Sandrine Cojean

Maître de Conférences à Université Paris-Saclay (Orsay) Ingénieure en Recherche Hospitalière à CNR Paludisme (Hôpital Bichat Claude Bernard, Paris)

Documents

Compétences

Biologie cellulaire, biologie moléculaire, protozoaires, résistance médicamenteuse Leishmania, Plasmodium

Publications

	Access to Natural and Unnatural 28-Norlupane Endoperoxides by Isayama–Mukaiyama Cobalt-Catalyzed Hydroperoxyl Silylation and Evaluation of Antiplasmodial Activity Zhonglian Ma , Claire Cuyamendous , Sandrine Houzé , Thomas Gaslonde , Gaelle Berte et al. Journal of Natural Products, 2026, 89 (2), pp.410-420. ⟨10.1021/acs.jnatprod.5c01135⟩ Article dans une revue hal-05550766v1
	Are hydrophilic deep eutectic solvents a potential vehicle for topical delivery of Amphotericin B against cutaneous leishmaniasis? An investigation of physicochemical properties, tolerability and antileishmanial efficacy Cảnh Hưng Nguyễn , Catherine Cailleau , Natalie Fournier , Luc Augis , Françoise Mercier-Nomé et al. International Journal of Pharmaceutics, 2026, 689, pp.126439. ⟨10.1016/j.ijpharm.2025.126439⟩ Article dans une revue hal-05397306v1
	Expanding the role of thiophilic metallodrugs in antiparasitic chemotherapy: multi-target approaches against protozoan parasites Inês C C Costa , Philippe M Loiseau , Maria L S Cristiano , Sandrine Cojean European Journal of Medicinal Chemistry Reports, 2026, 17, pp.100335. ⟨10.1016/j.ejmcr.2026.100335⟩ Article dans une revue hal-05707232v1
	Structure-based design of new pyrazole inhibitors targeting Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) Agnese C Pippione , Noemi Villella , Federico Fornaseri , Marta Giorgis , Manmohan Sharma et al. European Journal of Medicinal Chemistry, 2026, 309, pp.118753. ⟨10.1016/j.ejmech.2026.118753⟩ Article dans une revue hal-05707256v1
	Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2- a ]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy Lhana Tisseur , Cédric Logé , Sandrine Cojean , Khadidiatou Gassama , Lilian Karcher et al. RSC Medicinal Chemistry, 2025, 16, pp.3746-3763. ⟨10.1039/d5md00257e⟩ Article dans une revue hal-05173262v1
	Re-sensitization of antimony-resistant Leishmania by highly potent SbV-porphyrin through the involvement of ERG6-coding gene Ellen Gonçalves De Oliveira , Juliane Sousa Lanza , Sandrine Cojean , Paulo Otávio L. Moreira , Luiza Guimarães Tunes et al. Biomedicine and Pharmacotherapy, 2025, 187, pp.118059. ⟨10.1016/j.biopha.2025.118059⟩ Article dans une revue hal-05445980v1
	Resistance to Antileishmanial Drug Candidates: A Flowchart for an Early Phenotypic Evaluation of Risk Nalia Mekarnia , Sandrine Cojean , Philippe Loiseau Drugs and Drug Candidates, 2025, 4 (3), pp.38. ⟨10.3390/ddc4030038⟩ Article dans une revue hal-05235475v1
	Chemical analysis by molecular networking methods on extracts of Saba senegalensis (A.DC.) Pichon (Apocynaceae) and its anthelmintic activity on Caenorhabditis elegans Mohamed Belemlilga , Hazrina Hazni , Aristide Traore , Indira Dennemont , Sébastien Pomel et al. Clinical Traditional Medicine and Pharmacology, 2025, 6 (1), pp.200195. ⟨10.1016/j.ctmp.2025.200195⟩ Article dans une revue hal-05149228v1
	Assessment of ex vivo antimalarial drug efficacy in African Plasmodium falciparum parasite isolates, 2016–2023: a genotype–phenotype association study Jason Rosado , Abebe Fola , Sandrine Cojean , Véronique Sarrasin , Romain Coppée et al. EBioMedicine, 2025, 118 (1), pp.105835. ⟨10.1016/j.ebiom.2025.105835⟩ Article dans une revue hal-05169453v2
	Investigating the C2 Modulation of the Imidazo[1,2‐ a ]pyrazine‐Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition Lhana Tisseur , Sandrine Cojean , Khadidiatou Gassama , Cédric Logé , Fabrice Pagniez et al. ChemMedChem, 2025, 20 (6), pp.e202400862. ⟨10.1002/cmdc.202400862⟩ Article dans une revue hal-05181232v1
	Synthesis and in vitro/in silico evaluation of the antimalarial activity of potential amino-quinoline derivatives Moussa Touré , Abdoulaye Gassama , Oumar Sambou , Christian Cavé , Sandrine Cojean European Journal of Medicinal Chemistry Reports, 2025, 13, pp.100241. ⟨10.1016/j.ejmcr.2024.100241⟩ Article dans une revue hal-05445961v1
