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Is cholesterol a risk factor for breast cancer incidence and outcome?
Céline Ben Hassen
,
Caroline Goupille
,
Claire Vigor
,
Thierry Durand
,
Françoise Guéraud
et al.
Article dans une revue
hal-04165228
v1
|
|
27-hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor
Silia Ayadi
,
Silvia Friedrichs
,
Regis Soulès
,
Laly Pucheu
,
Dieter Lütjohann
et al.
Article dans une revue
inserm-04317313
v1
|
|
Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate: A non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate
Philippe de Medina
,
Silia Ayadi
,
Régis Soulès
,
Bruno Payre
,
Sandrine Rup-Jacques
et al.
Article dans une revue
hal-04509731
v1
|
|
Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles
Michel Record
,
Mehdi Attia
,
Kevin Carayon
,
Laly Pucheu
,
Julio Bunay
et al.
Article dans une revue
inserm-03649213
v1
|
|
Targeting NR1H/liver X receptor with dendrogenin A differentiates tumor cells to activate a new secretory pathway releasing immunogenic anti-tumor vesicles enriched in LC3-II-associated exosomes
Philippe de Medina
,
Julio Bunay
,
Marc Poirot
,
Michel Record
,
Sandrine Silvente-Poirot
Article dans une revue
inserm-03854248
v1
|
|
Oxysterols are potential physiological regulators of ageing
Philippe de Medina
,
Sandrine Silvente-Poirot
,
Marc Poirot
Article dans une revue
inserm-03629546
v1
|
|
Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy
Anne Montfort
,
Florie Bertrand
,
Julia Rochotte
,
Julia Gilhodes
,
Thomas Filleron
et al.
Article dans une revue
inserm-03402255
v1
|
|
The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets
Philippe Medina
,
Khadijetou Diallo
,
Emilie Huc‐claustre
,
Mehdi Attia
,
Régis Soulès
et al.
Article dans une revue
inserm-03394464
v1
|
|
Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia
Pierre-Luc Mouchel
,
Nizar Serhan
,
Rémy Bétous
,
Thomas Farge
,
Estelle Saland
et al.
Article dans une revue
inserm-03084630
v1
|
|
The 5,6-epoxycholesterol metabolic pathway in cancer: emergence of new pharmacological targets
Philippe de Médina
,
Khadijetou Diallo
,
Emilie Huc Claustre
,
Mehdi Attia
,
Régis Soulès
et al.
Article dans une revue
inserm-03086999
v1
|
|
Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo
Nizar Serhan
,
Pierre-Luc Mouchel
,
Philippe de Médina
,
Gregory Segala
,
Aurélie Mougel
et al.
Article dans une revue
inserm-03084638
v1
|
|
The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets
Philippe Medina
,
Khadijetou Diallo
,
Emilie Huc‐claustre
,
Mehdi Attia
,
Régis Soulès
et al.
Article dans une revue
inserm-03084636
v1
|
|
HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris
Vito Taddeo
,
Francesco Epifano
,
Francesca Preziuso
,
Serena Fiorito
,
Nicolas Caron
et al.
Article dans une revue
inserm-02380544
v1
|
|
Oxysterols: An expanding family of structurally diversified bioactive steroids
Marc Poirot
,
Sandrine Silvente-Poirot
Article dans une revue
inserm-02380490
v1
|
|
A fast UPLC–HILIC method for an accurate quantification of dendrogenin A in human tissues
Régis Soules
,
Fabien Audouard-Combe
,
Emilie Huc-Claustre
,
Philippe de Médina
,
Arnaud Rives
et al.
Article dans une revue
inserm-02380526
v1
|
|
Flavonoids differentially modulate liver X receptors activity—Structure-function relationship analysis
Allan Fouache
,
Nada Zabaiou
,
Cyrille de Joussineau
,
Laurent Morel
,
Sandrine Silvente-Poirot
et al.
Article dans une revue
inserm-02380571
v1
|
|
The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells
Mathilde Bauriaud-Mallet
,
Lavinia Vija-Racaru
,
Séverine Brillouet
,
Arnaud Mallinger
,
Philippe de Médina
et al.
Article dans une revue
inserm-02380538
v1
|
|
Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis
Salvatore Genovese
,
Francesco Epifano
,
Philippe de Médina
,
Nicolas Caron
,
Arnaud Rives
et al.
