rodolphe ALVES DE SOUSA

26
Documents

Publications

Publications

Inhibition of the Parkinson’s Disease-Related Protein DJ-1 by Endogenous Neurotoxins of the 1,2,3,4-Tetrahydroisoquinoline Family

Catherine Laurent , Gabrielle Poncet , Tristan Herskovits , Rodolphe Alves de Sousa , Laurent Le Corre et al.
ACS Chemical Neuroscience, 2025, 16 (6), pp.1034-1042. ⟨10.1021/acschemneuro.4c00559⟩
Article dans une revue hal-05291792 v1

Revisiting the nature and pharmacodynamics of tacrolimus metabolites

Rudy Mevizou , Hassan Aouad , François-Ludovic Sauvage , Hélène Arnion , Emilie Pinault et al.
Pharmacological Research, 2024, 209, pp.107438. ⟨10.1016/j.phrs.2024.107438⟩
Article dans une revue hal-05291791 v1

Targeted Strategies for Degradation of Key Transmembrane Proteins in Cancer

Vehary Sakanyan , Nina Iradyan , Rodolphe Alves de Sousa
BioTech, 2023, 12 (3), pp.57. ⟨10.3390/biotech12030057⟩
Article dans une revue hal-04220345 v1
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Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition

Simon Hayek , Nicolas Pietrancosta , Anna Hovhannisyan , Rodolphe Alves de Sousa , Nassima Bekaddour et al.
European Journal of Medicinal Chemistry, 2020, 186, pp.111855. ⟨10.1016/j.ejmech.2019.111855⟩
Article dans une revue hal-02372490 v1
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Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression

Alejandro Orrico-Sanchez , Laetitia Chausset-Boissarie , Rodolphe Alves de Sousa , Basile Coutens , Sara Rezai Amin et al.
Molecular Psychiatry, 2020, 25 (6), pp.1245-1259. ⟨10.1038/s41380-019-0548-4⟩
Article dans une revue inserm-03943549 v1
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Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death

Melkon Iradyan , Nina Iradyan , Philippe Hulin , Artur Hambardzumyan , Aram Gyulkhandanyan et al.
Cancers, 2019, 11 (8), pp.1094. ⟨10.3390/cancers11081094⟩
Article dans une revue hal-02321259 v2
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Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay

Simon Hayek , Nassima Bekaddour , Laurie Besson , Rodolphe Alves de Sousa , Nicolas Pietrancosta et al.
Slas Discovery, 2018, 24 (1), pp.25-37. ⟨10.1177/2472555218797078⟩
Article dans une revue hal-02324386 v1

SELECTIVE N-, S-ALKYLATION OF 4-ALLYL-3-[2-(4-ALKOXYPHENYL)- QUINOLIN-4-YL]-4,5-DIHYDRO-1H-1,2,4-TRIAZOLE-5-THIONES WITH SUBSTITUTED BENZYLCHLORIDES. SYNTHESIS, DOCKING ANALYSIS AND СYTOTOXIC ACTION

Rodolphe Alves de Sousa , М Ирадян , А Амбарцумян , Г Паносян , Р Тамазян et al.
Chemical Journal of Armenia, 2018
Article dans une revue hal-03652521 v1
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Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria

Anas Allam , Laure Maigre , Julia Vergalli , Estelle Dumont , Bertrand Cinquin et al.
Scientific Reports, 2017, 7 (1), pp.986. ⟨10.1038/s41598-017-00945-8⟩
Article dans une revue hal-01831783 v1

Erratum: Corrigendum: A unique peptide deformylase platform to rationally design and challenge novel active compounds

Sonia Fieulaine , Rodolphe Alves de Sousa , Laure Maigre , Karim Hamiche , Mickael Alimi et al.
Scientific Reports, 2017, 7 (1), pp.39365. ⟨10.1038/srep39365⟩
Article dans une revue hal-03652528 v1

New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria

Anas Allam , Laure Maigre , Rodolphe Alves de Sousa , Estelle Dumont , Julia Vergalli et al.
European Journal of Medicinal Chemistry, 2017, 127, pp.748-756. ⟨10.1016/j.ejmech.2016.10.054⟩
Article dans une revue hal-03652533 v1

Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria

Anas Allam , Laure Maigre , Julia Vergalli , Estelle Dumont , Bertrand Cinquin et al.
Scientific Reports, 2017, 7 (1), pp.986. ⟨10.1038/s41598-017-00945-8⟩
Article dans une revue hal-03652530 v1

A unique peptide deformylase platform to rationally design and challenge novel active compounds

Sonia Fieulaine , Rodolphe Alves de Sousa , Laure Maigre , Karim Hamiche , Mickael Alimi et al.
Scientific Reports, 2016, 6 (1), pp.35429. ⟨10.1038/srep35429⟩
Article dans une revue hal-03652534 v1
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Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1

