Sandrine Vadon - Le Goff

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A noncanonical‐ GPRC5A signaling regulates keratinocyte adhesion and migration by nuclear translocation

Sarah Chanteloube , Choua Ya , Gabrielle Le Provost , Aurore Berthier , Cindy Dieryckx et al.

FASEB Journal, 2025, 39 (2), pp.e70323. ⟨10.1096/fj.202400122R⟩

Article dans une revue hal-04933989v1
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PCPE-2 (procollagen C-proteinase enhancer-2): The non-identical twin of PCPE-1

Manon Napoli , Julien Bauer , Christelle Bonod , Sandrine Vadon-Le Goff , Catherine Moali

Matrix Biology, 2024, 134, pp.59-78. ⟨10.1016/j.matbio.2024.09.001⟩

Article dans une revue hal-04727512v1
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Mono- and Bi-specific Nanobodies Targeting the CUB Domains of PCPE-1 Reduce the Proteolytic Processing of Fibrillar Procollagens

Priscillia Lagoutte , Jean-Marie Bourhis , Natacha Mariano , Virginie Gueguen-Chaignon , David Vandroux et al.

Journal of Molecular Biology, 2024, 436 (16), pp.168667. ⟨10.1016/j.jmb.2024.168667⟩

Article dans une revue hal-04727482v1
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Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system

Marine Blanc , Clara Lettl , Jérémy Guérin , Anaïs Vieille , Sven Furler et al.

PLoS Pathogens, 2023, 19 (5), pp.e1011368. ⟨10.1371/journal.ppat.1011368⟩

Article dans une revue hal-04246055v1
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Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases

Sandrine Vadon-Le Goff , Agnès Tessier , Manon Napoli , Cindy Dieryckx , Julien Bauer et al.

Nature Communications, 2023, 14, pp.8020. ⟨10.1038/s41467-023-43401-0⟩

Article dans une revue hal-04350568v1
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Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1)

Urvashi Sharma , Sandrine Vadon-Le Goff , Karl Harlos , Yuguang Zhao , Natacha Mariano et al.

Scientific Reports, 2022, 12 (1), pp.14850. ⟨10.1038/s41598-022-18795-4⟩

Article dans une revue hal-03838405v1
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Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis

Priscillia Lagoutte , Emmanuel Bettler , Sandrine Vadon-Le Goff , Catherine Moali

Matrix Biology Plus, 2021, 11, pp.100062. ⟨10.1016/j.mbplus.2021.100062⟩

Article dans une revue hal-03368863v1
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BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1

Cyril Anastasi , Patricia Rousselle , Maya Talantikite , Agnès Tessier , Caroline Cluzel et al.

Science Signaling, 2020, 13 (639), pp.eaba3880. ⟨10.1126/scisignal.aba3880⟩

Article dans une revue hal-02991455v1

Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1

David Pulido , Urvashi Sharma , Sandrine Vadon-Le Goff , Sadaf-Ahmahni Hussain , Sarah Cordes et al.

Structure, 2018, 26 (10), pp.1384-1392.e3. ⟨10.1016/j.str.2018.06.011⟩

Article dans une revue hal-02342439v1
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Inhibitors of BMP-1/tolloid-like proteinases: efficacy, selectivity and cellular toxicity

Maya Talantikite , Pascaline Lecorché , Fabrice Beau , Odile Damour , Christoph Becker-Pauly et al.

FEBS Open Bio, 2018, 8 (12), pp.2011-2021. ⟨10.1002/2211-5463.12540⟩

Article dans une revue hal-02342437v1
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Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1

David Pulido , Urvashi Sharma , Sandrine Vadon-Le Goff , Sadaf-Ahmahni Hussain , Sarah Cordes et al.

Structure, 2018, 26 (10), pp.1384-1392.e3. ⟨10.1016/j.str.2018.06.011⟩

Article dans une revue hal-03094449v1

Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice

Philipp Arnold , Lara Koopmann , Florian Peters , Falk Birkenfeld , Sandrine Vadon-Le Goff et al.

Cell and Tissue Research, 2017, 367 (2), pp.351-358. ⟨10.1007/s00441-016-2498-3⟩

Article dans une revue hal-02342448v1

Structural basis of homo- and heterotrimerization of collagen I

Urvashi Sharma , Loïc Carrique , Sandrine Vadon-Le Goff , Natacha Mariano , Rainier-Numa Georges et al.

