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SLAP controls mTORC2 integrity via UBE3C-mediated non-degradative mLST8 ubiquitination to suppress colorectal tumorigenesis

Rudy Mevizou , Dana Naim , Florent Cauchois , Cécile Naudin , Georgia Greaves et al.

Cell Death and Differentiation, In press, Online ahead of print. ⟨10.1038/s41418-025-01633-1⟩

Article dans une revue hal-05421846v1
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Lipid-driven Src self-association modulates its transformation capacity

Irrem-Laareb Mohammad , Marina I Giannotti , Elise Fourgous , Yvan Boublik , Alejandro Fernández et al.

Life Science Alliance, 2025, 8 (5), pp.e202403019. ⟨10.26508/lsa.202403019⟩

Article dans une revue hal-05317927v1
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Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Julie Nguyen , Marie Lafitte , Maud Barbery , Kevin Espie , Maya Jeitany et al.

Advanced Science, In press, 12 (38), pp.e02136. ⟨10.1002/advs.202502136⟩

Article dans une revue hal-05213630v1
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Regulation of Src tumor activity by its N-terminal intrinsically disordered region

Emilie Aponte , Marie Lafitte , Audrey Sirvent , Valérie Simon , Maud Barbery et al.

Oncogene, 2022, 41 (7), pp.960-970. ⟨10.1038/s41388-021-02092-x⟩

Article dans une revue hal-03523417v1
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Oncogenic Signalling of PEAK2 Pseudokinase in Colon Cancer

Céline Lecointre , Elise Fourgous , Ingrid Montarras , Clément Kerneur , Valérie Simon et al.

Cancers, 2022, 14 (12), pp.2981. ⟨10.3390/cancers14122981⟩

Article dans une revue hal-05086826v1
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New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance

Audrey Sirvent , Kevin Espie , Evangelia Papadopoulou , Dana Naim , Serge Roche

Frontiers in Oncology, 2022, 12, pp.956926. ⟨10.3389/fonc.2022.956926⟩

Article dans une revue hal-03830459v1
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SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase

Youcef Ounoughene , Elise Fourgous , Yvan Boublik , Estelle Saland , Nathan Guiraud et al.

Cancers, 2021, 13 (24), pp.6344. ⟨10.3390/cancers13246344⟩

Article dans une revue hal-03515387v1
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Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis

Audrey Sirvent , Rudy Mevizou , Dana Naim , Marie Lafitte , Serge Roche

Cancers, 2020, 12 (8), pp.2014. ⟨10.3390/cancers12082014⟩

Article dans une revue hal-02989641v1
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Collagen Kinase Receptors as Potential Therapeutic Targets in Metastatic Colon Cancer

Marie Lafitte , Audrey Sirvent , Serge Roche

Frontiers in Oncology, 2020, 10, ⟨10.3389/fonc.2020.00125⟩

Article dans une revue hal-02989658v1

Roles of exosomes in metastatic colorectal cancer

Marie Lafitte , Céline Lecointre , Serge Roche

American Journal of Physiology - Cell Physiology, 2019, 317 (5), pp.C869-C880. ⟨10.1152/ajpcell.00218.2019⟩

Article dans une revue hal-02339517v1
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Control of Tyrosine Kinase Signalling by Small Adaptors in Colorectal Cancer

Rudy Mevizou , Audrey Sirvent , Serge Roche

Cancers, 2019, 11 (5), pp.669. ⟨10.3390/cancers11050669⟩

Article dans une revue hal-02339136v1

DDR1 inhibition as a new therapeutic strategy for colorectal cancer

Audrey Sirvent , Marie Lafitte , Serge Roche

Molecular & Cellular Oncology, 2018, 5 (4), ⟨10.1080/23723556.2018.1465882⟩

Article dans une revue hal-01905024v1
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Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer

Maya Jeitany , Cédric Leroy , Priscillia Tosti , Marie Lafitte , Jordy Le Guet et al.

EMBO Molecular Medicine, 2018, 10 (4), pp.e7918. ⟨10.15252/emmm.201707918⟩

Article dans une revue hal-01872978v1
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Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation

Céline Lecointre , Valérie Simon , Clément Kerneur , Frédéric Allemand , Aurélie Fournet et al.

Structure, 2018, 26 (4), pp.545-554.e4. ⟨10.1016/j.str.2018.01.017⟩

Article dans une revue hal-01872982v1

The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases

Miguel Arbesú , Mariano Maffei , Tiago N. Cordeiro , João M.C. Teixeira , Yolanda Pérez et al.

