philippe de Medina

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140
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Publications

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The Phospholipid Bis(monoacylglycero)Phosphate Confers Antitumour Immunogenicity to Exosomes Secreted by Dendrogenin A, Which Activates Its Biosynthesis in Tumour Cells

Julio Buñay , Michel Record , Philippe de Medina , Silia Ayadi , Laly Pucheu et al.
Journal of Extracellular Vesicles, 2026, 15 (2), pp.e70225. ⟨10.1002/jev2.70225⟩
Article dans une revue inserm-05495718 v1
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Liver X receptors and the hallmarks of aging: From molecular mechanisms to therapeutic opportunities

Marc Poirot , Julio Buñay , Silia Ayadi , Sandrine Silvente-Poirot , Philippe de Medina
Ageing Research Reviews - ARR, 2026, 114, pp.102967. ⟨10.1016/j.arr.2025.102967⟩
Article dans une revue inserm-05394944 v1
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Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate: A non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate

Philippe de Medina , Silia Ayadi , Régis Soulès , Bruno Payre , Sandrine Rup-Jacques et al.
Journal of Steroid Biochemistry and Molecular Biology, 2023, 234, pp.106396. ⟨10.1016/j.jsbmb.2023.106396⟩
Article dans une revue hal-04509731 v1
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27-hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor

Silia Ayadi , Silvia Friedrichs , Regis Soulès , Laly Pucheu , Dieter Lütjohann et al.
Journal of Lipid Research, In press, 64 (12), pp.100479. ⟨10.1016/j.jlr.2023.100479⟩
Article dans une revue inserm-04317313 v1
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Oxysterols are potential physiological regulators of ageing

Philippe de Medina , Sandrine Silvente-Poirot , Marc Poirot
Ageing Research Reviews - ARR, 2022, 77, pp.101615. ⟨10.1016/j.arr.2022.101615⟩
Article dans une revue inserm-03629546 v1
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Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles

Michel Record , Mehdi Attia , Kevin Carayon , Laly Pucheu , Julio Bunay et al.
Journal of Extracellular Vesicles, 2022, 11 (4), pp.e12211. ⟨10.1002/jev2.12211⟩
Article dans une revue inserm-03649213 v1
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Targeting NR1H/liver X receptor with dendrogenin A differentiates tumor cells to activate a new secretory pathway releasing immunogenic anti-tumor vesicles enriched in LC3-II-associated exosomes

Philippe de Medina , Julio Bunay , Marc Poirot , Michel Record , Sandrine Silvente-Poirot
Autophagy, 2022, 19 (3), pp.1036-1038. ⟨10.1080/15548627.2022.2116175⟩
Article dans une revue inserm-03854248 v1
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The 5,6-epoxycholesterol metabolic pathway in cancer: emergence of new pharmacological targets

Philippe de Médina , Khadijetou Diallo , Emilie Huc Claustre , Mehdi Attia , Régis Soulès et al.
British Journal of Pharmacology, 2020, 178 (16), pp.3248-3260. ⟨10.22541/au.159069407.75369904⟩
Article dans une revue inserm-03086999 v1
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Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia

Pierre-Luc Mouchel , Nizar Serhan , Rémy Bétous , Thomas Farge , Estelle Saland et al.
Cancers, 2020, 12 (10), pp.2933. ⟨10.3390/cancers12102933⟩
Article dans une revue inserm-03084630 v1
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Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo

Nizar Serhan , Pierre-Luc Mouchel , Philippe de Médina , Gregory Segala , Aurélie Mougel et al.
Cancers, 2020, 12 (7), pp.1725. ⟨10.3390/cancers12071725⟩
Article dans une revue inserm-03084638 v1
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Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis

Salvatore Genovese , Francesco Epifano , Philippe de Médina , Nicolas Caron , Arnaud Rives et al.
Bioorganic Chemistry, 2019, 87, pp.181-190. ⟨10.1016/j.bioorg.2019.03.026⟩
Article dans une revue inserm-02380542 v1
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HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris

Vito Taddeo , Francesco Epifano , Francesca Preziuso , Serena Fiorito , Nicolas Caron et al.
Molecules, 2019, 24 (3), pp.501. ⟨10.3390/molecules24030501⟩
Article dans une revue inserm-02380544 v1
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A fast UPLC–HILIC method for an accurate quantification of dendrogenin A in human tissues