Nature Communications, 2017, 8 (1), ⟨10.1038/ncomms14671⟩

Article dans une revue hal-02342446v1
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Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases

Monique Lacroix , Agnès Tessier , Chantal Dumestre-Pérard , Sandrine Vadon-Le Goff , Evelyne Gout et al.

Scientific Reports, 2017, 7, pp.16958. ⟨10.1038/s41598-017-17318-w⟩

Article dans une revue hal-01657764v1

Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets

Mourad Bekhouche , Cedric Leduc , Laura Dupont , Lauriane Janssen , Frédéric Delolme et al.

FASEB Journal, 2016, 30 (5), pp.1741-1756. ⟨10.1096/fj.15-279869⟩

Article dans une revue hal-02342452v1

Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics

Frédéric Delolme , Cyril Anastasi , Lindsay B Alcaraz , Valentin Mendoza , Sandrine Vadon-Le Goff et al.

Cellular and Molecular Life Sciences, 2015, 72 (5), pp.1009-1027. ⟨10.1007/s00018-014-1733-x⟩

Article dans une revue hal-02283031v1

BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling

Sandrine Vadon-Le Goff , David J.S. Hulmes , Catherine Moali

Matrix Biology, 2015, 44-46, pp.14-23. ⟨10.1016/j.matbio.2015.02.006⟩

Article dans une revue hal-02342455v1

Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics

Frédéric Delolme , Cyril Anastasi , Lindsay Alcaraz , Valentin Mendoza , Sandrine Vadon-Le Goff et al.

Cellular and Molecular Life Sciences, 2014, 72 (5), pp.1009-1027. ⟨10.1007/s00018-014-1733-x⟩

Article dans une revue hal-04766559v1

Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation.

Jean-Marie Bourhis , Sandrine Vadon-Le Goff , Hassnae Afrache , Natacha Mariano , Daniel Kronenberg et al.

Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (16), pp.6394-9

Article dans une revue hal-01322415v1

IMPROVED AND HIGH YIELD SYNTHESIS OF THE POTENT ARGINASE INHIBITOR : 2(S)-AMINO-6-BORONOHEXANOIC ACID

Sandrine Vadon-Le Goff , Sylvie Dijols , Daniel Mansuy , Jean-Luc Boucher

Organic Process Research and Development, 2005, 9, pp.677-679

Article dans une revue hal-00097853v1

SYNTHESIS AND EVALUATION OF NEW OMEGA-BORONO-ALPHA-AMINOACIDS AS RAT LIVER ARGINASE INHIBITORS

Olivier Busnel , François Carreaux , Bertrand Carboni , Stéphanie Pethe , Sandrine Vadon-Le Goff et al.

Bioorganic and Medicinal Chemistry, 2005, 13, pp.2373-2379

Article dans une revue hal-00097475v1

Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes.

S. Vadon-Legoff , M. Delaforge , Jl Boucher , M. Janosik , Jp Kraus et al.

Biochemical and Biophysical Research Communications, 2001, 283, pp.487-492

Article dans une revue hal-00315217v1

Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity.

H. Meurs , Ma Hamer , S. Pethe , S. Vadon-Legoff , Jl Boucher et al.

British Journal of Pharmacology, 2000, 130, pp.1793-1798

Article dans une revue hal-00315218v1

Biosynthèse du monoxyde d'azote (NO) : mécanisme, régulation et contrôle

Nicolas Sennequier , Sandrine Vadon-Le Goff

Médecine/Sciences, 1998, 14 (11), pp.1185-1195

Article dans une revue hal-00127937v1

Inhibition of arginase in rat alveolar macrophages (AM phi) promotes utilization of L-arginine by nitric oxide synthase (NOS).

C. Hey , Jl Boucher , S. Vadon , G. Ketterer , C. Stichnote et al.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1997, 355, pp.138-138

Article dans une revue hal-00315242v1

Inhibition of arginase in rat and rabbit alveolar macrophages by N omega-hydroxy-D,L-indospicine, effects on L-arginine utilization by nitric oxide synthase.

C. Hey , Jl Boucher , S. Vadon-Legoff , G. Ketterer , I. Wessler et al.

British Journal of Pharmacology, 1997, 121, pp.395-400

Article dans une revue hal-00315220v1

N-omega-OH-D,L-indospicine, a potent and selective: Inhibitor of arginase in rat and rabbit alveolar macrophages (AM phi) can promote utilization of L-arginine by nitric oxide synthase (NOS)

C. Hey , Jl Boucher , S. Vadon , G. Ketterer , C. Stichnote et al.

British Journal of Pharmacology, 1997, 120, pp.P48-P48

Article dans une revue hal-00315247v1

Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of N omega-hydroxyarginine, N omega-hydroxyindospicine and p-hydroxyamidinophenylalanine

S. Vadon , J. Custot , Jl Boucher , Xxxx Mansuyd

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1996, xxx, pp.645-648

Article dans une revue hal-00315239v1

Expression in yeast and purification of functional macrophage nitric oxide synthase. Evidence for cysteine-194 as iron proximal ligand.

