Sébastien ARTHAUD

Ingénieur de Recherche à l'Université Claude Bernard Lyon1
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Documents

Publications

Publications

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ALTERATIONS DU SOMMEIL AU COURS DE LA VIE CHEZ DES SOURIS MODELISANT L'ACCUMULATION HUMAINE DE NEUROMELANINE DANS LES NEURONES CATECHOLAMINERGIQUES

Sébastien Arthaud , Jean-Christophe Comte , Jiong Liu , Núria Peñuelas , Ariadna Laguna et al.
Le congrès du Sommeil 2025, SFRMS, Nov 2025, Strasbourg, France
Communication dans un congrès hal-05347198 v1

Modelling human REM sleep Behavior Disorder (RBD), a prodromal marker of synucleinopathies, using genetic tools in wild-type mice

Blandine Duval , Sébastien Arthaud , Justin Malcey , Amarine Chancel , Luppi Pierre-Hervé et al.
Neurofrance 2025, Société Française des Neurosciences (SDN), May 2025, Montpellier, France
Communication dans un congrès hal-05119309 v1
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Réseaux neuronaux de l'atonie musculaire : nouvelles données dans la compréhension fonctionnelle du trouble du comportement en sommeil paradoxal

Blandine Duval , Sébastien Arthaud , Justin Malcey , Amarine Chancel , Pierre-Hervé Luppi et al.
Le congrès du Sommeil 2025, SFRMS, Nov 2025, Strasbourg, France
Communication dans un congrès hal-05347171 v1
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Modeling EEG data using deep learning for automatic sleep stage classification in mice

L. Rose , A.N. Zahid , L. Piilgaard , C.G. Hviid , C.E. Jensen et al.
17th World Sleep Congress, Oct 2023, Rio de Janeiro, Brazil. pp.S411-S412, ⟨10.1016/j.sleep.2023.11.1104⟩
Communication dans un congrès hal-04788391 v1
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Moderate RBD symptoms in narcoleptic versus IRBD mice.

Maxime Grenot , Alexis Roman , Sébastien Arthaud , Paul-Antoine Libourel , Christelle Peyron
17th World Sleep Congress, Oct 2023, Rio de Janeiro, Brazil. pp.S200
Communication dans un congrès hal-04788236 v1

Evolution of the sleep-waking cycle in transgenic mice with an age-dependent accumulation of neuromelanin in catecholaminergic neurons, a new humanized model of Parkinson's Disease

Sébastien Arthaud , Jiong Liu , Nuria Peñuelas , Ariadana Laguna , Miquel Vila et al.
Forum Federation of European Neuroscience Societies (FENS), Jul 2022, PARIS, France
Communication dans un congrès hal-03748322 v1

Hypothalamic regulation of REM sleep

Luppi Pierre-Hervé , Olivier Clément , Emilie Sapin , Paul-Antoine Libourel , Sébastien Arthaud et al.
21st Congress of the European-Sleep-Research-Society, Sep 2012, Paris, France. pp.2-3
Communication dans un congrès hal-02345917 v1

Gliotransmission et sensibilité centrale au glucose : rôle des endozépines

Fabrice Morin , Damien Lanfray , Sébastien Arthaud , Johana Ouellet , Vincent Compère et al.
39ème colloque de la Société de Neuroendocrinologie, Sep 2013, Fès, Maroc
Communication dans un congrès hal-02454954 v1

Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models

Simon Guillot , Christina Lang , Marie Simonot , Daniel Beckett , Dorothée Lulé et al.
Science Translational Medicine, 2025, 17 (783), ⟨10.1126/scitranslmed.adm7580⟩
Article dans une revue hal-04934419 v1

Probability estimation of narcolepsy type 1 in DTA mice using unlabeled EEG and EMG data

Laura Rose , Alexander Neergaard Zahid , Louise Piilgaard , Christine Egebjerg , Frederikke Lynge Sørensen et al.
SLEEP Advances, 2025, 6 (2), ⟨10.1093/sleepadvances/zpaf025⟩
Article dans une revue hal-05120846 v1
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Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related neurodegenerative deficits

