Renaud Poincloux

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Publications

Capsule-mediated O-antigen masking protects hypervirulent Klebsiella pneumoniae from neutrophil killing

Karin Santoni , Joshua L.C Wong , Renaud Poincloux , Etienne Meunier , Gad Frankel
Article dans une revue hal-05018837 v1

Focal adhesions contain three specialized actin nanoscale layers

Reena Kumari , Katharina Ven , Megan Chastney , Shrikant Kokate , Johan Peränen et al.
Nature Communications, 2024, 15 (1), pp.2547. ⟨10.1038/s41467-024-46868-7⟩
Article dans une revue hal-04639883 v1
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Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics

Perrine Verdys , Javier Rey Barroso , Adeline Girel , Joseph Vermeil , Martin Bergert et al.
EMBO Journal, 2024, 43 (21), pp.4822-4845. ⟨10.1038/s44318-024-00173-7⟩
Article dans une revue hal-04735160 v1
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Lymphocyte migration and retention properties affected by ibrutibnib in chronic lymphocytic leukemia

Javier Rey-Barroso , Alice Munaretto , Nelly Rouquié , Aurélie Mougel , Malika Chassan et al.
Haematologica, 2024, 109 (3), pp.809-823. ⟨10.3324/haematol.2022.282466⟩
Article dans une revue hal-04218221 v1

Moesin activation controls bone resorption and tunneling nanotube-dependent osteoclast fusion

Ophélie Dufrancais , Perrine Verdys , Arnaud Métais , Marie Juzans , Thibaut Sanchez et al.
Article dans une revue hal-04639892 v1
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Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cells

Rémi Mascarau , Marie Woottum , Léa Fromont , Rémi Gence , Vincent Cantaloube-Ferrieu et al.
Journal of Cell Biology, 2023, Immune Cell Biology 2023, 222 (5), pp.e202205103. ⟨10.1083/jcb.202205103⟩
Article dans une revue hal-04087834 v1
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Super-resolved total internal reflection fluorescence microscopy using random illuminations

Kévin Affannoukoué , Simon Labouesse , Guillaume Maire , Laurent Gallais , Julien Savatier et al.
Optica, 2023, 10 (8), pp.1009. ⟨10.1364/optica.487003⟩
Article dans une revue hal-04172900 v1

Elasticity of podosome actin networks produces nanonewton protrusive forces

Marion Jasnin , Jordan Hervy , Stéphanie Balor , Anaïs Bouissou , Amsha Proag et al.
Nature Communications, 2022, 13 (1), pp.3842. ⟨10.1038/s41467-022-30652-6⟩
Article dans une revue hal-04639873 v1
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Dysregulation of the IFN-I signaling pathway by Mycobacterium tuberculosis leads to exacerbation of HIV-1 infection of macrophages

Maeva Dupont , Thien-Phong Vu Manh , Karine Pingris , Shanti Souriant , Tomàs Velez et al.
Journal of Leukocyte Biology, 2022, 112 (5), pp.1329-1342. ⟨10.1002/JLB.4MA0422-730R⟩
Article dans une revue hal-04738082 v1
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Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa

Karin Santoni , David Pericat , Leana Gorse , Julien Buyck , Miriam Pinilla et al.
PLoS Pathogens, 2022, 18 (7), pp.e1010305. ⟨10.1371/journal.ppat.1010305⟩
Article dans une revue hal-03738417 v1

Dysregulation of the IFN-I signaling pathway by Mycobacterium tuberculosis leads to exacerbation of HIV-1 infection of macrophages

Maeva Dupont , Stella Rousset , Thien-Phong Vu Manh , Sarah Catherine Monard , Karine Pingris et al.
Journal of Leukocyte Biology, 2022, 112 (5), pp.1329-1342. ⟨10.1002/JLB.4MA0422-730R⟩
Article dans une revue hal-03960144 v1
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Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts

Marion Portes , Thomas Mangeat , Natacha Escallier , Ophélie Dufrancais , Brigitte Raynaud-Messina et al.
eLife, 2022, 11, pp.e75610. ⟨10.7554/eLife.75610⟩
Article dans une revue hal-03763496 v1
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Elasticity of podosome actin networks produces nanonewton protrusive forces

Marion Jasnin , Jordan Hervy , Stéphanie Balor , Anaïs Bouissou , Amsha Proag et al.
Nature Communications, 2022, 13 (1), pp.3842. ⟨10.1038/s41467-022-30652-6⟩
Article dans une revue hal-03817191 v1
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Cellular and molecular actors of myeloid cell fusion: podosomes and tunneling nanotubes call the tune

Ophélie Dufrançais , Rémi Mascarau , Renaud Poincloux , Isabelle Maridonneau-Parini , Brigitte Raynaud-Messina et al.
Cellular and Molecular Life Sciences, 2021, 78 (17-18), pp.6087-6104. ⟨10.1007/s00018-021-03875-x⟩
Article dans une revue hal-03450669 v1
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Super-resolved live-cell imaging using Random Illumination Microscopy

Thomas Mangeat , Simon Labouesse , Marc Allain , Awoke Negash , Emmanuel Martin et al.
Cell Reports Methods, 2021, 1 (1), pp.100009. ⟨10.1016/j.crmeth.2021.100009⟩
Article dans une revue hal-02564126 v1
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HIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment

Rémi Mascarau , Florent Bertrand , Arnaud Labrousse , Isabelle Gennero , Renaud Poincloux et al.
International Journal of Molecular Sciences, 2020, 21 (9), pp.3154. ⟨10.3390/ijms21093154⟩
Article dans une revue hal-03020912 v1
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Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

Maeva Dupont , Shanti Souriant , Luciana Balboa , Thien-Phong Vu Manh , Karine Pingris et al.
Article dans une revue hal-02995702 v1

Genetic engineering of hoxb8 immortalized hematopoietic progenitors: a potent tool to study macrophage tissue migration

Solene Accarias , Thibaut Sanchez , Arnaud Labrousse , Myriam Ben-Neji , Aurélien Boyance et al.
Journal of Cell Science, 2020, 133 (5), pp.jcs236703. ⟨10.1242/jcs.236703⟩
Article dans une revue hal-03018738 v1

HIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment

Rémi Mascarau , Florent Bertrand , Arnaud Labrousse , Isabelle Gennero , Renaud Poincloux et al.
International Journal of Molecular Sciences, 2020, 21 (9), pp.3154. ⟨10.3390/ijms21093154⟩
Article dans une revue hal-04958886 v1
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Tuberculosis Exacerbates HIV-1 infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages

Shanti Souriant , Luciana Balboa , Maeva Dupont , Karine Pingris , Denise Kviatcovsky et al.
Cell Reports, 2019, 26 (13), pp.3586-3599.e7. ⟨10.1016/j.celrep.2019.02.091⟩
Article dans une revue hal-03034321 v2

Probing the mechanical landscape – new insights into podosome architecture and mechanics

Koen van den Dries , Stefan Linder , Isabelle Maridonneau-Parini , Renaud Poincloux
Journal of Cell Science, 2019, 132 (24), pp.jcs236828. ⟨10.1242/jcs.236828⟩
Article dans une revue hal-03034038 v1

Asb2 alpha-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development

Arnaud Metais , Isabelle Lamsoul , Armelle Melet , Sandrine Uttenweiler-Joseph , Renaud Poincloux et al.
Circulation Research, 2018, 122 (6), pp.E34+. ⟨10.1161/CIRCRESAHA.117.312015⟩
Article dans une revue hal-02544517 v1

The Protease-Dependent Mesenchymal Migration of Tumor-Associated Macrophages as a Target in Cancer Immunotherapy

Philippe Gui , Myriam Ben-Neji , Ekaterina Belozertseva , Florence Dalenc , Camille Franchet et al.
Cancer Immunology Research, 2018, 6 (11), pp.1337-1351. ⟨10.1158/2326-6066.CIR-17-0746⟩
Article dans une revue hal-02356000 v1
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Frustrated endocytosis controls contractility-independent mechanotransduction at clathrin-coated structures

