Philippe Bertolino

39
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Publications

Publications

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A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Khaled Tighanimine , José Américo Nabuco Leva Ferreira Freitas , Ivan Nemazanyy , Alexia Bankolé , Delphine Benarroch-Popivker et al.
Nature Metabolism, 2024, 6 (2), pp.323-342. ⟨10.1038/s42255-023-00972-y⟩
Article dans une revue hal-04511215 v1
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A non-canonical role of ELN protects from cellular senescence by limiting iron-dependent regulation of gene expression

Joanna Czarnecka-Herok , Kexin Zhu , Jean-Michel Flaman , Delphine Goehrig , Mathieu Vernier et al.
Redox Biology, 2024, 73, pp.103204. ⟨10.1016/j.redox.2024.103204⟩
Article dans une revue hal-04631521 v1
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Soft extracellular matrix drives endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells

Pierre-Alexandre Laval , Marie Piecyk , Paul Le Guen , Mirela-Diana Ilie , Aubepart Marion et al.
Acta Biomaterialia, 2024, 182, pp.93-110. ⟨10.1016/j.actbio.2024.05.033⟩
Article dans une revue hal-04733367 v2
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Pericyte stem cells induce <scp>Ly6G</scp> <sup>+</sup> cell accumulation and immunotherapy resistance in pancreatic cancer

Zhichong Wu , Kevin Thierry , Sophie Bachy , Xinyi Zhang , Pia Gamradt et al.
EMBO Reports, 2023, ⟨10.15252/embr.202256524⟩
Article dans une revue hal-04047023 v1

Inhibition of activin signalling reduces the growth of LβT2 gonadotroph pituitary tumours in mouse

Audrey Ziverec , Marie Chanal , Perrine Raymond , Mirela Diana Ilie , Dario de Alcubierre et al.
Endocrine-Related Cancer, 2023, 30 (3), ⟨10.1530/ERC-22-0245⟩
Article dans une revue hal-04115686 v1
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Biological and Therapeutic Implications of the Tumor Microenvironment in Pituitary Adenomas

Mirela-Diana Ilie , Alexandre Vasiljevic , Philippe Bertolino , Gérald Raverot
Endocrine reviews, 2023, 44 (2), pp.297-311. ⟨10.1210/endrev/bnac024⟩
Article dans une revue hal-04113463 v1
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Loss of Pla2r1 decreases cellular senescence and age‐related alterations caused by aging and Western diets

Amélie Massemin , Delphine Goehrig , Jean‐michel Flaman , Sara Jaber , Audrey Griveau et al.
Aging Cell, 2023, ⟨10.1111/acel.13971⟩
Article dans une revue hal-04225404 v1
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Stiffness-induced cancer-associated fibroblasts are responsible for immunosuppression in a platelet-derived growth factor ligand-dependent manner

Pia Gamradt , Kevin Thierry , Melissa Masmoudi , Zhichong Wu , Hector Hernandez-Vargas et al.
PNAS Nexus, 2023, 2 (12), ⟨10.1093/pnasnexus/pgad405⟩
Article dans une revue hal-04373776 v1
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scAN1.0: A reproducible and standardized pipeline for processing 10X single cell RNAseq data

Maxime Lepetit , Mirela Diana Ilie , Marie Chanal , Gérald Raverot , Philippe Bertolino et al.
In Silico Biology, 2023, 15, pp.11 - 21. ⟨10.3233/isb-220252⟩
Article dans une revue hal-04305326 v1
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Intratumoural spatial distribution of S100B + folliculostellate cells is associated with proliferation and expression of FSH and ERα in gonadotroph tumours

Mirela Diana Ilie , Alexandre Vasiljevic , Marie Chanal , Nicolas Gadot , Laura Chinezu et al.
Acta Neuropathologica Communications, 2022, 10 (1), pp.18. ⟨10.1186/s40478-022-01321-y⟩
Article dans une revue hal-03666692 v1
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Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

Michèle Mg Hillege , Andi Shi , Ricardo Galli , Gang Wu , Philippe Bertolino et al.
eLife, 2022, 11, ⟨10.7554/eLife.77610⟩
Article dans une revue hal-03766456 v1
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Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells

Nele Wagener , Malte Buchholz , Philippe Bertolino , Chang Zhang , Pietro Di Fazio
Apoptosis, 2022, 27 (1-2), pp.70-79. ⟨10.1007/s10495-021-01700-1⟩
Article dans une revue hal-03666683 v1
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EGFR-dependent aerotaxis is a common trait of breast tumour cells