Article dans une revue
inserm-02380542
v1
|
|
The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers
Sandrine Silvente-Poirot
,
Marc Poirot
Article dans une revue
inserm-02380575
v1
|
|
Extracellular vesicles: lipids as key components of their biogenesis and functions
Michel Record
,
Sandrine Silvente-Poirot
,
Marc Poirot
,
Michael J. O. Wakelam
Article dans une revue
inserm-02380557
v1
|
|
The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer
Sandrine Silvente-Poirot
,
Florence Dalenc
,
Marc Poirot
Article dans une revue
inserm-02380586
v1
|
|
Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment
Sandrine Silvente-Poirot
,
Gregory Segala
,
Mathias Poirot
,
Marc Poirot
Article dans une revue
inserm-02380583
v1
|
|
Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation
Farid Khallouki
,
Robert Owen
,
Sandrine Silvente-Poirot
,
Marc Poirot
Article dans une revue
inserm-02380570
v1
|
|
Chemistry, biochemistry, metabolic fate and mechanism of action of 6-oxo-cholestan-3β,5α-diol (OCDO), a tumor promoter and cholesterol metabolite
Marc Poirot
,
Régis Soules
,
Arnaud Mallinger
,
Florence Dalenc
,
Sandrine Silvente-Poirot
Article dans une revue
inserm-02380564
v1
|
|
Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study
Florence Dalenc
,
Luiggi Iuliano
,
Thomas Filleron
,
Chiara Zerbinati
,
Maud Voisin
et al.
Article dans une revue
inserm-02380620
v1
|
|
Quantitative analysis of the tumor suppressor dendrogenin A using liquid chromatography tandem mass spectrometry
Emmanuel Noguer
,
Régis Soules
,
Claude Netter
,
Citra Nagarathinam
,
Julie Leignadier
et al.
Article dans une revue
inserm-02380602
v1
|
|
Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS
Régis Soules
,
Emmanuel Noguer
,
Luigi Iuliano
,
Chiara Zerbinati
,
Julie Leignadier
et al.
Article dans une revue
inserm-02380612
v1
|
|
Improving the efficacy of hormone therapy in breast cancer: The role of cholesterol metabolism in SERM-mediated autophagy, cell differentiation and death
Julie Leignadier
,
Florence Dalenc
,
Marc Poirot
,
Sandrine Silvente-Poirot
Article dans une revue
inserm-02380608
v1
|
|
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Gregory Segala
,
Marion David
,
Philippe de Médina
,
Mathias Poirot
,
Nizar Serhan
et al.
Article dans une revue
inserm-02380591
v1
|
|
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
Maud Voisin
,
Philippe de Médina
,
Arnaud Mallinger
,
Florence Dalenc
,
Emilie Huc-Claustre
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (44), pp.E9346-E9355. ⟨10.1073/pnas.1707965114⟩
Article dans une revue
hal-02316171
v1
|
|
Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds
Farid Khallouki
,
Philippe de Médina
,
Stéphanie Caze-Subra
,
Kerstin Bystricky
,
Patrick Balaguer
et al.
Article dans une revue
hal-02271824
v1
|
|
When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite1
Marc Poirot
,
Sandrine Silvente-Poirot
Article dans une revue
inserm-02380631
v1
|
|
Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties
Florence Dalenc
,
Marc Poirot
,
Sandrine Silvente-Poirot
Article dans une revue
inserm-02380776
v1
|
|
Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies.
Michel Record
,
Kevin Carayon
,
Marc Poirot
,
Sandrine Silvente-Poirot
Article dans une revue
inserm-00968935
v1
|
|
One step synthesis of 6-oxo-cholestan-3β,5α-diol.
Maud Voisin
,
Sandrine Silvente-Poirot
,
Marc Poirot
Article dans une revue
inserm-00968933
v1
|
|
The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.
Shaden A. M. Khalifa
,
Philippe de Médina
,
Anna Erlandsson
,
Hesham R. El-Seedi
,
Sandrine Silvente-Poirot
et al.
Article dans une revue
inserm-00968932
v1
|
|
Cancer. Cholesterol and cancer, in the balance.
Sandrine Silvente-Poirot
,
Marc Poirot
Article dans une revue
inserm-00968924
v1
|
|
Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism
Brigitte Sola
,
Marc Poirot
,
Philippe de Médina
,
Sophie Bustany
,
Véronique Marsaud
et al.
Article dans une revue
inserm-00968940
v1
|
|
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells.
Gregory Segala
,
Philippe de Médina
,
Luigi Iuliano
,
Chiara Zerbinati
,
Michael R. Paillasse
et al.
Article dans une revue
inserm-00822322
v1
|
|
Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A.
Philippe de Médina
,
Michael R. Paillasse
,
Gregory Segala
,
Talal Al Saati
,
Jeannine Boyes
et al.
Article dans une revue
istex
inserm-00822283
v1
|
|
Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties.
Philippe de Médina
,
Michael R. Paillasse
,
Gregory Segala
,
Maud Voisin
,
Loubna Mhamdi
et al.
Article dans une revue
inserm-00823974
v1
|
|
Oxysterols and related sterols: Implications in pharmacology and pathophysiology.