Francesco Baschieri , Stéphane Dayot , Nadia Elkhatib , Nathalie Ly , Anahi Capmany et al.
Nature Communications, 2018, 9 (1), pp.3825. ⟨10.1038/s41467-018-06367-y⟩
Article dans une revue hal-04500570 v1
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The C-Type Lectin Receptor DC-SIGN Has an Anti-Inflammatory Role in Human M(IL-4) Macrophages in Response to Mycobacterium tuberculosis

Geanncarlo Lugo-Villarino , Anthony Troegeler , Luciana Balboa , Claire Lastrucci , Carine Duval et al.
Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.01123⟩
Article dans une revue hal-02348476 v1
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Podosomes, But Not the Maturation Status, Determine the Protease-Dependent 3D Migration in Human Dendritic Cells

Céline Cougoule , Claire Lastrucci , Romain Guiet , Rémi Mascarau , Etienne Meunier et al.
Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.00846⟩
Article dans une revue hal-02348486 v1

Podosome Force Generation Machinery: A Local Balance between Protrusion at the Core and Traction at the Ring

Christophe Thibault , Anais Bouissou , Amsha Proag , Nicolas Bourg , Karine Pingris et al.
ACS Nano, 2017, 11 (4), pp.4028 - 4040. ⟨10.1021/acsnano.7b00622⟩
Article dans une revue hal-01767661 v1
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C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells

Anthony Troegeler , Ingrid Mercier , Céline Cougoule , Danilo Pietretti , André Colom et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (4), pp.E540-E549. ⟨10.1073/pnas.1613254114⟩
Article dans une revue hal-02348507 v1

Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16+ monocyte population via the IL-10/STAT3 axis

Claire Lastrucci , Alan Bénard , Luciana Balboa , Karine Pingris , Shanti Souriant et al.
Cell Research, 2015, 25 (12), pp.1333-1351. ⟨10.1038/cr.2015.123⟩
Article dans une revue hal-02348517 v1

Working Together: Spatial Synchrony in the Force and Actin Dynamics of Podosome First Neighbors

Amsha Proag , Anais Bouissou , Thomas Mangeat , Raphael Voituriez , Patrick Delobelle et al.
ACS Nano, 2015, 9 (4), pp.3800 - 3813. ⟨10.1021/nn506745r⟩
Article dans une revue hal-01767608 v1
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Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes

Anna Labernadie , Anais Bouissou , Patrick Delobelle , Stephanie Balor , Raphael Voituriez et al.
Nature Communications, 2014, 5 (1), 31p. ⟨10.1038/ncomms6343⟩
Article dans une revue hal-01767580 v1
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Queuosine biosynthesis is required for <em>sinorhizobium meliloti</em>-induced cytoskeletal modifications on HeLa Cells and symbiosis with <em>Medicago truncatula</em>

Marta Marchetti , Delphine Capela , Renaud Poincloux , Nacer Benmeradi , Marie-Christine Auriac et al.
PLoS ONE, 2013, 8 (2), ⟨10.1371/journal.pone.0056043⟩
Article dans une revue hal-02650924 v1
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Macrophage Mesenchymal Migration Requires Podosome Stabilization by Filamin A

Romain Guiet , Christel Vérollet , Isabelle Lamsoul , Céline Cougoule , Renaud Poincloux et al.
Journal of Biological Chemistry, 2012, 287 (16), pp.13051-13062. ⟨10.1074/jbc.M111.307124⟩
Article dans une revue hal-02406507 v1

Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages.

Hélène Botella , Pascale Peyron , Florence Levillain , Renaud Poincloux , Yannick Poquet et al.
Cell Host and Microbe, 2011, 10 (3), pp.248-59. ⟨10.1016/j.chom.2011.08.006⟩
Article dans une revue hal-00674577 v1

Macrophage podosomes go 3D

Emeline van Goethem , Romain Guiet , Stephanie Balor , Guillaume Charriere , Renaud Poincloux et al.
European Journal of Cell Biology, 2011, 90 (2-3), pp.224-236. ⟨10.1016/j.ejcb.2010.07.011⟩
Article dans une revue istex hal-02356068 v1

Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures.