Ivan Mikaelian , Rudy Gadet , Mathieu Deygas , Philippe Bertolino , Ana Hennino et al.
Journal of experimental & clinical cancer research, 2022, 41 (1), pp.324. ⟨10.1186/s13046-022-02514-y⟩
Article dans une revue hal-04045454 v1
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The scaffold protein menin is essential for activating the MYC locus and MYC‐mediated androgen receptor transcription in androgen receptor‐dependent prostate cancer cells

Yakun Luo , Virginie Vlaeminck‐guillem , Romain Teinturier , Razan Abou Ziki , Philippe Bertolino et al.
Cancer Communications, 2021, 41 (12), pp.1427-1430. ⟨10.1002/cac2.12217⟩
Article dans une revue hal-03666677 v1
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Phospholipase A2 receptor 1 promotes lung cell senescence and emphysema in obstructive lung disease

Delphine Beaulieu , Aya Attwe , Marielle Breau , Larissa Lipskaia , Elisabeth Marcos et al.
European Respiratory Journal, 2021, 58 (2), pp.2000752. ⟨10.1183/13993003.00752-2020⟩
Article dans une revue inserm-03420591 v1

Men1 disruption in Nkx3.1-deficient mice results in ARlow/CD44+ microinvasive carcinoma development with the dysregulated AR pathway

Romain Teinturier , Yakun Luo , Myriam Decaussin-Petrucci , Virginie Vlaeminck-Guillem , Francis Vacherot et al.
Oncogene, 2021, 40 (6), pp.1118-1127. ⟨10.1038/s41388-020-01589-1⟩
Article dans une revue hal-03666659 v1
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PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging

Anda Huna , Audrey Griveau , David Vindrieux , Sara Jaber , Jean-Michel Flaman et al.
Cell Death and Disease, 2021, 12 (2), pp.190. ⟨10.1038/s41419-021-03468-3⟩
Article dans une revue inserm-03420490 v1
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Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Christos Karampelias , Habib Rezanejad , Mandy Rosko , Likun Duan , Jing Lu et al.
Nature Communications, 2021, 12 (1), pp.3362. ⟨10.1038/s41467-021-23673-0⟩
Article dans une revue hal-03666669 v1
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Reduced menin expression leads to decreased ERα expression and is correlated with the occurrence of human luminal B-like and ER-negative breast cancer subtypes

Romain Teinturier , Razan Abou Ziki , Loay Kassem , Yakun Luo , Lucie Malbeteau et al.
Breast Cancer Research and Treatment, 2021, 190 (3), pp.389-401. ⟨10.1007/s10549-021-06339-9⟩
Article dans une revue hal-03666672 v1
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Stroma Involvement in Pancreatic Ductal Adenocarcinoma: An Overview Focusing on Extracellular Matrix Proteins

Sophie Liot , Jonathan Balas , Alexandre Aubert , Laura Prigent , Perrine Mercier-Gouy et al.
Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.612271⟩
Article dans une revue hal-03281971 v1
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Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis

Hélène Lasolle , Mad-Hélénie Elsensohn , Anne Wierinckx , Eudeline Alix , Clément Bonnefille et al.
Acta Neuropathologica Communications, 2020, 8 (1), pp.190. ⟨10.1186/s40478-020-01067-5⟩
Article dans une revue hal-04383012 v1

Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A

Yajie Zhao , Zhichong Wu , Marie Chanal , Fabienne Guillaumond , Delphine Goehrig et al.
Cancer Research, 2020, 80 (16), pp.3359-3371. ⟨10.1158/0008-5472.CAN-19-3763⟩
Article dans une revue hal-03008999 v1
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Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

Kevin Berthenet , Camila Castillo Ferrer , Deborah Fanfone , Nikolay Popgeorgiev , David Neves et al.
Cell Reports, 2020, 31 (10), pp.107731. ⟨10.1016/j.celrep.2020.107731⟩
Article dans une revue hal-02999426 v1
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Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1

Sara Jaber , Delphine Goehrig , Philippe Bertolino , Amélie Massemin , Franck Bihl et al.
Scientific Reports, 2020, 10 (1), pp.8190. ⟨10.1038/s41598-020-64863-y⟩
Article dans une revue inserm-02865473 v1

Immune Landscape of Pituitary Tumors Reveals Association Between Macrophages and Gonadotroph Tumor Invasion

