Sandrine BETUING

Documents

Publications

PYK2 in the dorsal striatum of Huntington's disease R6/2 mouse model

Omar Al-Massadi , Mélody Labarchède , Benoit de Pins , Sophie Longueville , Albert Giralt et al.

Neurobiology of Disease, In press, pp.106840. ⟨10.1016/j.nbd.2025.106840⟩

Article dans une revue hal-04963950v1

Nuclear Calcium Signaling in D1 Receptor–Expressing Neurons of the Nucleus Accumbens Regulates Molecular, Cellular, and Behavioral Adaptations to Cocaine

Estefani Saint-Jour , Marie-Charlotte Allichon , Andry Andrianarivelo , Enrica Montalban , Claire Martin et al.

Biological Psychiatry, 2025, 98 (1), pp.34-45. ⟨10.1016/j.biopsych.2025.01.013⟩

Article dans une revue hal-05361412v1

Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum

Katleen Pinchaud , Chloé Masson , Baptiste Dayre , Coline Mounier , Jean-François Gilles et al.

International Journal of Molecular Sciences, 2023, 24 (13), pp.11001. ⟨10.3390/ijms241311001⟩

Article dans une revue hal-04177288v2

Altered Cholesterol Homeostasis in Huntington’s Disease

Radhia Kacher , Coline Mounier , Jocelyne Caboche , Sandrine Betuing

Frontiers in Aging Neuroscience, 2022, 14, pp.797220. ⟨10.3389/fnagi.2022.797220⟩

Article dans une revue hal-03818923v1

Editorial: Cholesterol and Neurodegenerative Diseases - Pressing Questions and How to Address Them

Sandrine Betuing , Irina A Pikuleva , Joseph M Castellano

Frontiers in Aging Neuroscience, 2022, 14, pp.948153. ⟨10.3389/fnagi.2022.948153⟩

Article dans une revue hal-03941798v1

Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation

Sabrina Aït Amiri , Cyrille Deboux , Feryel Soualmia , Nancy Chaaya , Maxime Louet et al.

Journal of Medicinal Chemistry, 2021, 64 (9), pp. 5667-5688. ⟨10.1021/acs.jmedchem.0c02175⟩

Article dans une revue hal-03281511v1

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing

Andry Andrianarivelo , Estefani Saint-Jour , Paula Pousinha , Sebastian P Fernandez , Anna Petitbon et al.

Science Advances , 2021, 7, pp.1-17. ⟨10.1126/sciadv.abg5970⟩

Article dans une revue hal-03389497v1

Rétablir le métabolisme cérébral du cholestérol est neuro-protecteur dans la maladie de Huntington

Jocelyne Caboche , Radhia Kacher , Sandrine Betuing

Médecine/Sciences, 2020, 36, pp.12 - 15. ⟨10.1051/medsci/2019253⟩

Article dans une revue hal-03053633v1

The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease

Clévio Nóbrega , André Conceição , Rafael G Costa , Rebekah Koppenol , Raquel L Sequeira et al.

BMC Research Notes, 2020, 13, pp.210. ⟨10.1186/s13104-020-05053-x⟩

Article dans une revue hal-03053649v1

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease

Radhia Kacher , Antonin Lamazière , Nicolas Heck , Vincent Kappes , Coline Mounier et al.

Brain - A Journal of Neurology , 2019, 142 (8), pp.2432-2450. ⟨10.1093/brain/awz174⟩

Article dans une revue hal-03429397v1

CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content

Lydie Boussicault , Radhia Kacher , Antonin Lamaziere , Peter Vanhoutte , Jocelyne Caboche et al.

Biochimie, 2018, 153, pp.70-79. ⟨10.1016/j.biochi.2018.07.019⟩

Article dans une revue hal-02350678v1

Rapid synaptogenesis in the Nucleus Accumbens is induced by a single cocaine administration and stabilized by MAP Kinase interacting kinase 1 activity

Marc dos Santos , Marine Salery , Benoit Forget , Maria Alexandra Garcia Perez , Sandrine Betuing et al.

Biological Psychiatry, 2017, 82 (11), pp.806-818. ⟨10.1016/j.biopsych.2017.03.014⟩

Article dans une revue hal-01500913v1

Rapid Synaptogenesis in the Nucleus Accumbens Is Induced by a Single Cocaine Administration and Stabilized by Mitogen-Activated Protein Kinase Interacting Kinase-1 Activity

Jocelyne Caboche , Marc Dos Santos , Marine Salery , Benoit Forget , Maria Alexandra et al.

