Ruben Hartkoorn

23
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Publications

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Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae

Anais Vieira da Cruz , Juan-Carlos Jiménez-Castellanos , Clara Börnsen , Laurye van Maele , Nina Compagne et al.

EMBO Molecular Medicine, 2023, 16 (1), pp.93-111. ⟨10.1038/s44321-023-00007-9⟩

Article dans une revue hal-04397794v1
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Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis

Bruna Gioia , Francesca Ruggieri , Alexandre Biela , Valérie Landry , Pascal Roussel et al.

International Journal of Molecular Sciences, 2023, 24 (24), pp.17395. ⟨10.3390/ijms242417395⟩

Article dans une revue hal-04339224v1
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A Novel Natural Siderophore Antibiotic Conjugate Reveals a Chemical Approach to Macromolecule Coupling

Thibault Caradec , Ernesto Anoz-Carbonell , Ravil Petrov , Muriel Billamboz , Kevin Antraygues et al.

ACS Central Science, 2023, 9 (11), pp.2138-2149. ⟨10.1021/acscentsci.3c00965⟩

Article dans une revue hal-04444864v1
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2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1

Vladimir Finger , Tomas Kucera , Radka Kafkova , Lubica Muckova , Rafael Dolezal et al.

European Journal of Medicinal Chemistry, 2023, 258, pp.115611. ⟨10.1016/j.ejmech.2023.115611⟩

Article dans une revue hal-04465147v1
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Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria

Nina Compagne , Anais Vieira da Cruz , Reinke Müller , Ruben C. Hartkoorn , Marion Flipo et al.

Antibiotics, 2023, 12 (1), pp.180. ⟨10.3390/antibiotics12010180⟩

Article dans une revue (article de synthèse) hal-03970073v1
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Characterization of pyridylpiperazine-based efflux pump inhibitors for Acinetobacter baumannii

Juan-Carlos Jiménez-Castellanos , Elizabeth Pradel , Nina Compagne , Anais Vieira da Cruz , Marion Flipo et al.

JAC-Antimicrobial Resistance, 2023, 5 (5), pp.2138-2149. ⟨10.1093/jacamr/dlad112⟩

Article dans une revue hal-04397896v1
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Optimization of pyridylpiperazine-based inhibitors of the Escherichia coli AcrAB-TolC efflux pump

Nina Compagne , Juan-Carlos Jiménez-Castellanos , Virginie Meurillon , Elizabeth Pradel , Anais Vieira da Cruz et al.

European Journal of Medicinal Chemistry, 2023, 259, pp.115630. ⟨10.1016/j.ejmech.2023.115630⟩

Article dans une revue hal-04165261v1
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Dactylosporolides: Glycosylated Macrolides from Dactylosporangium fulvum

Thibault Caradec , Xavier Trivelli , Eva Desmecht , Veronique Peucelle , Ruben Christiaan Hartkoorn et al.

Journal of Natural Products, 2022, 85 (12), pp.2714-2722. ⟨10.1021/acs.jnatprod.2c00484⟩

Article dans une revue hal-04464884v1
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Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases

Sushovan Dam , Salia Tangara , Claire Hamela , Theo Hattabi , Léo Faïon et al.

Journal of Medicinal Chemistry, 2022, 65 (24), pp.16651-16664. ⟨10.1021/acs.jmedchem.2c01493⟩

Article dans une revue hal-04017354v1
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Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps

Coline Plé , Heng-Keat Tam , Anais Vieira da Cruz , Nina Compagne , Juan-Carlos Jiménez-Castellanos et al.

Nature Communications, 2022, 13 (1), pp.115. ⟨10.1038/s41467-021-27726-2⟩

Article dans une revue hal-03521512v1

Rubrolone production by Dactylosporangium vinaceum: biosynthesis, modulation and possible biological function

Sophie Moureu , Thibault Caradec , Xavier Trivelli , Hervé Drobecq , Delphine Beury et al.

Applied Microbiology and Biotechnology, 2021, 105 (13), pp.5541-5551. ⟨10.1007/s00253-021-11404-w⟩

Article dans une revue hal-03360998v1

Intragenic Distribution of IS 6110 in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic Resistance

Rudy Antoine , Cyril Gaudin , Ruben Christiaan Hartkoorn

Microbiology Spectrum, 2021, 9 (1), ⟨10.1128/Spectrum.00019-21⟩

Article dans une revue hal-04462804v1

Synthesis and Structure–Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin

Maryline Kienle , Patrick Eisenring , Barbara Stoessel , Oliver Horlacher , Samuel Hasler et al.

Journal of Medicinal Chemistry, 2020, 63 (3), pp.1105-1131. ⟨10.1021/acs.jmedchem.9b01457⟩

Article dans une revue hal-04462810v1

Pyrrolomycins Are Potent Natural Protonophores

Katherine Valderrama , Elizabeth Pradel , Alexander M. Firsov , Hervé Drobecq , Hélène Bauderlique-Le Roy et al.

Antimicrobial Agents and Chemotherapy, 2019, 63 (10), pp.e01450-19. ⟨10.1128/AAC.01450-19⟩

Article dans une revue hal-03361019v1
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Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides

Nathalie Ollivier , Thomas Toupy , Ruben Hartkoorn , Rémi Desmet , Jean-Christophe Monbaliu et al.

Nature Communications, 2018, 9 (1), pp.2847. ⟨10.1038/s41467-018-05264-8⟩

Article dans une revue hal-02133846v1

Total Synthesis of Ripostatin B and Structure–Activity Relationship Studies on Ripostatin Analogs

Florian Glaus , Darija Dedić , Priyanka Tare , Valakunja Nagaraja , Liliana Rodrigues et al.

Journal of Organic Chemistry, 2018, 83 (13), pp.7150-7172. ⟨10.1021/acs.joc.8b00193⟩

Article dans une revue hal-04462820v1

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters

Csilla Temesszentandrási-Ambrus , Szilárd Tóth , Rinkee Verma , Péter Bánhegyi , István Szabadkai et al.

PLoS ONE, 2018, 13 (9), pp.e0202749. ⟨10.1371/journal.pone.0202749⟩

Article dans une revue hal-04462816v1

Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis

Lijiang Song , Matthew Jenner , Joleen Masschelein , Cerith Jones , Matthew Bull et al.

Journal of the American Chemical Society, 2017, 139 (23), pp.7974-7981. ⟨10.1021/jacs.7b03382⟩

Article dans une revue hal-04462832v1

A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

Sunil Kumar Dogga , Budhaditya Mukherjee , Damien Jacot , Tobias Kockmann , Luca Molino et al.

eLife, 2017, 6, ⟨10.7554/eLife.27480⟩

Article dans une revue hal-04462826v1

MoS2/TiO2/SiNW surface as an effective substrate for LDI-MS detection of glucose and glutathione in real samples

Abderrahmane Hamdi , Ioana Silvia Hosu , Ahmed Addad , Ruben Hartkoorn , Hervé Drobecq et al.

Talanta, 2017, 171, pp.101-107. ⟨10.1016/j.talanta.2017.04.061⟩

Article dans une revue hal-02133897v1

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

Giorgia Mori , Laurent Chiarelli , Marta Esposito , Vadim Makarov , Marco Bellinzoni et al.

Chemistry and Biology, 2015, 22 (7), pp.917-927. ⟨10.1016/j.chembiol.2015.05.016⟩

Article dans une revue pasteur-03096090v1