Régis Soules , Fabien Audouard-Combe , Emilie Huc-Claustre , Philippe de Médina , Arnaud Rives et al.
Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105447. ⟨10.1016/j.jsbmb.2019.105447⟩
Article dans une revue istex inserm-02380526 v1

Deciphering the metabolic secret of longevity through the analysis of metabolic response to stress on long-lived species

Philippe de Medina
Medical Hypotheses, 2019, 122, pp.62-67. ⟨10.1016/j.mehy.2018.10.019⟩
Article dans une revue istex hal-04967584 v1
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The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells

Mathilde Bauriaud-Mallet , Lavinia Vija-Racaru , Séverine Brillouet , Arnaud Mallinger , Philippe de Médina et al.
Journal of Steroid Biochemistry and Molecular Biology, 2019, 192, pp.105390. ⟨10.1016/j.jsbmb.2019.105390⟩
Article dans une revue inserm-02380538 v1

Xenohormesis in early life: New avenues of research to explore anti-aging strategies through the maternal diet

Philippe de Medina
Medical Hypotheses, 2017, 109, pp.126-130. ⟨10.1016/j.mehy.2017.10.005⟩
Article dans une revue istex hal-04967588 v1
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Dendrogenin A drives LXR to trigger lethal autophagy in cancers

Gregory Segala , Marion David , Philippe de Médina , Mathias Poirot , Nizar Serhan et al.
Nature Communications, 2017, 8 (1), pp.1903. ⟨10.1038/s41467-017-01948-9⟩
Article dans une revue inserm-02380591 v1
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Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS

Régis Soules , Emmanuel Noguer , Luigi Iuliano , Chiara Zerbinati , Julie Leignadier et al.
Chemistry and Physics of Lipids, 2017, 207, pp.92-98. ⟨10.1016/j.chemphyslip.2017.05.006⟩
Article dans une revue inserm-02380612 v1
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Quantitative analysis of the tumor suppressor dendrogenin A using liquid chromatography tandem mass spectrometry

Emmanuel Noguer , Régis Soules , Claude Netter , Citra Nagarathinam , Julie Leignadier et al.
Chemistry and Physics of Lipids, 2017, 207, pp.81-86. ⟨10.1016/j.chemphyslip.2017.06.010⟩
Article dans une revue inserm-02380602 v1
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Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor

Maud Voisin , Philippe de Médina , Arnaud Mallinger , Florence Dalenc , Emilie Huc-Claustre et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (44), pp.E9346-E9355. ⟨10.1073/pnas.1707965114⟩
Article dans une revue hal-02316171 v1
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Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds

Farid Khallouki , Philippe de Médina , Stéphanie Caze-Subra , Kerstin Bystricky , Patrick Balaguer et al.
Frontiers in Oncology, 2016, 5, ⟨10.3389/fonc.2015.00287⟩
Article dans une revue hal-02271824 v1

The NR4A nuclear receptors as potential targets for anti-aging interventions

Michael Paillasse , Philippe de Medina
Medical Hypotheses, 2015, 84 (2), pp.135-140. ⟨10.1016/j.mehy.2014.12.003⟩
Article dans une revue istex hal-04967581 v1
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The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.

Shaden A. M. Khalifa , Philippe de Médina , Anna Erlandsson , Hesham R. El-Seedi , Sandrine Silvente-Poirot et al.
Biochemical and Biophysical Research Communications, 2014, 446 (3), pp.681-686. ⟨10.1016/j.bbrc.2013.12.134⟩
Article dans une revue inserm-00968932 v1
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5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells.

Gregory Segala , Philippe de Médina , Luigi Iuliano , Chiara Zerbinati , Michael R. Paillasse et al.
Biochemical Pharmacology, 2013, 86 (1), pp.175-89. ⟨10.1016/j.bcp.2013.02.031⟩
Article dans une revue inserm-00822322 v1
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Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism

Brigitte Sola , Marc Poirot , Philippe de Médina , Sophie Bustany , Véronique Marsaud et al.
Oncotarget, 2013, 4 (6), pp.911-922. ⟨10.18632/oncotarget.1066⟩
Article dans une revue inserm-00968940 v1
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Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A.

