Philippe-Henri Secretan

Maître de conférences
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Compétences

Chimie analytique Spectrométrie de masse Elucidation structurale Chimie théorique Réglementation pharmaceutique

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Publications

Hybrid GPP–hospital control strategy for semi-solid extrusion 3D printing of ONC201 chewable units in pediatric oncology

Stephanie Ramos , Marina Vignes , Philippe-Henri Secretan , François-Xavier Legrand , Maxime Annereau et al.

European Journal of Pharmaceutical Sciences, 2026, 216, pp.107326. ⟨10.1016/j.ejps.2025.107326⟩

Article dans une revue hal-05318721v1
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A Risk-Based Framework for Hospital Compounding: Integrating Degradation Mechanisms and Predictive Toxicology

Philippe-Henri Secretan , Maxime Annereau , Bernard Do

Pharmaceutics, 2025, 17 (9), pp.1202. ⟨10.3390/pharmaceutics17091202⟩

Article dans une revue hal-05314035v1
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Stability-Guided Formulation of a Light-Sensitive D-LSD Capsule for Clinical Investigation

Bernard Do , Luc Mallet , Maxime Annereau , Danielle Libong , Audrey Solgadi et al.

Pharmaceutics, 2025, 17 (6), pp.767. ⟨10.3390/pharmaceutics17060767⟩

Article dans une revue hal-05314044v1

Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS

Edith Nicol , Bernard Do , Marina Vignes , Maxime Annereau , Muriel Paul et al.

Pharmaceutical Development and Technology, 2024, 29 (8), pp.855-861. ⟨10.1080/10837450.2024.2405829⟩

Article dans une revue hal-04981715v1

Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and stability

Maxime Annereau , Philippe-Henri Secretan , Marina Vignes , Stéphanie Ramos , Jacques Grill et al.

International Journal of Pharmaceutics, 2024, 667 (Part B), pp.124965. ⟨10.1016/j.ijpharm.2024.124965⟩

Article dans une revue hal-04878417v1
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PREFORMULATION EVALUATION OF SELUMETINIB FOR TOPICAL APPLICATION: SKIN DISTRIBUTION AND PHOTODEGRADATION ANALYSIS USING MALDI IMAGING AND LC-MS/MS

Edith Nicol , Bernard Do , Marina Vignes , Maxime Annereau , Muriel Paul et al.

Pharmaceutical Development and Technology, 2024, 29 (8), pp.855-861. ⟨10.1080/10837450.2024.2405829⟩

Article dans une revue hal-05314030v1

Physicochemical Stability of Doravirine (Pifeltro®): Characterization of Main Degradation Products and Assessment of Stability of Tablets Repackaged in Single-Dose Unit Containers

Moïse Houssen , Philippe-Henri Secretan , Loup Nobilet , Kilian Jossot , Laura Guichard et al.

Pharmaceutics, 2024, 16 (8), pp.977. ⟨10.3390/pharmaceutics16080977⟩

Article dans une revue hal-05314018v1
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Identification of Degradation Products of the New Anticancer Drug Substance ONC201 by Liquid Chromatography–High-Resolution Multistage Mass Spectrometry

Maxime Annereau , Marina Vignes , Tahar Sif Eddine Bouchema , Lucas Denis , Audrey Solgadi et al.

Chemosensors, 2023, 11 (5), pp.294. ⟨10.3390/chemosensors11050294⟩

Article dans une revue hal-05314012v1
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Evolution of the Chronic Venous Leg Ulcer Microenvironment and Its Impact on Medical Devices and Wound Care Therapies

Gisele Abreu Coelho , Philippe-Henri Secretan , Lionel Tortolano , Loïc Charvet , Najet Yagoubi

Journal of Clinical Medicine, 2023, 12 (17), pp.5605. ⟨10.3390/jcm12175605⟩

Article dans une revue hal-05314003v1

3D-Printed, Liquid-Filled Capsules of Concentrated and Stabilized Polyphenol Epigallocatechin Gallate, Developed in a Clinical Trial

Philippe-Henri Secretan , Victoire Vieillard , Olivier Thirion , Maxime Annereau , Hassane Sadou Yayé et al.

Antioxidants , 2023, 12 (2), pp.424. ⟨10.3390/antiox12020424⟩

Article dans une revue hal-04099659v1

Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution

Maxime Annereau , Marina Vignes , Lucas Denis , André Rieutord , François-Xavier Legrand et al.

Pharmaceutics, 2023, 15 (10), pp.2371. ⟨10.3390/pharmaceutics15102371⟩

Article dans une revue hal-04270374v1

Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies

Philippe-Henri Secretan , Maxime Annereau , Willy Kini-Matondo , Bastien Prost , Jade Prudhomme et al.