Emeline van Goethem , Renaud Poincloux , Fabienne Gauffre , Isabelle Maridonneau-Parini , Véronique Le Cabec
Journal of Immunology, 2010, 184 (2), pp.1049-61. ⟨10.4049/jimmunol.0902223⟩
Article dans une revue hal-03038501 v1

Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis

Céline Cougoule , Véronique Le Cabec , Renaud Poincloux , Talal Al Saati , Jean-Louis Mege et al.
Blood, 2010, 115 (7), pp.1444-1452. ⟨10.1182/blood-2009-04-218735⟩
Article dans une revue hal-02356257 v1

The oncogenic activity of the Src family kinase Hck requires the cooperative action of the plasma membrane- and lysosome-associated isoforms

Renaud Poincloux , Talal Al Saati , Isabelle Maridonneau-Parini , Véronique Le Cabec
European Journal of Cancer, 2009, 45 (3), pp.321-327. ⟨10.1016/j.ejca.2008.11.020⟩
Article dans une revue istex hal-02356076 v1

Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells

Floria Lizarraga , Renaud Poincloux , Marise Romao , Guillaume Montagnac , Gaëlle Le Dez et al.
Cancer Research, 2009, 69 (7), pp.2792-2800. ⟨10.1158/0008-5472.CAN-08-3709⟩
Article dans une revue hal-02659942 v1

Hematopoietic cell kinase (Hck) isoforms and phagocyte duties – From signaling and actin reorganization to migration and phagocytosis

R Guiet , R. Poincloux , J. Castandet , L. Marois , A. Labrousse et al.
European Journal of Cell Biology, 2008, 87 (8-9), pp.527-542. ⟨10.1016/j.ejcb.2008.03.008⟩
Article dans une revue istex hal-02356077 v1

MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7.

Anika Steffen , Gaëlle Le Dez , Renaud Poincloux , Chiara Recchi , Pierre Nassoy et al.
Current Biology, 2008, 18 (12), pp.926-31. ⟨10.1016/j.cub.2008.05.044⟩
Article dans une revue hal-00319422 v1

Tyrosine-phosphorylated STAT5 accumulates on podosomes in Hck-transformed fibroblasts and chronic myeloid leukemia cells.

Renaud Poincloux , Céline Cougoule , Thomas Daubon , Isabelle Maridonneau-Parini , Véronique Le Cabec
Journal of Cellular Physiology, 2007, 213 (1), pp.212-20. ⟨10.1002/jcp.21112⟩
Article dans une revue istex hal-00177912 v1

Re-arrangements of podosome structures are observed when Hck is activated in myeloid cells.

Renaud Poincloux , Claire Vincent , Arnaud Labrousse , Jerôme Castandet , Maxime Rigo et al.
European Journal of Cell Biology, 2006, 85 (3-4), pp.327-32. ⟨10.1016/j.ejcb.2005.09.012⟩
Article dans une revue istex hal-00177921 v1

Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes.

Céline Cougoule , Sébastien Carréno , Jerôme Castandet , Arnaud Labrousse , Catherine Astarie-Dequeker et al.
Traffic, 2005, 6 (8), pp.682-94. ⟨10.1111/j.1600-0854.2005.00307.x⟩
Article dans une revue hal-00177916 v1

Fungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules.