Philippe de Médina , Michael R. Paillasse , Gregory Segala , Talal Al Saati , Jeannine Boyes et al.
Biochimie, 2013, 95 (3), pp.482-488. ⟨10.1016/j.biochi.2012.06.001⟩
Article dans une revue istex inserm-00822283 v1
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Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties.

Philippe de Médina , Michael R. Paillasse , Gregory Segala , Maud Voisin , Loubna Mhamdi et al.
Nature Communications, 2013, 4, pp.1840. ⟨10.1038/ncomms2835⟩
Article dans une revue inserm-00823974 v1
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MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy.

Salome Paillas , Annick Causse , Laetitia Marzi , Philippe de Médina , Marc Poirot et al.
Autophagy, 2012, 8 (7), pp.1098-112. ⟨10.4161/auto.20268⟩
Article dans une revue inserm-00705786 v1
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Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles.

Michael R. Paillasse , Nathalie Saffon , Heinz Gornitzka , Sandrine Silvente-Poirot , Marc Poirot et al.
Journal of Lipid Research, 2012, 53 (4), pp.718-725. ⟨10.1194/jlr.M023689⟩
Article dans une revue inserm-00743457 v1
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Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands.

Philippe de Médina , Michael R. Paillasse , Gregory Ségala , Farid Khallouki , Severine Brillouet et al.
Chemistry and Physics of Lipids, 2011, 164 (6), pp.432-437. ⟨10.1016/j.chemphyslip.2011.05.005⟩
Article dans une revue istex inserm-00743454 v1

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

Caroline Subra , David Grand , Karine Laulagnier , Alexandre Stella , Gerard Lambeau et al.
Quarterly Reviews of Biophysics, 2010, 34 (3), epub ahead of print. ⟨10.1194/jlr.M003657⟩
Article dans une revue hal-00497229 v1
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Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors.

Philippe de Médina , Salvatore Genovese , Michael R. Paillasse , Mahta Mazaheri , Stéphanie Caze-Subra et al.
Molecular Pharmacology, 2010, 78 (5), pp.827-36. ⟨10.1124/mol.110.065250⟩
Article dans une revue inserm-00519166 v1
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Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands.

Philippe de Médina , Michael R. Paillasse , Grégory Segala , Marc E. Poirot , Sandrine Silvente-Poirot
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (30), pp.13520-13525. ⟨10.1073/pnas.1002922107⟩
Article dans une revue inserm-00519159 v1
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Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism.

Philippe de Médina , Bruno Payré , Nadia Boubekeur , Justine Bertrand-Michel , François Tercé et al.
Cell Death and Differentiation, 2009, 16 (10), pp.1372-1384. ⟨10.1038/cdd.2009.62⟩
Article dans une revue inserm-00519149 v1
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Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.

Michael R. Paillasse , Philippe de Médina , Guillaume Amouroux , Loubna Mhamdi , Marc E. Poirot et al.
Journal of Lipid Research, 2009, 50 (11), pp.2203-2211. ⟨10.1194/jlr.M800668-JLR200⟩
Article dans une revue inserm-00519146 v1
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Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation.

Philippe de Médina , Sandrine Silvente-Poirot , Marc E. Poirot
Autophagy, 2009, 5 (7), pp.1066-1067. ⟨10.4161/auto.5.7.9820⟩
Article dans une revue inserm-00519150 v1
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Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases.

Philippe de Médina , Michael R. Paillasse , Bruno Payré , Sandrine Silvente-Poirot , Marc E. Poirot
Journal of Medicinal Chemistry, 2009, 52 (23), pp.7765-7777. ⟨10.1021/jm901063e⟩
Article dans une revue inserm-00519151 v1
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Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism.

Bruno Payré , Philippe de Médina , Nadia Boubekeur , Loubna Mhamdi , Justine Bertrand-Michel et al.
Molecular Cancer Therapeutics, 2008, 7 (12), pp.3707-3718. ⟨10.1158/1535-7163.MCT-08-0507⟩
Article dans une revue inserm-00519145 v1
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Insights into the cholecystokinin 2 receptor binding site and processes of activation.