Pharmaceutics, 2022, 14 (8), pp.1720. ⟨10.3390/pharmaceutics14081720⟩

Article dans une revue hal-03882694v1
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Mixed Polymeric Micelles for Rapamycin Skin Delivery

Guillaume Le Guyader , Bernard Do , Ivo Rietveld , Pascale Coric , Serge Bouaziz et al.

Pharmaceutics, 2022, 14 (3), pp.569. ⟨10.3390/pharmaceutics14030569⟩

Article dans une revue hal-03843621v1

Identification of the Major Degradation Pathways of Selumetinib

Tahar Sif Eddine Bouchema , Maxime Annereau , Victoire Vieillard , Raphael Boquet , Gisele Abreu Coelho et al.

Pharmaceutics, 2022, 14 (12), pp.2651. ⟨10.3390/pharmaceutics14122651⟩

Article dans une revue hal-04415612v1

Ruxolitinib photodegradation mechanisms by theoretical and experimental chemistry

Philippe-Henri Secretan , Joel Schlatter , Salvatore Cisternino , Marie Antignac , Olivier Thirion et al.

Journal of Pharmaceutical and Biomedical Analysis, 2021, 197, pp.113983. ⟨10.1016/j.jpba.2021.113983⟩

Article dans une revue hal-03244949v1
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Simple Approach to Enhance Green Tea Epigallocatechin Gallate Stability in Aqueous Solutions and Bioavailability: Experimental and Theoretical Characterizations

Philippe-Henri Secretan , Olivier Thirion , Hassane Sadou Yayé , Thibaud Damy , Alain Astier et al.

Pharmaceuticals, 2021, 14 (12), pp.1242. ⟨10.3390/ph14121242⟩

Article dans une revue hal-03510527v1

Stability of Pentobarbital Hydrogel for Rectal Administration in Pediatric Procedural Sedation

Sephora Belo , Justine Touchard , Philippe-Henri Secretan , Fabrice Vidal , Vincent Boudy et al.

Hospital Pharmacy, 2020, ⟨10.1177/0018578719901276⟩

Article dans une revue hal-03290925v1
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Voriconazole topical cream formulation: evidence for stability and antifungal activity

Camille Bouchand , David Nguyen , Philippe-Henri Secretan , Fabrice Vidal , Romain Guery et al.

International Journal of Antimicrobial Agents, 2020, 56 (3), pp.106083. ⟨10.1016/j.ijantimicag.2020.106083⟩

Article dans une revue hal-03492491v1
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Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries

Philippe-Henri Secretan , Marie Antignac , Najet Yagoubi , Mélisande Bernard , Marie Cécile Perier et al.

BMJ Open, 2020, 10 (11), pp.e039252. ⟨10.1136/bmjopen-2020-039252⟩

Article dans une revue hal-03066000v1
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Physical and chemical stability of a generic etoposide formulation as an alternative to etoposide phosphate

Hassane Sadou Yayé , Lamia Hassani , Philippe-Henri Secrétan , Martine Babiard , Haroun Aouati et al.

Journal of Pharmaceutical and Biomedical Analysis, 2019, 178, pp.112896. ⟨10.1016/j.jpba.2019.112896⟩

Article dans une revue hal-02356006v1

Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies

Hassane Sadou Yaye , Ivo Rietveld , Maria Barrio , Philippe-Henri Secrétan , Antoine Faucheron et al.

European Journal of Pharmaceutical Sciences, 2017, 107, pp.62 - 70. ⟨10.1016/j.ejps.2017.06.031⟩

Article dans une revue hal-01928273v1

Density functional theory and liquid chromatography-multistage mass spectrometry to characterize raltitrexed photo-degradation mechanisms

Hassane Sadou-Yayé , Maher Karoui , Philippe-Henri Secrétan , Noureddine Ghermani , Jean-Michel Gillet et al.

RSC Advances, 2016, 6 (96), pp.93801-93814. ⟨10.1039/c6ra13144a⟩

Article dans une revue hal-02316986v1
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Identification of dabigatran etexilate major degradation pathways by liquid chromatography coupled to multi stage high-resolution mass spectrometry

Fatma Amrani , Philippe Henri Secrétan , Hassane Sadou-Yayé , Caroline Aymes-Chodur , Mélisande Bernard et al.

RSC Advances, 2015, ⟨10.1039/c5ra04251h⟩

Article dans une revue hal-03514920v1
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A comprehensive study of apixaban's degradation pathways under stress conditions using liquid chromatography coupled to multistage mass spectrometry

Philippe Henri Secrétan , Hassane Sadou-Yayé , Caroline Aymes-Chodur , Mélisande Bernard , Audrey Solgadi et al.

RSC Advances, 2015, ⟨10.1039/c5ra00171d⟩

Article dans une revue hal-03514797v1