Romain Haudecoeur

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Publications

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Aurones as new modulators of hypoxia inducible factor-1 (HIF-1) to prevent cardiac cell death

Léa Di Maria , Brayan Roulier , Morane Beaumet , Romain Haudecoeur , Ahcène Boumendjel et al.

Results in Chemistry, 2025, 17, pp.102609. ⟨10.1016/j.rechem.2025.102609⟩

Article dans une revue hal-05234686v1
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Bistable and Water‐Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light

Letícia da Mata Lazinski , Morane Beaumet , Frédérique Loiseau , Cyril Goudet , Martial Boggio‐pasqua et al.

ChemistryEurope, 2025, 3 (5), pp.e202500221. ⟨10.1002/ceur.202500221⟩

Article dans une revue hal-05339073v1
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Tyrosinase Inhibition and Antimelanogenic Effects of Resorcinol‐Containing Compounds

Morane Beaumet , Leticia M Lazinski , Marc Maresca , Romain Haudecoeur

ChemMedChem, 2024, ⟨10.1002/cmdc.202400314⟩

Article dans une revue hal-04768568v1
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Design and synthesis of 4-amino-2',4'-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells

Leticia Lazinski , Morane Beaumet , Brayan Roulier , Rémy Gay , Guy Royal et al.

European Journal of Medicinal Chemistry, 2024, 266, pp.116165. ⟨10.1016/j.ejmech.2024.116165⟩

Article dans une revue hal-04768565v1
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Expanding Chemical Frontiers: Approaches for Generating Diverse and Bioactive Natural Product-Like Compounds Libraries from Extracts

Aurélien Beato , Romain Haudecoeur , Benjamin Boucherle , Marine Peuchmaur

Chemistry - A European Journal, 2024, 30 (26), pp.e202304166. ⟨10.1002/chem.202304166⟩

Article dans une revue (article de synthèse) hal-04604571v1
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Aurones and derivatives as promising New Delhi metallo-β-lactamase (NDM-1) inhibitors

Jérémy Caburet , Federica Verdirosa , Matis Moretti , Brayan Roulier , Giorgia Simoncelli et al.

Bioorganic and Medicinal Chemistry Letters, 2024, 97, pp.117559. ⟨10.1016/j.bmc.2023.117559⟩

Article dans une revue hal-04429770v1
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Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities

Attilio Di Maio , Hamza Olleik , Elise Courvoisier-Dezord , Sophie Guillier , Fabienne Neulat-Ripoll et al.

Antibiotics, 2024, 13 (4), pp.300. ⟨10.3390/antibiotics13040300⟩

Article dans une revue hal-04588387v1
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Catechol-mimicking transition-state analogues as non-oxidizable inhibitors of tyrosinases

Morane Beaumet , Leticia Lazinski , Marc Maresca , Romain Haudecoeur

European Journal of Medicinal Chemistry, 2023, 259, pp.115672. ⟨10.1016/j.ejmech.2023.115672⟩

Article dans une revue hal-04768562v1
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Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells

Brayan Roulier , Inbal Rush , Leticia Lazinski , Basile Pérès , Hamza Olleik et al.

European Journal of Medicinal Chemistry, 2023, 246, pp.114972. ⟨10.1016/j.ejmech.2022.114972⟩

Article dans une revue hal-03998028v1
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Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives

Leticia Lazinski , Guy Royal , Maxime Robin , Marc Maresca , Romain Haudecoeur

Journal of Medicinal Chemistry, 2022, 65 (19), pp.12594-12625. ⟨10.1021/acs.jmedchem.2c01150⟩

Article dans une revue hal-03826221v1
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β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy

Aurélien Beato , Anthonin Gori , Benjamin Boucherle , Marine Peuchmaur , Romain Haudecoeur

Journal of Medicinal Chemistry, 2021, 64 (3), pp.1392-1422. ⟨10.1021/acs.jmedchem.0c01887⟩

Article dans une revue hal-04020932v1
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Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity

Lionel Froux , Ahmad Elbahnsi , Benjamin Boucherle , Arnaud Billet , Nesrine Baatallah et al.

European Journal of Medicinal Chemistry, 2020, 190, pp.112116. ⟨10.1016/j.ejmech.2020.112116⟩

Article dans une revue hal-02924784v1
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Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations

Brayan Roulier , Basile Pérès , Romain Haudecoeur

Journal of Medicinal Chemistry, 2020, 63 (22), pp.13428-13443. ⟨10.1021/acs.jmedchem.0c00994⟩

Article dans une revue hal-04768552v1
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Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens

Hamza Olleik , Samir Yahiaoui , Brayan Roulier , Elise Courvoisier-Dezord , Josette Perrier et al.