Biological Psychiatry, 2017, 82 (11), pp.806-818. ⟨10.1016/j.biopsych.2017.03.014⟩

Article dans une revue hal-03365856v1

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

Lydie Boussicault , Sandro Alves , Antonin Lamazière , Anabelle Planques , Nicolas Heck et al.

Brain - A Journal of Neurology , 2016, 139 (3), pp.953-970. ⟨10.1093/brain/awv384⟩

Article dans une revue hal-01299208v1

Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin

Beatriz Galan-Rodriguez , Elodie Martin , Emmanuel Brouillet , Nicole Déglon , Sandrine Betuing et al.

European Journal of Neuroscience, 2016, 45 (1), pp.198-206. ⟨10.1111/ejn.13415⟩

Article dans une revue hal-01396567v1

AAV-CYP46A1 brain administration restores cholesterol metabolism and is neuroprotective in Huntington's disease

N. Cartier , L. Boussicault , S. Alves , R. Kacher , A. Lamaziere et al.

Human Gene Therapy, 2016, 27 (11), pp.A24

Article dans une revue hal-01536676v1

B16 Mitogen And Stress-activated Kinase-1 Deficiency And Transcriptional Dysregulation In Huntington’s Disease

L. Moumne , K. Brami-Cherrier , S. Betuing , S. Le Crom , J. Girault et al.

Journal of Neurology, Neurosurgery and Psychiatry, 2014, 85 (1), pp.A14. ⟨10.1136/jnnp-2014-309032.44⟩

Article dans une revue hal-01541325v1

BENEFICIAL EFFECTS OF STRIATAL RESTORATION OF CYP46A1 EXPRESSION ON CHOLESTEROL METABOLISM AND NEURODEGENERATION IN HUNTINGTON'S DISEASE MOUSE MODEL (R6/2)

S. Betuing , A. Planques , L. Moumne , A. Lamazieres , L. Boussicault et al.

Journal of Neurology, Neurosurgery and Psychiatry, 2014, 85 (1), pp.A17-A18. ⟨10.1136/jnnp-2014-309032.53⟩

Article dans une revue hal-01541327v1

Multiple aspects of gene dysregulation Huntington's disease

Jocelyne Caboche , Lara Moumne , Sandrine Betuing

Frontiers in Neurology, 2013, 4, pp.127. ⟨10.3389/fneur.2013.00127⟩

Article dans une revue hal-01541330v1

A deconvolution method to improve automated 3D-analysis of dendritic spines: application to a mouse model of Huntington’s disease

Nicolas Heck , Sandrine Betuing , Peter Vanhoutte , Jocelyne Caboche

Brain Structure and Function, 2012, 217 (2), pp.421-434. ⟨10.1007/s00429-011-0340-y⟩

Article dans une revue istex hal-02372594v1

A deconvolution method to improve automated 3D-analysis of dendritic spines: application to a mouse model of Huntington's disease

Nicolas Heck , Sandrine Betuing , Peter Vanhoutte , Jocelyne Caboche

Brain Structure and Function, 2012, 217 (2), pp.421-434. ⟨10.1007/s00429-011-0340-y⟩

Article dans une revue istex hal-01541333v1

Mitogen and Stress-activated Kinase-1 deficiency and transcriptional dysregulation in Huntington's Disease

Lara Moumne , Karen Brami-Cherrier , Sandrine Betuing , Elodie Martin , Stephane Le Crom et al.

Human Gene Therapy, 2012, 23 (10), pp.A72-A73

Article dans une revue hal-01541335v1

Beneficial effects of striatal restoration of CYP46A1 expression using AAVrh10 serotype in Huntington's disease mice model (R6/2)

Anabelle Planques , Amelie Hu , Francoise Piguet , Lara Moumne , Fathia Djelti et al.

Human Gene Therapy, 2012, 23 (10), pp.A73

Article dans une revue hal-01541336v1

Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers

Jean-Michel Peyrin , Bérangère Deleglise , Laure Saias , Maeva Vignes , Paul Gougis et al.

Lab on a Chip, 2011, 11 (21), pp.3663. ⟨10.1039/c1lc20014c⟩

Article dans une revue hal-02372610v1

Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse.