Structure, 2017, 25 (4), pp.630--640.e4. ⟨10.1016/j.str.2017.02.011⟩

Article dans une revue hal-01875247v1

Syntenin mediates SRC function in exosomal cell-to-cell communication

Naga Sailaja Imjeti , Kerstin Menck , Antonio Luis Egea-Jimenez , Céline Lecointre , Frédérique Lembo et al.

Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (47), pp.12495 - 12500. ⟨10.1073/pnas.1713433114⟩

Article dans une revue hal-01765373v1
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The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer

Cécile Naudin , Clément Chevalier , Serge Roche

Oncotarget, 2016, 7, pp.11033-11055. ⟨10.18632/oncotarget.6929⟩

Article dans une revue inserm-01292961v1

Vesicular trafficking regulators are new players in breast cancer progression: Role of TOM1L1 in ERBB2-dependent invasion

Clément Chevalier , Serge Roche , Christine Bénistant

Molecular & Cellular Oncology, 2016, 3 (4), pp.e1182241. ⟨10.1080/23723556.2016.1182241⟩

Article dans une revue hal-01878026v1
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TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

Clément Chevalier , Guillaume Collin , Simon Descamps , Heiani Touaitahuata , Valérie Simon et al.

Nature Communications, 2016, 7 (1), pp.10765. ⟨10.1038/ncomms10765⟩

Article dans une revue hal-01299292v1

YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells

Fanny Dubois , Cédric Leroy , Valérie Simon , Christine Benistant , Serge Roche

American Journal of Cancer Research, 2015, 5 (6), pp.1972--1987

Article dans une revue hal-01883466v1

The SH3 Domain Acts as a Scaffold for the N-Terminal Intrinsically Disordered Regions of c-Src

Mariano Maffei , Miguel Arbesú , Anabel-Lise Le~roux , Irene Amata , Serge Roche et al.

Structure, 2015, 23 (5), pp.893--902. ⟨10.1016/j.str.2015.03.009⟩

Article dans une revue hal-01883500v1

Progastrin a new pro-angiogenic factor in colorectal cancer

S Najib , A Kowalski-Chauvel , C Do , S Roche , E Cohen-Jonathan-Moyal et al.

Oncogene, 2015, 34 (24), pp.3120--3130. ⟨10.1038/onc.2014.255⟩

Article dans une revue hal-01883491v1
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ABL Tyrosine Kinase Inhibition Variable Effects on the Invasive Properties of Different Triple Negative Breast Cancer Cell Lines

Clément Chevalier , Aude Cannet , Simon Descamps , Audrey Sirvent , Valérie Simon et al.

PLoS ONE, 2015, 10 (3), pp.e0118854. ⟨10.1371/journal.pone.0118854⟩

Article dans une revue hal-01883471v1

CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia: CBL controls kinase expression

Romain Gioia , Claire Trégoat , Pierre-Yves Dumas , Valérie Lagarde , Valérie Prouzet-Mauléon et al.

Journal of Pathology, 2015, 237 (1), pp.14--24. ⟨10.1002/path.4561⟩

Article dans une revue istex hal-01883494v1

Contribution of phosphoproteomics in understanding SRC signaling in normal and tumor cells

Audrey Sirvent , Serge Urbach , Serge Roche

Proteomics, 2015, 15 (2-3), pp.232--244. ⟨10.1002/pmic.201400162⟩

Article dans une revue istex hal-01883488v1

SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2

Cécile Naudin , Audrey Sirvent , Cédric Leroy , Romain Larive , Valérie Simon et al.

Nature Communications, 2014, 5, pp.3159. ⟨10.1038/ncomms4159⟩

Article dans une revue hal-01944933v1
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Analyse in vivo de la signalisation tumorale induite par les tyrosinekinases par protéomique quantitative

Audrey Sirvent , Serge Urbach , Serge Roche

Médecine/Sciences, 2014, 30 (5), pp.558--566. ⟨10.1051/medsci/20143005020⟩

Article dans une revue hal-01942937v1

The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors

C Fialin , C Larrue , F Vergez , J Sarry , S Bertoli et al.

Leukemia, 2012, 27 (2), pp.325-335. ⟨10.1038/leu.2012.240⟩

Article dans une revue hal-04784565v1
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Specific Oncogenic Activity of the Src-Family Tyrosine Kinase c-Yes in Colon Carcinoma Cells.