	Biological properties and in silico studies of thiazolopyrimidine derivatives active against visceral and cutaneous Leishmania spp. amastigote forms Gulsah Bayraktar , Pascal Marchand , Euzébio Guimarães Barbosa , Marilia Cecilia da Silva , Karen Cacilda Weber et al. European Journal of Medicinal Chemistry Reports, 2024, 12, pp.100228. ⟨10.1016/j.ejmcr.2024.100228⟩ Article dans une revue hal-05088062v1
	The Synthesis of 2′-Hydroxychalcones under Ball Mill Conditions and Their Biological Activities Imen Abid , Wassim Moslah , Sandrine Cojean , Nicolas Imbert , Philippe M Loiseau et al. Molecules, 2024, 29 (8), pp.1819. ⟨10.3390/molecules29081819⟩ Article dans une revue hal-04550832v1
	Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones Thibault Gendron , Don Antoine Lanfranchi , Nicole I Wenzel , Hripsimée Kessedjian , Beate Jannack et al. Molecules, 2024, 29 (7), pp.1620. ⟨10.3390/molecules29071620⟩ Article dans une revue hal-04583951v1
	Effect of Phlebotomus papatasi on the fitness, infectivity and antimony-resistance phenotype of antimony-resistant Leishmania major Mon-25 Nalia Mekarnia , Kamal-Eddine Benallal , Jovana Sádlová , Barbora Vojtková , Aurélie Mauras et al. International journal for parasitology. Drugs and drug resistance, 2024, 25, pp.100554. ⟨10.1016/j.ijpddr.2024.100554⟩ Article dans une revue hal-04632483v1
	Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani Lília Cabral , Sébastien Pomel , Sandrine Cojean , Patrícia Amado , Philippe Loiseau et al. Molecules, 2020, 25 (3), pp.465. ⟨10.3390/molecules25030465⟩ Article dans une revue hal-05149167v1
	Antiprotozoal activity of medicinal plants used by Iquitos-Nauta road communities in Loreto (Peru) Pedro Vásquez-Ocmín , Sandrine Cojean , Elsa Rengifo , Soulaf Suyyagh-Albouz , Carlos Amasifuen Guerra et al. Journal of Ethnopharmacology, 2018, 210, pp.372-385. ⟨10.1016/j.jep.2017.08.039⟩ Article dans une revue istex hal-05149102v1
	New Water-Soluble Polymeric Prodrugs of 2-n-propylquinoline: Synthesis and Evaluation of In Vitro and In Vivo Activities Against Leishmania donovani Vasanthan Ravichandran , Nalia Mekarnia , Sébastien Pomel , Sandrine Cojean , Laurent Ferrié et al. Regenerative Engineering and Translational Medicine, 2018, 4 (1), pp.11-20. ⟨10.1007/s40883-018-0045-3⟩ Article dans une revue hal-05149115v1
	Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine Gustav Komlaga , Grégory Genta-Jouve , Sandrine Cojean , Rita Dickson , Merlin L.K. Mensah et al. Tetrahedron Letters, 2017, 58 (38), pp.3754-3756. ⟨10.1016/j.tetlet.2017.08.045⟩ Article dans une revue istex hal-05521917v1
	Antiplasmodial activity of selected medicinal plants used to treat malaria in Ghana Gustav Komlaga , Sandrine Cojean , Rita Dickson , Mehdi Beniddir , Soulaf Suyyagh-Albouz et al. Parasitology Research, 2016, 115 (8), pp.3185-3195. ⟨10.1007/s00436-016-5080-8⟩ Article dans une revue hal-05521857v1
	Targeting sterol metabolism for the development of antileishmanials Sébastien Pomel , Sandrine Cojean , Philippe Loiseau Trends in Parasitology, 2015, 31 (1), pp.5-7. ⟨10.1016/j.pt.2014.11.007⟩ Article dans une revue istex hal-05148982v1
	In vitro and in vivo antileishmanial properties of a 2-n-propylquinoline hydroxypropyl β-cyclodextrin formulation and pharmacokinetics via intravenous route Kaluvu Balaraman , Nashira Campos Vieira , Fathi Moussa , Joël Vacus , Sandrine Cojean et al. Biomedicine and Pharmacotherapy, 2015, 76, pp.127-133. ⟨10.1016/j.biopha.2015.10.028⟩ Article dans une revue istex hal-05149031v1
	The Antimalarial Potential of Three Ghanaian Medicinal Plants Gustav Komlaga , Sandrine Cojean , Mehdi A Beniddir Herbal Medicine: Open Access, 2015, 1 (1), ⟨10.21767/2472-0151.10004⟩ Article dans une revue hal-05521840v1
	VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis Galina Lepesheva , Tatiana Hargrove , Girish Rachakonda , Zdzislaw Wawrzak , Sébastien Pomel et al. Journal of Infectious Diseases, 2015, 212 (9), pp.1439-1448. ⟨10.1093/infdis/jiv228⟩ Article dans une revue hal-05149012v1
	Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives Zahra Abada , Sandrine Cojean , Sébastien Pomel , Laurent Ferrié , Bernardin Akagah et al. European Journal of Medicinal Chemistry, 2013, 67 (2), pp.158-165. ⟨10.1016/j.ejmech.2013.06.002⟩ Article dans une revue hal-05148876v1