Michaël Paillasse , Céline Deraeve , Philippe de Médina , Loubna Mhamdi , Gilles Favre et al.
Molecular Pharmacology, 2006, 70 (6), pp.1935-1945. ⟨10.1124/mol.106.029967⟩
Article dans une revue inserm-00519168 v1
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The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-n-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors

Philippe de Médina , Nadia Boubekeur , Patrick Balaguer , Gilles Favre , Sandrine Silvente-Poirot et al.
Journal of Pharmacology and Experimental Therapeutics, 2006, 319 (1), pp.139-149. ⟨10.1124/jpet.106.104349⟩
Article dans une revue inserm-00090770 v1
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Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators.

Philippe de Médina , Robert Casper , Jean-François Savouret , Marc E. Poirot
Journal of Medicinal Chemistry, 2005, 48 (1), pp.287-291. ⟨10.1021/jm0498194⟩
Article dans une revue istex inserm-00090771 v1
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Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells.

Philippe de Médina , Bruno Payré , José Bernad , Isabelle Bosser , Bernard Pipy et al.
Journal of Pharmacology and Experimental Therapeutics, 2004, 308 (3), pp.1165-1173. ⟨10.1124/jpet.103.060426⟩
Article dans une revue inserm-00090774 v1
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Multiple targeting by the antitumor drug tamoxifen: a structure-activity study.

Philippe de Médina , Gilles Favre , Marc E. Poirot
Current Medicinal Chemistry Anticancer Agents, 2004, 4 (6), pp.491-508. ⟨10.2174/1568011043352696⟩
Article dans une revue inserm-00090772 v1
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Molecular characterization of the microsomal tamoxifen binding site.

Blandine Kedjouar , Philippe de Médina , Mustapha Oulad-Abdelghani , Bruno Payré , Sandrine Silvente-Poirot et al.
Journal of Biological Chemistry, 2004, 279 (32), pp.34048-34061. ⟨10.1074/jbc.M405230200⟩
Article dans une revue inserm-00090773 v1
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Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS).

Marc E. Poirot , Philippe de Médina , Frédéric Delarue , Jean-Jacques Perie , Alain Klaebe et al.
Bioorganic and Medicinal Chemistry, 2000, 8 (8), pp.2007-2016. ⟨10.1016/s0968-0896(00)00119-x⟩
Article dans une revue inserm-00090778 v1

PHYTOSTEROL DERIVATIVES, AND COMPOSITIONS COMPRISING THE SAME, FOR USE AS MEDICAMENTS

Sandrine Silvente-Poirot , Philippe de Medina , M Poirot
France, Patent n° : EP2025064259. 2025
Brevet inserm-05110310 v1

Methods for the treatment of cancers

Sandrine Silvente-Poirot , Julio Buñay , Michel Record , Philippe de Medina , M Poirot
France, Patent n° : EP25305623.8. 2025
Brevet inserm-05110314 v1

Phytosterol derivatives, and compositions comprising the same, for use as medicaments

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : EP24305827. 2024
Brevet inserm-04773991 v1

Methods for the treatment of breast cancer

Marc Poirot , Philippe de Medina , Khadijetou Diallo , Sandrine Silvente-Poirot
France, Patent n° : EP2430515.8.2024. 2024
Brevet inserm-04773966 v1

Radiotraceurs de tomographie par émission de positrons (TEP) de fluoro-oxystérols

Marc Poirot , Frédéric Courbon , Mohammad Samadi , Philippe de Medina , Sandrine Silvente-Poirot et al.
France, N° de brevet: WO2024146880A1. 2024
Brevet inserm-04773942 v1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REPROGRAMING IMMUNE ENVIRONMENT IN A SUBJECT IN NEED THEREOF

Marc Poirot , Julie Leignadier , Philippe de Medina , Michel Record , Sandrine Silvente-Poirot
United States, Patent n° : US2023138400A1. 2023
Brevet inserm-04773900 v1

Fluoro-oxysterols positron emission tomography (PET) radiotracers

Marc Poirot , Frédéric Courbon , Mohammad Samadi , Philippe de Medina , Sandrine Silvente-Poirot et al.
France, Patent n° : European patent, EP23305003.8. 2023
Brevet hal-04842549 v1

PROCEDE POUR LA PREPARATION DE DERIVES DE STEROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Canada, N° de brevet: CA2856609C. 2021
Brevet inserm-04772970 v1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REPROGRAMING IMMUNE ENVIRONMENT IN A SUBJECT IN NEED THEREOF

