crystallization in complex with fasciculin

Pascale Marchot , Raimond B.G. Ravelli , Mia Raves , Yves Bourne , Daniel Vellom
Protein Science, 1996, 5 (4), pp.672-679. ⟨10.1002/pro.5560050411⟩
Journal articles hal-03262129v1

Structure of fasciculin 2 from green mamba snake venom: evidence for unusual loop flexibility

Marie-Hélène Le Du , Pascale Marchot , D. Housset , P. Bougis , J. Navaza
Acta crystallographica Section D : Structural biology [1993-..], 1996, 52 (1), pp.87-92. ⟨10.1107/S0907444995007517⟩
Journal articles hal-03262107v1

Afaacytin, an alphabeta-fibrinogenase from Cerastes cerastes (Horned Viper) Venom, Activates Purified Factor X and Induces Serotonin Release from Human Blood Platelets

Fatirna Laraba-Djebari , Marie-France Martin-Eauclaire , Gerard Mauco , Pascale Marchot
European Journal of Biochemistry, 1995, 233 (3), pp.756-765. ⟨10.1111/j.1432-1033.1995.756_3.x⟩
Journal articles hal-03261962v1

Structural bases for the specificity of cholinesterase catalysis and inhibition

Palmer Taylor , Zoran Radic , Natilie Hosea , Shelley Camp , Pascale Marchot
Toxicology Letters, 1995, 82-83, pp.453-458. ⟨10.1016/0378-4274(95)03575-3⟩
Journal articles hal-03262048v1
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Acetylcholinesterase Inhibition by Fasciculin: Crystal Structure of the Complex

Yves Bourne , Palmer Taylor , Pascale Marchot
Cell, 1995, 83 (3), pp.503-512. ⟨10.1016/0092-8674(95)90128-0⟩
Journal articles hal-03262026v1

Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase

Harald van den Born , Zoran Radić , Pascale Marchot , Palmer Taylor , Igor Tsigelny
Protein Science, 1995, 4 (4), pp.703-715. ⟨10.1002/pro.5560040410⟩
Journal articles hal-03261936v1
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Binding of 125I-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate

Pascale Marchot , Akila Khelif , Yong-Hua Ji , Pascal Mansuelle , Pierre E. Bougis
Journal of Biological Chemistry, 1993, 268 (17), pp.12458-12467
Journal articles hal-03261921v1
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1.9 A resolution structure of fasciculin 1, an anti-acetylcholinesterase toxin from green mamba snake venom

Marie-Hélène Le Du , Pascale Marchot , Pierre E Bougis , Juan-Carlos Fontecilla-Camps
Journal of Biological Chemistry, 1992, 267 (31), pp.22122-22130. ⟨10.2210/pdb1fas/pdb⟩
Journal articles hal-03261892v1

A fibrinogen-clotting serine proteinase from Cerastes cerastes (horned viper) venom with arginine-esterase and amidase activities. Purification, characterization and kinetic parameter determination

Fatima Laraba-Djebari , Marie-France Martin-Eauclaire , Pascale Marchot
Toxicon, 1992, 30 (11), pp.1399-1410. ⟨10.1016/0041-0101(92)90515-7⟩
Journal articles hal-03261910v1

Neurotoxicité chez la souris de portions riches en cystéines des protéines Tat du virus visna et de VIH-1

Isabelle Gourdou , Kamel Mabrouk , Gordon Harkiss , Pascale Marchot , Neil Watt
Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, 1990, 311 (4), pp.149-55
Journal articles hal-03363668v1

Homologues of a K+ channel blocker α-dendrotoxin: characterization of synaptosomal binding sites and their coupling to elevation of cytosolic free calcium concentration

Z.M. Muniz , G.R. Tibbs , Pascale Marchot , P. Bougis , D.G. Nicholls
Neurochemistry International, 1990, 16 (1), pp.105-112. ⟨10.1016/0197-0186(90)90130-L⟩
Journal articles hal-03261848v1
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Crystals of fasciculin 2 from green mamba snake venom. Preparation and preliminary x-ray analysis

Marie Hélène Le Du , Pascale Marchot , Pierre E Bougis , Juan-C Fontecilla-Camps
Journal of Biological Chemistry, 1989, 264 (35), pp.21401-21402. ⟨10.1016/S0021-9258(19)30094-8⟩
Journal articles hal-03261830v1

Selective distinction at equilibrium between the two alpha-neurotoxin binding sites of Torpedo acetylcholine receptor by microtitration

