PB

Philippe BERTRAND

Maitre de Conférences HDR classe exceptionnel
29
Documents

Présentation


Compétences

Synthèse organique épigénétique chimie médicinale immunologie vectorisation nanoparticules

Publications

Publications

Image document

Benign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases

Michele Rossi , Bianca Martinengo , Eleonora Diamanti , Alessandra Salerno , Nicola Rizzardi et al.
ACS Medicinal Chemistry Letters, 2024, 15 (9), pp.1506 - 1515. ⟨10.1021/acsmedchemlett.4c00242⟩
Article dans une revue inserm-04731809 v1

Selective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell proliferation

Rafael Rincon , Isabel Coira , Antoine Richieu , Fedaa Attana , Muriel Urwyler et al.
Cell Death Discovery, 2024, ⟨10.1101/2024.05.14.594071⟩
Article dans une revue hal-05023113 v1

Benign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases

Michele Rossi , Bianca Martinengo , Eleonora Diamanti , Alessandra Salerno , Nicola Rizzardi et al.
ACS Medicinal Chemistry Letters, 2024, 15 (9), pp.1506-1515. ⟨10.1021/acsmedchemlett.4c00242⟩
Article dans une revue hal-05023101 v1
Image document

Evaluation of Aquivion® as Recyclable Superacid Solid Catalyst in the Oxidation of Furfurylamines with Hydrogen Peroxide to 3‐Hydroxypyridines

Antoine Richieu , Philippe Bertrand
ChemistrySelect, 2023, 8 (42), ⟨10.1002/slct.202303423⟩
Article dans une revue hal-04736253 v1

Aptamers Targeting the PD-1/PD-L1 Axis: A Perspective

Philippe Bertrand
Journal of Medicinal Chemistry, 2023, 66 (16), pp.10878-10888. ⟨10.1021/acs.jmedchem.3c00551⟩
Article dans une revue hal-05023105 v1
Image document

Convergent micro-wave assisted synthesis of quinazolinone and its precursor using the bio-sourced solvent pinane

Antoine Richieu , Philippe Bertrand
RSC Advances, 2023, 13, pp.20646-20650. ⟨10.1039/d3ra03702a⟩
Article dans une revue hal-05023059 v1
Image document

Inside PD-1/PD-L1,2 with their inhibitors

Nicolas Boisgerault , Philippe Bertrand
European Journal of Medicinal Chemistry, 2023, 256, pp.115465. ⟨10.1016/j.ejmech.2023.115465⟩
Article dans une revue hal-05023020 v1
Image document

Evaluation of Aquivion® as Recyclable Superacid Solid Catalyst in the Oxidation of Furfurylamines with Hydrogen Peroxide to 3‐Hydroxypyridines

Antoine Richieu , Philippe Bertrand
ChemistrySelect, 2023, 8, ⟨10.1002/slct.202303423⟩
Article dans une revue hal-05023037 v1
Image document

Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling

Samuel Bouchet , Camille Linot , Dusan Ruzic , Danica Agbaba , Benoit Fouchaq et al.
ACS Medicinal Chemistry Letters, 2019, 10 (6), pp.863-868. ⟨10.1021/acsmedchemlett.8b00440⟩
Article dans une revue inserm-02265954 v1
Image document

Epigenetic metalloenzymes

Christophe Blanquart , Camille Linot , Pierre-François Cartron , Daniela Tomaselli , Antonello Mai et al.
Current Medicinal Chemistry, 2019, 26 (15), pp.2748-2785. ⟨10.2174/0929867325666180706105903⟩
Article dans une revue inserm-01885512 v1
Image document

The ROMP: A Powerful Approach to Synthesize Novel pH-Sensitive Nanoparticles for Tumor Therapy

Philippe Bertrand , Christophe Blanquart , Valérie Héroguez
Biomolecules, 2019, 9 (2), pp.60. ⟨10.3390/biom9020060⟩
Article dans une revue inserm-02055136 v1
Image document

Physical and chemical assessment of 1,3 Propanediol as a potential substitute of propylene glycol in refill liquid for electronic cigarettes

Philippe Bertrand , Vincent Bonnarme , Antoine Piccirilli , Philippe Ayrault , Laurent Lemée et al.
Scientific Reports, 2018, 8 (1), pp.10702. ⟨10.1038/s41598-018-29066-6⟩
Article dans une revue hal-01899506 v1

HDAC inhibitors: a 2013–2017 patent survey

Micaela Faria Freitas , Muriel Cuendet , Philippe Bertrand
Expert Opinion on Therapeutic Patents, 2018, 28 (5), pp.365-381. ⟨10.1080/13543776.2018.1459568⟩
Article dans une revue hal-04074145 v1
Image document

Application au mésothéliome, le cancer de l'amiante

Valérie Héroguez , Christophe Blanquart , Philippe Bertrand
L'Actualité Chimique, 2018, 425, pp.33-38
Article dans une revue inserm-01981403 v1