Marc Poirot , Julie Leignadier , Philippe de Medina , Michel Record , Sandrine Silvente-Poirot
United States, Patent n° : US2020016177A1. 2020
Brevet inserm-04773893 v1

MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES PERMETTANT LA REPROGRAMMATION DE L'ENVIRONNEMENT IMMUNITAIRE CHEZ UN SUJET EN AYANT BESOIN

Marc Poirot , Julie Leignadier , Philippe de Medina , Michel Record , Sandrine Silvente-Poirot
France, N° de brevet: EP3515453A1. 2019
Brevet inserm-04773879 v1

Dendrogenina A y agentes antineoplásicos para el tratamiento de tumores quimiosensibles o quimiorresistentes

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
España, N° de brevet: ES2734425T3. 2019
Brevet inserm-04773729 v1

Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, Patent n° : US10188666B2. 2019
Brevet inserm-04773745 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: EP3272350B1. 2019
Brevet inserm-04773717 v1

Endrogenina A y agentes antineoplásicos para el tratamiento de tumores quimiosensibles o quimiorresistentes

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
España, N° de brevet: ES2656913T3. 2018
Brevet inserm-04773723 v1

甾醇衍生物的制备方法

Marc Poirot , Michaël Paillasse , Philippe de Medina , Sandrine Silvente-Poirot
China, Patent n° : CN104039807B. 2018
Brevet inserm-04773150 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: EP3272350A1. 2018
Brevet inserm-04773712 v1

MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES PERMETTANT LA REPROGRAMMATION DE L'ENVIRONNEMENT IMMUNITAIRE CHEZ UN SUJET EN AYANT BESOIN

Marc Poirot , Julie Leignadier , Philippe de Medina , Michel Record , Sandrine Silvente-Poirot
France, N° de brevet: WO2018055080A1. 2018
Brevet inserm-04773906 v1

Sales de adición de ácidos de 5alfa-hidroxi-6beta-[2-(1H-imidazol-4-il)etilamino]colestan-3beta-ol

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Francia, N° de brevet: ES2650914T3. 2018
Brevet inserm-04772765 v1

Proceso para la preparación de derivados de esterol

Marc Poirot , Michaël Paillasse , Philippe de Medina , Sandrine Silvente-Poirot
España, N° de brevet: ES2613753T3. 2017
Brevet inserm-04773222 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: EP3041477B1. 2017
Brevet inserm-04773704 v1

processo para o preparo de derivados de esterol

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Brazil, Patent n° : BR112014012458A2. 2017
Brevet inserm-04772921 v1

ACID ADDITION SALTS OF 5a-HYDROXY-6ß-[2-(1H-IMIDAZOL-4-YL)ETHYL AMINO]CHOLESTAN-3ß-OL.

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX351610B. 2017
Brevet inserm-04772804 v1

Process for the preparation of sterol derivatives

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Austria, Patent n° : AU2012342460B2. 2017
Brevet inserm-04772907 v1

ACID ADDITION SALTS OF 5ALPHA-HYDROXY-6BETA -[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3BETA -OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : EP2768841B1. 2017
Brevet inserm-04772755 v1

Methods for Determining the Oncogenic Condition of Cell, Uses Thereof, and Methods for Treating Cancer

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : US2017176446A1. 2017
Brevet inserm-04772284 v1

ステロール誘導体の調製方法

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : JP6157492B2. 2017
Brevet inserm-04773268 v1

Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
China, Patent n° : CN105611934A. 2016
Brevet inserm-04773695 v1

PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE STÉROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: EP2782923B1. 2016
Brevet inserm-04773181 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX343787B. 2016
Brevet inserm-04773308 v1

Process for the preparation of sterol derivatives

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
United States, Patent n° : US9447141B2. 2016
Brevet inserm-04773449 v1

化学療法感受性又は化学療法抵抗性腫瘍の治療のためのデンドロゲニンA及び抗腫瘍薬

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
Japan, Patent n° : JP2016532709A. 2016
Brevet inserm-04773739 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: EP3041477A1. 2016
Brevet inserm-04773700 v1

Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
Australia, Patent n° : AU2014317117A1. 2016
Brevet inserm-04773484 v1

MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: EP2446276B9. 2016
Brevet inserm-04772270 v1

DENDROGENIN A AND ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CHEMOSENSITIVE OR CHEMORESISTANT TUMORS

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
United States, Patent n° : US2016193233A1. 2016
Brevet inserm-04773751 v1

METHODS FOR DETERMINING THE ONCOGENIC CONDITION OF CELL, USES THEREOF, AND METHODS FOR TREATING CANCER

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : PL2446276T3. 2015
Brevet inserm-04772282 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASIQUES POUR LE TRAITEMENT DE TUMEURS CHIMIOSENSIBLES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: WO2015032838A1. 2015
Brevet inserm-04773825 v1

СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ СТЕРИНА

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : RU2014125435A. 2015
Brevet inserm-04773440 v1

КИСЛОТНО-АДДИТИВНЫЕ СОЛИ 5α-ГИДРОКСИ-6β-[2-(1H-ИМИДАЗОЛ-4-ИЛ)ЭТИЛАМИНО]ХОЛЕСТАН-3β-ОЛА

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Russia, Patent n° : RU2014119929A. 2015
Brevet inserm-04772821 v1

DENDROGENINE A ET AGENTS ANTINEOPLASIQUES POUR LE TRAITEMENT DE TUMEURS CHIMIOSENSIBLES OU CHIMIORESISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
Canada, N° de brevet: CA2922715A1. 2015
Brevet inserm-04773546 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
India, Patent n° : IN976MUN2014A. 2015
Brevet inserm-04773233 v1

ACID ADDITION SALTS OF 5ALFA-HYDROXY-6BETA-[2-(1H-IMIDAZOL-4-YL)ETHYL AMINO]CHOLESTAN-3BETA-OL.

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX2014004744A. 2015
Brevet inserm-04772791 v1

ステロール誘導体の調製方法

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Japan, Patent n° : JP2015502934A. 2015
Brevet inserm-04773250 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
South Africa, Patent n° : ZA201403736B. 2015
Brevet inserm-04773467 v1

細胞の腫瘍形成状態を決定する方法、その使用、及び癌の治療方法

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : JP5765587B2. 2015
Brevet inserm-04772280 v1

Aminoalkylsterol compounds with antitumoral and neuroprotective activity

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : US8957055B2. 2015
Brevet inserm-04772244 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX2014006303A. 2014
Brevet inserm-04773301 v1

ACID ADDITION SALTS OF 5α-HYDROXY-6β-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3β-OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
South Korea, Patent n° : KR20140083014A. 2014
Brevet inserm-04772786 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES.

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX2014006303A. 2014
Brevet inserm-04773292 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
United States, Patent n° : US2014309417A1. 2014
Brevet inserm-04773447 v1

Acid addition salts of 5alpha-hydroxy-6beta-[2-(1H-imidazol-4-yl)ethylamino]cholestan-3beta-ol

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : AU2012324980A1. 2014
Brevet inserm-04772297 v1

5α−ヒドロキシ−6β−[2−(1H−イミダゾール−4−イル)エチルアミノ]コレスタン−3β−オールの酸付加塩

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Japan, Patent n° : JP2014530245A. 2014
Brevet inserm-04772775 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
United States, Patent n° : US2014309417A1. 2014
Brevet inserm-04772885 v1

PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE STÉROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: EP2782923A1. 2014
Brevet inserm-04773167 v1

Process for the preparation of sterol derivatives

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
China, Patent n° : CN104039807A. 2014
Brevet inserm-04773135 v1

ACID ADDITION SALTS OF 5ALPHA-HYDROXY-6BETA-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3BETA-OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
United States, Patent n° : US2014274984A1. 2014
Brevet inserm-04772841 v1

Acid addition salts of 5[alpha]-hydroxy-6[beta]-[2-(1h-imidazol-4-yl)ethylamino]cholestan-3[beta]-ol

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : CN103958541A. 2014
Brevet inserm-04772748 v1

Process for the preparation of sterol derivatives

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Austria, Patent n° : AU2012342460A1. 2014
Brevet inserm-04772895 v1

Methods for determining the oncogenic condition of cell, uses thereof, and methods for treating cancer