Pascale Marchot , Paule Frachon , Pierre Bougis
European Journal of Biochemistry, 1988, 174 (3), pp.537-542. ⟨10.1111/j.1432-1033.1988.tb14132.x⟩
Journal articles hal-03261788v1

Localization of the toxic site of Naja mossambica cardiotoxins: small synthetic peptides express an in vivo lethality

Pascale Marchot , P.E. Bougis , B. Ceard , J. van Rietschoten , H. Rochat
Biochemical and Biophysical Research Communications, 1988, 153 (2), pp.642-647. ⟨10.1016/s0006-291x(88)81143-4⟩
Journal articles hal-03261771v1

Selective loss of binding sites for the iodinated alpha-neurotoxin I from Naja mossambica mossambica venom upon enzymatic deglycosylation of Torpedo electric organ membranes

Saadia Zeghloul , Pascale Marchot , Pierre Bougis , Catherine Ronin
European Journal of Biochemistry, 1988, 174 (3), pp.543-550. ⟨10.1111/j.1432-1033.1988.tb14133.x⟩
Journal articles hal-03261835v1

Monitoring the purification by high-performance liquid chromatography of cardiotoxins from Naja mossambica mossambica using phase-sensitive two-dimensional nuclear magnetic resonance

Gottfried Otting , Pascale Marchot , Pierre E Bougis , Hervé Rochat , Kurt Wüthrich
European Journal of Biochemistry, 1987, 168 (3), pp.603-607. ⟨10.1111/j.1432-1033.1987.tb13459.x⟩
Journal articles hal-03261768v1

Use of high performance liquid chromatography to demonstrate quantitative variation in components of venom from the scorpion Androctonus australis hector

M.F Martin , Hervé Rochat , Pascale Marchot , Pierre E Bougis
Toxicon, 1987, 25 (5), pp.569-573. ⟨10.1016/0041-0101(87)90293-5⟩
Journal articles hal-03261750v1

In vivo synergy of cardiotoxin and phospholipase A2 from the elapid snake Naja mossambica mossambica

Pierre E Bougis , Pascale Marchot , Hervé Rochat
Toxicon, 1987, 25 (4), pp.427-431. ⟨10.1016/0041-0101(87)90076-6⟩
Journal articles hal-03261744v1

Characterization of elapidae snake venom components using optimized reverse-phase high-performance liquid chromatographic conditions and screening assays for alpha-neurotoxin and phospholipase A2 activities

Pierre E Bougis , Pascale Marchot , Hervé Rochat
Biochemistry, 1986, 25 (22), pp.7235-43. ⟨10.1021/bi00370a070⟩
Journal articles hal-03261741v1
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Diversity in the binding interactions of nicotinic ligands to the nAChRs and associated conformational fluctuations − Insights into the core motif dictating antagonism

Yves Bourne , Gerlind Sulzenbacher , Zoran Radić , Laurent Chabaud , Rómulo Aráoz
RT26 – 26th Meeting of the French Society of Toxinology – Bioengineering of Toxins, French Society of Toxinology (SFET), Dec 2019, Paris, France
Conference papers hal-04469851v1
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Evolution of the first disulfide bond in the cholinesterase-carboxylesterase (coesterase) family: possible consequences for cholinesterase expression in prokaryotes

Arnaud Chatonnet , Xavier Brazzolotto , Thierry Hotelier , Nicolas Lenfant , Pascale Marchot
13th International Meeting on Cholinesterases - 7th International Conference on Paraoxonases, Sep 2018, Hradec Kralove, Czech Republic. pp.55
Conference papers hal-03541521v1

Diversity in the binding interactions of marine phycotoxins to AChBP, the soluble nAChR surrogate

Pascale Marchot , Gerlind Sulzenbacher , Zoran Radic , Rómulo Aráoz , Emmanuelle Reynaud
XVth International Symposium on Cholinergic Mechanisms, Oct 2017, Marseille, France. pp.196, ⟨10.1111/jnc.13925⟩
Conference papers hal-02334376v1

Tracking origin and divergence of Cholinesterases and Neuroligins

Nicolas Lenfant , Thierry Hotelier , Yves Bourne , Pascale Marchot , Arnaud Chatonnet
14. International Symposium on Cholinergic Mechanisms, May 2013, Hangzhou, China. 1 p
Conference papers hal-01837602v1

New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins

Ludovic Renault , Vincent Negre , Thierry Hotelier , Xavier Cousin , Pascale Marchot
8. International Meeting on Cholinesterases, Sep 2004, Perugia, Italy. ⟨10.1016/j.cbi.2005.10.100⟩
Conference papers hal-02764503v1