Inside HDACs with more selective HDAC inhibitors

Joëlle Roche , Philippe Bertrand
European Journal of Medicinal Chemistry, 2016, 121, pp.451-483. ⟨10.1016/j.ejmech.2016.05.047⟩
Article dans une revue hal-04074140 v1
Image document

Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates

Vincent Zwick , Alessandra Nurisso , Claudia Simões-Pires , Samuel Bouchet , Nadine Martinet et al.
Bioorganic and Medicinal Chemistry Letters, 2016, ⟨10.1016/j.bmcl.2015.11.011⟩
Article dans une revue inserm-01299475 v1
Image document

Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy

Fatima El Bahhaj , Iza Denis , Pichavant Loic , Régis Delatouche , Floraine Collette et al.
Theranostics, 2016, 6 (6), pp.795-807. ⟨10.7150/thno.13725⟩
Article dans une revue inserm-01299450 v1

Chemistry for oncotheranostic gold nanoparticles

Anne-Juliette Trouiller , Seydou Hebié , Fatima El Bahhaj , Teko W. Napporn , Philippe Bertrand
European Journal of Medicinal Chemistry, 2015, 99, pp.92-112. ⟨10.1016/j.ejmech.2015.05.024⟩
Article dans une revue hal-01365816 v1

Activating somatic mutations in diffuse large B-cell lymphomas: lessons from next generation sequencing and key elements in the precision medicine era

Elodie Bohers , Sylvain Mareschal , Philippe Bertrand , Pierre Julien Viailly , Sydney Dubois et al.
Leukemia & lymphoma, 2014, 56 (5), pp.1213-1222. ⟨10.3109/10428194.2014.941836⟩
Article dans une revue hal-02332349 v1

Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities

Fatima El Bahhaj , Jerome Desire , Christophe Blanquart , Nadine Martinet , Vincent Zwick et al.
Tetrahedron, 2014, 70 (51 ), pp.9702-9708 ⟨10.1016/j.tet.2014.10.053⟩
Article dans une revue hal-01314516 v1

Delivery of epidrugs

Fatima El Bahhaj , Frank J. Dekker , Nadine Martinet , Philippe Bertrand
Drug Discovery Today, 2014, 19 (9), pp.1337-1352. ⟨10.1016/j.drudis.2014.03.017⟩
Article dans une revue hal-01201998 v1
Image document

New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells

Fabien Gueugnon , Pierre-Francois Cartron , Cédric Charrier , Philippe Bertrand , Jean-François Fonteneau et al.
Oncotarget, 2014, 5 (12), pp.4504-4515. ⟨10.18632/oncotarget.2056⟩
Article dans une revue hal-04969886 v1

Vorinostat-Polymer Conjugate Nanoparticles for Acid-Responsive Delivery and Passive Tumor Targeting

Iza Denis , Fatima El Bahhaj , Floraine Collette , Régis Delatouche , Fabien Gueugnon et al.
Biomacromolecules, 2014, 15 (12), pp.4534-4543. ⟨10.1021/bm501338r⟩
Article dans une revue hal-01369441 v1

Nanoparticles Produced by Ring-Opening Metathesis Polymerization Using Norbornenyl-poly(ethylene oxide) as a Ligand-Free Generic Platform for Highly Selective In Vivo Tumor Targeting

Fabien Gueugnon , Iza Denis , Daniel Pouliquen , Floraine Collette , Régis Delatouche et al.
Biomacromolecules, 2013, 14 (7), pp.2396-2402. ⟨10.1021/bm400516b⟩
Article dans une revue hal-00916100 v1

Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy

Régis Delatouche , Iza Denis , Marion Grinda , Fatima El Bahhaj , Estelle Baucher et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2013, 85 (3), pp.862-872. ⟨10.1016/j.ejpb.2013.03.006⟩
Article dans une revue istex hal-04074175 v1

Extending Triazolyl-Based Release under Mildly Acidic Conditions To Give Aniline Derivatives

R. Delatouche , C. Bachmann , G. Frapper , P. Bertrand
Synthesis: Journal of Synthetic Organic Chemistry, 2012, 44 (7), pp.1090-1094. ⟨10.1055/s-0031-1289719⟩
Article dans une revue hal-00829565 v1

Small molecules DNA methyltransferases inhibitors

N. Martinet , B.Y. Michel , P. Bertrand , R. Benhida
MedChemComm, 2012, 3 (3), pp.263-273. ⟨10.1039/c1md00194a⟩
Article dans une revue hal-00834226 v1

Investigations into Competitive Cycloaddition/Cyclization or Elimination from 1,1-Dimethyl-propargylcarbamates of Anilines

Régis Delatouche , Aurélien Lesage , Floraine Collette , Valérie Héroguez , Philippe Bertrand
Australian Journal of Chemistry, 2011, 64 (2), pp.166-173. ⟨10.1071/CH10344⟩
Article dans une revue hal-00947153 v1

Interpreting clinical assays for histone deacetylase inhibitors

Philippe Bertrand , Nadine Martinet
Cancer Management and Research, 2011, pp.117. ⟨10.2147/CMR.S9661⟩
Article dans une revue hal-04074156 v1