European Journal of Medicinal Chemistry, 2019, 165, pp.133-141. ⟨10.1016/j.ejmech.2019.01.022⟩

Article dans une revue hal-01988325v1

Glycosyl-Substituted Dicarboxylates as Detergents for the Extraction, Overstabilization, and Crystallization of Membrane Proteins

Kim-Anh Nguyen , Marine Peuchmaur , Sandrine Magnard , Romain Haudecoeur , Cédric Boyère et al.

Angewandte Chemie International Edition, 2018, 57 (11), pp.2948-2952. ⟨10.1002/anie.201713395⟩

Article dans une revue hal-02329303v1

Piperidinyl-embeded chalcones possessing anti PI3K delta inhibitory properties exhibit anti-atopic properties in preclinical models

Charles Dumontet , Guillaume Beck , Fabrice Gardebien , Romain Haudecoeur , Doriane Mahe et al.

European Journal of Medicinal Chemistry, 2018, 158, pp.405-413. ⟨10.1016/j.ejmech.2018.09.033⟩

Article dans une revue hal-02621220v1
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Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: A review

Romain Haudecoeur , Marine Peuchmaur , Basile Pérès , Maxime Rome , Germain Sotoing Taïwe et al.

Journal of Ethnopharmacology, 2018, 212, pp.106-136. ⟨10.1016/j.jep.2017.10.011⟩

Article dans une revue hal-04019717v1

2-Hydroxypyridine- N -oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors

Romain Haudecoeur , Marc Carotti , Aurélie Gouron , Marc Maresca , Elina Buitrago et al.

ACS Medicinal Chemistry Letters, 2017, 8 (1), pp.55 - 60. ⟨10.1021/acsmedchemlett.6b00369⟩

Article dans une revue hal-01617843v1

Nauclea latifolia: biological activity and alkaloid phytochemistry of a West African tree

Benjamin Boucherle , Romain Haudecoeur , Emerson Ferreira Queiroz , Michel de Waard , Jean-Luc Wolfender et al.

Natural Product Reports, 2016, 33 (9), pp.1034-1043. ⟨10.1039/c6np00039h⟩

Article dans une revue hal-02141583v1

Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

Elina Buitrago , Renaud M Hardré , Romain Haudecoeur , Hélène Jamet , Catherine Belle et al.

Current Topics in Medicinal Chemistry, 2016, 16 (27), pp.3033 - 3047. ⟨10.2174/1568026616666160216160112⟩

Article dans une revue istex hal-01644550v1

Recombinant Tyrosinase from Polyporus arcularius : Overproduction in Escherichia coli , Characterization, and Use in a Study of Aurones as Tyrosinase Effectors

Eva Marková , Michael Kotik , Alena Křenková , Petr Man , Romain Haudecoeur et al.

Journal of Agricultural and Food Chemistry, 2016, 64 (14), pp.2925-2931. ⟨10.1021/acs.jafc.6b00286.s001⟩

Article dans une revue hal-01948810v1

Synthetic G-Quartets as Versatile Nanotools for the Luminescent Detection of G-Quadruplexes

Aurélien Laguerre , Marine Levillain , Loïc Stefan , Romain Haudecoeur , Fares Katranji et al.

CHIMIA International Journal for Chemistry, 2015, 69 (9), pp.530-536. ⟨10.2533/chimia.2015.530⟩

Article dans une revue hal-02125788v1

Biomimetic synthesis of Tramadol

Florine Lecerf-Schmidt , Romain Haudecoeur , Basile Peres , Marc Ferreira Queiroz , Marc Marcourt et al.

Chemical Communications, 2015, 51 (77), pp.14451 - 14453. ⟨10.1039/c5cc05948h⟩

Article dans une revue hal-01683298v1

Investigation of Binding-Site Homology between Mushroom and Bacterial Tyrosinases by Using Aurones as Effectors

Romain Haudecoeur , Aurélie Gouron , Carole Dubois , Hélène Jamet , Mark Lightbody et al.

ChemBioChem, 2014, 15 (9), pp.1325 - 1333. ⟨10.1002/cbic.201402003⟩

Article dans une revue istex hal-01652214v1
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B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

Amel Meguellati , Abdelhakim Ahmed-Belkacem , Wei Yi , Romain Haudecoeur , Marie Crouillère et al.

European Journal of Medicinal Chemistry, 2014, 80, pp.579-592. ⟨10.1016/j.ejmech.2014.04.005⟩

Article dans une revue hal-04015683v1

Multitasking Water-Soluble Synthetic G-Quartets: From Preferential RNA-Quadruplex Interaction to Biocatalytic Activity

Romain Haudecoeur , Loïc Stefan , David Monchaud

Chemistry - A European Journal, 2013, 19 (38), pp.12739-12747. ⟨10.1002/chem.201300791⟩

Article dans une revue istex hal-02125745v1
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Occurrence of the Synthetic Analgesic Tramadol in an African Medicinal Plant.