Ma Sari , S. Booker , M. Jaouen , S. Vadon , Ji Boucher et al.

Biochemistry, 1996, 35, pp.7204-7213

Article dans une revue hal-00315221v1

Oxidation of arylamidoximes by hydrogen peroxide and horseradish peroxidase in water: Easy preparation and X-ray structure of O-(arylimidoyl)arylamidoximes.

Jl Boucher , S. Vadon , A. P. Tomas , B. Viossat , Xxxx Mansuyd

Tetrahedron Letters, 1996, 37, pp.3113-3116

Article dans une revue hal-00315240v1

N omega-hydroxyamino-alpha-amino acids as a new class of very strong inhibitors of arginases

J. Custot , Jl Boucher , S. Vadon , C. Guedes , S. Dijols et al.

Journal of Biological Inorganic Chemistry, 1996, 1, pp.73-82

Article dans une revue hal-00315238v1

N-OMEGA-HYDROXY-L-ARGININE, AN INTERMEDIATE IN THE L-ARGININE TO NITRIC-OXIDE PATHWAY, IS A STRONG INHIBITOR OF LIVER AND MACROPHAGE ARGINASE

Jl Boucher , J. Custot , S. Vadon , M. Delaforge , M. Lepoivre et al.

Biochemical and Biophysical Research Communications, 1994, 203, pp.1614-1621

Article dans une revue hal-00315241v1

N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase.

Jl Boucher , J. Custot , S. Vadon , M. Delaforge , M. Lepoivre et al.

Biochemical and Biophysical Research Communications, 1994, 203, pp.1614-1621

Article dans une revue hal-00315248v1

Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s.

Jp Renaud , Jl Boucher , S. Vadon , M. Delaforge , D. Mansuy

Biochemical and Biophysical Research Communications, 1993, 192, pp.53-60

Article dans une revue hal-00315222v1

Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins.

Jl Boucher , A. Genet , S. Vadon , M. Delaforge , D. Mansuy

Biochemical and Biophysical Research Communications, 1992, 184, pp.1158-1164

Article dans une revue hal-00315224v1

Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline.

Jl Boucher , A. Genet , S. Vadon , M. Delaforge , Y. Henry et al.

Biochemical and Biophysical Research Communications, 1992, 187, pp.880-886

Article dans une revue hal-00315223v1

Structural and biochemical analysis of Mini-Procollagen I C-terminal maturation

Oskar Lipinski , Cindy Dieryckx , Natacha Mariano , Loic Carrique , Sandrine Vadon-Le Goff et al.

Fourth Annual Meeting of the ProteoCure COST Action, May 2025, Heraklion (Grèce), Greece

Communication dans un congrès hal-05400016v1

Recombinant mini-procollagens as tools for the biochemical characterization of collagen maturation

Oskar Lipinski , Cindy Dieryckx , Natacha Mariano , Agnès Tessier , Jean-Baptiste Vincourt et al.

Congrès annuel de la Société Française de Biochimie et Biologie Moléculaire, Jul 2024, Lyon, France

Communication dans un congrès hal-05396745v1

The dark side of procollagen C-proteinase enhancer-2 (PCPE-2): inhibition of bone morphogenetic protein-1/tolloid-like proteinases

Sandrine Vadon-Le Goff , Agnès Tessier , Manon Napoli , Mélissa Dussoyer , Priscillia Lagoutte et al.

ANNUAL MEETING OF THE FRENCH SOCIETY FOR EXTRACELLULAR MATRIX BIOLOGY, Nov 2023, Strasbourg (FRANCE), France

Communication dans un congrès hal-05400034v1

Nanobodies directed against procollagen C-proteinase enhancer 1 efficiently slow down the proteolytic maturation of fibrillar procollagens

Priscillia Lagoutte , Jean-Marie Bourhis , Virginie Gueguen-Chaignon , Natacha Mariano , David Vandroux et al.