	Aminopyrimidine-thioethers targeting trypanothione reductase show in vitro and in vivo activity against Leishmania donovani Sandrine Cojean Congrès annuel de la Société Française de Parasitologie, de la Société Française de Mycologie Médicale et 5ème Journée Franco-Maghrébine de Parasitologie-Mycologie, Stéphane Ranque et son équipe, Apr 2026, Marseille, France Communication dans un congrès hal-05619102v1
	Résistance médicamenteuse et coût biologique associé chez Leishmania infantum sélectionnée sous pression médicamenteuse in vitro Sandrine Cojean congrès annuel de la Société Française de Parasitologie, de la Société Française de Mycologie Médicale et 5ème Journée Franco-Maghrébine de Parasitologie-Mycologie, Stéphane Ranque et son équipe, Apr 2026, Marseille, France Communication dans un congrès hal-05619096v1
	In silico and in vitro assessments of thio-linked pyrimidine-based compounds against Leishmania donovani Ines Carreira Costa , Margarida Gonçalves , José A. Paixão , Philippe M Loiseau , Sandrine Cojean et al. Journée de l'école doctorale, École doctorale du médicament du fondamental à l'appliqué, Jun 2025, Orsay, France Communication dans un congrès hal-05173445v1
	In silico and in vitro assessments of thio-linked pyrimidine-based compounds against Leishmania donovani Inês Costa , Margarida M. Alves , Rita C. Guedes , José A. Paixão , Philippe M Loiseau et al. CAPF, May 2025, Lille, France Communication dans un congrès hal-05173401v1
	Modifying positions 2 or 8 of the imidazo[1,2-a]pyrazine lead compound CTN1122 affects its antileishmanial activity, L-CK1.2 kinase inhibition, and safety profile Lhana Tisseur , Marc-Antoine Bazin , Sandrine Cojean , Fabrice Pagniez , Cédric Logé et al. GP2A 2024, Aug 2024, Coimbra, Portugal Communication dans un congrès hal-04708945v1
	Synthesis of flavonoid derivatives precursors of active pharmaceutical ingredients by mechanochemistry Imen Abid , Wassim Moslah , Sandrine Cojean , Nicolas Imbert , P.M. Loiseau et al. GreenChem-24 : 6th International conference on green chemistry and sustainable engineering, Jul 2024, Lisbonne, Portugal Communication dans un congrès hal-04883885v1