Ariadna Laguna , Núria Peñuelas , Marta Gonzalez-Sepulveda , Alba Nicolau , Sébastien Arthaud et al.
Nature Communications, 2024, 15 (1), pp.8819. ⟨10.1038/s41467-024-53168-7⟩
Article dans une revue hal-04767989 v1
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Major alteration of motor control during rapid eye movements sleep in mice models of sleep disorders

Maxime Grenot , Alexis Roman , Manon Villalba , Anne-Laure Morel , Patrice Fort et al.
Article dans une revue hal-04768098 v1
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Two polygenic mouse models of major depressive disorders identify TMEM161B as a potential biomarker of disease in humans

Malika El Yacoubi , Claire Altersitz , Violaine Latapie , Elari Rizkallah , Sébastien Arthaud et al.
Neuropsychopharmacology, 2024, 49, pp.1129-1139. ⟨10.1038/s41386-024-01811-8⟩
Article dans une revue inserm-04444848 v1

Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy

Raphaël Bernard-Valnet , David Frieser , Xuan-Hung Nguyen , Leila Khajavi , Clémence Quériault et al.
Brain - A Journal of Neurology , 2022, 145 (6), pp.2018-2030. ⟨10.1093/brain/awab455⟩
Article dans une revue hal-03669984 v1
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Effects of sex and estrous cycle on sleep and cataplexy in narcoleptic mice

Sébastien Arthaud , Manon Villalba , Camille Blondet , Anne-Laure Morel , Christelle Peyron
Sleep, 2022, 45 (7), ⟨10.1093/sleep/zsac089⟩
Article dans une revue hal-03748304 v1
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Granule cells in the infrapyramidal blade of the dentate gyrus are activated during paradoxical (REM) sleep hypersomnia but not during wakefulness: a study using TRAP mice

Risa Yamazaki , Dianru Wang , Anna de Laet , Renato Maciel , Claudio Agnorelli et al.
Sleep, 2021, 44 (12), pp.zsab173. ⟨10.1093/sleep/zsab173⟩
Article dans une revue hal-03400920 v1
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Is REM sleep a paradoxical state?: Different neurons are activated in the cingulate cortices and the claustrum during wakefulness and paradoxical sleep hypersomnia

Renato Maciel , Risa Yamazaki , Dianru Wang , Anna de Laet , Sébastien Cabrera et al.
Biochemical Pharmacology, 2021, 191, pp.114514. ⟨10.1016/j.bcp.2021.114514⟩
Article dans une revue hal-03285342 v1

Insights into paradoxical (REM) sleep homeostatic regulation in mice using an innovative automated sleep deprivation method

Sébastien Arthaud , Paul-Antoine Libourel , Pierre-Hervé Luppi , Christelle Peyron
Sleep, 2020, 43 (7), ⟨10.1093/sleep/zsaa003⟩
Article dans une revue hal-03104247 v1
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Targeted recombination in active populations as a new mice genetic model to study sleep‐active neuronal populations: Demonstration that Lhx6+ neurons in the ventral zona incerta are activated during paradoxical sleep hypersomnia

Hyun‐sook Lee , Risa Yamazaki , Dianru Wang , Sébastien Arthaud , Patrice Fort et al.
Journal of Sleep Research, 2020, ⟨10.1111/jsr.12976⟩
Article dans une revue hal-02996227 v1
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Defining and measuring paradoxical (REM) sleep in animal models of sleep disorders

Christelle Peyron , Sébastien Arthaud , Manon Villalba , Patrice Fort
Current Opinion in Physiology, 2020, 15, pp.203-209. ⟨10.1016/j.cophys.2020.03.008⟩
Article dans une revue hal-02996296 v1
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Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder

Sara Valencia Garcia , Frédéric Brischoux , Olivier Clément , Paul-Antoine Libourel , Sébastien Arthaud et al.
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-017-02761-0⟩
Article dans une revue hal-02104823 v1