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : CN102498404B. 2014
Brevet inserm-04772266 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
South Korea, Patent n° : KR20140098131A. 2014
Brevet inserm-04773285 v1

SELS D'ADDITION D'ACIDE DE 5Alpha-HYDROXY-6Beta-[2-(1H-IMIDAZOL-4-YL)- ÉTHYLAMINO]CHOLESTAN-3Beta-OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: WO2013057148A1. 2013
Brevet inserm-04772848 v1

PROCEDE POUR LA PREPARATION DE DERIVES DE STEROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Canada, N° de brevet: CA2856609A1. 2013
Brevet inserm-04772952 v1

PROCÉDÉ POUR LA PRÉPARATION DE DÉRIVÉS DE STÉROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: WO2013076257A1. 2013
Brevet inserm-04773460 v1

SELS D'ADDITION D'ACIDE DE 5'-HYDROXY-6'-[2-(1H-IMIDAZOL-4-YL)- ETHYLAMINO]CHOLESTAN-3'-OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: CA2852622A1. 2013
Brevet inserm-04772735 v1

Aminoalkylsterol compounds with antitumoral and neuroprotective activity

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : US8524694B2. 2013
Brevet inserm-04772236 v1

Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : US7947668B2. 2011
Brevet inserm-04772230 v1

DETECTION DE L'ETAT ONCOGENE DE CELLULES HUMAINES OU DE MAMMIFERES PAR PRESENCE D'UN MARQUEUR ET EVALUATION DE L'ACTIVITE D'UN MEDICAMENT PAR DOSAGE DUDIT MARQUEUR

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : FR2947340B1. 2011
Brevet inserm-04772274 v1

METHODES POUR DETERMINER L'ETAT ONCOGENIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET METHODES POUR TRAITER LE CANCER

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : CA2766011A1. 2010
Brevet inserm-04772259 v1

Aminoalkylsterol compounds having antitumor and neuroprotective activity

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : JP4601297B2. 2010
Brevet inserm-04772227 v1

MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: WO2010149941A1. 2010
Brevet inserm-04772286 v1

AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : EP1497309B1. 2009
Brevet inserm-04772209 v1

AMINOALKYLSTERINVERBINDUNGEN MIT ANTI-KREBS UND NEUROPROTEKTIVER AKTIVITÄT

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : ATE420888T1. 2009
Brevet inserm-04772185 v1

COMPUESTOS AMINOALQUILESTEROLES CON ACTIVIDAD ANTITUMORAL Y NEUROPROTECTORA

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : ES2321287T3. 2009
Brevet inserm-04772212 v1

Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity

Philippe de Medina , Sandrine Silvente-Poirot , Marc Poirot
France, Patent n° : AU2003262422B8. 2008
Brevet inserm-04772197 v1

COMPOSES AMINOALKYLSTEROLES AVEC ACTIVITE ANTI-TUMEUR ET NEUROPROTECTRICE

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : EP1497309A2. 2005
Brevet inserm-04772177 v1

NEW STILBENE DERIVATIVES AND THEIR USE AS ARYL HYDROCARBON RECEPTOR LIGAND ANTAGONISTICS

Jean-François Savouret , Marc Poirot , Philippe de Medina , Robert F Casper
France, Patent n° : EP1418164A1. 2004
Brevet inserm-04772124 v1

STEROL DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND MEDICAMENTS COMPRISING SAME

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : WO03089449A2. 2003
Brevet inserm-04772249 v1

Nouveaux derivés de stilbène et leur utilisation en tant que antagonistes des ligands du recepteur des arylhydrocarbures

Robert F Casper , Jean-François Savouret , Marc Poirot , Philippe de Medina
France, Patent n° : EP03773372A. 2003
Brevet inserm-04772141 v1

AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : CA2481561A1. 2003
Brevet inserm-04772202 v1

DERIVES DE STEROLS, LEUR PROCEDE DE PREPARATION ET MEDICAMENTS LES COMPORTANT

Marc Poirot , Philippe de Medina
France, N° de brevet: FR0204912A. 2002
Brevet inserm-04772155 v1

Biochemical and structural evidences that the human glutathion S-transferase A1 catalyzes the biosynthesis of dendrogenins.

