Pablo VARGAS

Group leader "Leukomotion Lab"
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Publications

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Kinesin-1 coordinates cross-talk between microtubule and actin cytoskeletons during dendritic cell migration

Pierre Duquesne , Céline Aoun , Mathieu Kurowska , Brieuc Perot , Kerui Zhang et al.

Science Advances , 2025, 11 (42), pp.eadx7672. ⟨10.1126/sciadv.adx7672⟩

Article dans une revue hal-05326533v1

Lamin A/C Expression in Hematopoietic Cells Declines During Human Aging and Constrains Atherosclerosis in Mice

Marta Amorós-Pérez , Alberto del Monte-Monge , Pilar Gonzalo , María J Andrés-Manzano , Cristina Rius et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2025, 45 (9), pp.1616 - 1635. ⟨10.1161/atvbaha.124.322893⟩

Article dans une revue hal-05551694v1
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Human inherited CCR2 deficiency underlies progressive polycystic lung disease

Anna-Lena Neehus , Brenna Carey , Marija Landekic , Patricia Panikulam , Gail Deutsch et al.

Cell, 2024, 187 (2), pp.390-408.e23. ⟨10.1016/j.cell.2023.11.036⟩

Article dans une revue hal-04701934v1

Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement

Tania Gajardo , Mathilde Bernard , Marie Lô , Elisa Turck , Claire Leveau et al.

Journal of Allergy and Clinical Immunology, 2023, 152 (4), pp.949-960. ⟨10.1016/j.jaci.2023.06.016⟩

Article dans une revue hal-04279730v1
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DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity

Charlotte Boussard , Laure Delage , Tania Gajardo , Alexandre Kauskot , Maxime Batignes et al.

Blood, 2023

Article dans une revue hal-04246983v1
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DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity

Charlotte Boussard , Laure Delage , Tania Gajardo , Alexandre Kauskot , Maxime Batignes et al. Article dans une revue hal-04455529v1
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The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration

Marta Mastrogiovanni , Pablo Vargas , Thierry Rose , Céline Cuche , Elric Esposito et al.

Science Advances , 2022, 8 (15), pp.eabl5942. ⟨10.1126/sciadv.abl5942⟩

Article dans une revue pasteur-03681845v1

Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability

Bianca Calì , Mathieu Deygas , Fabio Munari , Elisabetta Marcuzzi , Antonino Cassará et al.

Science Signaling, 2022, 15 (761), ⟨10.1126/scisignal.abk2552⟩

Article dans une revue (data paper) hal-04290477v1
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Rubella vaccine–induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity

Miriam Gross , Carsten Speckmann , Annette May , Tania Gajardo-Carrasco , Katharina Wustrau et al.

Journal of Allergy and Clinical Immunology, In press, ⟨10.1016/j.jaci.2021.05.007⟩

Article dans une revue hal-03432275v1
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Pinching the cortex of live cells reveals thickness instabilities caused by myosin II motors

Valentin Laplaud , Nicolas Levernier , Judith Pineau , Mabel San , Lucie Barbier et al.

Science Advances , 2021

Article dans une revue hal-03395597v1
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Pinching the cortex of live cells reveals thickness instabilities caused by myosin II motors

Valentin Laplaud , Nicolas Levernier , Judith Pineau , Lucie Barbier , Pablo J Sáez et al.

Science Advances , 2021, 7 (27), pp.eabe3640. ⟨10.1126/sciadv.abe3640⟩

Article dans une revue hal-03278532v1

Deterministic actin waves as generators of cell polarization cues

Luiza Stankevicins , Nicolas Ecker , Emmanuel Terriac , Paolo Maiuri , Rouven Schoppmeyer et al.

Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (2), pp.826-835. ⟨10.1073/pnas.1907845117⟩

Article dans une revue hal-03697356v1
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Predicting Confined 1D Cell Migration from Parameters Calibrated to a 2D Motor-Clutch Model

Louis S Prahl , Maria R Stanslaski , Pablo Vargas , Matthieu Piel , David J Odde

Biophysical Journal, 2020, 118 (7), pp.1709-1720. ⟨10.1016/j.bpj.2020.01.048⟩

Article dans une revue hal-03036509v1
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A statistical inference approach to reconstruct intercellular interactions in cell migration experiments

Elena Agliari , Pablo J Sáez , Adriano Barra , Matthieu Piel , Pablo Vargas et al.

Science Advances , 2020, 6 (11), pp.eaay2103. ⟨10.1126/sciadv.aay2103⟩

Article dans une revue hal-03036516v1
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Sliding walls: a new paradigm for fluidic actuation and protocol implementation in microfluidics

Bastien Venzac , Yang Liu , Ivan Ferrante , Pablo Vargas , Ayako Yamada et al.

Microsystems & Nanoengineering, 2020, 6 (1), ⟨10.1038/s41378-019-0125-7⟩

Article dans une revue hal-03041894v2
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Myosin II Activity Is Selectively Needed for Migration in Highly Confined Microenvironments in Mature Dendritic Cells

Lucie Barbier , Pablo J Sáez , Rafaele Attia , Ana-Maria Lennon-Duménil , Ido Lavi et al.