INTRAMUSCULAR ADMINISTRATION OF KETAMINE-MEDETOMIDINE ASSURES STABLE ANAESTHESIA NEEDED FOR LONG-TERM SURGERY IN THE ARGENTINE TEGU SALVATOR MERIANAE

Baptiste Barrillot , Johanna Roux , Sébastien Arthaud , Laëtitia Averty , Angeline Clair et al.
Journal of Zoo and Wildlife Medicine, 2018, 49 (2), pp.291-296. ⟨10.1638/2017-0089.1⟩
Article dans une revue hal-02105781 v1
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ONEIROS, a new miniature standalone device for recording sleep electrophysiology, physiology, temperatures and behavior in the lab and field

Bertrand Massot , Sébastien Arthaud , Baptiste Barrillot , Johanna Roux , Gianina Ungurean et al.
Journal of Neuroscience Methods, 2018, ⟨10.1016/j.jneumeth.2018.08.030⟩
Article dans une revue hal-01890562 v1

The inappropriate occurrence of rapid eye movement sleep in narcolepsy is not due to a defect in homeostatic regulation of rapid eye movement sleep

Alexis Roman , Soraya Meftah , Sébastien Arthaud , Pierre-Hervé Luppi , C. Peyron
Sleep, 2018, 41 (6), pp.zsy046. ⟨10.1093/sleep/zsy046⟩
Article dans une revue hal-02368936 v1
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Partial homologies between sleep states in lizards, mammals, and birds suggest a complex evolution of sleep states in amniotes

Paul-Antoine Libourel , Baptiste Barrillot , Sébastien Arthaud , Bertrand Massot , Anne-Laure Morel et al.
PLoS Biology, 2018, 16 (10), pp.e2005982. ⟨10.1371/journal.pbio.2005982⟩
Article dans une revue hal-02105758 v1

REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP

Pascal Ravassard , Al Mahdy Hamieh , Mickaël Antoine Joseph , Nicolas Fraize , Paul-Antoine Libourel et al.
Cerebral Cortex, 2016, 26 (4), pp.1488-1500. ⟨10.1093/cercor/bhu310⟩
Article dans une revue hal-03398976 v1

REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP

Pascal Ravassard , Al Mahdy Hamieh , Mickaël Antoine Joseph , Nicolas Fraize , Paul-Antoine Libourel et al.
Cerebral Cortex, 2016, 26 (4), pp.1488-1500. ⟨10.1093/cercor/bhu310⟩
Article dans une revue hal-04773763 v1

CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice

Raphaël Bernard-Valnet , Lidia Yshii , Clémence Quériault , Xuan-Hung Nguyen , Sébastien Arthaud et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (39), pp.10956 - 10961. ⟨10.1073/pnas.1603325113⟩
Article dans une revue hal-01824562 v1

Sleep architecture and homeostasis in mice with partial ablation of melanin-concentrating hormone neurons

Christophe Varin , Sébastien Arthaud , Denise Salvert , Nadine Gay , Paul-Antoine Libourel et al.
Behavioural Brain Research, 2016, 298, pp.100-110. ⟨10.1016/j.bbr.2015.10.051⟩
Article dans une revue hal-02336931 v1

Paradoxical (REM) sleep deprivation in mice using the small-platforms-over-water method: polysomnographic analyses and melanin-concentrating hormone and hypocretin/orexin neuronal activation before, during and after deprivation

Sébastien Arthaud , Christophe Varin , Nadine Gay , Paul-Antoine Libourel , Frédéric Chauveau et al.
Journal of Sleep Research, 2015, 24 (3), pp.309-319. ⟨10.1111/jsr.12269⟩
Article dans une revue hal-02336938 v1
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Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism

Christophe Varin , Armelle Rancillac , Hélène Geoffroy , Sébastien Arthaud , Patrice Fort et al.
Journal of Neuroscience, 2015, 35 (27), pp.9900-9911. ⟨10.1523/JNEUROSCI.0609-15.2015⟩
Article dans une revue inserm-02121070 v1
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Biochemical Characterization of a Caspase-3 Far-red Fluorescent Probe for Non-invasive Optical Imaging of Neuronal Apoptosis