Ahcène Boumendjel , Germain Sotoing Taïwe , Elisabeth Ngo Bum , Tanguy Chabrol , Chantal Beney et al.

Angewandte Chemie International Edition, 2013, 52 (45), pp.11780-4. ⟨10.1002/anie.201305697⟩

Article dans une revue istex inserm-00874145v1

African tree gets to the root of pain

Ahcène Boumendjel , Germain Sotoing Taïwe , Elisabeth Ngo Gum , Tanguy Chabrol , Chantal Beney et al.

Nature, 2013, 501 (7467), pp.285 - 285. ⟨10.1038/501285b⟩

Article dans une revue hal-01683403v1

Porphyrin-templated synthetic G-quartet (PorphySQ): a second prototype of G-quartet-based G-quadruplex ligand

Hai-Jun Xu , Loïc Stefan , Romain Haudecoeur , Sophie Vuong , Philippe R. Richard et al.

Organic & Biomolecular Chemistry, 2012, 10 (27), pp.5212. ⟨10.1039/C2OB25601K⟩

Article dans une revue hal-02125728v1

A Model of Smart G-Quadruplex Ligand

Romain Haudecoeur , Loïc Stefan , Franck Denat , David Monchaud

Journal of the American Chemical Society, 2012, 135 (2), pp.550-553. ⟨10.1021/ja310056y⟩

Article dans une revue hal-02125742v1
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Discovery of Naturally Occurring Aurones That Are Potent Allosteric Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase.

Romain Haudecoeur , Abdelhakim Ahmed-Belkacem , Wei Yi , Antoine Fortuné , Rozenn Brillet et al.

Journal of Medicinal Chemistry, 2011, 54 (15), pp.5395-5402. ⟨10.1021/jm200242p⟩

Article dans une revue inserm-00618322v1

Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase

Wei Yi , Carole Dubois , Samir Yahiaoui , Romain Haudecoeur , Catherine Belle et al.

European Journal of Medicinal Chemistry, 2011, 46 (9), pp.4330 - 4335. ⟨10.1016/j.ejmech.2011.07.003⟩

Article dans une revue istex hal-01655567v1

Hemiindigos as acetylcholinesterase inhibitors for photopharmacological applications

Letícia da Mata Lazinski , Morane Beaumet , Guy Royal , Romain Haudecoeur

Journées scientifiques Photosciences 24, May 2024, Grenoble (38000), France

Poster de conférence hal-04769182v1

Synthesis and evaluation of the inhibitory activity of resorcinol-based derivatives against tyrosinase and melanin genesis in human melanoma cells

Morane Beaumet , Letícia da Mata Lazinski , Brayan Roulier , Marc Maresca , Romain Haudecoeur

31e Journées Jeunes Chercheurs de la Société de Chimie Thérapeutique, Feb 2024, Grenoble (38000), France

Poster de conférence hal-04769236v1

Synthesis of hemiindigos as cholinesterase inhibitors for photopharmacological applications

Letícia da Mata Lazinski , Morane Beaumet , Guy Royal , Romain Haudecoeur

Common scientific days of GDR Solar Fuels and Photo Electro Stimulation, Jun 2024, Grenoble (38000), France

Poster de conférence hal-04769148v1

Synthesis of hemiindigos as cholinesterase inhibitors for photopharmacological applications

Letícia da Mata Lazinski , Morane Beaumet , Guy Royal , Romain Haudecoeur

20th Congress of the European Society for Photobiology, Aug 2023, Lyon, France

Poster de conférence hal-04769166v1

Design and synthesis of inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells

Morane Beaumet , Letícia da Mata Lazinski , Brayan Roulier , Marc Maresca , Romain Haudecoeur

5th Scientific day of Grenoble Drug Discovery Club, Nov 2023, Grenoble (38000), France

Poster de conférence hal-04769202v1

Synthesis of hemiindigos as cholinesterase inhibitors for photopharmacological applications

Letícia da Mata Lazinski , Guy Royal , Romain Haudecoeur

Journée Scientifique du Médicament, Jun 2023, Grenoble (38000), France

Poster de conférence hal-04769132v1

Nanoliposomal formulations for controlled drug release

Núria Pujol-Solé , Letícia da Mata Lazinski , Nazareth Milagros Carigga Gutierrez , Malika Kadri , Tristan Le Clainche et al.

18e Forum de la recherche en cancérologie (CLARA), Apr 2023, Lyon, France

Poster de conférence hal-04806805v1
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Pharmacochimie des aurones pour la modulation d'enzymes

Romain Haudecoeur

Autre. Université de Grenoble; Université de Genève (Genève, Suisse). Faculté des sciences, 2011. Français. ⟨NNT : 2011GRENV063⟩

Thèse tel-00828395v1