Marc Poirot
,
Sandrine Silvente-Poirot
Article dans une revue
istex
inserm-00832422
v1
|
|
Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles.
Michael R. Paillasse
,
Nathalie Saffon
,
Heinz Gornitzka
,
Sandrine Silvente-Poirot
,
Marc Poirot
et al.
Article dans une revue
inserm-00743457
v1
|
|
Cholesterol-5,6-epoxides: Chemistry, biochemistry, metabolic fate and cancer.
Marc Poirot
,
Sandrine Silvente-Poirot
Article dans une revue
istex
inserm-00743461
v1
|
|
Cholesterol metabolism and cancer: the good, the bad and the ugly.
Sandrine Silvente-Poirot
,
Marc Poirot
Article dans une revue
istex
inserm-00822284
v1
|
|
Cholesterol metabolism and resistance to tamoxifen.
Marc Poirot
,
Sandrine Silvente-Poirot
,
Ralph R. Weichselbaum
Article dans une revue
istex
inserm-00743466
v1
|
|
Cholesterol epoxide hydrolase and cancer.
Sandrine Silvente-Poirot
,
Marc Poirot
Article dans une revue
istex
inserm-00743463
v1
|
|
Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands.
Philippe de Médina
,
Michael R. Paillasse
,
Gregory Ségala
,
Farid Khallouki
,
Severine Brillouet
et al.
Article dans une revue
istex
inserm-00743454
v1
|
|
Exosomes as intercellular signalosomes and pharmacological effectors.
Michel Record
,
Caroline Subra
,
Sandrine Silvente-Poirot
,
Marc Poirot
Article dans une revue
istex
inserm-00743451
v1
|
|
Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors.
Philippe de Médina
,
Salvatore Genovese
,
Michael R. Paillasse
,
Mahta Mazaheri
,
Stéphanie Caze-Subra
et al.
Article dans une revue
inserm-00519166
v1
|
|
Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting.
Sandra Dorbes
,
Béatrice Mestre-Voegtlé
,
Yvon Coulais
,
Claude Picard
,
Sandrine Silvente-Poirot
et al.
Article dans une revue
istex
inserm-00519153
v1
|
|
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands.
Philippe de Médina
,
Michael R. Paillasse
,
Grégory Segala
,
Marc E. Poirot
,
Sandrine Silvente-Poirot
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (30), pp.13520-13525. ⟨10.1073/pnas.1002922107⟩
Article dans une revue
inserm-00519159
v1
|
|
Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: from molecular modeling to in vivo evaluation.
Séverine Brillouet
,
Sandra Dorbes
,
Frédéric Courbon
,
Claude Picard
,
Jean Pierre Delord
et al.
Article dans une revue
istex
inserm-00519158
v1
|
|
Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.
Caroline Subra
,
David Grand
,
Karine Laulagnier
,
Alexandre Stella
,
Gerard Lambeau
et al.
Article dans une revue
hal-00497229
v1
|
|
Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism.
Philippe de Médina
,
Bruno Payré
,
Nadia Boubekeur
,
Justine Bertrand-Michel
,
François Tercé
et al.
Article dans une revue
inserm-00519149
v1
|
|
Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.
Michael R. Paillasse
,
Philippe de Médina
,
Guillaume Amouroux
,
Loubna Mhamdi
,
Marc E. Poirot
et al.
Article dans une revue
inserm-00519146
v1
|
|
Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation.
Philippe de Médina
,
Sandrine Silvente-Poirot
,
Marc E. Poirot
Article dans une revue
inserm-00519150
v1
|
|
Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases.
Philippe de Médina
,
Michael R. Paillasse
,
Bruno Payré
,
Sandrine Silvente-Poirot
,
Marc E. Poirot
Article dans une revue
inserm-00519151
v1
|
|
Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism.
Bruno Payré
,
Philippe de Médina
,
Nadia Boubekeur
,
Loubna Mhamdi
,
Justine Bertrand-Michel
et al.
Article dans une revue
inserm-00519145
v1
|
|
Insights into the cholecystokinin 2 receptor binding site and processes of activation.
Michaël Paillasse
,
Céline Deraeve
,
Philippe de Médina
,
Loubna Mhamdi
,
Gilles Favre
et al.
Article dans une revue
inserm-00519168
v1
|
|
The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-n-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors
Philippe de Médina
,
Nadia Boubekeur
,
Patrick Balaguer
,
Gilles Favre
,
Sandrine Silvente-Poirot
et al.
Article dans une revue
inserm-00090770
v1
|
|
The peripheral cholecystokinin receptors
Sandrine Silvente-Poirot
,
Marlène Dufresne
,
Nicole Vaysse
,
Daniel Fourmy
Article dans une revue
inserm-04974721
v1
|
|
Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells.
Philippe de Médina
,
Bruno Payré
,
José Bernad
,
Isabelle Bosser
,
Bernard Pipy
et al.