Valérie Jolivel , Sébastien Arthaud , Béatrice Botia , Christophe Portal , Bruno Delest et al.
Journal of Molecular Neuroscience, 2014, 54 (3), pp.451-462. ⟨10.1007/s12031-014-0325-4⟩
Article dans une revue hal-01196843 v1

Concordant localization of functional urotensin II and urotensin II-related peptide binding sites in the rat brain: Atypical occurrence close to the fourth ventricle

Christine Bucharles , Patrice Bizet , Sébastien Arthaud , Arnaud Arabo , Jérôme Leprince et al.
Journal of Comparative Neurology, 2014, 522 (11), pp.2634-2649. ⟨10.1002/cne.23553⟩
Article dans une revue istex hal-01958600 v1
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The Inhibition of the Dorsal Paragigantocellular Reticular Nucleus Induces Waking and the Activation of All Adrenergic and Noradrenergic Neurons: A Combined Pharmacological and Functional Neuroanatomical Study

Olivier Clément , Sara Valencia Garcia , Paul-Antoine Libourel , Sébastien Arthaud , Patrice Fort et al.
PLoS ONE, 2014, 9 (5), pp.e96851. ⟨10.1371/journal.pone.0096851⟩
Article dans une revue hal-02337032 v1

Gliotransmission and Brain Glucose Sensing: Critical Role of Endozepines

Damien Lanfray , Sébastien Arthaud , Johanne Ouellet , Vincent Compère , Jean-Luc Do Rego et al.
Diabetes, 2013, 62 (3), pp.801 - 810. ⟨10.2337/db11-0785⟩
Article dans une revue hal-01939215 v1
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Gliotransmission and Brain Glucose Sensing: Critical Role of Endozepines

Damien Lanfray , Sébastien Arthaud , Johanne Ouellet , Vincent Compère , Jean-Luc Do Rego et al.
Diabetes, 2013, 62 (3), pp.801-810. ⟨10.2337/db11-0785⟩
Article dans une revue hal-01962799 v1

The Lateral Hypothalamic Area Controls Paradoxical (REM) Sleep by Means of Descending Projections to Brainstem GABAergic Neurons

Olivier Clément , Emilie Sapin , Paul-Antoine Libourel , Sébastien Arthaud , Frédéric Brischoux et al.
Journal of Neuroscience, 2012, 32 (47), pp.16763-16774. ⟨10.1523/JNEUROSCI.1885-12.2012⟩
Article dans une revue hal-02339533 v1
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The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes.

Yannick Tanguy , Anthony Falluel-Morel , Sébastien Arthaud , Loubna Boukhzar , Destiny-Love Manecka et al.
Endocrinology, 2011, 152 (11), pp.4322-35. ⟨10.1210/en.2011-1246⟩
Article dans une revue hal-00682913 v1

Balanced effect of PACAP and FasL on granule cell death during cerebellar development: a morphological, functional and behavioural characterization.

Aurélie Allais , Delphine Burel , Vincent Roy , Sébastien Arthaud , Ludovic Galas et al.
Journal of Neurochemistry, 2010, 113 (2), pp.329-40. ⟨10.1111/j.1471-4159.2009.06555.x⟩
Article dans une revue pasteur-00819614 v1
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Functional remodeling of gap junction-mediated electrical communication between adrenal chromaffin cells in stressed rats.

Claude Colomer , Luis A. Olivos Ore , Nathalie Coutry , Marie-Noëlle Mathieu , Sébastien Arthaud et al.
Journal of Neuroscience, 2008, 28 (26), pp.6616-26. ⟨10.1523/JNEUROSCI.5597-07.2008⟩
Article dans une revue inserm-00281272 v1
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LIFESPAN SLEEP ALTERATION IN MICE MODELLING THE HUMAN NEUROMELANIN ACCUMULATION IN CATECHOLAMINERGIC NEURONS

Sébastien Arthaud , Jean-Christophe Comte , Jiong Liu , Núria Peñuelas , Anna Lagunas et al.
Neurofrance 2025, May 2025, Montpellier, France. 2025
Poster de conférence hal-05119338 v1