Diversity in the binding interactions of nicotinic ligands to the nAChRs and associated conformational fluctuations − Insights into the core motif dictating antagonism

Yves Bourne , Gerlind Sulzenbacher , Zoran Radić , Laurent Chabaud , Rómulo Aráoz
RT26 – 26th Meeting of the French Society of Toxinology – Bioengineering of Toxins, Dec 2019, Paris, France
Conference poster hal-04471364v1

ESTHER database: update on the alpha/beta hydrolase fold superfamily of proteins

Arnaud Chatonnet , Pascale Marchot , Yves Bourne , Nicolas Lenfant , Thierry Hotelier
15th International Symposium on Cholinergic Mechanisms (ISCM), Oct 2016, Marseille, France. Wiley-Blackwell, Journal of Neurochemistry, 142 (Supplément 2), 226 p., 2017, Journal of Neurochemistry
Conference poster hal-01604848v1

Evolution of animal cholinesterases

Nicolas Lenfant , Murray E. Selkirk , Thierry Hotelier , Yves Bourne , Pascale Marchot
15th International Symposium on Cholinergic Mechanisms (ISCM), Oct 2016, Marseille, France. Wiley-Blackwell, Journal of Neurochemistry, 142 (Supplément 2), 226 p., 2017, Journal of Neurochemistry
Conference poster hal-01602789v1
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Advances and new technologies in Toxinology

Julien Barbier , Evelyne Benoit , Pascale Marchot , César Mattei , Denis Servent
SFET Publications, Gif-sur-Yvette, France, pp.186, 2010
Books hal-00738636v1
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Toxins and Signalling

Evelyne Benoit , Françoise Goudey-Perriere , Pascale Marchot , Denis Servent
SFET Publications, Châtenay-Malabry, France, pp.204, 2009
Books hal-00738643v1
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Toxines et fonctions cholinergiques neuronales et non neuronales

Evelyne Benoit , Françoise Goudey-Perriere , Pascale Marchot , Denis Servent
SFET Publications, Châtenay-Malabry, France, pp.160, 2008
Books hal-00738646v1

Toxines émergentes: nouveaux risques, (Coll. Rencontres en toxinologie)

Françoise Goudey-Perriere , Evelyne Benoit , Pascale Marchot , Michel R Popoff
F. Goudey-Perrière, E. Benoit, P. Marchot & MR Popoff (Eds.). Librairie Lavoisier, Paris, France, pp.208, 2007
Books hal-00204750v1

Toxines et cancer (Coll. Rencontres en Toxinologie)

Françoise Goudey-Perriere , Evelyne Benoit , Max Goyffon , Pascale Marchot
F. Goudey-Perrière, E. Benoit, M. Goyffon & P. Marchot (Eds.). Librairie Lavoisier, Paris, France, pp.326, 2006
Books hal-00203288v1

Utilisation des " protéines liant l'acétylcholine " (AChBP) en toxinologie structurale : nouveaux exemples

Yves Bourne , Z. Radic , Tt Talley , S. Conrod , P. Taylor
Toxines et fonctions cholinergiques neuronales et non neuronales, SFET Publications, Châtenay-Malabry, France, pp.27-8, 2008, Collection Rencontres en Toxinologie
Book sections hal-00738967v1

Crystal structure of mouse acetylcholinesterase

Yves Bourne , P Taylor , J R Kanter , Pierre E Bougis , Pascale Marchot
Doctor BP, Taylor P, Quinn DM, Rotundo RL, & Gentry MK, Eds. Structure and Function of Cholinesterases and Related Proteins, Plenum Publishing Corp, pp.315-322, 1998, 978-1-4899-1540-5
Book sections hal-03338905v1

Acetylcholinesterase, recombinant monomeric form (mouse) / fasciculin 2 (mamba) complex

Yves Bourne , P Taylor , Pascale Marchot
Macromolecular Structures, Hendrickson WA & Wüthrich K, Eds, pp.8-9, 1996, 978-9997819673
Book sections hal-03338882v1

Structural determinants of fasciculin specificity for acetylcholinesterase

Pascale Marchot , Shelley Camp , Zoran Radić , Pierre E Bougis , Palmer Taylor
Enzymes of the Cholinesterase Family, Plenum Publishing Corp, 1995, 978-1-4899-1051-6
Book sections hal-03338447v1

Fasciculin 1 (Green mamba)

Marie-Hélène Le Du , Pascale Marchot , Pierre E Bougis , Juan Carlos Fontecilla-Camps
Macromolecular Structures, Hendrickson WA & Wüthrich K, pp.152-153, 1993, 978-1859221884
Book sections hal-03338432v1