ECM Pharmacology Congress 2022, Jun 2022, Copenaghen, Denmark

Communication dans un congrès hal-05396731v1

Strong alterations of collagen biosynthesis and fibrillogenesis in the dermis of recessive dystrophic epidermolysis bullosa mice

Mélissa Dussoyer , Adeline Page , Frédéric Delolme , Dimitra Kiritsi , Sandrine Vadon-Le Goff et al.

WOUND REPAIR AND REGENERATION - European Tissue Repair Society Meeting-2022, European Tissue Repair Society, Sep 2022, Lyon, France. pp.A30-A31

Communication dans un congrès hal-04911707v1

Development of an anti-fibrotic drug candidate targeting the PCPE regulators of BMP-1/tolloid like proteases

Sandrine Vadon-Le Goff , Priscillia Lagoutte , Laura Chastagnier , Julien Bauer , Olivier Bouchot et al.

13th general Meeting of the International Proteolysis Society, Oct 2025, Buzios (Brazil), Brazil

Poster de conférence hal-05397879v1

Insight into Procollagen I C-terminal maturation through structural and biochemical studies

Oskar Lipinski , Cindy Dieryckx , Natacha Mariano , Loic Carrique , Sandrine Vadon-Le Goff et al.

Congrès 2025 de la Société Française de Biologie de la Matrice Extracellulaire, Sep 2025, Toulouse, France

Poster de conférence hal-05397907v1

Structural and Biochemical Analysis of Mini-Procollagen I C-Terminal Maturation

Oskar Lipinski , Cindy Dieryckx , Natacha Mariano , Loic Carrique , Sandrine Vadon-Le Goff et al.

4th MOSBRI (MOlecular-Scale Biophysics Research Infrastructure) Scientific Conference, Jun 2025, Paris, France

Poster de conférence hal-05397918v1

Insights into the mechanism of action of PCPE-2, the endogenous inhibitor of human BMP-1/tolloid-like proteinases

Julien Bauer , Priscillia Lagoutte , Jonathan Vaneyck , Loic Carrique , Mireille Dumoulin et al.

Matrix Biology Europe 2024, Sep 2024, Lyon, France

Poster de conférence hal-05400090v1

Investigating collagen maturation biochemistry through recombinant mini procollagens

Oskar Lipinski , Cindy Dieryckx , Natacha Mariano , Jean-Baptiste Vincourt , Loic Carrique et al.

Matrix Biology Europe 2024, Sep 2024, Lyon, France

Poster de conférence hal-05400117v1

Insights into the mechanism of action of PCPE-2, the endogenous inhibitor of human BMP-1/tolloid-like proteinases

Julien Bauer , Jonathan Vaneyck , Mireille Dumoulin , Catherine Moali , Sandrine Vadon-Le Goff

Congrès annuel de la Société Française de Biochimie et Biologie Moléculaire, Jul 2024, Lyon, France

Poster de conférence hal-05400147v1

The dark side of procollagen C-proteinase enhancer-2 (PCPE-2): inhibition of bone morphogenetic protein-1/tolloid-like proteinases

Sandrine Vadon-Le Goff , Agnès Tessier , Manon Napoli , Mélissa Dussoyer , Priscillia Lagoutte et al.

ECM Pharmacology Congress 2024, Jun 2024, Copenhagen, Denmark

Poster de conférence hal-05396726v1

The dark side of procollagen C-proteinase enhancer-2 (PCPE-2): inhibition of bone morphogenetic protein-1/tolloid-like proteinases

Sandrine Vadon-Le Goff , Agnès Tessier , Manon Napoli , Mélissa Dussoyer , Priscillia Lagoutte et al.

Gordon Research Conference Collagen 2023, Jul 2023, New London (New Hampshire), United States

Poster de conférence hal-05396719v1

Nanobodies directed against procollagen C-proteinase enhancer 1 efficiently slow down the proteolytic maturation of fibrillar procollagens

Priscillia Lagoutte , Jean-Marie Bourhis , Virginie Gueguen-Chaignon , Natacha Mariano , David Vandroux et al.

Joint Meeting on Proteostasis and Cellular Proteolysis, May 2023, Paris, France

Poster de conférence hal-05396690v1

Nanobodies directed against procollagen C-proteinase enhancer 1 efficiently slow down the proteolytic maturation of fibrillar procollagens

Priscillia Lagoutte , Jean-Marie Bourhis , Virginie Gueguen-Chaignon , Natacha Mariano , David Vandroux et al.

Matrix Biology Europe, Sep 2022, Firenze, Italy, Italy

Poster de conférence hal-05396676v1