Florence Sancier , Aurélie Dumont , Audrey Sirvent , Ludmilla Paquay de Plater , Thomas Edmonds et al.

PLoS ONE, 2011, 6 (2), pp.e17237. ⟨10.1371/journal.pone.0017237⟩

Article dans une revue hal-00581348v1
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Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization.

Audrey Sirvent , C. Bénistant , Julie Pannequin , L. Veracini , V. Simon et al.

Oncogene, 2010, 29 (9), pp.1303-15. ⟨10.1038/onc.2009.450⟩

Article dans une revue hal-00443776v1
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Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells.

Cédric Leroy , Camille Fialin , Audrey Sirvent , Valérie Simon , Serge Urbach et al.

Cancer Research, 2009, 69 (6), pp.2279-86. ⟨10.1158/0008-5472.CAN-08-2354⟩

Article dans une revue hal-00367875v1

Evidence that Resistance to Nilotinib May Be Due to BCR-ABL, Pgp, or Src Kinase Overexpression

François-Xavier Mahon , Sandrine Hayette , Valérie Lagarde , Francis Belloc , Béatrice Turcq et al.

Cancer Research, 2008, 68 (23), pp.9809-9816. ⟨10.1158/0008-5472.CAN-08-1008⟩

Article dans une revue hal-03155362v1
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Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells.

Audrey Sirvent , Christine Benistant , Serge Roche

Biology of the Cell, 2008, 100 (11), pp.617-31. ⟨10.1042/BC20080020⟩

Article dans une revue hal-00346793v1
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The Src-like adaptor protein regulates PDGF-induced actin dorsal ruffles in a c-Cbl-dependent manner.

Audrey Sirvent , C. Leroy , A. Boureux , V. Simon , Serge Roche

Oncogene, 2008, 27 (24), pp.3494-500. ⟨10.1038/sj.onc.1211011⟩

Article dans une revue hal-00211547v1
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The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1.

Laurence Veracini , Valérie Simon , Véronique Richard , Burkhart Schraven , Vaclav Horejsi et al.

Journal of Cell Biology, 2008, 182 (3), pp.603-14. ⟨10.1083/jcb.200705102⟩

Article dans une revue hal-00348407v1
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The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells.

Audrey Sirvent , A. Boureux , V. Simon , C. Leroy , Serge Roche

Oncogene, 2007, 26 (52), pp.7313-7323. ⟨10.1038/sj.onc.1210543⟩

Article dans une revue hal-00189107v1
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The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities.

Guillaume Collin , Mélanie Franco , Valérie Simon , Christine Bénistant , Serge Roche

Molecular and Cellular Biology, 2007, 27 (21), pp.7631-40. ⟨10.1128/MCB.00543-07⟩

Article dans une revue hal-00189124v1

A Function for Phosphoinositide 3-Kinase β Lipid Products in Coupling βγ to Ras Activation in Response to Lysophosphatidic Acid

Armelle Yart , Serge Roche , Reinhard Wetzker , Muriel Laffargue , Nicholas Tonks et al.

Journal of Biological Chemistry, 2002, 277 (24), pp.21167-21178. ⟨10.1074/jbc.M110411200⟩

Article dans une revue hal-03191860v1

A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor

Armelle Yart , Muriel Laffargue , Patrick Mayeux , Stany Chretien , Christine Pérès et al.

Journal of Biological Chemistry, 2001, 276 (12), pp.8856-8864. ⟨10.1074/jbc.M006966200⟩

Article dans une revue hal-03191837v1

An Epidermal Growth Factor Receptor/Gab1 Signaling Pathway Is Required for Activation of Phosphoinositide 3-Kinase by Lysophosphatidic Acid

Muriel Laffargue , Patrick Raynal , Armelle Yart , Christine Pérès , Bernard Payrastre et al.

Journal of Biological Chemistry, 1999, 274 (46), pp.32835-32841. ⟨10.1074/jbc.274.46.32835⟩

Article dans une revue hal-03192161v1

A Function for Phosphatidylinositol 3-Kinase β (p85α-p110β) in Fibroblasts during Mitogenesis: Requirement for Insulin- and Lysophosphatidic Acid-Mediated Signal Transduction

Serge Roche , J. Downward , Patrick Raynal , Sara Courtneidge

Molecular and Cellular Biology, 1998, 18 (12), pp.7119-7129. ⟨10.1128/MCB.18.12.7119⟩

Article dans une revue hal-03191846v1