Frontiers in Immunology, 2019, 10 (10), pp.993-1004. ⟨10.3389/fimmu.2019.00747⟩

Article dans une revue hal-02466630v1

Reconstitution of cell migration at a glance

Juan Manuel Garcia-Arcos , Renaud Chabrier , Mathieu Deygas , Guilherme Nader , Lucie Barbier et al.

Journal of Cell Science, 2019, 132 (4), pp.jcs225565. ⟨10.1242/jcs.225565⟩

Article dans une revue hal-02466691v1

Role of calcium permeable channels in dendritic cell migration

Pablo J Sáez , Juan Sáez , Ana-Maria Lennon-Duménil , Pablo Vargas

Current Opinion in Immunology, 2018, 52 (1), pp.74-80. ⟨10.1016/j.coi.2018.04.005⟩

Article dans une revue hal-02466785v1
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Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation

Mirjana Weimershaus , Francois-Xavier Mauvais , Loredana Saveanu , Cézaire Adiko , Joel Babdor et al.

Cell Reports, 2018, 24 (13), pp.3568-3581. ⟨10.1016/j.celrep.2018.08.041⟩

Article dans une revue hal-02466698v1

Diversification of human plasmacytoid predendritic cells in response to a single stimulus

Solana Alculumbre , Violaine Saint-André , Jérémy Di Domizio , Pablo Vargas , Philemon Sirven et al.

Nature Immunology, 2018, 19 (1), pp.63-75. ⟨10.1038/s41590-017-0012-z⟩

Article dans une revue hal-02349815v1

Diversification of human plasmacytoid predendritic cells in response to a single stimulus.

Solana G. Alculumbre , Violaine Saint-André , Jeremy Di Domizio , Pablo Vargas , Philemon Sirven et al.

Nature immunology, 2018, 19, pp.63--75

Article dans une revue hal-04024846v1

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

Sophia Maschalidi , Paula Nunes-Hasler , Clarissa Nascimento , Ignacio Sallent , Valérie Lannoy et al.

Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-01601-5⟩

Article dans une revue hal-02365944v1
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UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

Sophia Maschalidi , Paula Nunes-Hasler , Clarissa R Nascimento , Ignacio Sallent , Valérie Lannoy et al.

Nature Communications, 2017, 8 (1), pp.1640. ⟨10.1038/s41467-017-01601-5⟩

Article dans une revue hal-04059179v1
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A tuneable microfluidic system for long duration chemotaxis experiments in a 3D collagen matrix

Koceila Aizel , Andrew Clark , Anthony Simon , Sara Geraldo , Anette Funfak et al.

Lab on a Chip, 2017, 17 (22), pp.3851-3861. ⟨10.1039/C7LC00649G⟩

Article dans une revue hal-04788653v1
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UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

Sophia Maschalidi , Paula Nunes-Hasler , Clarissa R Nascimento , Ignacio Sallent , Valérie Lannoy et al.

Nature Communications, 2017, 8, ⟨10.1038/s41467-017-01601-5⟩

Article dans une revue hal-03103691v1
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Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

Hawa-Racine Thiam , Pablo Vargas , Nicolas Carpi , Carolina Lage Crespo , Matthew Raab et al.

Nature Communications, 2016, 7 (1), pp.10997. ⟨10.1038/ncomms10997⟩

Article dans une revue hal-05551260v1
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Space exploration by dendritic cells requires maintenance of myosin II activity by IP3 receptor 1.

Paola Solanes , Mélina L Heuzé , Mathieu Maurin , Marine Bretou , Franziska Lautenschlaeger et al.

EMBO Journal, 2015, 34 (6), pp.798-810. ⟨10.15252/embj.201489056⟩

Article dans une revue hal-02947479v1
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Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

Mélanie Chabaud , Mélina L Heuzé , Marine Bretou , Pablo Vargas , Paolo Maiuri et al.

Nature Communications, 2015, 6 (1), pp.7526. ⟨10.1038/ncomms8526⟩

Article dans une revue hal-05551261v1

The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.

Fulvia Vascotto , Danielle Lankar , Gabrielle Faure-André , Pablo Vargas , Jheimmy Diaz et al.

Journal of Cell Biology, 2007, 176 (7), pp.1007-19. ⟨10.1083/jcb.200611147⟩

Article dans une revue hal-00316389v1

NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells

Ariel Savina , Carolina Jancic , Stephanie Hugues , Pierre Guermonprez , Pablo Vargas et al.

Cell, 2006, 126, pp.205 - 218. ⟨10.1016/j.cell.2006.05.035⟩

Article dans une revue hal-05551675v1

Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens

Pablo Vargas , Claudio Cortés , Leonardo Vargas , Mario Rosemblatt , María Rosa Bono

Immunobiology, 2006, 211, pp.29 - 36. ⟨10.1016/j.imbio.2005.09.002⟩

Article dans une revue hal-05551681v1