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Philippe-Henri Secretan

Maître de conférences
16
Documents

Domaines de recherche


Compétences

Chimie analytique Spectrométrie de masse Elucidation structurale Chimie théorique Réglementation pharmaceutique

Publications

Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution

Maxime Annereau , Marina Vignes , Lucas Denis , André Rieutord , François-Xavier Legrand
Pharmaceutics, 2023, 15 (10), pp.2371. ⟨10.3390/pharmaceutics15102371⟩
Article dans une revue hal-04270374v1

3D-Printed, Liquid-Filled Capsules of Concentrated and Stabilized Polyphenol Epigallocatechin Gallate, Developed in a Clinical Trial

Philippe-Henri Secretan , Victoire Vieillard , Olivier Thirion , Maxime Annereau , Hassane Sadou Yayé
Antioxidants , 2023, 12 (2), pp.424. ⟨10.3390/antiox12020424⟩
Article dans une revue hal-04099659v1

Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies

Philippe-Henri Secretan , Maxime Annereau , Willy Kini-Matondo , Bastien Prost , Jade Prudhomme
Pharmaceutics, 2022, 14 (8), pp.1720. ⟨10.3390/pharmaceutics14081720⟩
Article dans une revue hal-03882694v1

Identification of the Major Degradation Pathways of Selumetinib

Tahar Sif Eddine Bouchema , Maxime Annereau , Victoire Vieillard , Raphael Boquet , Gisele Abreu Coelho
Pharmaceutics, 2022, 14 (12), pp.2651. ⟨10.3390/pharmaceutics14122651⟩
Article dans une revue hal-04415612v1
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Mixed Polymeric Micelles for Rapamycin Skin Delivery

Guillaume Le Guyader , Bernard Do , Ivo Rietveld , Pascale Coric , Serge Bouaziz
Pharmaceutics, 2022, 14 (3), pp.569. ⟨10.3390/pharmaceutics14030569⟩
Article dans une revue hal-03843621v1
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Simple Approach to Enhance Green Tea Epigallocatechin Gallate Stability in Aqueous Solutions and Bioavailability: Experimental and Theoretical Characterizations

Philippe-Henri Secretan , Olivier Thirion , Hassane Sadou Yayé , Thibaud Damy , Alain Astier
Pharmaceuticals, 2021, 14 (12), pp.1242. ⟨10.3390/ph14121242⟩
Article dans une revue hal-03510527v1

Ruxolitinib photodegradation mechanisms by theoretical and experimental chemistry

Philippe-Henri Secretan , Joel Schlatter , Salvatore Cisternino , Marie Antignac , Olivier Thirion
Journal of Pharmaceutical and Biomedical Analysis, 2021, 197, pp.113983. ⟨10.1016/j.jpba.2021.113983⟩
Article dans une revue hal-03244949v1
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Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries

Philippe-Henri Secretan , Marie Antignac , Najet Yagoubi , Mélisande Bernard , Marie Cécile Perier
BMJ Open, 2020, 10 (11), pp.e039252. ⟨10.1136/bmjopen-2020-039252⟩
Article dans une revue hal-03066000v1

Stability of Pentobarbital Hydrogel for Rectal Administration in Pediatric Procedural Sedation

Sephora Belo , Justine Touchard , Philippe-Henri Secretan , Fabrice Vidal , Vincent Boudy
Hospital Pharmacy, 2020, ⟨10.1177/0018578719901276⟩
Article dans une revue hal-03290925v1
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Voriconazole topical cream formulation: evidence for stability and antifungal activity

Camille Bouchand , David Nguyen , Philippe-Henri Secretan , Fabrice Vidal , Romain Guery
International Journal of Antimicrobial Agents, 2020, 56 (3), pp.106083. ⟨10.1016/j.ijantimicag.2020.106083⟩
Article dans une revue hal-03492491v1
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Physical and chemical stability of a generic etoposide formulation as an alternative to etoposide phosphate

Hassane Sadou Yayé , Lamia Hassani , Philippe-Henri Secrétan , Martine Babiard , Haroun Aouati
Journal of Pharmaceutical and Biomedical Analysis, 2019, 178, pp.112896. ⟨10.1016/j.jpba.2019.112896⟩
Article dans une revue hal-02356006v1

Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies

Hassane Sadou Yaye , Ivo Rietveld , Maria Barrio , Philippe-Henri Secrétan , Antoine Faucheron
European Journal of Pharmaceutical Sciences, 2017, 107, pp.62 - 70. ⟨10.1016/j.ejps.2017.06.031⟩
Article dans une revue hal-01928273v1

Density functional theory and liquid chromatography-multistage mass spectrometry to characterize raltitrexed photo-degradation mechanisms

Hassane Sadou-Yayé , Maher Karoui , Philippe-Henri Secrétan , Noureddine Ghermani , Jean-Michel Gillet
RSC Advances, 2016, 6 (96), pp.93801-93814. ⟨10.1039/c6ra13144a⟩
Article dans une revue hal-02316986v1
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Identification of dabigatran etexilate major degradation pathways by liquid chromatography coupled to multi stage high-resolution mass spectrometry

Fatma Amrani , Philippe Henri Secrétan , Hassane Sadou-Yayé , Caroline Aymes-Chodur , Mélisande Bernard
RSC Advances, 2015, ⟨10.1039/c5ra04251h⟩
Article dans une revue hal-03514920v1
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A comprehensive study of apixaban's degradation pathways under stress conditions using liquid chromatography coupled to multistage mass spectrometry

Philippe Henri Secrétan , Hassane Sadou-Yayé , Caroline Aymes-Chodur , Mélisande Bernard , Audrey Solgadi
RSC Advances, 2015, ⟨10.1039/c5ra00171d⟩
Article dans une revue hal-03514797v1