Silia Ayadi , Georges Ndikoum-Matip , Philippe de Medina , Regis Soules , Virginie Nahoum et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029665 v1

Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate, a non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate

Philippe de Medina , Silia Ayadi , Regis Soules , Bruno Payre , Sandrine Rup-Jacques et al.
12th ENOR symposium : Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029639 v1

Metabolic switching from tumor promoter activities of oncosterone and 27-hydroxycholesterol to 27-hydroxy-oncosterone with antiproliferative properties

Silia Ayadi , Silvia Friedrichs , Regis Soulès , Laly Pucheu , Dieter Lütjohann et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029635 v1

The oxysterol dendrogenin A increases the activation of migratory dendritic cells by acting through the LXRβ.

Julio Buñay , Laly Pucheu , Silia Ayadi , Michel Record , Philippe de Medina et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029673 v1

Synthesis and cellular evaluation of new bi-specific estrogen receptor modulators and ACAT/SOAT inhibitors as anticancer agents

Farid Khallouki , M Poirot , Stéphanie Caze-Subra , Kerstin Bystricky , Sandrine Silvente-Poirot et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029726 v1

Combined OCDO/DDA extraction and quantification method for a fast and accurate HPLC-MS analysis

Regis Soules , Philippe de Medina , Silia Ayadi , Étienne Chatelut , Sandrine Silvente-Poirot et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029741 v1

GSTA1-1 is a multifunctional enzyme involved in 5,6α-epoxycholesterol conjugation with biological nucleophiles

Silia Ayadi , Georges Ndikoum-Matip , Philippe de Medina , Virginie Nahoum , Laurent Maveyraud et al.
11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway
Communication dans un congrès inserm-05029750 v1

Reprogramming tumor cells with the oxysterol, dendrogenin A, to release immunogenic anti-tumor small extracellular vesicles enriched in exosomes.

Julio Buñay , Michel Record , Laly Pucheu , M Poirot , Philippe de Medina et al.
11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway
Communication dans un congrès inserm-05029772 v1

Chemical synthesis and biological properties of cholestane-5α,6β-diol-3-sulfonate, a non-hydrolyzable analogue of cholestane-5α,6β-diol-3-O-sulfate

Philippe de Medina , Mohammad Samadi , Silia Ayadi , Sandrine Rup-Jacques , Regis Soules et al.
11th ENOR symposium (European Network for Oxysterol Research), ENOR, Sep 2022, Oslo, Norway
Communication dans un congrès inserm-05029757 v1

Comparative Studies on the metabolism of 5,6-epoxycholesterol, cholestane-3β,5α,6β-triol and Oncosterone in the cancer cell lines MCF-7, MDA-MB-231 and HEPG2.

Philippe de Medina , Silia Ayadi , Dieter Lütjohann , Sandrine Silvente-Poirot , M Poirot
11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway
Communication dans un congrès inserm-05029763 v1

New targeting in oxysterol metabolism for triple negative breast cancer therapy.

Khadijetou Diallo , Philippe de Medina , Regis Soules , Laly Pucheu , Arnaud Mallinger et al.
10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom
Communication dans un congrès inserm-05029825 v1

Side chain hydroxylation of cholestane-3β,5α,6β-triol and Oncosterone lead to the production of new endogenous oxysterols potentially involved in breast cancer development.

Tifany Lalande , Regis Soules , Sandrine Silvente-Poirot , Philippe de Medina , M Poirot
10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom
Communication dans un congrès inserm-05029836 v1

Inhibition of oncosterone biosynthesis as a new pharmacological anticancer strategy in breast cancer.

Philippe de Medina , Rabea Bartölke , Regis Soules , Sandrine Silvente-Poirot , M Poirot
10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom
Communication dans un congrès inserm-05029843 v1

Characterization of a cholesterol metabolic switch controlling breast carcinogenesis

Philippe de Medina , Silia Ayadi , Emmanuel Noguer , Lisa Barrett , Regis Soules et al.
10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom
Communication dans un congrès inserm-05029820 v1

Design, synthesis and cellular evaluation of new bi-specific estrogen receptor modulators and ACAT inhibitors as anticancer agents

Farid Khallouki , Guillaume Amouroux , Stéphanie Caze-Subra , Kerstin Bystricky , Patrick Balaguer et al.
9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edinbourg, Ecosse, United Kingdom
Communication dans un congrès inserm-05029855 v1