Vehary Sakanyan , Philippe Hulin , Rodolphe Alves de Sousa , Viviane Silva , Artur Hambardzumyan et al.
Scientific Reports, 2016, 6 (1), pp.21088. ⟨10.1038/srep21088⟩
Article dans une revue hal-03652537 v1
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A unique peptide deformylase platform to rationally design and challenge novel active compounds

Sonia Fieulaine , Rodolphe Alves de Sousa , Laure Maigre , Karim Hamiche , Mickael Alimi et al.
Scientific Reports, 2016, 6, pp.35429. ⟨10.1038/srep35429⟩
Article dans une revue hal-01412212 v1

Straightforward Detection of Reactive Compound Binding to Multiple Proteins in Cancer Cells: Towards a Better Understanding of Electrophilic Stress

Rodolphe Alves de Sousa , Vehary Sakanyan
Annals of Clinical & Experimental Metabolism, 2016
Article dans une revue hal-03662587 v1

New Peptides with Metal Binding Abilities and Their Use as Drug Carriers

Anas Allam , Laure Maigre , Mickael Alimi , Rodolphe Alves de Sousa , Assia Hessani et al.
Bioconjugate Chemistry, 2014, 25 (10), pp.1811-1819. ⟨10.1021/bc500317u⟩
Article dans une revue hal-03652539 v1

New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity

Emilie Goemaere , Armelle Melet , Valéry Larue , Aurélie Lieutaud , Rodolphe Alves de Sousa et al.
Journal of Antimicrobial Chemotherapy, 2012, 67 (6), pp.1392-1400. ⟨10.1093/jac/dks058⟩
Article dans une revue hal-03652545 v1

New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity.

Emilie Goemaere , Armelle Melet , Valéry Larue , Aurélie Lieutaud , Rodolphe Alves de Sousa et al.
Journal of Antimicrobial Chemotherapy, 2012, 67 (6), pp.1392-400. ⟨10.1093/jac/dks058⟩
Article dans une revue hal-00851369 v1

Bis-β-sulfanylethylester and cyclic disulfide-S-oxides as precursors of bifunctionalized anionic derivatives with two oxidized sulfurs

Rodolphe Alves de Sousa , Isabelle Artaud
Tetrahedron, 2008, 64 (9), pp.2198-2206. ⟨10.1016/j.tet.2007.12.023⟩
Article dans une revue istex hal-03652546 v1

Discovery and Refinement of a New Structural Class of Potent Peptide Deformylase Inhibitors

Adrien Boularot , Carmela Giglione , Sylvain Petit , Yann Duroc , Rodolphe Alves de Sousa et al.
Journal of Medicinal Chemistry, 2007, 50 (1), pp.10-20. ⟨10.1021/jm060910c⟩
Article dans une revue hal-03652549 v1

Synthesis of cyclic mono- and bis-disulfides and their selective conversion to mono- and bis-thiosulfinates

Emilie Bourlès , Rodolphe Alves de Sousa , Erwan Galardon , Mohamed Selkti , Alain Tomas et al.
Tetrahedron, 2007, 63 (11), pp.2466-2471. ⟨10.1016/j.tet.2007.01.002⟩
Article dans une revue istex hal-03652551 v1

Discovery and Refinement of a New Structural Class of Potent Peptide Deformylase Inhibitors.

Adrien Boularot , Carmela Giglione , Sylvain Petit , Yann Duroc , Rodolphe Alves de Sousa et al.
Journal of Medicinal Chemistry, 2007, 50 (1), pp.10-20. ⟨10.1021/jm060910c⟩
Article dans une revue hal-00123257 v1

Direct Synthesis of a Thiolato-S and Sulfinato-S CoIII Complex Related to the Active Site of Nitrile Hydratase: A Pathway to the Post-Translational Oxidation of the Protein

Emilie Bourles , Rodolphe Alves de Sousa , Erwan Galardon , Michel Giorgi , Isabelle Artaud
Angewandte Chemie International Edition, 2005, 44 (38), pp.6162-6165. ⟨10.1002/anie.200500814⟩
Article dans une revue istex hal-03652558 v1

Oxidation of Zn(N2S2) complexes to disulfonates: relevance to zinc-finger oxidation under oxidative stress

Rodolphe Alves de Sousa , Erwan Galardon , Mathieu Rat , Michel Giorgi , Isabelle Artaud
Journal of Inorganic Biochemistry, 2005, 99 (3), pp.690-697. ⟨10.1016/j.jinorgbio.2004.11.019⟩
Article dans une revue istex hal-03652562 v1