Moitza Principe , Marie Chanal , Mirela Diana Ilie , Audrey Ziverec , Alexandre Vasiljevic et al.
Journal of Clinical Endocrinology and Metabolism, 2020, 105 (11), pp.3459-3473. ⟨10.1210/clinem/dgaa520⟩
Article dans une revue hal-03666638 v1
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Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer

Delphine Goehrig , Jérémy Nigri , Rémi Samain , Zhichong Wu , Paola Cappello et al.
Gut, 2019, 68 (4), pp.693-707. ⟨10.1136/gutjnl-2018-317570⟩
Article dans une revue hal-02526963 v1
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The Microenvironment of Pituitary Tumors—Biological and Therapeutic Implications

Mirela Diana Ilie , Alexandre Vasiljevic , Gérald Raverot , Philippe Bertolino
Cancers, 2019, 11 (10), pp.1605. ⟨10.3390/cancers11101605⟩
Article dans une revue hal-03666599 v1
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Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.

Rami Jaafar , Joffrey de Larichaudy , Stéphanie Chanon , Vanessa Euthine , Christine Durand et al.
Cell Communication and Signaling, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩
Article dans une revue inserm-00868745 v1

Assignment testing reveals multiple introduced source populations including potential ash hybrids (Fraxinus excelsior x F. angustifolia) in Ireland

M. Thomasset , Jf. Fernandez-Manjarres , G.C Douglas , P. Bertolino , Nathalie Frascaria-Lacoste et al.
European Journal of Forest Research, 2013, 132, pp.195-209
Article dans une revue hal-01569267 v1

Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.

J. Lu , Z. Hamze , R. Bonnavion , N. Herath , C. Pouponnot et al.
Oncogene, 2012, 31 (31), pp.3647-54. ⟨10.1038/onc.2011.538⟩
Article dans une revue hal-00723094 v1
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Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway

David Vincent , Johann Gout , Nicolas Chuvin , Vanessa Arfi , Roxane M. Pommier et al.
American Journal of Pathology, 2012, 180 (6), pp.2214-2221. ⟨10.1016/j.ajpath.2012.02.006⟩
Article dans une revue hal-02954464 v1

Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis

Nader Hussein , Huguette Casse , Sandra Fontanière , Anne-Marie Morera , Marie Asensio et al.
European Journal of Cancer, 2007, 43 (2), pp.402-414
Article dans une revue hal-02659050 v1

Death by neglec as a deletional machanism of peripheral tolerance.

P. Bertolino , Trescol-Biemont M.C. , J. Thomas , Fazekas de St Groth B. , M. Philgren et al.
International Immunology, 1999, 11, pp.1225-1238
Article dans une revue hal-00144472 v1

Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation.

P. Bertolino , M Staschewski , M Trescol-Biémont , I Freisewinkel , K Schenck et al.
Journal of Immunology, 1995, 154 (11), pp.5620-9
Article dans une revue hal-02475206 v1

Invariant Chain Expression Similarly Controls Presentation of Endogenously Synthesized and Exogenous Antigens by MHC Class II Molecules

S. Lombard-Platet , P. Bertolino , C. Gimenez , M. Humbert , D. Gerlier et al.
Cellular Immunology, 1993, 148 (1), pp.60-70. ⟨10.1006/cimm.1993.1091⟩
Article dans une revue istex hal-02475535 v1

Inhibition by chloroquine of the class II major histocompatibility complex-restricted presentation of endogenous antigens varies according to the cellular origin of the antigen-presenting cells, the nature of the T-cell epitope, and the responding T cell.

S Lombard-Platlet , P. Bertolino , H. Deng , D. Gerlier
Immunology, 1993, 80 (4), pp.566-73
Article dans une revue hal-02475532 v1

Soft matrix maintains the molecular traits of pulmonary basal cells

Pierre-Alexandre Laval , Marie Piecyk , Paul Le Guen , Mirela-Diana Ilie , Joelle Fauvre et al.
Journée collaborative Lyon Biopole, Oct 2023, GRENOBLE, France
Poster de conférence hal-04585211 v1
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Exploring the transcriptional landscape of gonadotroph tumor microenvironment with single cell RNA-seq

Benoît Aliaga , Julie Ripoll , Marie Chanal , Hector Hernandez-Vargas , Emmanuel Jouanneau et al.
SFBI. JOBIM 2021 - 21es Journées Ouvertes en Biologie, Informatique et Mathématiques, Jul 2021, Paris, France. , 2021
Poster de conférence lirmm-03544671 v1