Karen Brami-Cherrier , Emmanuel Roze , Jean-Antoine Girault , Sandrine Betuing , Jocelyne Caboche

Journal of Neurochemistry, 2009, 108 (6), pp.1323-35. ⟨10.1111/j.1471-4159.2009.05879.x⟩

Article dans une revue hal-00407701v1

[Pathophysiology of Huntington's disease: an update]

E. Roze , S. Betuing , C. Deyts , M. Vidailhet , J. Caboche

Revue Neurologique, 2008, 164 (12), pp.977-94. ⟨10.1016/j.neurol.2008.03.006⟩

Article dans une revue hal-00407690v1

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death

Emmanuel Roze , Sandrine Betuing , Carole Deyts , Estelle Marcon , Karen Brami-Cherrier et al.

FASEB Journal, 2008, 22 (4), pp.1083-1093. ⟨10.1096/fj.07-9814⟩

Article dans une revue hal-00258860v1

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.

Delphine Charvin , Emmanuel Roze , Valérie Perrin , Carole Deyts , Sandrine Betuing et al.

Neurobiology of Disease, 2007, 29 (1), pp.22-29. ⟨10.1016/j.nbd.2007.07.028⟩

Article dans une revue hal-00181915v1

Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protéine localized in the nucleus.

D. Charvin , C. Cifuentes-Diaz , Nuria Fonknechten , V. Joshi , J. Hazan et al.

Human Molecular Genetics, 2003, 12, pp.71-78. ⟨10.1093/hmg/ddg004⟩

Article dans une revue hal-00079650v1

Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

Darrell Belke , Sandrine Betuing , Martin Tuttle , Christophe Graveleau , Martin Young et al.

Journal of Clinical Investigation, 2002, 109 (5), pp.629-639. ⟨10.1172/JCI13946⟩

Article dans une revue hal-03941833v1

Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes.

Sandrine Bétuing , Danièle Daviaud , Céline Pagès , Elisabeth Bonnard , Philippe Valet et al.

Journal of Biological Chemistry, 1998, 273 (25), pp.15804-10

Article dans une revue inserm-00110175v1

Regulation of Fat-Cell Function by α2-Adrenergic Receptors

M. Lafontan , S. Betuing , J-S. Saulnier-Blache , P. Valet , A. Bouloumié et al.

Adv Phamacol, 1997, Advances in Pharmacology, 42, pp.496-498. ⟨10.1016/s1054-3589(08)60797-8⟩

Article dans une revue hal-03941816v1

Functional Consequences of Constitutively Active α2A-Adrenergic Receptor Expression in 3T3F442A Preadipocytes and Adipocytes

Sandrine Bétuing , Philippe Valet , Sophie Lapalu , Delphine Peyroulan , Gilles Hickson et al.

Biochemical and Biophysical Research Communications, 1997, 235 (3), pp.765-773. ⟨10.1006/bbrc.1997.6887⟩

Article dans une revue istex hal-03941822v1

alpha2-Adrenoceptor stimulation promotes actin polymerization and focal adhesion in 3T3F442A and BFC-1beta preadipocytes.

S Bétuing , D Daviaud , P Valet , A Bouloumié , M Lafontan et al.

Endocrinology, 1996, 137 (12), pp.5220-5229. ⟨10.1210/endo.137.12.8940338⟩

Article dans une revue hal-03941827v1

Liver X Receptor activation is associated with behavioural and neuropathological improvements in Huntington’s disease

Sandrine Betuing

European Network of Oxysteral Meeting, Sep 2023, Toulouse, France

Communication dans un congrès hal-04299227v1

Liver X Receptor signaling in the striatum and neuroprotection in Huntington’s Disease

Sandrine Betuing

European Huntington's disease Network meeting, Sep 2021, Bologna (ITALY), Italy

Communication dans un congrès hal-04299188v1

Striatal regulation of cholesterol metabolism by cyp46a1 is associated with multiple benefits in Huntington’s disease knock-in mice models

Sandrine Betuing

Mediterranean Neuroscience Society Meeting, Jun 2019, Marrachech, Morocco

Communication dans un congrès hal-04299193v1

Cholesterol metabolism alteration in Huntington's disease

Sandrine Betuing

CHDI meeting, Nov 2018, Boston (MA), United States

Communication dans un congrès hal-04299209v1

CYP46A1 restores cholesterol metabolism in zQ175 mice model of Huntington’s disease

Sandrine Betuing

European Network of Oxysterol Meeting, Sep 2017, Brussel, Belgium

Communication dans un congrès hal-04299199v1

Cellular and Molecular Mechanisms of Neuronal Dysfunction in Huntington's Disease

J. Caboche , P. Vanhoutte , L. Boussicault , E. Roze , S. Betuing

Handbook of basal ganglia Structure and function, pp.889-906, 2016, ⟨10.1016/B978-0-12-802206-1.00045-3⟩

Chapitre d'ouvrage hal-02372748v1

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