Frédéric Francis , Claire Marty-Detraves , Renaud Poincloux , Laurent Baricault , Didier Fournier et al.
European Journal of Cell Biology, 2003, 82 (10), pp.515-22. ⟨10.1078/0171-9335-00338⟩
Article dans une revue hal-00177744 v1

Macrophage mechanics, from cell migration to phagocytosis

Renaud Poincloux
Immunobiophysics seminar series, Mar 2025, Online, France
Communication dans un congrès hal-05018885 v1

Macrophage mechanics, from cell migration to phagocytosis

Renaud Poincloux
Symposium on Monocytes and Macrophages, Nov 2025, Lyon, France
Communication dans un congrès hal-05018878 v1

Macrophage mechanics, from cell migration to phagocytosis

Renaud Poincloux
20th meeting of the Canceropole GSO, Nov 2024, Perpignan, France
Communication dans un congrès hal-05019217 v1

ERM proteins and the macrophage cortex

Renaud Poincloux
Les Avancées Scientifiques de la Recherche Biomédicale Toulousaine, Nov 2024, Toulouse, France
Communication dans un congrès hal-05019226 v1

Macrophage compression forces during migration and phagocytosis

Renaud Poincloux
Cellular and Molecular Organisation on Engineered Micropatterns and 3D Structures, Nov 2023, Paris, France
Communication dans un congrès hal-05019236 v1

Nanoscale mechanics of macrophage podosomes

Renaud Poincloux
ENS/ESPCI biophysics seminars, Apr 2021, Online, France
Communication dans un congrès hal-05019249 v1

Nanoscale architecture and mechanics of macrophage podosomes

Renaud Poincloux
Invadosome meeting, Jun 2019, London, United Kingdom
Communication dans un congrès hal-05019265 v1

Nanoscale architecture and mechanics of macrophage podosomes

Renaud Poincloux
CellTiss days, Nov 2019, Giens, France
Communication dans un congrès hal-05019258 v1

Identification of a unique TUBB3 + cell population in the tuberculosis granuloma

Sarah Monard , Arnaud Métais , Maxime Pingret , Caroline Buscail , Maxime Caouaille et al.
2025
Pré-publication, Document de travail hal-05018831 v1
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Inhibition of glycolysis in tuberculosis-mediated metabolic rewiring reduces HIV-1 spread across macrophages

Zoï Vahlas , Natacha Faivre , Sarah C Monard , Quentin Hertel , Mariano Maio et al.
2024
Pré-publication, Document de travail hal-04739994 v1

Inhibition of glycolysis in tuberculosis-mediated metabolic rewiring reduces HIV-1 spread across macrophages

Zoï Vahlas , Natacha Faivre , Sarah Monard , Quentin Hertel , Mariano Maio et al.
2025
Pré-publication, Document de travail hal-04958912 v1

Moesin controls cell-cell fusion and osteoclast function

Ophélie Dufrancais , Perrine Verdys , Marianna Plozza , Arnaud Métais , Marie Juzans et al.
2025
Pré-publication, Document de travail hal-04958903 v1
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Megakaryocytes build a cage of extracellular matrix that controls their maturation and anchoring to the vascular niche

Claire Masson , Cyril Scandola , Jean-Yves Rinckel , Fabienne Proamer , Emily Janus-Bell et al.
2024
Pré-publication, Document de travail pasteur-04721499 v1
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The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics

Perrine Verdys , Javier Rey Barroso , Joseph Vermeil , Thibaut Sanchez , Arnaud Métais et al.
2023
Pré-publication, Document de travail hal-04234772 v1

Super-resolved live-cell imaging using Random Illumination Microscopy

Thomas Mangeat , Simon Labouesse , Marc Allain , Emmanuel Martin , Renaud Poincloux et al.
2021
Pré-publication, Document de travail hal-03101965 v1

Elasticity of dense actin networks produces nanonewton protrusive forces

Marion Jasnin , Jordan Hervy , Stéphanie Balor , Anais Bouissou , Amsha Proag et al.
2021
Pré-publication, Document de travail hal-03423297 v1

Pseudomonas aeruginosa infection reveals a Caspase-1-dependent neutrophil pyroptosis pathway that restrains damaging Histone release

Rémi Planès , Karin Santoni , Salimata Bagayoko , David Pericat , Pierre-Jean Bordignon et al.
2021
Pré-publication, Document de travail hal-03452379 v1