Article dans une revue
inserm-00090774
v1
|
|
Molecular characterization of the microsomal tamoxifen binding site.
Blandine Kedjouar
,
Philippe de Médina
,
Mustapha Oulad-Abdelghani
,
Bruno Payré
,
Sandrine Silvente-Poirot
et al.
Article dans une revue
inserm-00090773
v1
|
|
Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.
Céline Galés
,
Marc E. Poirot
,
Julien Taillefer
,
Bernard Maigret
,
Jean Martinez
et al.
Article dans une revue
inserm-00090776
v1
|
|
High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor.
Céline Galés
,
Didier Sanchez
,
Marc E. Poirot
,
Stéphane Pyronnet
,
Louis Buscail
et al.
Article dans une revue
inserm-00090775
v1
|
|
structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists
Daniel Fourmy
,
Chantal Escrieu
,
Elodie Archer
,
Céline Galès
,
Véronique Gigoux
et al.
Pharmacology and Toxicology -Copenhagen-, 2002, 91, pp.313-320
Article dans une revue
hal-00358676
v1
|
|
The Biologically Crucial C Terminus of Cholecystokinin and the Non-peptide Agonist SR-146,131 Share a Common Binding Site in the Human CCK1 Receptor
Chantal Escrieut
,
Véronique Gigoux
,
Elodie Archer
,
Sophie Verrier
,
Bernard Maigret
et al.
Article dans une revue
inserm-04974775
v1
|
|
The Third Intracellular Loop of the Rat and Mouse Cholecystokinin-A Receptors Is Responsible for Different Patterns of Gene Activation
Roya Poosti
,
Laure Di Malta
,
Didier Gagne
,
Nicole Bernad
,
Jean-Claude Galleyrand
et al.
Article dans une revue
inserm-04974769
v1
|
|
Mutation of Asn-391 within the Conserved NPXXY Motif of the Cholecystokinin B Receptor Abolishes Gq Protein Activation without Affecting Its Association with the Receptor
Céline Galés
,
Aline Kowalski-Chauvel
,
Marie Noelle Dufour
,
Catherine Seva
,
Luis Moroder
et al.
Article dans une revue
inserm-04974763
v1
|
|
Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin
Véronique Gigoux
,
Chantal Escrieu
,
Jean-Alain Fehrentz
,
Sandrine Silvente-Poirot
,
Bernard Maigret
et al.
Article dans une revue
hal-00357552
v1
|
|
evidence for a direct inetraction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor
Sandrine Silvente-Poirot
,
Chantal Escrieu
,
Céline Galès
,
Jean-Alain Fehrentz
,
Achim Escherich
et al.
Journal of Biological Chemistry, 1999, 274 (33), pp.23191-23197
Article dans une revue
hal-00357548
v1
|
|
Evidence for a Direct Interaction between the Penultimate Aspartic Acid of Cholecystokinin and Histidine 207, Located in the Second Extracellular Loop of the Cholecystokinin B Receptor
Sandrine Silvente-Poirot
,
Chantal Escrieut
,
Céline Galès
,
Jean-Alain Fehrentz
,
Achim Escherich
et al.
Article dans une revue
inserm-04974753
v1
|
|
Arginine 197 of the cholecystokinin a receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin
Véronique Gigoux
,
Bernard Maigret
,
Chantal Escrieu
,
Sandrine Silvente-Poirot
,
Michelle Buisson
et al.
Article dans une revue
hal-00357556
v1
|
|
Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state
Véronique Gigoux
,
Chantal Escrieu
,
Sandrine Silvente-Poirot
,
Bernard Maigret
,
Laurent Goullieux
et al.
Article dans une revue
hal-00357491
v1
|
|
Role of the Extracellular Domains of the Cholecystokinin Receptor in Agonist Binding
Sandrine Silvente-Poirot
,
Chantal Escrieut
,
Stephen Wank
Article dans une revue
inserm-04974746
v1
|
|
Ligand-induced Internalization of Cholecystokinin Receptors
Markus Pohl
,
Sandrine Silvente-Poirot
,
Joseph Pisegna
,
Nadya Tarasova
,
Stephen Wank
Article dans une revue
inserm-04974735
v1
|
|
A Segment of Five Amino Acids in the Second Extracellular Loop of the Cholecystokinin-B Receptor Is Essential for Selectivity of the Peptide Agonist Gastrin
Sandrine Silvente-Poirot
,
Stephen Wank
Article dans une revue
inserm-04974732
v1
|
|
Electric properties of photoaffinity-labelled pancreatic A-subtype cholecystokinin
J. Jiménez
,
M. Dufresne
,
Sandrine Silvente-Poirot
,
N. Vaysse
,
Daniel Fourmy
Article dans une revue
inserm-04974698
v1
|