Nouveau modèle expérimental de trouble du comportement en sommeil paradoxal (TCSP) chez la souris sauvage

Blandine Duval , Sebastien Arthaud , Justin Malcey , Amarine Chancel , Pierre-Hervé Luppi et al.
Le congrès du Sommeil 2024, Nov 2024, Lille, France. 22 (1), pp.85, 2025, ⟨10.1016/j.msom.2025.01.137⟩
Poster de conférence hal-05119375 v1

DEVELOPMENT OF A PRECLINICAL MODEL OF REM SLEEP BEHAVIOR DISORDER (RBD), A PRODROMAL PARASOMNIA OF PARKINSON’S DISEASE, IN M83 TRANSGENIC MICE

Sébastien Arthaud , Maxime Grenot , Latifa Lakhdar , Thierry Baron , Patrice Fort
Neurofrance 2023, May 2023, LYON, France
Poster de conférence hal-04178071 v1

EVOLUTION WITH AGING OF SLEEP MICROARCHITECTURE IN MICE ACCUMULATING NEUROMELANIN IN CATECHOLAMINERGIC NEURONS, A NEW HUMANIZED PARKINSON’S DISEASE MODEL

Patrice Fort , Romain Bouet , Maxime Grenot , Jiong Liu , Nuria Peñuelas et al.
NeuroFrance 2023, May 2023, Lyon, France
Poster de conférence hal-04178056 v1

Evolution of the sleep-waking cycle in transgenic mice with an age-dependent accumulation of neuromelanin in catecholaminergic neurons, a new humanized model of Parkinson’s Disease

Sébastien Arthaud , Jiong Liu , Nuria Peñuelas , Ariadana Laguna , Miquel Vila et al.
FENS Forum, Jul 2022, PARIS, France
Poster de conférence hal-04176874 v1

Modulation of hypothalamic MCH-expressing neurons by pharmacogenetic tools strongly alters the sleep-waking cycle in mice

Christophe Varin , Sébastien Arthaud , Yohan Cherasse , Michael Lazarus , Thierry Gallopin et al.
22nd Congress of the European-Sleep-Research-Society, Sep 2014, Tallinn, Estonia. Journal of sleep Research, 23 (P808), pp.254, 2014
Poster de conférence hal-02345870 v1

Efficient paradoxical (REM) sleep homeostatic regulation in mice: reports on sleep architecture and neuronal activation

Sébastien Arthaud , Christophe Varin , Paul-Antoine Libourel , Patrice Fort , Pierre-Hervé Luppi et al.
22nd Congress of the European-Sleep-Research-Society, Sep 2014, Tallinn, Estonia. Journal of leep Research, 23 (P854), pp.270-71, 2014
Poster de conférence hal-02345904 v1

Unsupervised paradoxical sleep deprivation using real-time sleep scoring in rats: a new alternative to the 'flower pot' technique

Paul-Antoine Libourel , Sonia Jego , Patrice Fort , Frédéric Brischoux , Jérémy Nigri et al.
21st Congress of the European-Sleep-Research-Society, Sep 2012, Paris, France. 21, pp.326-327, 2012
Poster de conférence hal-02347128 v1

Evidence that the lateral hypothalamic area controls paradoxical (REM) sleep by means of descending projections to brainstem GABAergic neurons

Clément Olivier , Emilie Sapin , Paul-Antoine Libourel , Sébastien Arthaud , Patrice Fort et al.
21st Congress of the European-Sleep-Research-Society, Sep 2012, Paris, France. Journal of Sleep Research, 21, pp.193, 2012
Poster de conférence hal-02347007 v1

Selective paradoxical sleep deprivation in mice using a new unsupervised automatic method

Sébastien Arthaud , Paul-Antoine Libourel , Patrice Fort , Damien Gervasoni , Pierre-Hervé Luppi
21st Congress of the European-Sleep-Research-Society, Sep 2012, Paris, France. 21, pp.326, 2012
Poster de conférence hal-02369336 v1