	In silico and in vitro assessments of thio-linked pyrimidine-based compounds against Leishmania donovani Ines Carreira Costa , Margarida M Alves , Rita C. Guedes , José A. Paixão , Philippe M Loiseau et al. Congrès SFP SFMM, Jun 2025, Amiens, France Poster de conférence hal-05173348v1

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Sandrine Cojean

Compétences

Publications

Publications

Access to Natural and Unnatural 28-Norlupane Endoperoxides by Isayama–Mukaiyama Cobalt-Catalyzed Hydroperoxyl Silylation and Evaluation of Antiplasmodial Activity

Are hydrophilic deep eutectic solvents a potential vehicle for topical delivery of Amphotericin B against cutaneous leishmaniasis? An investigation of physicochemical properties, tolerability and antileishmanial efficacy

Expanding the role of thiophilic metallodrugs in antiparasitic chemotherapy: multi-target approaches against protozoan parasites

Structure-based design of new pyrazole inhibitors targeting Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH)

Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2- a ]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy

Re-sensitization of antimony-resistant Leishmania by highly potent SbV-porphyrin through the involvement of ERG6-coding gene

Resistance to Antileishmanial Drug Candidates: A Flowchart for an Early Phenotypic Evaluation of Risk

Chemical analysis by molecular networking methods on extracts of Saba senegalensis (A.DC.) Pichon (Apocynaceae) and its anthelmintic activity on Caenorhabditis elegans

Assessment of ex vivo antimalarial drug efficacy in African Plasmodium falciparum parasite isolates, 2016–2023: a genotype–phenotype association study

Investigating the C2 Modulation of the Imidazo[1,2‐ a ]pyrazine‐Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition

Synthesis and in vitro/in silico evaluation of the antimalarial activity of potential amino-quinoline derivatives

Biological properties and in silico studies of thiazolopyrimidine derivatives active against visceral and cutaneous Leishmania spp. amastigote forms

The Synthesis of 2′-Hydroxychalcones under Ball Mill Conditions and Their Biological Activities

Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones

Effect of Phlebotomus papatasi on the fitness, infectivity and antimony-resistance phenotype of antimony-resistant Leishmania major Mon-25

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani

Antiprotozoal activity of medicinal plants used by Iquitos-Nauta road communities in Loreto (Peru)

New Water-Soluble Polymeric Prodrugs of 2-n-propylquinoline: Synthesis and Evaluation of In Vitro and In Vivo Activities Against Leishmania donovani

Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

Antiplasmodial activity of selected medicinal plants used to treat malaria in Ghana

Targeting sterol metabolism for the development of antileishmanials

In vitro and in vivo antileishmanial properties of a 2-n-propylquinoline hydroxypropyl β-cyclodextrin formulation and pharmacokinetics via intravenous route

The Antimalarial Potential of Three Ghanaian Medicinal Plants

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives

Aminopyrimidine-thioethers targeting trypanothione reductase show in vitro and in vivo activity against Leishmania donovani

Résistance médicamenteuse et coût biologique associé chez Leishmania infantum sélectionnée sous pression médicamenteuse in vitro

In silico and in vitro assessments of thio-linked pyrimidine-based compounds against Leishmania donovani

In silico and in vitro assessments of thio-linked pyrimidine-based compounds against Leishmania donovani

Modifying positions 2 or 8 of the imidazo[1,2-a]pyrazine lead compound CTN1122 affects its antileishmanial activity, L-CK1.2 kinase inhibition, and safety profile

Synthesis of flavonoid derivatives precursors of active pharmaceutical ingredients by mechanochemistry

In silico and in vitro assessments of thio-linked pyrimidine-based compounds against Leishmania donovani